Helminths in the hygiene hypothesis:Sooner or later?

There is increasing recognition that exposures to infectious agents evoke fundamental effects on the development and behaviour of the immune system. Moreover, where infections (especially parasitic infections) have declined, immune responses appear to be increasingly prone to hyperactivity. For example, epidemiological studies of parasite-endemic areas indicate that prenatal or early-life experience of infections can imprint an individual's immunological reactivity. However, the ability of helminths to dampen pathology in established inflammatory diseases implies that they can have therapeutic effects even if the immune system has developed in a low-infection setting. With recent investigations of how parasites are able to modulate host immune pathology at the level of individual parasite molecules and host cell populations, we are now able to dissect the nature of the host–parasite interaction at both the initiation and recall phases of the immune response. Thus the question remains – is the influence of parasites on immunity one that acts primarily in early life, and at initiation of the immune response, or in adulthood and when recall responses occur? In short, parasite immunosuppression – sooner or later

I wouldn’t mind moving actually: exploring student mobility in Northern Ireland

WOS:000288508300006 (Nº de Acesso Web of Science)This article examines orientations towards future geographical mobility amongst young people in Northern Ireland presently studying at third level educational institutions. Following contextualisation of youth mobility as pertaining to students in this region, the results of recent quantitative and qualitative research are discussed. Over half of these young people, 55 per cent, see themselves living outside Northern Ireland at some point in the future. Furthermore, in response to a number of statements on family relationships, peer associations and community attachments, young people with mobility intentions are found to be more likely to have families who support migration intentions. These potentially mobile young people also tend to have peers and siblings with prior experience of geographical mobility and show signs of being less deeply attached to their local communities and/or local identities. A number of qualitative case studies further illustrate the diversity of mobility orientations within the sample, ranging from those positively predisposed towards migration to those more averse to such movement

STOL aircraft transient ground effects. Part 1: Fundamental analytical study

The first phases of a fundamental analytical study of STOL ground effects were presented. Ground effects were studied in two dimensions to establish the importance of nonlinear effects, to examine transient aspects of ascent and descent near the ground, and to study the modelling of the jet impingement on the ground. Powered lift system effects were treated using the jet-flap analogy. The status of a three-dimensional jet-wing ground effect method was presented. It was shown, for two-dimensional unblown airfoils, that the transient effects are small and are primarily due to airfoil/freestream/ground orientation rather than to unsteady effects. The three-dimensional study showed phenomena similar to the two-dimensional results. For unblown wings, the wing/freestream/ground orientation effects were shown to be of the same order of magnitude as for unblown airfoils. This may be used to study the nonplanar, nonlinear, jet-wing ground effect

Electrical Characterization of PbZr0.4Ti0.6O3 Capacitors

We have conducted a careful study of current-voltage (I-V) characteristics in fully integrated commercial PbZr0.4Ti0.6O3 thin film capacitors with Pt bottom and Ir/IrO2 top electrodes. Highly reproducible steady state I-V were obtained at various temperatures over two decades in voltage from current-time data and analyzed in terms of several common transport models including space charge limited conduction, Schottky thermionic emission under full and partial depletion and Poole-Frenkel conduction, showing that the later is the most plausible leakage mechanism in these high quality films. In addition, ferroelectric hysteresis loops and capacitance-voltage data were obtained over a large range of temperatures and discussed in terms of a modified Landau-Ginzburg-Devonshire theory accounting for space charge effects.Comment: 17 pages, 7 figure

Combinatorics of unique maximal factorization families (UMFFs)

Suppose a set W of strings contains exactly one rotation (cyclic shift) of every primitive string on some alphabet Σ. Then W is a circ-UMFF if and only if every word in Σ+ has a unique maximal factorization over W. The classic circ-UMFF is the set of Lyndon words based on lexicographic ordering (1958). Duval (1983) designed a linear sequential Lyndon factorization algorithm; a corresponding PRAM parallel algorithm was described by J. Daykin, Iliopoulos and Smyth (1994). Daykin and Daykin defined new circ-UMFFs based on various methods for totally ordering sets of strings (2003), and further described the structure of all circ-UMFFs (2008). Here we prove new combinatorial results for circ-UMFFs, and in particular for the case of Lyndon words. We introduce Acrobat and Flight Deck circ-UMFFs, and describe some of our results in terms of dictionaries. Applications of circ-UMFFs pertain to structured methods for concatenating and factoring strings over ordered alphabets, and those of Lyndon words are wide ranging and multidisciplinary

Marginally unstable Holmboe modes

Marginally unstable Holmboe modes for smooth density and velocity profiles are studied. For a large family of flows and stratification that exhibit Holmboe instability, we show that the modes with phase velocity equal to the maximum or the minimum velocity of the shear are marginally unstable. This allows us to determine the critical value of the control parameter R (expressing the ratio of the velocity variation length scale to the density variation length scale) that Holmboe instability appears R=2. We then examine systems for which the parameter R is very close to this critical value. For this case we derive an analytical expression for the dispersion relation of the complex phase speed c(k) in the unstable region. The growth rate and the width of the region of unstable wave numbers has a very strong (exponential) dependence on the deviation of R from the critical value. Two specific examples are examined and the implications of the results are discussed.Comment: Submitted to Physics of Fluid

Phosphorus fertilizer placement and profitability.

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Micronutrient fertilization on a typic acrorthox at Manaus, Brazil.

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Lime and gypsum applications.

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