The value of coronary artery calcium score in the early diagnosis of coronary artery disease in patients with stable chronic obstructive pulmonary disease

Context view, showing the west elevation of Red Square; The trapezoidal building features an interesting combination of elements of Russian medieval architecture and a steel framework and glass roof, a similar style to the great Victorian train stations of London. Each arcade is on three levels, linked by walkways of reinforced concrete. Shukhov was the inventor of a new family of doubly-curved structural forms. These forms, based on non-Euclidean hyperbolic geometry, are known today as hyperboloids of revolution. Shukhov developed not only many varieties of light-weight hyperboloid towers and roof systems, but also the mathematics for their analysis. It is still open today, and is a popular tourist destination for those visiting Moscow. Source: Wikipedia; http://en.wikipedia.org/wiki/Main_Page (accessed 6/22/2009

The importance of the neutrophil-to-lymphocyte ratio in patients with hypertrophic cardiomyopathy

Introduction: Previous studies have demonstrated the predictive value of the neutrophil-to-lymphocyte ratio (NLR) in many cardiovascular disorders. The aim of this study was to assess whether NLR is associated with echocardiographic or electrocardiographic parameters, or with predicted five-year risk of sudden cardiac death (SCD), in patients with hypertrophic cardiomyopathy (HCM)

Heart rate variability improvement in children using transcatheter atrial septal defect closure

Objective: We evaluated autonomic behavior by examining heart rate variability (HRV) in the time domain and frequency domain in pediatric patients who underwent transcatheter closure of atrial septal defect (ASD)

Heart rate variability improvement in children using transcatheter atrial septal defect closure

Objective: We evaluated autonomic behavior by examining heart rate variability (HRV) in the time domain and frequency domain in pediatric patients who underwent transcatheter closure of atrial septal defect (ASD)

Is the Glu298Asp polymorphism of Endothelial Nitric Oxide Synthesis Increase the Risk of Stent Thrombosis ?

29th Turkish Cardiology Congress of the Turkish-Society-of-Cardiology (TSC) with International Participation -- OCT 26-29, 2013 -- Antalya, TURKEYWOS: 000329858401024…Turkish Soc Cardio

Favipiravir pharmacokinetics in COVID-19 patients with moderate to severe kidney dysfunction:Lessons learned

Objective: There is limited information on favipiravir pharmacokinetics in critically ill patients and no studies on pharmacokinetics in patients with moderate and severe kidney dysfunction. The aim was to determine favipiravir pharmacokinetics (oral, 1,600 mg, q12h on day 1, then 600 mg, q12h for 4 days) in critically ill COVID-19 patients with kidney dysfunction and to compare those with observations reported in healthy adults. Materials and methods: In a descriptive study, blood samples taken from patients meeting the relevant criteria (estimated glomerular filtration rate &lt; 60 mL/ min) were collected and analyzed. Analysis of blood samples was done by high performance liquid chromatography (HPLC), and the maximal concentration (C max), the time of maximal concentration (t max), half-life (T 1/2) and area under the curve (AUC 0–12h) of favipiravir were calculated (WinNonlin) and compared to reported data in healthy subjects after first administration. Results: Based on analysis of samples collected in 7 patients, the C max (29.99 vs. 64.5 µg/mL) of favipiravir was decreased, T 1/2 (5.8 vs. 4.8 hours) longer, t max delayed, while total exposure was lower (AUC 0–12: 192.53 vs. 446.09 μg/ mL) compared to reported data in healthy subjects after first administration. Exposure remained lower up to day 5. Conclusion: In patients with kidney dysfunction related to COVID-19, favipiravir did not reach the expected exposure. This may be due to poorer and delayed absorption, and subsequent altered disposition. Population pharmacokinetic and mechanistic studies are needed to better explore the relevant covariates and to determine the optimal dose in these patients, as this drug is likely of relevance for other indications.</p

Assessment of the association between the presence of fragmented QRS and the predicted risk score of sudden cardiac death at 5 years in patients with hypertrophic cardiomyopathy

Objective: It has been shown that the presence of fragmented QRS (fQRS) is associated with poor prognosis in many cardiovascular diseases and in patients with hypertrophic cardiomyopathy (HCM). However, no study has shown an association with the absolute risk score of sudden cardiac death. The aim of this study was to determine the relationship between QRS and the predicted risk score of sudden cardiac death at 5 years (HCM Risk-SCD) in HCM patients

Predictive values of D-dimer assay, GRACE scores and TIMI scores for adverse outcome in patients with non-ST-segment elevation myocardial infarction

Ozyilmaz, Sinem/0000-0003-4829-8400WOS: 000397951200001PubMed: 28408834Purpose: To determine the predictive values of D-dimer assay, Global Registry of Acute Coronary Events (GRACE) and Thrombolysis in Myocardial Infarction (TIMI) risk scores for adverse outcome in patients with non-ST-segment elevation myocardial infarction (NSTEMI). Patients and methods: A total of 234 patients (mean age: 57.2 +/- 11.7 years, 75.2% were males) hospitalized with NSTEMI were included. Data on D-dimer assay, GRACE and TIMI risk scores were recorded. Logistic regression analysis was conducted to determine the risk factors predicting increased mortality. Results: Median D-dimer levels were 349.5 (48.0-7,210.0) ng/mL, the average TIMI score was 3.2 +/- 1.2 and the GRACE score was 90.4 +/- 27.6 with high GRACE scores (>118) in 17.5% of patients. The GRACE score was correlated positively with both the D-dimer assay (r= 0.215, P= 0.01) and TIMI scores (r= 0.504, P= 0.000). Multivariate logistic regression analysis revealed that higher creatinine levels (odds ratio = 18.465, 95% confidence interval: 1.059-322.084, P= 0.046) constituted the only significant predictor of increased mortality risk with no predictive values for age, D-dimer assay, ejection fraction, glucose, hemoglobin A1c, sodium, albumin or total cholesterol levels for mortality. Conclusion: Serum creatinine levels constituted the sole independent determinant of mortality risk, with no significant values for D-dimer assay, GRACE or TIMI scores for predicting the risk of mortality in NSTEMI patients