Blood-Flow-Restriction-Training-Induced Hormonal Response is not Associated with Gains in Muscle Size and Strength

The aim of this study was to determine whether increases in post-exercise endocrine response to low-load resistance exercise with blood flow restriction and high-load resistance exercise would have association with increases in muscle size and strength after an 8-week training period. Twenty-nine untrained men were randomly allocated into three groups: low-load resistance exercise with (LL-BFR) or without blood flow restriction (LL), and high-load resistance exercise (HL). Participants from LL-BFR and LL groups performed leg extension exercise at 20% of one repetition maximum (1RM), four sets of 15 repetitions and the HL group performed four sets of eight repetitions at 80% 1RM. Before the first training session, growth hormone (GH), insulin-like growth factor 1 (IGF-1), testosterone, cortisol, and lactate concentration were measured at rest and 15 min after the exercise. Quadriceps CSA and 1RM knee extension were assessed at baseline and after an 8-week training period. GH increased 15 min after exercise in the LL-BFR (p = 0.032) and HL (p \u3c 0.001) groups, with GH concentration in the HL group being higher than in the LL group (p = 0.010). There was a time effect for a decrease in testosterone (p = 0.042) and an increase in cortisol (p = 0.005), while IGF-1 remained unchanged (p = 0.346). Both muscle size and strength were increased after training in LL-BFR and HL groups, however, these changes were not associated with the acute post-exercise hormone levels (p \u3e 0.05). Our data suggest that other mechanisms than the acute post-exercise increase in systemic hormones induced by LL-BFR and HL produce changes in muscle size and strength

Rehabilitation with implant-supported overdentures in total edentulous patients: a review

Objectives: The main aim of this review article is to discuss implant-supported overdentures (ISOs) as treatment in edentulous patients. Besides, we will try to discuss among the different treatment options in such patients and to analyze their validity when ISOs are compared with other clinical modalities. At the same time, we will try to suggest clinical guidelines supported by current clinical studies. Material and methods: We performed a Medline search and review of pertinent articles on the mentioned subject from 1986 to 2011. As a searching strategy, we used the following words: implant-supported overdentures, attachment systems, Locator attachment, cantilever, fixed prosthesis. Results and conclusions: Implant-supported overdentures constitute an accurate and predictable treatment option and achieve a higher patient's satisfaction. This type of treatment constitutes a cheaper treatment than fixed prostheses and in some patients, with loss of lip support or with an interoclusal space larger than 15 mm, the choice of implant-supported overdentures seems to prevent future aesthetic or phonetic problems

Effects of different tooth bleaching systems on the roughness and superficial morphology of enamel and a restorative composite resin

Objetivo: Avaliar as alterações de rugosidade e morfologia superficial do esmalte e da resina composta após diferentes técnicas de clareamento dental. Material e método: incisivos bovinos íntegros foram selecionados, sendo que cavidades padronizadas foram confeccionadas na face vestibular, as quais foram restauradas com resina composta. Os dentes foram distribuídos em grupos, de acordo com o tratamento proposto: G1-clareamento com peróxido de carbamida (PC) 10%; G2 - clareamento com peróxido de hidrogênio (PH) a 38%; G3- clareamento com PH a 38% associado à foto-ativação com LED. Para G1, o agente clareador foi aplicado por 8 horas diárias durante 21 dias. Para\ud G2 e G3, foram realizadas 3 sessões de clareamento, caracterizadas por 3 aplicações do gel clareador por 15 minutos, com intervalos de 7 dias entre as sessões, sendo que em G3 o gel clareador foi ativado com LED (470nm) por 6 minutos. As superfícies do esmalte e da resina composta foram avaliadas antes e após o procedimento clareador através de um rugosímetro e de um microscópio de força atômica. Resultados: Os resultados demonstraram diferença significante da rugosidade do esmalte antes e após o clareamento apenas para G1, em relação ao controle (Wilcoxon, p<0,05). Para a resina composta, nenhum dos grupos apresentou diferença estatística em relação ao controle (Mann-Whitney, p>0,05). Conclusão: O aumento da rugosidade do esmalte aconteceu apenas quando o clareamento foi realizado através da aplicação de um gel com 10% de PC. Nenhum dos procedimentos clareadores avaliados nesta pesquisa interferiram na rugosidade e morfologia da resina composta.CNPq (135181/2010-0; 30129/2010-1

Relação entre dinapenia, sarcopenia e mobilidade funcional em idosos frágeis institucionalizados

Introduction: Among the disabling events with advancing age, there is the Frail Elderly Syndrome (FES), resulting in a higher risk of falls, disability, hospitalization and even death. Objective: verify the relationship between dynapenia, sarcopenia and functional mobility of institutionalized frail elderly. Methods: A descriptive correlational study was conducted with 26 institutionalized elderly men and women with average 82,3 ±6 years. All participants had three or more fragile characteristics according to established criteria. Measuring instruments used as inclusion criteria were the Mini Mental State Examination and the Geriatric Depression Scale. As specific instruments were International Physical Activity Questionnaire, Timed Up and Go Test, handgrip dynamometer, handheld dynamometer to assess large muscle groups and the Lee equation to estimate the total muscle mass. Results: Functional mobility correlated significantly only with muscle strength measurements (handgrip r-0,50, upper limbs 0,59, lower limbs r-0.61 and the appendicular muscle strength, considering the four limbs r-0.63). Conclusion: Programs for prevention and treatment of FES depend on accurate clinical diagnosis. The accuracy of the evaluation of muscle strength is essential, and the use of dynamometry can make a decisive contribution for this purposeIntrodução: Dentre os eventos incapacitantes com o avanço da idade, destaca-se a Síndrome da Fragilidade do Idoso (SFI), implicando em maior risco de quedas, incapacidade, hospitalização e até mesmo a morte. Objetivo: verificar a relação entre dinapenia, sarcopenia e mobilidade funcional de idosos frágeis institucionalizados. Material e Métodos: Um estudo descritivo correlacional foi conduzido com 26 idosos institucionalizados de ambos os sexos com idade média de 82,3 ±6 anos. Todos os participantes apresentavam três ou mais características de fragilidade segundo critérios estabelecidos. Os instrumentos de medida utilizados como critérios de inclusão foram o Mini Exame do Estado Mental e a Escala de Depressão Geriátrica. Os instrumentos específicos foram o Questionário Internacional de Atividade Física, Timed Up and Go Test, dinamômetro de preensão manual, dinamômetro portátil para avaliar grandes grupos musculares e a equação de Lee para estimar da massa muscular total. Resultados: A mobilidade funcional correlacionou-se de forma significativa apenas com as medidas de força muscular (preensão manual r-0,50, membros superiores r-0,59, membros inferiores r-0,61 e a força muscular apendicular, considerando os quatro membros r-0,63). Conclusão: Programas de prevenção e tratamento da SFI dependem do preciso diagnóstico clínico. A acurácia da avaliação da força muscular é fundamental, e a utilização da dinamometria pode contribuir de forma decisiva para esta finalidad

Ancient Migratory Events in the Middle East: New Clues from the Y-Chromosome Variation of Modern Iranians

Knowledge of high resolution Y-chromosome haplogroup diversification within Iran provides important geographic context regarding the spread and compartmentalization of male lineages in the Middle East and southwestern Asia. At present, the Iranian population is characterized by an extraordinary mix of different ethnic groups speaking a variety of Indo-Iranian, Semitic and Turkic languages. Despite these features, only few studies have investigated the multiethnic components of the Iranian gene pool. In this survey 938 Iranian male DNAs belonging to 15 ethnic groups from 14 Iranian provinces were analyzed for 84 Y-chromosome biallelic markers and 10 STRs. The results show an autochthonous but non-homogeneous ancient background mainly composed by J2a sub-clades with different external contributions. The phylogeography of the main haplogroups allowed identifying post-glacial and Neolithic expansions toward western Eurasia but also recent movements towards the Iranian region from western Eurasia (R1b-L23), Central Asia (Q-M25), Asia Minor (J2a-M92) and southern Mesopotamia (J1-Page08). In spite of the presence of important geographic barriers (Zagros and Alborz mountain ranges, and the Dasht-e Kavir and Dash-e Lut deserts) which may have limited gene flow, AMOVA analysis revealed that language, in addition to geography, has played an important role in shaping the nowadays Iranian gene pool. Overall, this study provides a portrait of the Y-chromosomal variation in Iran, useful for depicting a more comprehensive history of the peoples of this area as well as for reconstructing ancient migration routes. In addition, our results evidence the important role of the Iranian plateau as source and recipient of gene flow between culturally and genetically distinct population

Mitochondrial echoes of first settlement and genetic continuity in El Salvador

Background: From Paleo-Indian times to recent historical episodes, the Mesoamerican isthmus played an important role in the distribution and patterns of variability all around the double American continent. However, the amount of genetic information currently available on Central American continental populations is very scarce. In order to shed light on the role of Mesoamerica in the peopling of the New World, the present study focuses on the analysis of the mtDNA variation in a population sample from El Salvador. Methodology/Principal Findings: We have carried out DNA sequencing of the entire control region of the mitochondrial DNA (mtDNA) genome in 90 individuals from El Salvador. We have also compiled more than 3,985 control region profiles from the public domain and the literature in order to carry out inter-population comparisons. The results reveal a predominant Native American component in this region: by far, the most prevalent mtDNA haplogroup in this country (at ~90%) is A2, in contrast with other North, Meso- and South American populations. Haplogroup A2 shows a star-like phylogeny and is very diverse with a substantial proportion of mtDNAs (45%; sequence range 16090–16365) still unobserved in other American populations. Two different Bayesian approaches used to estimate admixture proportions in El Salvador shows that the majority of the mtDNAs observed come from North America. A preliminary founder analysis indicates that the settlement of El Salvador occurred about 13,400±5,200 Y.B.P.. The founder age of A2 in El Salvador is close to the overall age of A2 in America, which suggests that the colonization of this region occurred within a few thousand years of the initial expansion into the Americas. Conclusions/Significance: As a whole, the results are compatible with the hypothesis that today's A2 variability in El Salvador represents to a large extent the indigenous component of the region. Concordant with this hypothesis is also the observation of a very limited contribution from European and African women (~5%). This implies that the Atlantic slave trade had a very small demographic impact in El Salvador in contrast to its transformation of the gene pool in neighbouring populations from the Caribbean facade