Evaluation of the Clinimetric Properties of the Upper Limb Subscales of the Motor Assessment Scale Using a Rasch Analysis Model.

OBJECTIVES: To apply Rasch analysis to evaluate the psychometric properties of the composite score of the 3 upper limb subscales of the Motor Assessment Scale (UL-MAS) when administered in the acute/subacute phase post-stroke. DESIGN: Prospective data collection of UL-MAS scores. PARTICIPANTS: Eighty Eighty individuals a mean of 64.8 days (standard deviation 53.3; range 4-193 days) following the onset of unilateral stroke. METHODS: All UL-MAS test items were administered in 30 participants assessed longitudinally over 3 occasions, and in 50 participants assessed on a single occasion. These 140 observations were pooled to be evaluated using Rasch analysis. RESULTS: With the elimination of the wrist radial deviation test item, the UL-MAS demonstrated uni-dimensionality with no significant test item response bias. The test item difficulty hierarchy was validated in the Upper Arm and Hand Movements subscales, but not in the Advanced Hand Activities subscale. The acceptable floor (14%) and ceiling (9%) effects and the high Person Separation Reliability Index (0.96) indicated that the scale was appropriately targeted to discriminate statistically between groups of acute/subacute stroke participants with differing upper limb motor recovery. CONCLUSION: The findings support the psychometric properties of the composite UL-MAS score in this clinical population

Attentional shifting differences in autism: Domain general, domain specific, or both?

Atypical attention is considered to have an important role in the development of autism. Yet, it remains unclear whether these attentional difficulties are specific to the social domain. The study aimed to examine attentional orienting in autistic (A) and non-autistic (NA) adults from and to non-social and social stimuli. We utilized a modified gap-overlap task with schematic images (Experiment 1: A=27, NA=26) and photographs (Experiment 2: A=18, NA=17). Eye-tracking data (i.e., saccadic latencies) were then compared across condition and type of stimulus (social or non-social) using multi-level modelling. Autistic adults exhibited mostly typical gap and overlap effects, as well as a bias towards social stimuli. Yet, autistic participants benefited from exogenous disengagement when orienting to social information more than non-autistic participants. Neither a domain general nor social domain specific account for attentional atypicalities in autism was supported separately. Yet, subtle combined domain differences were revealed in the gap condition

Question your teaspoons : tea-drinking, coping and commercialisation across three planning organisations

Purpose As part of a wider ethnographic project that examines the significance of the public interest across three public and private sector UK planning organisations, this paper uses tea-drinking as a lens to understand structural forces around outsourcing and commercialisation. Reflecting across the five case studies, the analysis supports Burawoy's (2017) recent critique of Desmond's Relational Ethnography (2014). Using Perec's (1997[1973]) notion of the “infra-ordinary” as an anchor, it highlights the insight that arises from an intimate focus on mundane rituals and artefacts. Design/methodology/approach The data were gathered through participant observation, chronicling the researchers' encounters with tea in each of the sites. A respondent-led photography exercise was successful at two sites. Up to 40 days of ethnographic fieldwork were carried out in each site. Findings The tea-drinking narratives, while providing an intact description of discrete case study sites, exist in conversation with each other, providing an opportunity for comparison that informs the analysis and helping us to understand the meaning-making process of the planners both in and across these contexts. Originality/value The paper contributes to critical planning literature (Murphy and Fox-Rogers, 2015; Raco et al., 2016), illuminating structural forces around outsourcing and commercialisation. It also generates methodological reflection on using an everyday activity to probe organisational culture and promote critical reflection on “weighty” issues across study sites

Activity And Localization Of Maltodextrin Binding Site Mutants Of Glycogen Synthase In Saccharomyces Cerevisiae

Mentor: Wayne A. WilsonGlycogen is a glucose polymer formed by the enzyme glycogen synthase and is used in many organisms to store chemical energy. Saccharomyces cerevisiae (baker’s yeast) was used to study the activity and localization of glycogen synthase. Genes GSY1 and GSY2 encode glycogen synthase. GSY2 is responsible for the formation of Gsy2p, whose action accounts for ~90% of glycogen synthase activity; the remainder of total glycogen synthase activity stems from Gsy1p. Because glycogen synthase binds to glycogen, it can be used to determine glycogen localization. Glycogen synthase can appear in distinct patterns throughout the cell. Gsy2p has been shown to be regulated by phosphorylation. Phosphorylation of Gsy2p leads to inactivation of the enzyme, a decrease in glycogen storage, and a more localized pattern of glycogen synthase. Conversely, lowering the phosphorylation state of Gsy2p results in increased glycogen production and delocalization of glycogen synthase throughout the cell. Glucose-6-P (glucose-6-phosphate) activates glycogen synthase regardless of its phosphorylation state. We obtained a set of plasmids from a collaborator, encoding Gsy2p mutated at sites believed to be involved with maltodextrin binding. Maltodextrin is a chain of 20 or fewer dextrose molecules with α (1→4) glycosidic bonds. A protein sequence involved in maltodextrin binding likely would also bind to glycogen. Our task was to discover the localization pattern shown by the maltodextrin binding site mutants of glycogen synthase using a GFP tag on GSY2. The goal of this study was to determine the 16 effects of Gsy2p maltodextrin binding mutants on glycogen synthase activity, localization, and glycogen accumulation

Atropine-resistant bradycardia due to hyperkalaemia

Symptomatic sinus bradycardia is routinely treated in the emergency department with atropine and pacing. Two cases are presented that illustrate the importance of considering hyperkalaemia, particularly in the presence of atropine-resistant symptomatic bradycardia. The administration of calcium in such cases acts to stabilise the myocardium and resolve the bradycardia. Blood gas analysis provides a rapid estimate of serum potassium concentrations, facilitating timely treatment

Inclined to see it your way: do altercentric intrusion effects in visual perspective taking reflect an intrinsically social process?

It has been suggested that some aspects of mental state understanding recruit a rudimentary, but fast and efficient, processing system, demonstrated by the obligatory slowing down of judgements about what the self can see when this is incongruent with what another can see. We tested the social nature of this system by investigating to what extent these altercentric intrusions are elicited under conditions that differed in their social relevance and, further, how these related to self-reported social perspective taking and empathy (Davis, 1983). In Experiment 1, adult participants were asked to make ‘self’ or ‘other’ perspective-taking judgements during congruent (‘self’ and ‘other’ can see the same items) or incongruent conditions (‘self’ and ‘other’ cannot see the same items) in conditions that were social (i.e., involving a social agent), semi-social (an arrow) or non-social (a dual-coloured block). Reaction time indices of altercentric intrusion effects were present across all conditions, but were significantly stronger for the social compared to the less social conditions. Self-reported perspective taking and empathy correlated with altercentric intrusion effects in the social condition only. In Experiment 2, the significant correlations for the social condition were replicated, but this time with gaze duration indices of altercentric intrusion effects. Findings are discussed with regard to the degree to which this rudimentary system is socially specialized and how it is linked to more conceptual understanding

Uncertainty in the availability of natural resources: Fossil fuels, critical metals and biomass

Energy policies are strongly influenced by resource availability and recoverability estimates. Yet these estimates are often highly uncertain, frequently incommensurable, and regularly contested. This paper explores how the uncertainties surrounding estimates of the availability of fossil fuels, biomass and critical metals are conceptualised and communicated. The contention is that a better understanding of the uncertainties surrounding resource estimates for both conventional and renewable energy resources can contribute to more effective policy decision making in the long term. Two complementary approaches for framing uncertainty are considered in detail: a descriptive typology of uncertainties and a framework that conceptualises uncertainty as alternative states of incomplete knowledge. Both have the potential to be useful analytical and communication tools. For the three resource types considered here we find that data limitations, inconsistent definitions and the use of incommensurable methodologies present a pervasive problem that impedes comparison. Many aspects of resource uncertainty are also not commonly captured in the conventional resource classification schemes. This highlights the need for considerable care when developing and comparing aggregate resource estimates and when using these to inform strategic energy policy decisions