WHO global research priorities for antimicrobial resistance in human health

The WHO research agenda for antimicrobial resistance (AMR) in human health has identified 40 research priorities to be addressed by the year 2030. These priorities focus on bacterial and fungal pathogens of crucial importance in addressing AMR, including drug-resistant pathogens causing tuberculosis. These research priorities encompass the entire people-centred journey, covering prevention, diagnosis, and treatment of antimicrobial-resistant infections, in addition to addressing the overarching knowledge gaps in AMR epidemiology, burden and drivers, policies and regulations, and awareness and education. The research priorities were identified through a multistage process, starting with a comprehensive scoping review of knowledge gaps, with expert inputs gathered through a survey and open call. The priority setting involved a rigorous modified Child Health and Nutrition Research Initiative approach, ensuring global representation and applicability of the findings. The ultimate goal of this research agenda is to encourage research and investment in the generation of evidence to better understand AMR dynamics and facilitate policy translation for reducing the burden and consequences of AMR

Round Table Club, Wyoming, Delaware

Real photo postcard depicting view of club building

Round Table Club, Wyoming, Delaware

Real photo postcard depicting view of club building

Round Table Club, Wyoming, Delaware

Real photo postcard depicting view of club building

Search for excited quarks in the gamma plus jet final state in proton-proton collisions at root s=8 TeV

A search for excited quarks decaying into the gamma + jet final state is presented. The analysis is based on data corresponding to an integrated luminosity of 19.7 fb(-1) collected by the CMS experiment in proton-proton collisions at root s = 8 TeV at the LHC. Events with photons and jets with high transverse momenta are selected and the gamma + jet invariant mass distribution is studied to search for a resonance peak. The 95% confidence level upper limits on the product of cross section and branching fraction are evaluated as a function of the excited quark mass. Limits on excited quarks are presented as a function of their mass and coupling strength; masses below 3.5 TeV are excluded at 95% confidence level for unit couplings to their standard model partners

Constraints on the Higgs boson width from off-shell production and decay to Z-boson pairs

Constraints are presented on the total width of the recently discovered Higgs boson, Gamma(H), using its relative on-shell and off-shell production and decay rates to a pair of Z bosons, where one Z boson decays to an electron or muon pair, and the other to an electron, muon, or neutrino pair. The analysis is based on the data collected by the CMS experiment at the LHC in 2011 and 2012, corresponding to integrated luminosities of 5.1 fb(-1) at a center-of-mass energy root s = 7 TeV and 19.7 fb(-1) at root s = 8 TeV. A simultaneous maximum likelihood fit to the measured kinematic distributions near the resonance peak and above the Z-boson pair production threshold leads to an upper limit on the Higgs boson width of Gamma(H) < 22 MeV at a 95% confidence level, which is 5.4 times the expected value in the standard model at the measured mass of m(H) = 125.6 GeV

Search for top-squark pairs decaying into Higgs or Z bosons in pp collisions at root s=8 TeV

A search for supersymmetry through the direct pair production of top squarks, with Higgs (H) or Z bosons in the decay chain, is performed using a data sample of proton-proton collisions at root s = 8 TeVcollected in 2012 with the CMS detector at the LHC. The sample corresponds to an integrated luminosity of 19.5 fb(-1). The search is performed using a selection of events containing leptons and bottom-quark jets. No evidence for a significant excess of events over the standard model background prediction is observed. The results are interpreted in the context of simplified supersymmetric models with pair production of a heavier top-squark mass eigenstate (t) over tilde (2) decaying to a lighter top-squark mass eigenstate (t) over tilde (1) via either (t) over tilde (2) -> H (t) over tilde (1) or (t) over tilde (2) -> Z (t) over tilde (1), followed in both cases by (t) over tilde (1) -> t (chi) over tilde (0)(1), where (chi) over tilde (0)(1) is an undetected, stable, lightest supersymmetric particle. The interpretation is performed in the region where the mass difference between the (t) over tilde (1) and (chi) over tilde (0)(1) states is approximately equal to the top-quark mass (m((t) over tilde )1) - m((chi) over tilde 10) similar or equal to m(t)) which is not probed by searches for direct (t) over tilde (1) squark pair production. The analysis excludes top squarks with masses m((t) over tilde2) 1) < 400 GeVat a 95% confidence level

Measurement of the production cross section ratio sigma(chi b2(1P))/sigma(chi b1(1P)) in pp collisions at root s=8TeV

A measurement of the production cross section ratio sigma(chi b2(1P))/sigma(chi b1(1P)) is presented. The chi b1 (1P) and chi b2 (1P) bottomonium states, promptly produced in pp collisions at root s = 8TeV, are detected by the CMS experiment at the CERN LHC through their radiative decays chi b1,2(1P) -> Y(1S) + gamma. The emitted photons are measured through their conversion to e(+) e(-) pairs, whose reconstruction allows the two states to be resolved. The Y(1S) is measured through its decay to two muons. An event sample corresponding to an integrated luminosity of 20.7 fb(-1) is used to measure the cross section ratio in a phase-space region defined by the photon pseudorapidity, vertical bar eta(gamma)vertical bar < 1.0; the Y(1S) rapidity, vertical bar y(Y)vertical bar < 1.5; and the Y(1S) transverse momentum, 7 < p(T)(Y) < 40 GeV. The cross section ratio shows no significant dependence on the.(1S) transverse momentum, with a measured average value of 0.85 +/- 0.07 (stat + syst) +/- 0.08 (BF), where the first uncertainty is the combination of the experimental statistical and systematic uncertainties and the second is from the uncertainty in the ratio of the chi b branching fractions

Search for pair production of third-generation scalar leptoquarks and top squarks in proton-proton collisions at v root s=8 TeV

A search for pair production of third-generation scalar leptoquarks and supersymmetric top quark partners, top squarks, in final states involving tau leptons and bottom quarks is presented. The search uses events from a data sample of proton-proton collisions corresponding to an integrated luminosity of 19.7 fb(-1), collected with the CMS detector at the LHC with root s = 8 TeV. The number of observed events is found to be in agreement with the expected standard model background. Third-generation scalar leptoquarks with masses below 740 GeV are excluded at 95% confidence level, assuming a 100% branching fraction for the leptoquark decay to a tau lepton and a bottom quark. In addition, this mass limit applies directly to top squarks decaying via an R-parity violating coupling. lambda(') (333). The search also considers a similar signature from top squarks undergoing a chargino-mediated decay involving the Rparity violating coupling. lambda(')(3jk). Each top squark decays to a tau lepton, a bottom quark, and two light quarks. Top squarks in this model with masses below 580 GeV are excluded at 95% confidence level. The constraint on the leptoquark mass is the most stringent to date, and this is the first search for top squarks decaying via. lambda(')(3jk)