ОСОБЛИВОСТІ ПРОВЕДЕННЯ БАГАТООБ’ЄКТНИХ СУДОВО-ПОЧЕРКОЗНАВЧИХ ЕКСПЕРТИЗ

The specifics of multiobject forensic handwriting examination is considered. Urgency of their performing and the importance for making decisions on the case are underlined. Attention is drawn to the solution of specific problems that require different approaches, depending on the nature of research objects. Multistage character of research on a multitude of handwriting objects is singled out and features of a separate stage, namely preliminary research are considered. Importance of this stage for the further research planning, selection of the corresponding separate techniques by expert, construction of expert versions is revealed. It is pointed out that methods of performing multiobject handwriting examination at the stage of preliminary research has features that distinguish it from other handwriting methods. Issues related to familiarization with the submitted materials, verification of comparability of samples and establishment of comparative material sufficiency are touched upon. Importance of resolving the issue regarding the need to send an application by a expert is noted. Also, the completion of the preliminary research stage by the formulation of general and private versions per se of the tasks assigned to expert is noted. Recently expert practice requires from experts not only to update methodological approaches in solving handwriting tasks when granting a large number of objects, but also to improve methods of performing relevant research. Above mentioned sequence of research stages can be one of the types of guarantee for full and comprehensive objective research on a large number of objects, an serve the basis for a correct expert decision. Consideration of the issues of features on the stage of preliminary research in carrying out a multiobject handwriting examination is important for handwriting experts, both beginners and with great experience.Рассмотрена специфика многообъектной судебно-почерковедческой экспертизы. Подчеркнута актуальность их проведения и значение для принятия решений по делу. Обращено внимание на решение конкретных задач, которые требуют разных подходов, в зависимости от характера объектов исследования. Выделен многоступенчатый характер исследования множества почерковых объектов и рассмотрены особенности отдельной стадии – предварительного исследования. Раскрыта важность проведения этого этапа для дальнейшего планирования исследования, выбора экспертом соответствующих отдельных методик, построения экспертных версий. Указано, что методика проведения многообъектных почерковедеских экспертиз уже на стадии предварительного исследования имеет особенности, которые отличают ее от других почерковедческих методик. Затронуты вопросы, касающиеся ознакомления с представленными материалами, проверки сопоставимости образцов и установления достаточности сравнительного материала. Отмечена важность решения вопроса о необходимости направления ходатайства экспертом, а также завершения этапа предварительного исследования формулированием общих и частных версий по сути поставленных эксперту задач. Экспертная практика в последнее время требует от экспертов не только обновления методических подходов к решению почерковедческих задач при предоставлении большого количества объектов, но и усовершенствования методов проведения соответствующих исследований. Приведенная последовательность этапов исследования может быть одним из видов гарантии полного и всестороннего объективного проведения исследования большого количества объектов, служить почвой для принятия правильного экспертного решения. Рассмотрение вопросов особенностей стадии предварительного исследования при проведении многообъектной почерковедческой экспертизы имеет важное значение для экспертов-почерковедов как начинающих, так и с большим опытом работы.Розглянуто специфіку багатооб’єктної судово-почеркознавчої експертизи та особливості її окремої стадії – попереднього дослідження. Наведена послідовність етапів дослідження може бути одним із видів гарантії повного й усебічного об’єктивного проведення дослідження значної кількості об’єктів, слугувати підґрунтям для прийняття вірного експертного рішення

Prospects of combined antihypertensive-psychocorrective therapy in women with arterial hypertension and anxiety-depressive disorders: clinical randomized placebo uncontrolled trial

Background. Anxiety-depressive disorders (ADD) afflict almost half of patients with arterial hypertension (AH). AH aggravation by psychoemotional disorders causes a more severe illness and rapid target organ injury, particularly, the increased arterial stiffness and central aortic pressure (CAP). However, the prospects of combined antihypertensive-antidepressant treatments in AH-ADD patients remain largely unexplored.Objectives. The effect assessment in combined antihypertensive-psychocorrective therapy on circadian blood pressure (BP), vascular stiffness and CAP, anxiety and depression in women with AH and ADD.Methods. The study enrolled 60 AH-ADD women randomised between two cohorts. Cohort 1 received a fixed combination of valsartan and hydrochlorothiazide, bisoprolol and sertraline antidepressant; cohort 2 only had same combined AH therapy. Past 24 weeks of trial, all patients had a general clinical examination and daily blood pressure monitoring (DBPM) with BpLab Vasotens (Petr Telegin Ltd., Russia) and control of daily BP, CAP and vascular stiffness. The psychometric HADS and CES-D scales were used along with psychiatric counselling.Results. Past four weeks of treatment, the target blood pressure (TBP) was revealed in 60 and 36.7% patients, and in 90 and 66.6% — past eight weeks in cohorts 1 and 2, respectively. Cohort 1 vs. 2 required a lower valsartan dose to attain TBP. Past six months, both cohorts showed improved main DBPM values reflecting vascular stiffness and CAP. However, a statistical decrease in nocturnal central and peripheral BP, as well as improved BP variability and vascular stiffness were registered at antidepressant use. A normalised daily BP profile was significantly more frequent in cohort 1. In addition, sertraline had a significant ADD-reductive impact.Conclusion. An antidepressant-combined conventional AH therapy in AH-ADD women facilitated a faster TBP achievement at lower AH agent doses and the significantly improved DBPM (nocturnal specifically), arterial stiffness and CAP values. A sertraline treatment improved the psychoemotional patient state

РЕСУРС ТЕПЛОВОЗНЫХ ДИЗЕЛЕЙ: РЕТРОСПЕКТИВНЫЙ АНАЛИЗ

This is the final part of the review article (for the first part see World of Transport and Transportation, 2014, Vol.12, Iss. 6, pp.212–221) showing that diesel engines of the first post-war II generation were characterized by inherent structural deficiencies of new developments, unfinished ideas. The results of studies carried out in that period are considered, technical solutions taken at that time are critically analyzed, including those that aimed at addressing identified problems. The analysis allowed the authors, in particular, to draw conclusions that for this generation of diesel engines brands of used metals, wear resistance and fatigue strength of cast iron, features of bearing fillets, cylinder block group, the quality of welded joints had the fundamental importance. As follows from the obtained data, engine components are not equal in their impact on engine reliability and working life, form their levels of importance, have their own «place» in the design of the engine structure as a system.В публикуемой обзорной статье (начало см.: «МТ», 2014, № 6) показано, что для тепловозных дизелей первого послевоенного поколения были характерны свойственные новым разработкам конструкционные недостатки, незавершенные идеи. Рассмотрены результаты исследований, выполненных в тот период, проанализированы с критических позиций принятые в то время технические решения, в том числе нацеленные и на устранение выявленных проблем. Анализ позволил, в частности, сделать выводы о том, что для дизелей этого поколения принципиально важными являлись марки применяемых металлов, износостойкость и усталостная прочность чугуна, особенности галтелей коленчатого вала, элементов блока цилиндров, качество сварных соединений.

РЕСУРС ТЕПЛОВОЗНЫХ ДИЗЕЛЕЙ: РЕТРОСПЕКТИВНЫЙ АНАЛИЗ

This published review article shows that diesel engines of the first post World II generation were characterized by inherent structural deficiencies of new developments, unfinished ideas. The results of studies carried out in that period are considered, technical solutions taken at that time are critically analyzed, including those that aimed at addressing identified problems. The analysis allowed the authors, in particular, to draw conclusions that there were brands of used metals, wear resistance and fatigue strength of cast iron, features of bearing fillets, cylinder block group, the quality of welded joints that had fundamental importance for that generation of diesel engines. As follows from the obtained data, engine components are not equivalent in their impact on its reliability and working life, form a certain hierachy as for their importance for design of the engine structure as a system.В публикуемой обзорной статье показано, что для тепловозных дизелей первого послевоенного поколения были характерны свойственные новым разработкам конструкционные недостатки, незавершенные идеи. Рассмотрены результаты исследований, выполненных в тот период, проанализированы с критических позиций принятые в то время технические решения, в том числе нацеленные и на устранение выявленных проблем. Как вытекает из полученных данных, узлы двигателя неравнозначны по влиянию на его безотказность и ресурс, образуют свои уровни по значимости, «месту» в конструкции дизеля как системы

Charged current events with neutral strange particles in high-energy antineutrino interactions

The results of a study of strange particle production in charged current interactions in the Fermilab 15 ft bubble chamber filled with a heavy Ne---H2 mixture are presented. Production rates and average multiplicities of K0's and [Lambda]'s as functions of W2 and Q2 are given. The experimental data agree well with the quark-parton model predictions if a yield of 0.06 +/- 0.02 of K0's and [Lambda]'s from charm production is included. Upper limits for D-meson production are given and the shape of the charmed quark fragmentation function is discussed. Inclusive production of the K*(890) and [Sigma](1385) resonances is measured and it is shown that only about 5% of the K0 mesons and [Lambda] hyperons results from resonance decays. Relative production rates of neutral strange particles on proton and neutron targets are studied.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/24478/1/0000753.pd

Cryogenic controls for Fermilab's SRF cavities and test facility

A new superconducting radio frequency (SRF) cavities test facility is now operational at Fermilab's Meson Detector Building (MDB). The facility is supplied cryogens from the Cryogenic Test Facility (CTF) located in a separate building 500-m away. The design incorporates ambient temperature pumping for super-fluid helium production, as well as three 0.6-kW at 4.5-K refrigerators, five screw compressors, a helium purifier, helium and nitrogen inventory, cryogenic distribution system, and a variety of test cryostats. To control and monitor the vastly distributed cryogenic system, a flexible scheme has been developed. Both commercial and experimental physics tools are used. APACS+{trademark}, a process automation control system from Siemens-Moore, is at the heart of the design. APACS+{trademark} allows engineers to configure an ever evolving test facility while maintaining control over the plant and distribution system. APACS+{trademark} nodes at CTF and MDB are coupled by a fiber optic network. DirectLogic205 PLC's by KOYO{reg_sign} are used as the field level interface to most I/O. The top layer of this system uses EPICS (Experimental Physics and Industrial Control System) as a SCADA/HMI. Utilities for graphical display, control loop setting, real time/historical plotting and alarming have been implemented by using the world-wide library of applications for EPICS. OPC client/server technology is used to bridge across each different platform. This paper presents this design and its successful implementation

The A‐dependenc of ψ production in π− nucleus collisions at 530 GeV/c

The E672/E706 Spectrometer, located in the MW beam at Fermilab, was used to collect data on events containing a pair of muons in the final state with large effective mass. The momentum of incident pions and protons was 530 GeV/c. Nuclear targets included Be, C, Al, Cu and Pb. We report on a preliminary measurement of the A‐dependence of the per nucleus cross section for forward J/ψ production. The apparatus also detected charged particles and γ’s produced in association with the muon pair. The expected physics results on the hadroproduction of χ states and beauty particles are discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87663/2/624_1.pd

Azolo[1,5-a]pyrimidines and Their Condensed Analogs with Anticoagulant Activity

Hypercytokinemia, or cytokine storm, is one of the severe complications of viral and bacterial infections, involving the release of abnormal amounts of cytokines, resulting in a massive inflammatory response. Cytokine storm is associated with COVID-19 and sepsis high mortality rate by developing epithelial dysfunction and coagulopathy, leading to thromboembolism and multiple organ dysfunction syndrome. Anticoagulant therapy is an important tactic to prevent thrombosis in sepsis and COVID-19, but recent data show the incompatibility of modern direct oral anticoagulants and antiviral agents. It seems relevant to develop dual-action drugs with antiviral and anticoagulant properties. At the same time, it was shown that azolo[1,5-a]pyrimidines are heterocycles with a broad spectrum of antiviral activity. We have synthesized a new family of azolo[1,5-a]pyrimidines and their condensed polycyclic analogs by cyclocondensation reactions and direct CH-functionalization and studied their anticoagulant properties. Five compounds among 1,2,4-triazolo[1,5-a]pyrimidin-7-ones and 5-alkyl-1,3,4-thiadiazolo[3,2-a]purin-8-ones demonstrated higher anticoagulant activity than the reference drug, dabigatran etexilate. Antithrombin activity of most active compounds was confirmed using lipopolysaccharide (LPS)-treated blood to mimic the conditions of cytokine release syndrome. The studied compounds affected only the thrombin time value, reliably increasing it 6.5–15.2 times as compared to LPS-treated blood. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.Funding: This research was funded within the framework of the grant agreement as government subsidies from the federal budget in accordance with paragraph 4 of article 78.1 of the Budget Code of the Russian Federation (Moscow, 1 October 2020, No. 075-15-2020-777)

GEANT4 : a simulation toolkit

Abstract Geant4 is a toolkit for simulating the passage of particles through matter. It includes a complete range of functionality including tracking, geometry, physics models and hits. The physics processes offered cover a comprehensive range, including electromagnetic, hadronic and optical processes, a large set of long-lived particles, materials and elements, over a wide energy range starting, in some cases, from 250 eV and extending in others to the TeV energy range. It has been designed and constructed to expose the physics models utilised, to handle complex geometries, and to enable its easy adaptation for optimal use in different sets of applications. The toolkit is the result of a worldwide collaboration of physicists and software engineers. It has been created exploiting software engineering and object-oriented technology and implemented in the C++ programming language. It has been used in applications in particle physics, nuclear physics, accelerator design, space engineering and medical physics. PACS: 07.05.Tp; 13; 2