304 research outputs found

    Kryptovaluuttojen käyttö ja tulevaisuus

    Get PDF
    Kryptovaluutat ovat uusi ilmiö rahayhteiskunnassamme. Maailma hiljalleen siirtyy käteisestä digitaaliseen rahaan, ja seuraavaksi tulevaisuuden ilmiöksi povataan kryptovaluuttojen laaja-alaista hyväksyntää muun muassa maksuvälineinä yhteiskunnan keskuudessa niiden helppouden, nopeuden ja puolueettomuuden vuoksi. Tämän opinnäytetyön tavoitteena on tutkia kryptovaluuttoja, ja niiden tulevaisuutta yhteiskunnassa. Opinnäytetyössä tarkastellaan mitä raha ja kryptovaluutat ovat, kryptovaluuttojen roolia tulevaisuuden yhteiskunnassa maksuvälineenä, lohkoketjuteknologiaa, ja vertaillaan eri kryptovaluuttoja toisiinsa. Tutkimus on rajattu viiteen eri kryptovaluuttaan ja yksityishenkilöille suunnattuun kyselyyn. Tavoitteena vertailussa on tutkia viittä eri kryptovaluuttaa teknologian, päämäärän, käytettävyyden ja tulevaisuuden näkymien näkökulmasta. Vertailun tutkimuksen kohteena ovat: Bitcoin, Ethereum, Monero, Ripple ja ChainLink. Kyselyssä on keskitytty kohderyhmän sijoituskäyttäytymiseen, ja ajatuksiin ja mietteisiin koskien kryptovaluuttoja ja niiden tulevaisuutta. Opinnäytetyö on laadullinen, sillä tutkimuksessa on käytetty kvalitatiivista tutkimusmenetelmää. Tutkimus on toteutettu vertailu- ja kyselytutkimuksella. Aineiston analysointi menetelminä on käytetty sisältöanalyysiä ja etnografiaa. Sisältöanalyysiä on käytetty työn empiirisessä osassa ja vertailututkimuksessa. Etnografiaa on käytetty työn kyselytutkimuksessa, jossa on tarkoituksena selvittää kyselyyn vastanneiden henkilöiden näkökulmia ja ajatuksia kryptovaluutoista. Vertailututkimuksen tulokseksi saatiin, että vertaillut kryptovaluutat eroavat toisistaan todella paljon valittujen ominaisuuksien puolesta ja kryptovaluuttojen tulevaisuuden kannalta, vain kryptovaluutat joilla todetaan olevan käyttötarkoitus ja päämäärä tulevat selviämään ja olemaan mahdollisesti laaja-alaisessa käytössä tulevaisuudessa. Kyselytutkimuksen tulokseksi saatiin, että kyselyyn vastanneet henkilöt ovat positiivisia kryptovaluuttojen tulevaisuuden kannalta, mutta he odottavat vielä niiden laaja-alaista käyttö ja hyväksyntää maailmalla sekä kokevat tarpeelliseksi kryptovaluutoille regulaation lisäämistä ja laillistamista muun muassa maksuvälineinä

    Guided by Light, Inhabiting the Horizontal

    Get PDF
    Given, a box, to be transformed into a dwelling

    Expanding the role of design: developing holistic food systems

    Get PDF
    Post World War II, technological and political factors prioritized economic efficiency in food production, distribution and access. Although this currently delivers benefits such as the doubling of caloric production and food availability despite geographic constraints, the food system is becoming implicated both directly and indirectly with a host of environmental and social issues. This thesis re-frames food system issues as wicked problems (Buchanan, 1992, 15) and develops a framework of design tactics . The framework is used as a matrix for analyzing past and current theory and practice based design approaches that engage the food system and two university food systems. The analysis reveals the practical potential in design tactics for creating incremental shifts towards holistic food systems that are economically viable and have environmental and social components, thereby addressing contemporary food system issues

    Tailoring a Social Needs Assessment Tool for an Urban Latino Population

    Get PDF
    Tailoring a Social Needs Assessment Tool for an Urban Latino Population Jasmine K. Singh1 Beth A. Careyva, M.D.1,2 1Department of Family Medicine, Lehigh Valley Health Network 2Research Scholar Program Mentor Abstract Introduction: Patient Reported Outcome (PRO) measures are methods for patients to report on their health-related quality of life. The purpose of this study is to adapt a social needs assessment tool, Beacon Patient Reported Outcome Quality of Life (PROQOL), to identify and address unfulfilled social needs in the Lehigh Valley Health Network (LVHN) patient population. Approximately 40% of health outcomes are due to unmet social needs, therefore the identification of such needs by Beacon PROQOL can enable providers to better meet both the social and medical demands of their patients. Specific Aims: This study aims to develop a list of priority social need domains and to generate a collection of appropriate images to represent the identified social need domains. This information will be used to adapt or create a new social needs assessment tool tailored to the unique social needs of the LVHN patient population. Methods: In Phase 1, four focus groups of 42 participants were conducted in order to assess social needs and current utilization of community resources in the LVHN population. In Phase 2, 18 focus groups divided by ethnicity, preferred language, and age will be administered in order to assess patient impression of the text and icons of the Beacon PROQOL tool and to compile a list of priority social need domains with corresponding icons. Results: Phase 1 identified a diverse group of unmet social needs including transportation, food and nutrition, affording medications, access to health insurance, opportunities for recreation, financial support, access to healthcare, and access to mental health and addiction services. After identifying the barriers that seem to be limiting patient ability to maintain health, participants identified existing resources, gaps/barriers within resources, and ideas/opportunities that may serve as potential modes to surmount the named social barriers. The barriers with fewer corresponding resources may represent priority social areas with greatest need. Discussion: In 4 focus groups of 42 participants in Phase 1, there were a diverse group of unmet social needs identified in the community. While the groups were able to articulate more resources for some barriers than others, there are still many resources not named by participants. This indicates that a comprehensive and accessible database of resources per geographic area, such as the one currently used by the Children’s Hospital of Philadelphia, would better enable patients to locate the necessary resources to surmount barriers that limit their access to health care. Now that we have an understanding of some of the areas of need, we will do a more in depth evaluation of the specific priority areas during Phase 2. The ultimate goal is to use all of this exploratory information to adapt or develop a new tool to be systematically incorporated into an adaptation of the Health Leads (HL) model developed by the Boston Medical Center. Further study will assess how many social needs, once identified, were addressed, as well as the impact of this intervention on overall health, quality of life, and cost of care. Keywords Health information technology, social needs, patient-reported outcomes, health disparities Introduction Patient Reported Outcome (PRO) measures are methods for patients to report on their health-related quality of life.[i] These tools serve to improve the quality of healthcare by allowing providers to respond to patient identified needs. With the shift to patient-centered approaches in health care represented by the Patient Centered Outcomes Research Institute (PCORI) and the ease of access to technological tools (such as iPads, web-based tools, and kiosks), PRO measure implementation is more feasible than ever before.[ii] The purpose of this study is to adapt a social needs assessment tool, Beacon Patient Reported Outcome Quality of Life (PROQOL), to discern unfulfilled social needs in the Lehigh Valley Health Network (LVHN) patient population. Beacon PROQOL (see Figure 1 in appendix) is a computerized interactive survey tool, previously developed by the Mayo Clinic, which serves to collect PRO data in 9 priority areas. Originally, Beacon PROQOL was designed for patients with diabetes[iii]; thus, a goal of this study is to expand the use of the tool to effectively assess a wide range of social needs across a diverse patient population. According to Marshall et. al (2006), a multi-dimensional PRO tool, such as the one being developed by the expansion of Beacon PROQOL, is necessary for the desired shift to patient-centered care.[iv] Approximately 40% of health outcomes are due to unmet social needs[v], therefore the identification of such needs by Beacon PROQOL can enable providers to better meet both the social and medical demands of their patients. The desired outcomes of this project are to develop a list of the critical social needs of our community and to determine relevant images to represent the social needs identified. This data can then be utilized in order to adapt Beacon PROQOL to the social needs of our community. Furthermore, this will allow for the generation of social prescriptions in order to compile a list of potential resources to address the identified unmet need that is unique to the Lehigh Valley. Ideally, adaptation of Beacon PROQOL to identify the social needs of the LVHN patient population will lead to the development of a model that resembles the Health Leads (HL) model established by the Boston Medical Center in 1996. The HL model serves to address patients’ unmet social needs by a systematic approach. In this model, the patient completes a pre-visit screening survey to assess their unique social needs; based on needs revealed by this survey, the patient is referred to HL where undergraduate volunteers then work to connect patients with community-based resources in an effort to improve patient outcomes.[vi] In order to eventually replicate this model, it is the goal of this study to adapt Beacon PROQOL to accurately identify the social needs unique to the LVHN patient population for use as the pre-visit screening survey mentioned in the HL model. Specific Aims As shown in Table 1 (see appendix), the three main goals of this study are to determine the priority social need domains, to identify images to represent these social need domains, and to use this data to adapt Beacon PROQOL to address the unique needs of the LVHN patient population. Methods After IRB approval, the scope of the social needs of the LVHN patient population was evaluated by the administration of four focus groups of 42 participants during Phase 1 of this study (see Figure 2 in appendix). Two of these groups were conducted in English, while the other two groups were held in Spanish. The ethnicities, ages, and genders of the groups were mixed; however, patients below age 18 were excluded from the study. Focus groups were recorded and transcribed. After obtainment of informed consent, patient demographic information and patient perception of priority social needs in the community were acquired. Qualitative analysis was performed to identify key themes for the responses on experiences with and preferences for community resources. Responses were grouped according to the corresponding existing resources, gaps/barriers, and ideas/opportunities for each social need identified (i.e. transportation, access to nutritious food, etc.). The purpose of Phase 2 of this study is to qualitatively assess patient perception of Beacon PROQOL as a tool to identify the priority social needs of patients in our unique community and to obtain patient opinions on the most recognizable icons to represent these social need domains. Identifying appropriate images with the social need domains will be critical for those with low literacy. These goals will be accomplished through the administration of eighteen focus groups, described in Table 2. As shown, focus groups will be divided by ethnicity, preferred language, and age. There will be six Hispanic – English speaking focus groups, six Hispanic – Spanish speaking focus groups, and six Non-Hispanic – English speaking focus groups. Each category of focus groups, just described, will have two groups in each of the following age categories: 18-34, 35-64, 65 and over. The reason for the division of groups by age is the thought that older patients will be less comfortable with use of iPads than younger individuals. In addition, the priority social needs of patients may differ with age; older patients are more likely to be plagued with chronic illnesses, while younger patients may have concerns related to the workforce or their families. After attainment of informed consent, focus group participants will be given iPads prepared with the Beacon PROQOL tool. After being given time to explore the program, they will be asked questions to evaluate their impressions of the texts and graphics of the tool. Focus group participants will also be shown a packet of images that correspond to social need domains in order to evaluate which icons are most representative for each domain, in addition to the icons currently being used within the PROQOL tool. Furthermore, they will be asked to rank their top three priority social need domains and preferences for icons. Focus group participants will be remunerated with a $25 Wawa gift card. Mixed methods data from these focus groups will be analyzed with descriptive statistics for the ranked social need areas and icons and with qualitative analysis for the contextual themes. Data obtained from these focus groups will be analyzed qualitatively to compile a final list of social need domains and corresponding icons. Phase 2 of this study is currently in the patient enrollment stage, with focus groups anticipated to begin in early August. Results The results of Phase 1 can be represented as a list of priority social barriers for which there is a need in our community, as well as existing community resources that are available to assist patients in overcoming these barriers. The priority social need areas identified by 42 participants in 4 focus groups were transportation, food and nutrition, affording medications, access to health insurance, opportunities for recreation, financial support, access to healthcare, and access to mental health and addiction services. After identifying the barriers that seem to be limiting patient ability to maintain health, participants identified existing resources within the community that may serve as potential modes to surmount the gaps and barriers that they identified. Additionally, participants generated new ideas and opportunities that may serve to bridge the gaps they identified. In Figure 3 (see appendix), the identified barriers and their corresponding resources are shown. The barriers with fewer corresponding resources may represent priority social areas with greatest need. As evident in Figure 3 (see appendix), three of the main priority social need areas identified were financial support, affording medications, and health insurance. These barriers are identified as priority areas because they have fewer corresponding resources that allow community members to overcome these gaps. For example, only three resources were listed to aid patients in gaining financial support, they are: LVHN Reduced Cost Care (RCC) Plan, Financial Assistance Program (welfare), and shelters. However, even these resources did not entirely seem to address the problem of financial support as many patients expressed the sentiment that they are “not poor enough, but…not able to afford it.” Focus group participants thought that the establishment of a resource to instruct people on how to budget their money or the sharing of time frames of re-certifications for welfare and RCC might be alternative methods to surmount the barrier of financial support. Poor access to medications was another barrier identified for which participants could only report five existing community resources: lower cost prescriptions at Walmart, Giant, and Wegmans, home delivery services/90 day prescriptions, free samples, discount cards, and the Lehigh Drug Store (One Pharmacy). Several patients explained that purchasing their medication often requires a sacrifice of other necessities, such as food. This often results in what physicians perceive as patient non-compliance to their medication schedule. As one patient explained: “Instead of it [medication] lasting thirty days, I’d try to make it last sixty so that I can afford my medication.” Focus group participants believed that incorporation of prescription coverage into LVHN’s RCC program would improve the ability of many patients to afford their medications. Finally, a lack of health insurance was also identified as a barrier to access to healthcare in the LVHN patient population. Resources identified by focus group participants were government health plans, services to provide assistance in selecting an insurance product, Medicare, APPRISE volunteers, AARP, and Main Street Financial Partners. Despite these available resources, the focus groups still revealed an uninsured population without access to care. For example, as one participant shared: “It’s been ten years since he’s been to a doctor for a check up. Look how old he is, and that is all due to the lack of resources.” The focus group participants expressed no ideas on how their access to health insurance could be improved. Discussion The purpose of this research project is to adapt Beacon PROQOL, a social needs assessment tool, to the unique social needs of the LVHN patient population. In four focus groups of 42 participants there were a diverse group of unmet social needs identified in the community. A list of eight priority social needs was compiled from the Phase 1 focus groups. Of the identified barriers, financial support, affording medications, and access to health insurance were identified as potentially having the greatest need due to the deficiency of existing community resources that serve to relieve obstacles created by such barriers. While the groups were able to articulate more resources for some barriers than others, there were still several gaps in needed resources, as well as ideas for future opportunities to better serve the community. For this reason, the gaps in resources revealed by this data can be used to develop and expand on the resources available to help patients overcome the identified barriers. However, it is important to note that there are many more resources available that were not named by participants. This indicates that a comprehensive and accessible database of resources per geographic area, such as the one currently used by the Children’s Hospital of Philadelphia, would better enable patients to locate the necessary resources to surmount barriers that limit their access to health care.[vii] Overall, the preliminary feedback gathered from the first set of focus groups identified social needs in the community, including some of the needs that are presently listed on the PROQOL tool. Now that we have a better understanding of some of the areas for need in our patient population, we will do a more in depth evaluation of the specific priority areas in subsequent phases of the study. The goal of Phase 2 is to affirm the social need areas identified in the Phase 1 focus groups across diverse age groups and ethnicities to ensure a comprehensive list of high priority social needs. Additionally, Phase 2 aims to assess patient preferences for the text and graphics of Beacon PROQOL in order to effectively remodel the tool. In recognition of low literacy and low health literacy in this population, images that correspond to the needs will be evaluated to see which are most recognizable in our community. A challenge to data collection that may propagate through Phases 1 and 2 of this study is determent from the primary research question within focus groups. That is, due to the utilization of focus groups to assess patient priority social need areas, a potential challenge to data accumulation is the difficulty of maintaining participant focus on the primary research topic.[viii] This challenge may limit the amount of valuable data obtained from the focus groups. The ultimate goal is to use all of this exploratory information to allow for the adaptation or development of a social needs assessment tool (during Phase 3) to be systematically incorporated at the point of care in order to identify and address unmet social needs by connecting each unmet social need to a list of possible resources. Therefore, the implementation of Phase 4 will result in a replication of the HL model. Further study will assess how many social needs, once identified, were addressed, as well as the impact of this intervention on overall health, quality of life, and cost of care. Acknowledgements I would like to acknowledge all of the people who supported and mentored me throughout my experience in LVHN’s Summer Research Scholar Program. Thank you to Dr. Careyva, the primary investigator for this study, for mentoring and guiding me throughout my summer experience. In addition, thank you to all of the research team members who continue to work on this project: Cathy Coyne, PhD; Melanie Johnson, MPA; Kyle Shaak, BS; Brian Stello, MD; and Tim Friel, MD. I would also like to acknowledge the Anne and Carl Anderson Trust for funding this study. Thank you, also, to Dr. Huang for coordinating the Summer Research Scholar Program and to Senior Medical Librarian, Kristine Petre, for her assistance in source identification. Appendix: Figures: Figure 1: The Beacon Patient Reported Outcome Quality of Life (PROQOL) interface. Figure 2: Proposed plan for ongoing study utilizing local medical and community resources. Figure 3: The barriers and number of corresponding community resources identified in Phase 1 focus groups. Tables: Table 1: Specific Aims and Outcomes Specific Aims Outcomes AIM 1: Assess patient priority areas via focus groups to determine preferences for social need domains within our population A list of the priority social need domains with contextual themes AIM 2: Evaluate images for social need domains via focus groups A collection of appropriate images to represent the identified social need domains with contextual themes AIM 3: Adapt a social needs assessment tool based on patient preferences for domains, subdomains, and images Adapted social needs assessment tool with patient preferences from our community Table 1: The specific aims and outcomes of the study. Table 2: Focus Group Composition Ethnicity Preferred Language Age 18-34 35-64 65+ Hispanic English 2 groups 2 groups 2 groups Spanish 2 groups 2 groups 2 groups Non-Hispanic English 2 groups 2 groups 2 groups Table 2: Composition of Phase 2 focus groups. References: [i] Black, N. (2013). Patient reported outcome measures could help transform healthcare. BMJ, 346, f167. [ii] Hostetter, M., & Klein, S. (2012). Using patient-reported outcomes to improve health care quality. Quality Matters, The Commonwealth Fund. [iii] Ridgeway, J. L., Beebe, T. J., Chute, C. G., Eton, D. T., Hart, L. A., Frost, M. H., ... & Sloan, J. A. (2013). A brief Patient-Reported Outcomes Quality of Life (PROQOL) instrument to improve patient care. [iv] Marshall, S., Haywood, K., & Fitzpatrick, R. (2006). Impact of patient‐reported outcome measures on routine practice: a structured review. Journal of evaluation in clinical practice, 12(5), 559-568. [v] Booske, B. C., Athens, J. K., Kindig, D. A., Park, H., & Remington, P. L. (2010). Different perspectives for assigning weights to determinants of health. University of Wisconsin Population Health Institute Web site. [vi] Garg, A., Marino, M., Vikani, A. R., & Solomon, B. S. (2012). Addressing Families’ Unmet Social Needs Within Pediatric Primary Care The Health Leads Model. Clinical pediatrics, 51(12), 1191-1193. [vii] CHOP Community Resource Database. Retrieved July 27, 2015, from http://www.chop.edu/health-resources/chop-community-resourcedatabase#.VbZ RMnhbk20 [viii] Staniszewska, S., Haywood, K. L., Brett, J., & Tutton, L. (2012). Patient and public involvement in patient-reported outcome measures. The Patient-Patient-Centered Outcomes Research, 5(2), 79-87

    Columbus Museum of Industrial and Design Objects

    Get PDF
    The Columbus Museum of Industrial + Design Objects offers a range of experiences between individual and collective spaces. Individual spaces, which evoke a self-contained atmosphere, offer an intimate dialogue with light, shadow, and designed objects. And collective spaces, that facilitate a more interactive experience with the objects and other users

    Extensive muscle spasms after unprovoked dog bite: Is it rabies?

    Get PDF
    We report a 7-year-old incompletely immunized male child who presented with intermittent dyspnea, fever, and extensive muscle spasms following an alleged history of unprovoked Category III dog bite 20 days back with inadequate post-exposure prophylaxis. This case highlights the importance of detailed clinical evaluation including minor signs such as trismus, persistent tetanic muscle contraction in intervening period between muscle spasms and preservation of normal sensorium in the absence of aerophagia and hydrophobia in ruling out a possible diagnosis of rabies in this child, and establishment of diagnosis of less sinister treatable disease with better prognosis

    The inhibitory effect of newly synthesized guar, chitosan and cellulose resins on the growth of pathogenic bacteria

    Get PDF
    Guar, Chitosan and Cellulose based new chelating ionexchangeresins were synthesized. The inhibitory activity of Chitosan triazine phenyl alanine hydroxamate [CT-PAH],Guar-triazine phenyl alanine hydroxamate [GT-PAH], Celluloseepoxy leucine hydroxamate [CE-LH] and Cellulose epoxy histidine hydroxamate [CE-HH], against growth ofEscherichia coli, Staphylococcus aureus, Klebsiella pnemoniaeand Pseudomonas aeruginosa was evaluated.These newly synthesized resins were characterized byFT-IR, elemental analysis, NMR and Mass-spectra. Otherresin characteristics like bulk density, moisture content,ion-exchange capacity, bulk volume and pH titrations werealso studied. The antibacterial activity was carried out usingagar disk diffusion method in which CT-PAH and CELHshowed bigger zones of inhibition than GT-PAH andCE-HH. The results revealed that newly synthesized CTPAHand CE-LH can be used as anti-microbial agents forpreservation and safety of edibles or eatables

    Role of senescence and mitotic catastrophe in cancer therapy

    Get PDF
    Senescence and mitotic catastrophe (MC) are two distinct crucial non-apoptotic mechanisms, often triggered in cancer cells and tissues in response to anti-cancer drugs. Chemotherapeuticals and myriad other factors induce cell eradication via these routes. While senescence drives the cells to a state of quiescence, MC drives the cells towards death during the course of mitosis. The senescent phenotype distinguishes tumor cells that survived drug exposure but lost the ability to form colonies from those that recover and proliferate after treatment. Although senescent cells do not proliferate, they are metabolically active and may secrete proteins with potential tumor-promoting activities. The other anti-proliferative response of tumor cells is MC that is a form of cell death that results from abnormal mitosis and leads to the formation of interphase cells with multiple micronuclei. Different classes of cytotoxic agents induce MC, but the pathways of abnormal mitosis differ depending on the nature of the inducer and the status of cell-cycle checkpoints. In this review, we compare the two pathways and mention that they are activated to curb the growth of tumors. Altogether, we have highlighted the possibilities of the use of senescence targeting drugs, mitotic kinases and anti-mitotic agents in fabricating novel strategies in cancer control

    ISOLATION, CHARACTERIZATION, AND ANTIMICROBIAL ACTIVITY OF ACTINOMYCETES ISOLATED FROM GARDEN SOIL

    Get PDF
    Five different strains of Actinomycetes were isolated from rhizosphere soil sample taken from Tulsi gardens of Kayathar, Tuticorin District. Heat treated Tulsi growing rhizosphere soil samples (Kayathar, Tuticorin District) were subjected to serial dilution and plated on starch casein medium, incubated at 37 °C for 7 - 14 days. The isolated strains were subjected to morphological, biochemical and cultural characterisation to study their spore morphology, asexual reproductive spores, substrate mycelial growth and enzyme degradation. Tests were performed as per International Streptomyces Project (ISP). Morphological and cultural characteristics showed that the strains AJ1, AJ2, AJ3, AJ4 and AJ5 belonged to the genus Actinomycete. The cultures showed substrate and aerial mycelial growth and also soluble pigments. Based on their morphology the isolates were subjected to antimicrobial activity against pathogens. Antimicrobial activity was performed against seven clinical isolates. AJ1 was found to show maximum activity against Klebsiella, S.typhi and Enterobacter whereas AJ5 was found to show inhibitory activity against Klebsiella
    corecore