Calculating the 3D magnetic field of ITER for European TBM studies

The magnetic perturbation due to the ferromagnetic test blanket modules (TBMs) may deteriorate fast ion confinement in ITER. This effect must be quantified by numerical studies in 3D. We have implemented a combined finite element method (FEM) -- Biot-Savart law integrator method (BSLIM) to calculate the ITER 3D magnetic field and vector potential in detail. Unavoidable geometry simplifications changed the mass of the TBMs and ferritic inserts (FIs) up to 26%. This has been compensated for by modifying the nonlinear ferromagnetic material properties accordingly. Despite the simplifications, the computation geometry and the calculated fields are highly detailed. The combination of careful FEM mesh design and using BSLIM enables the use of the fields unsmoothed for particle orbit-following simulations. The magnetic field was found to agree with earlier calculations and revealed finer details. The vector potential is intended to serve as input for plasma shielding calculations.Comment: In proceedings of the 28th Symposium on Fusion Technolog

Decomposition products of oxygen scavengers and their effect on corrosion of steam generator materials – I. Diethyl-hydroxylamine and carbohydrazide

Hydrazine used as oxygen scavenger in the secondary circuit of pressurized water reactors is hazardous to the environment and potentially carcinogenic, thus, suitable replacement chemicals for it are actively sought. In the present paper, decomposition products of two potential replacements – carbohydrazide and diethyl-hydroxylamine – are analyzed, and their effect on secondary water chemistry and corrosion of the main steam generator materials – carbon steel 22 K, stainless steel 0X18H10T and Alloy 690 – is studied by in-situ electrochemical techniques complemented by ex-situ analyses of the formed oxides by spectroscopic and microscopic methods. Quantitative interpretation of the electrochemical impedance data with the Mixed-Conduction Model allowed for the estimation of oxidation and corrosion release rates depending on scavenger formulation, alloy type and temperature. Conclusions on the extent of interaction of decomposition products with construction materials are drawn based on the experimental and calculational results.<br/

Fractionation in young cores: Direct determinations of nitrogen and carbon fractionation in HCN

We aim to determine the $^{14}$N/$^{15}$N and $^{12}$C/$^{13}$C ratios for HCN in six starless and prestellar cores and compare the results between the direct method using radiative transfer modeling and the indirect double isotope method assuming a fixed $^{12}$C/$^{13}$C ratio. We present IRAM 30m observations of the HCN 1-0, HCN 3-2, HC15N 1-0 and H13CN 1-0 transitions toward six embedded cores. The ${}^{14}$N/${}^{15}$N ratio was derived using both the indirect double isotope method and directly through non-local thermodynamic equilibrium (NLTE) 1D radiative transfer modeling of the HCN emission. The latter also provides the ${}^{12}$C/${}^{13}$C ratio, which we compared to the local interstellar value. The derived ${}^{14}$N/${}^{15}$N ratios using the indirect method are generally in the range of 300-550. This result could suggest an evolutionary trend in the nitrogen fractionation of HCN between starless cores and later stages of the star formation process. However, the direct method reveals lower fractionation ratios of around $\sim$250, mainly resulting from a lower ${}^{12}$C/${}^{13}$C ratio in the range $\sim$20-40, as compared to the local interstellar medium value of 68. This study reveals a significant difference between the nitrogen fractionation ratio in HCN derived using direct and indirect methods. This can influence the interpretation of the chemical evolution and reveal the pitfalls of the indirect double isotope method for fractionation studies. However, the direct method is challenging, as it requires well-constrained source models to produce accurate results. No trend in the nitrogen fractionation of HCN between earlier and later stages of the star formation process is evident when the results of the direct method are considered.Comment: Accepted for publication in A&

Similar levels of deuteration in the pre-stellar core L1544 and the protostellar core HH211

In the centre of pre-stellar cores, deuterium fractionation is enhanced due to the low temperatures and high densities. Therefore, the chemistry of deuterated molecules can be used to study the earliest stages of star formation. We analyse the deuterium fractionation of simple molecules, comparing the level of deuteration in the envelopes of the pre-stellar core L1544 in Taurus and the protostellar core HH211 in Perseus. We used single-dish observations of CCH, HCN, HNC, HCO$^+$, and their $^{13}$C-, $^{18}$O- and D-bearing isotopologues, detected with the Onsala 20m telescope. We derived the column densities and the deuterium fractions of the molecules. Additionally, we used radiative transfer simulations and results from chemical modelling to reproduce the observed molecular lines. We used new collisional rate coefficients for HNC, HN$^{13}$C, DNC, and DCN that consider the hyperfine structure of these molecules. We find high levels of deuteration for CCH (10%) in both sources, consistent with other carbon chains, and moderate levels for HCN (5-7%) and HNC (8%). The deuterium fraction of HCO$^+$ is enhanced towards HH211, most likely caused by isotope-selective photodissociation of C$^{18}$O. Similar levels of deuteration show that the process is likely equally efficient towards both cores, suggesting that the protostellar envelope still retains the chemical composition of the original pre-stellar core. The fact that the two cores are embedded in different molecular clouds also suggests that environmental conditions do not have a significant effect on the deuteration within dense cores. Radiative transfer modelling shows that it is necessary to include the outer layers of the cores to consider the effects of extended structures. Besides HCO$^+$ observations, HCN observations towards L1544 also require the presence of an outer diffuse layer where the molecules are relatively abundant.Comment: 27 pages, 17 figures, accepted for publication in A&

Body Weight, Physical Activity, and Risk of Cancer in Lynch Syndrome

Lynch syndrome (LS) increases cancer risk. There is considerable individual variation in LS cancer occurrence, which may be moderated by lifestyle factors, such as body weight and physical activity (PA). The potential associations of lifestyle and cancer risk in LS are understudied. We conducted a retrospective study with cancer register data to investigate associations between body weight, PA, and cancer risk among Finnish LS carriers. The participants (n = 465, 54% women) self-reported their adulthood body weight and PA at 10-year intervals. Overall cancer risk and colorectal cancer (CRC) risk was analyzed separately for men and women with respect to longitudinal and near-term changes in body weight and PA using extended Cox regression models. The longitudinal weight change was associated with an increased risk of all cancers (HR 1.02, 95% CI 1.00–1.04) and CRC (HR 1.03, 1.01–1.05) in men. The near-term weight change was associated with a lower CRC risk in women (HR 0.96, 0.92–0.99). Furthermore, 77.6% of the participants retained their PA category over time. Men in the high-activity group had a reduced longitudinal cancer risk of 63% (HR 0.37, 0.15–0.98) compared to men in the low-activity group. PA in adulthood was not associated with cancer risk among women. These results emphasize the role of weight maintenance and high-intensity PA throughout the lifespan in cancer prevention, particularly in men with LS

Body Weight, Physical Activity, and Risk of Cancer in Lynch Syndrome

Lynch syndrome (LS) increases cancer risk. There is considerable individual variation in LS cancer occurrence, which may be moderated by lifestyle factors, such as body weight and physical activity (PA). The potential associations of lifestyle and cancer risk in LS are understudied. We conducted a retrospective study with cancer register data to investigate associations between body weight, PA, and cancer risk among Finnish LS carriers. The participants (n = 465, 54% women) self-reported their adulthood body weight and PA at 10-year intervals. Overall cancer risk and colorectal cancer (CRC) risk was analyzed separately for men and women with respect to longitudinal and near-term changes in body weight and PA using extended Cox regression models. The longitudinal weight change was associated with an increased risk of all cancers (HR 1.02, 95% CI 1.00–1.04) and CRC (HR 1.03, 1.01–1.05) in men. The near-term weight change was associated with a lower CRC risk in women (HR 0.96, 0.92–0.99). Furthermore, 77.6% of the participants retained their PA category over time. Men in the high-activity group had a reduced longitudinal cancer risk of 63% (HR 0.37, 0.15–0.98) compared to men in the low-activity group. PA in adulthood was not associated with cancer risk among women. These results emphasize the role of weight maintenance and high-intensity PA throughout the lifespan in cancer prevention, particularly in men with LS

Deuterium fractionation in cold dense cores in the low-mass star forming region L1688

In this work, we study deuterium fractionation in four starless cores in the low-mass star-forming region L1688 in the Ophiuchus molecular cloud. We study how the deuterium fraction ($R_D$) changes with environment, compare deuteration of ions and neutrals, core centre and its envelope, and attempt to reproduce the observed results with a gas-grain chemical model. We chose high and low gas density tracers to study both core centre and the envelope. With the IRAM 30m antenna, we mapped N$_2$H$^+$(1-0), N$_2$D$^+$(1-0), H$^{13}$CO$^+$ (1-0) and (2-1), DCO$^+$(2-1), and $p$-NH$_2$D(1$_{11}$-1$_{01}$) towards the chosen cores. The missing $p$-NH$_3$ and N$_2$H$^+$(1-0) data were taken from the literature. To measure the molecular hydrogen column density, dust and gas temperature within the cores, we used the Herschel/SPIRE dust continuum emission data, the GAS survey data (ammonia), and the COMPLETE survey data to estimate the upper limit on CO depletion. We present the deuterium fraction maps for three species towards four starless cores. Deuterium fraction of the core envelopes traced by DCO$^+$/H$^{13}$CO$^+$ is one order of magnitude lower ($\sim$0.08) than that of the core central parts traced by the nitrogen-bearing species ($\sim$0.5). Deuterium fraction increases with the gas density as indicated by high deuterium fraction of high gas density tracers and low deuterium fraction of lower gas density tracers and by the decrease of $R_D$ with core radii, consistent with the predictions of the chemical model. Our model results show a good agreement with observations for $R_D$(N$_2$D$^+$/N$_2$H$^+$) and R$_D$(DCO$^+$/HCO$^+$) and underestimate the $R_D$(NH$_2$D/NH$_3$).Comment: 30 pages with 22 figures, accepted for publication in MNRA

Menopause and adipose tissue : miR-19a-3p is sensitive to hormonal replacement

Tissue-specific effects of 17 beta-estradiol are delivered via both estrogen receptors and microRNAs (miRs). Menopause is known to affect the whole-body fat distribution in women. This investigation aimed at identifying menopause-and hormone replacement therapy (HRT)-associated miR profiles and miR targets in subcutaneous abdominal adipose tissue and serum from the same women. A discovery phase using array technology was performed in 13 women, including monozygotic twin pairs discordant for HRT and premenopausal young controls. Seven miRs, expressed in both adipose tissue and serum, were selected for validation phase in 34 women from a different cohort. An age/menopause-related increase of miRs-16-5p, -451a, -223-3p, -18a-5p, -19a-3p,-486-5p and -363-3p was found in the adipose tissue, but not in serum. MiR-19a-3p, involved in adipocyte development and estrogen signaling, resulted to be higher in HRT users in comparison with non-users. Among the identified targets, AKT1, BCL-2 and BRAF proteins showed lower expression in both HRT and No HRT users in comparison with premenopausal women. Unexpectedly, ESR1 protein expression was not modified although its mRNA was lower in No HRT users compared to premenopausal women and HRT users. Thus, both HRT and menopause appear to affect adipose tissue homeostasis via miR-mediated mechanism.Peer reviewe