3,991 research outputs found
TSH-CHECK-1 test: diagnostic accuracy and potential application to initiating treatment for hypothyroidism in patients on anti-tuberculosis drugs.
Thyroid-stimulating hormone (TSH) promotes expression of thyroid hormones which are essential for metabolism, growth, and development. Second-line drugs to treat tuberculosis (TB) can cause hypothyroidism by suppressing thyroid hormone synthesis. Therefore, TSH levels are routinely measured in TB patients receiving second-line drugs, and thyroxin treatment is initiated where indicated. However, standard TSH tests are technically demanding for many low-resource settings where TB is prevalent; a simple and inexpensive test is urgently needed
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A digital long pulse integrator
A prototype digital integrator with very long integration capabilities has been developed and field tested on an inductive magnetic sensor on the DIII-D Tokamak. The integrator is being developed for use on ITER with a pulse length of 1000 s, and has direct applications for other long pulse Tokamaks. Inductive magnetic sensors are routinely used on existing Tokamaks, are well understood, and are extremely robust, however, they require integration of the signal to determine the magnetic field strength. The next generation of Tokamaks, will have pulse lengths of 1000 s or longer, require integrators with drift and noise characteristics compatible with the very long pulse lengths. This paper will discuss the architecture, algorithms, and programming of the Long Pulse Integrator (LPI). Of particular interest are the noise control and the built-in offset correction techniques used in this application
The expression, localisation and interactome of pigeon CRY2
Cryptochromes (CRY) are highly conserved signalling molecules that regulate circadian rhythms and are candidate radical pair based magnetoreceptors. Birds have at least four cryptochromes (CRY1a, CRY1b, CRY2, and CRY4), but few studies have interrogated their function. Here we investigate the expression, localisation and interactome of clCRY2 in the pigeon retina. We report that clCRY2 has two distinct transcript variants, clCRY2a, and a previously unreported splice isoform, clCRY2b which is larger in size. We show that clCRY2a mRNA is expressed in all retinal layers and clCRY2b is enriched in the inner and outer nuclear layer. To define the localisation and interaction network of clCRY2 we generated and validated a monoclonal antibody that detects both clCRY2 isoforms. Immunohistochemical studies revealed that clCRY2a/b is present in all retinal layers and is enriched in the outer limiting membrane and outer plexiform layer. Proteomic analysis showed clCRY2a/b interacts with typical circadian molecules (PER2, CLOCK, ARTNL), cell junction proteins (CTNNA1, CTNNA2) and components associated with the microtubule motor dynein (DYNC1LI2, DCTN1, DCTN2, DCTN3) within the retina. Collectively these data show that clCRY2 is a component of the avian circadian clock and unexpectedly associates with the microtubule cytoskeleton
Chaotic memristor
We suggest and experimentally demonstrate a chaotic memory resistor
(memristor). The core of our approach is to use a resistive system whose
equations of motion for its internal state variables are similar to those
describing a particle in a multi-well potential. Using a memristor emulator,
the chaotic memristor is realized and its chaotic properties are measured. A
Poincar\'{e} plot showing chaos is presented for a simple nonautonomous circuit
involving only a voltage source directly connected in series to a memristor and
a standard resistor. We also explore theoretically some details of this system,
plotting the attractor and calculating Lyapunov exponents. The multi-well
potential used resembles that of many nanoscale memristive devices, suggesting
the possibility of chaotic dynamics in other existing memristive systems.Comment: Applied Physics A (in press
Optical and Infrared Photometry of the Unusual Type Ia Supernova 2000cx
We present optical and infrared photometry of the unusual Type Ia supernova
2000cx. With the data of Li et al. (2001) and Jha (2002), this comprises the
largest dataset ever assembled for a Type Ia SN, more than 600 points in
UBVRIJHK. We confirm the finding of Li et al. regarding the unusually blue B-V
colors as SN 2000cx entered the nebular phase. Its I-band secondary hump was
extremely weak given its B-band decline rate. The V minus near infrared colors
likewise do not match loci based on other slowly declining Type Ia SNe, though
V-K is the least ``abnormal''. In several ways SN 2000cx resembles other slow
decliners, given its B-band decline rate (Delta m_15(B) = 0.93), the appearance
of Fe III lines and weakness of Si II in its pre-maximum spectrum, the V-K
colors and post-maximum V-H colors. If the distance modulus derived from
Surface Brightness Fluctuations of the host galaxy is correct, we find that the
rate of light increase prior to maximum, the characteristics of the bolometric
light curve, and the implied absolute magnitude at maximum are all consistent
with a sub-luminous object with Delta m_15(B) ~ 1.6-1.7 having a higher than
normal kinetic energy.Comment: 46 pages, 17 figures, to be published in Publications of the
Astronomical Society of the Pacifi
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A hybrid digital-analog long pulse integrator
A digital-analog integrator has been developed for use with inductive magnetic sensors in long-pulse tokamaks. Continuous compensation of input offsets is accomplished by alternating analog-to-digital convertor samples from the sensor and a dummy load, while an RC network provides passive integration between samples. Typically a sampling rate of 10 kHz is used. In operational tests on the DIII-D tokamak, digital and analog integration of tokamak data show good agreement. The output drift error during a 1200 s integration interval corresponds to a few percent of the anticipated signal for poloidal field probes in International Thermonuclear Experimental Reactor (ITER), and bench tests suggest that the error can be reduced further
Space-time versus particle-hole symmetry in quantum Enskog equations
The non-local scattering-in and -out integrals of the Enskog equation have
reversed displacements of colliding particles reflecting that the -in and -out
processes are conjugated by the space and time inversions. Generalisations of
the Enskog equation to Fermi liquid systems are hindered by a request of the
particle-hole symmetry which contradicts the reversed displacements. We resolve
this problem with the help of the optical theorem. It is found that space-time
and particle-hole symmetry can only be fulfilled simultaneously for the
Bruckner-type of internal Pauli-blocking while the Feynman-Galitskii form
allows only for particle-hole symmetry but not for space-time symmetry due to a
stimulated emission of Bosons
Three-Dimensional Spectral Classification of Low-Metallicity Stars Using Artificial Neural Networks
We explore the application of artificial neural networks (ANNs) for the
estimation of atmospheric parameters (Teff, logg, and [Fe/H]) for Galactic F-
and G-type stars. The ANNs are fed with medium-resolution (~ 1-2 A) non
flux-calibrated spectroscopic observations. From a sample of 279 stars with
previous high-resolution determinations of metallicity, and a set of (external)
estimates of temperature and surface gravity, our ANNs are able to predict Teff
with an accuracy of ~ 135-150 K over the range 4250 <= Teff <= 6500 K, logg
with an accuracy of ~ 0.25-0.30 dex over the range 1.0 <= logg <= 5.0 dex, and
[Fe/H] with an accuracy ~ 0.15-0.20 dex over the range -4.0 <= [Fe/H] <= +0.3.
Such accuracies are competitive with the results obtained by fine analysis of
high-resolution spectra. It is noteworthy that the ANNs are able to obtain
these results without consideration of photometric information for these stars.
We have also explored the impact of the signal-to-noise ratio (S/N) on the
behavior of ANNs, and conclude that, when analyzed with ANNs trained on spectra
of commensurate S/N, it is possible to extract physical parameter estimates of
similar accuracy with stellar spectra having S/N as low as 13. Taken together,
these results indicate that the ANN approach should be of primary importance
for use in present and future large-scale spectroscopic surveys.Comment: 51 pages, 11 eps figures, uses aastex; to appear in Ap
Quantized charge transport through a static quantum dot using a surface acoustic wave
We present a detailed study of the surface acoustic wave mediated quantized
transport of electrons through a split gate device containing an impurity
potential defined quantum dot within the split gate channel. A new regime of
quantized transport is observed at low RF powers where the surface acoustic
wave amplitude is comparable to the quantum dot charging energy. In this regime
resonant transport through the single-electron dot state occurs which we
interpret as turnstile-like operation in which the traveling wave amplitude
modulates the entrance and exit barriers of the quantum dot in a cyclic fashion
at GHz frequencies. For high RF powers, where the amplitude of the surface
acoustic wave is much larger than the quantum dot energies, the quantized
acoustoelectric current transport shows behavior consistent with previously
reported results. However, in this regime, the number of quantized current
plateaus observed and the plateau widths are determined by the properties of
the quantum dot, demonstrating that the microscopic detail of the potential
landscape in the split gate channel has a profound influence on the quantized
acoustoelectric current transport.Comment: 9 page
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