4,937 research outputs found
Probing the Superfluid to Mott Insulator Transition at the Single Atom Level
Quantum gases in optical lattices offer an opportunity to experimentally
realize and explore condensed matter models in a clean, tunable system. We
investigate the Bose-Hubbard model on a microscopic level using single
atom-single lattice site imaging; our technique enables space- and
time-resolved characterization of the number statistics across the
superfluid-Mott insulator quantum phase transition. Site-resolved probing of
fluctuations provides us with a sensitive local thermometer, allows us to
identify microscopic heterostructures of low entropy Mott domains, and enables
us to measure local quantum dynamics, revealing surprisingly fast transition
timescales. Our results may serve as a benchmark for theoretical studies of
quantum dynamics, and may guide the engineering of low entropy phases in a
lattice
Applying OGC sensor web enablement to ocean observing systems
The complexity of marine installations
for ocean observing systems has grown significantly in
recent years. In a network consisting of tens, hundreds
or thousands of marine instruments, manual
configuration and integration becomes very
challenging. Simplifying the integration process in
existing or newly established observing systems would
benefit system operators and is important for the
broader application of different sensors. This article
presents an approach for the automatic configuration
and integration of sensors into an interoperable
Sensor Web infrastructure. First, the sensor
communication model, based on OGC's SensorML
standard, is utilized. It serves as a generic driver
mechanism since it enables the declarative and
detailed description of a sensor's protocol. Finally, we
present a data acquisition architecture based on the
OGC PUCK protocol that enables storage and
retrieval of the SensorML document from the sensor
itself, and automatic integration of sensors into an
interoperable Sensor Web infrastructure. Our
approach adopts Efficient XML Interchange (EXI) as
alternative serialization form of XML or JSON. It
solves the bandwidth problem of XML and JSON.Peer ReviewedPostprint (author's final draft
William Mitchell College of Law\u27s Hybrid Program for J.D. Study: Answering the Call for Innovation
In January 2015, William Mitchell College of Law will launch the first American Bar Association (ABA)-approved, on-campus/ online J.D. program to further the college\u27s mission: to provide accessible, experiential, rigorous training for tomorrow\u27s lawyers. Known as the hybrid program, it will offer a legal education to talented, hard-working students who cannot access a traditional J.D. program because of location or family or work commitments. In this article, we explain the origins and pedagogical foundations of the program, as well as give an overview of the program
Yoga for generalized anxiety disorder: design of a randomized controlled clinical trial.
Generalized anxiety disorder (GAD) is a common disorder associated with significant distress and interference. Although cognitive behavioral therapy (CBT) has been shown to be the most effective form of psychotherapy, few patients receive or have access to this intervention. Yoga therapy offers another promising, yet under-researched, intervention that is gaining increasing popularity in the general public, as an anxiety reduction intervention. The purpose of this innovative clinical trial protocol is to investigate the efficacy of a Kundalini Yoga intervention, relative to CBT and a control condition. Kundalini yoga and CBT are compared with each other in a noninferiority test and both treatments are compared to stress education training, an attention control intervention, in superiority tests. The sample will consist of 230 individuals with a primary DSM-5 diagnosis of GAD. This randomized controlled trial will compare yoga (N=95) to both CBT for GAD (N=95) and stress education (N=40), a commonly used control condition. All three treatments will be administered by two instructors in a group format over 12 weekly sessions with four to six patients per group. Groups will be randomized using permuted block randomization, which will be stratified by site. Treatment outcome will be evaluated bi-weekly and at 6month follow-up. Furthermore, potential mediators of treatment outcome will be investigated. Given the individual and economic burden associated with GAD, identifying accessible alternative behavioral treatments will have substantive public health implications.R01 AT007257 - NCCIH NIH HHS; R01 AT007258 - NCCIH NIH HH
Substituent effects on the gasâphase fragmentation reactions of protonated peptides containing benzylamineâderivatized lysyl residues
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90273/1/rcm6141.pd
Long-term calorie restriction in humans is not associated with indices of delayed immunologic aging: A descriptive study.
BACKGROUND: Delayed immunologic aging is purported to be a major mechanism through which calorie restriction (CR) exerts its anti-aging effects in non-human species. However, in non-obese humans, the effect of CR on the immune system has been understudied relative to its effects on the cardiometabolic system. OBJECTIVE: To examine whether CR is associated with delayed immunologic aging in non-obese humans. METHODS: We tested whether long-term CR practitioners (average 10.03 years of CR) evidenced decreased expression of T cell immunosenescence markers and longer immune cell telomeres compared to gender-, race/ethnicity-, age-, and education-matched "healthy" Body Mass Index (BMI) and "overweight"/"obese" BMI groups. RESULTS: Long-term human CR practitioners had lower BMI (pâ<â 0.001) and fasting glucose (pâ<â 0.001), as expected. They showed similar frequencies of pre-senescent cells (CD8+CD28- T cells and CD57 and PD-1 expressing T cells) to the comparison groups. Even after adjusting for covariates, including cytomegalovirus status, we observed shorter peripheral blood mononuclear cell telomeres in the CR group (pâ=â0.012) and no difference in granulocyte telomeres between groups (pâ=â0.42). CONCLUSIONS: We observed no clear evidence that CR as it is currently practiced in humans delays immune aging related to telomere length or T cell immunosenescent markers
Feedback Control as a Framework for Understanding Tradeoffs in Biology
Control theory arose from a need to control synthetic systems. From
regulating steam engines to tuning radios to devices capable of autonomous
movement, it provided a formal mathematical basis for understanding the role of
feedback in the stability (or change) of dynamical systems. It provides a
framework for understanding any system with feedback regulation, including
biological ones such as regulatory gene networks, cellular metabolic systems,
sensorimotor dynamics of moving animals, and even ecological or evolutionary
dynamics of organisms and populations. Here we focus on four case studies of
the sensorimotor dynamics of animals, each of which involves the application of
principles from control theory to probe stability and feedback in an organism's
response to perturbations. We use examples from aquatic (electric fish station
keeping and jamming avoidance), terrestrial (cockroach wall following) and
aerial environments (flight control in moths) to highlight how one can use
control theory to understand how feedback mechanisms interact with the physical
dynamics of animals to determine their stability and response to sensory inputs
and perturbations. Each case study is cast as a control problem with sensory
input, neural processing, and motor dynamics, the output of which feeds back to
the sensory inputs. Collectively, the interaction of these systems in a closed
loop determines the behavior of the entire system.Comment: Submitted to Integr Comp Bio
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