Advances in Real-Time Database Systems Research Special Section on RTDBS of ACM SIGMOD Record 25(1), March 1996.

A Real-Time DataBase System (RTDBS) can be viewed as an amalgamation of a conventional DataBase Management System (DBMS) and a real-time system. Like a DBMS, it has to process transactions and guarantee ACID database properties. Furthermore, it has to operate in real-time, satisfying time constraints imposed on transaction commitments. A RTDBS may exist as a stand-alone system or as an embedded component in a larger multidatabase system. The publication in 1988 of a special issue of ACM SIGMOD Record on Real-Time DataBases signaled the birth of the RTDBS research area -- an area that brings together researchers from both the database and real-time systems communities. Today, almost eight years later, I am pleased to present in this special section of ACM SIGMOD Record a review of recent advances in RTDBS research. There were 18 submissions to this special section, of which eight papers were selected for inclusion to provide the readers of ACM SIGMOD Record with an overview of current and future research directions within the RTDBS community. In this paper [below], I summarize these directions and provide the reader with pointers to other publications for further information. -Azer Bestavros, Guest Edito

Integrating Temporal, Real-Time, and Active Databases

To meet the needs of many real-world control applications, concepts from Temporal, Real-Time, and Active Databases must be integrated: ffl Since the system's data is supposedto reflect the environment being controlled, they must be updated frequently to maintain temporal validity; ffl Many activities, including those that perform the updates, work under time constraints; ffl The occurrence of events, for example, emergency events, trigger actions. In these systems, meeting timeliness, predictability, and QoS guarantee requirements -- through appropriate resource and overload management -- become very important. So, algorithms and protocols for concurrency control, recovery, and scheduling are needed. These algorithms must exploit semantics of the data and the transactions to be responsive and efficient. Whereas time cognizant scheduling,concurrency control and conflict resolution have been studied in the literature, recovery issues have not. We have developed strategies for data pl..

Plasma CXCL8 and MCP-1 as surrogate plasma biomarkers of latent tuberculosis infection among household contacts-A cross-sectional study

Early detection of latent tuberculosis infection (LTBI) is critical to TB elimination in the current WHO vision of End Tuberculosis Strategy. The study investigates whether detecting plasma cytokines could aid in diagnosing LTBI across household contacts (HHCs) positive for IGRA, HHCs negative for IGRA, and healthy controls. The plasma cytokines were measured using a commercial Bio-Plex Pro Human Cytokine 17-plex assay. Increased plasma CXCL8 and decreased MCP-1, TNF-a, and IFN-? were associated with LTBI. Regression analysis showed that a combination of CXCL8 and MCP-1 increased the risk of LTBI among HHCs to 14-fold. Our study suggests that CXCL-8 and MCP-1 could serve as the surrogate biomarkers of LTBI, particularly in resource-limited settings. Further laboratory investigations are warranted before extrapolating CXCL8 and MCP-1 for their usefulness as surrogate biomarkers of LTBI in resource-limited settings