Self-determination of youth and traditional moral values: the role of Russian literature

The article aims to prove the assumption that along with the known approaches to encouraging cultural diversity in education (critical, pluralistic, acculturation), a new methodological approach should be defined – that of forming the culturally-oriented world-view on the basis of personal self-determination in the traditional moral values, as represented in the national culture. The authors present their own definition of traditional moral values and analyse the way they are reflected in the classical Russian literature. The authors present the results of a field study designed to determine whether this reflective tradition is followed or interrupted in the modern Russian prose in the end of ХХth – beginning of XXIst centuries

ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling

Whereas genomic aberrations in the SLIT-ROBO pathway are frequent in pancreatic ductal adenocarcinoma (PDAC), their function in the pancreas is unclear. Here we report that in pancreatitis and PDAC mouse models, epithelial Robo2 expression is lost while Robo1 expression becomes most prominent in the stroma. Cell cultures of mice with loss of epithelial Robo2 (Pdx1 ;Robo2 ) show increased activation of Robo1 myofibroblasts and induction of TGF-β and Wnt pathways. During pancreatitis, Pdx1 ;Robo2 mice present enhanced myofibroblast activation, collagen crosslinking, T-cell infiltration and tumorigenic immune markers. The TGF-β inhibitor galunisertib suppresses these effects. In PDAC patients, ROBO2 expression is overall low while ROBO1 is variably expressed in epithelium and high in stroma. ROBO2 ;ROBO1 patients present the poorest survival. In conclusion, Robo2 acts non-autonomously as a stroma suppressor gene by restraining myofibroblast activation and T-cell infiltration. ROBO1/2 expression in PDAC patients may guide therapy with TGF-β inhibitors or other stroma /immune modulating agents

Self-determination of youth and traditional moral values: the role of Russian literature

The article aims to prove the assumption that along with the known approaches to encouraging cultural diversity in education (critical, pluralistic, acculturation), a new methodological approach should be defined – that of forming the culturally-oriented world-view on the basis of personal self-determination in the traditional moral values, as represented in the national culture. The authors present their own definition of traditional moral values and analyse the way they are reflected in the classical Russian literature. The authors present the results of a field study designed to determine whether this reflective tradition is followed or interrupted in the modern Russian prose in the end of ХХth – beginning of XXIst centuries