434 research outputs found
Networks and Language in the 2010 Election
The midterm (2010) election in the U.S. presented a unique opportunity to study the online social media strategy of various political groups. Although candidates had previously leveraged social media, the prevalence of use during this election allows us to study a significant percentage of candidates and a novel glimpse into their networks and messaging. In combination, the networks and associated content reflect positioning of candidates both structurally and in framing in relation to other politicians. In our work, we study the use of Twitter by House, Senate and gubernatorial candidates during the midterm elections in the U.S. Our data includes almost 700 candidates and over 460k tweets that they produced in the 3.5 years leading to the elections. We utilize graph and text mining techniques to analyze differences between Democrats, Republicans and Tea Party candidates, and suggest a novel use of language modeling for estimating content cohesiveness. Our findings show significant differences in the usage patterns of social media, and suggest conservative candidates used this medium more effectively, conveying a coherent message and maintaining a dense graph of connections. Despite the lack of party leadership, we find Tea Party members display both structural and languageâbased cohesiveness. Finally, we investigate the relation between network structure, content and election results by creating a proofâofâconcept model that extends incumbency models to predict candidate victory
High-resolution, H band Spectroscopy of Be Stars with SDSS-III/APOGEE: I. New Be Stars, Line Identifications, and Line Profiles
APOGEE has amassed the largest ever collection of multi-epoch,
high-resolution (R~22,500), H-band spectra for B-type emission line (Be) stars.
The 128/238 APOGEE Be stars for which emission had never previously been
reported serve to increase the total number of known Be stars by ~6%. We focus
on identification of the H-band lines and analysis of the emission peak
velocity separations (v_p) and emission peak intensity ratios (V/R) of the
usually double-peaked H I and non-hydrogen emission lines. H I Br11 emission is
found to preferentially form in the circumstellar disks at an average distance
of ~2.2 stellar radii. Increasing v_p toward the weaker Br12--Br20 lines
suggests these lines are formed interior to Br11. By contrast, the observed IR
Fe II emission lines present evidence of having significantly larger formation
radii; distinctive phase lags between IR Fe II and H I Brackett emission lines
further supports that these species arise from different radii in Be disks.
Several emission lines have been identified for the first time including
~16895, a prominent feature in the spectra for almost a fifth of the sample
and, as inferred from relatively large v_p compared to the Br11-Br20, a tracer
of the inner regions of Be disks. Unlike the typical metallic lines observed
for Be stars in the optical, the H-band metallic lines, such as Fe II 16878,
never exhibit any evidence of shell absorption, even when the H I lines are
clearly shell-dominated. The first known example of a quasi-triple-peaked Br11
line profile is reported for HD 253659, one of several stars exhibiting intra-
and/or extra-species V/R and radial velocity variation within individual
spectra. Br11 profiles are presented for all discussed stars, as are full
APOGEE spectra for a portion of the sample.Comment: accepted in A
Alterations in cortical thickness development in preterm-born individuals:Implications for high-order cognitive functions
AbstractVery preterm birth (gestational age <33weeks) is associated with alterations in cortical thickness and with neuropsychological/behavioural impairments. Here we studied cortical thickness in very preterm born individuals and controls in mid-adolescence (mean age 15years) and beginning of adulthood (mean age 20years), as well as longitudinal changes between the two time points. Using univariate approaches, we showed both increases and decreases in cortical thickness in very preterm born individuals compared to controls. Specifically (1) very preterm born adolescents displayed extensive areas of greater cortical thickness, especially in occipitotemporal and prefrontal cortices, differences which decreased substantially by early adulthood; (2) at both time points, very preterm-born participants showed smaller cortical thickness, especially in parahippocampal and insular regions. We then employed a multivariate approach (support vector machine) to study spatially discriminating features between the two groups, which achieved a mean accuracy of 86.5%. The spatially distributed regions in which cortical thickness best discriminated between the groups (top 5%) included temporal, occipitotemporal, parietal and prefrontal cortices. Within these spatially distributed regions (top 1%), longitudinal changes in cortical thickness in left temporal pole, right occipitotemporal gyrus and left superior parietal lobe were significantly associated with scores on language-based tests of executive function. These results describe alterations in cortical thickness development in preterm-born individuals in their second decade of life, with implications for high-order cognitive processing
A Small-molecule Inhibitor Directed against the Chemokine Receptor CXCR4 Prevents its Use as an HIV-1 Coreceptor
The chemokine receptor CXCR4 is the major coreceptor used for cellular entry by T cellâ tropic human immunodeficiency virus (HIV)-1 strains, whereas CCR5 is used by macrophage (M)-tropic strains. Here we show that a small-molecule inhibitor, ALX40-4C, inhibits HIV-1 envelope (Env)-mediated membrane fusion and viral entry directly at the level of coreceptor use. ALX40-4C inhibited HIV-1 use of the coreceptor CXCR4 by T- and dual-tropic HIV-1 strains, whereas use of CCR5 by M- and dual-tropic strains was not inhibited. Dual-tropic viruses capable of using both CXCR4 and CCR5 were inhibited by ALX40-4C only when cells expressed CXCR4 alone. ALX40-4C blocked stromal-derived factor (SDF)-1αâmediated activation of CXCR4 and binding of the monoclonal antibody 12G5 to cells expressing CXCR4. Overlap of the ALX40-4C binding site with that of 12G5 and SDF implicates direct blocking of Env interactions, rather than downregulation of receptor, as the mechanism of inhibition. Thus, ALX40-4C represents a small-molecule inhibitor of HIV-1 infection that acts directly against a chemokine receptor at the level of Env-mediated membrane fusion
Chemical abundance gradients from open clusters in the Milky Way disk: results from the APOGEE survey
Metallicity gradients provide strong constraints for understanding the
chemical evolution of the Galaxy. We report on radial abundance gradients of
Fe, Ni, Ca, Si, and Mg obtained from a sample of 304 red-giant members of 29
disk open clusters, mostly concentrated at galactocentric distances between ~8
- 15 kpc, but including two open clusters in the outer disk. The observations
are from the APOGEE survey. The chemical abundances were derived automatically
by the ASPCAP pipeline and these are part of the SDSS III Data Release 12. The
gradients, obtained from least squares fits to the data, are relatively flat,
with slopes ranging from -0.026 to -0.033 dex/kpc for the alpha-elements [O/H],
[Ca/H], [Si/H] and [Mg/H] and -0.035 dex/kpc and -0.040 dex/kpc for [Fe/H] and
[Ni/H], respectively. Our results are not at odds with the possibility that
metallicity ([Fe/H]) gradients are steeper in the inner disk (R_GC ~7 - 12 kpc)
and flatter towards the outer disk. The open cluster sample studied spans a
significant range in age. When breaking the sample into age bins, there is some
indication that the younger open cluster population in our sample (log age <
8.7) has a flatter metallicity gradient when compared with the gradients
obtained from older open clusters.Comment: 4 pages, 3 figures, To appear in Astronomische Nachrichten, special
issue "Reconstruction the Milky Way's History: Spectroscopic surveys,
Asteroseismology and Chemo-dynamical models", Guest Editors C. Chiappini, J.
Montalb\'an, and M. Steffen, AN 2016 (in press)
The Open Cluster Chemical Analysis and Mapping Survey: Local Galactic Metallicity Gradient with APOGEE using SDSS DR10
The Open Cluster Chemical Analysis and Mapping (OCCAM) Survey aims to produce
a comprehensive, uniform, infrared-based dataset for hundreds of open clusters,
and constrain key Galactic dynamical and chemical parameters from this sample.
This first contribution from the OCCAM survey presents analysis of 141 members
stars in 28 open clusters with high-resolution metallicities derived from a
large uniform sample collected as part of the SDSS-III/Apache Point Observatory
Galactic Evolution Experiment (APOGEE). This sample includes the first
high-resolution metallicity measurements for 22 open clusters. With this
largest ever uniformly observed sample of open cluster stars we investigate the
Galactic disk gradients of both [M/H] and [alpha/M]. We find basically no
gradient across this range in [alpha/M], but [M/H] does show a gradient for
R_{GC} < 10 kpc and a significant flattening beyond R_{GC} = 10 kpc. In
particular, whereas fitting a single linear trend yields an [M/H] gradient of
-0.09 +/- 0.03$ dex/kpc --- similar to previously measure gradients inside 13
kpc --- by independently fitting inside and outside 10 kpc separately we find a
significantly steeper gradient near the Sun (7.9 <= R_{GC} <= 10) than
previously found (-0.20 +/- 0.08 dex/kpc) and a nearly flat trend beyond 10 kpc
(-0.02 +/- 0.09 dex/kpc).Comment: 6 pages, 4 figures, ApJ letters, in pres
Dual Vortex Theory of Strongly Interacting Electrons: Non-Fermi Liquid to the (Hard) Core
As discovered in the quantum Hall effect, a very effective way for
strongly-repulsive electrons to minimize their potential energy is to aquire
non-zero relative angular momentum. We pursue this mechanism for interacting
two-dimensional electrons in zero magnetic field, by employing a representation
of the electrons as composite bosons interacting with a Chern-Simons gauge
field. This enables us to construct a dual description in which the fundamental
constituents are vortices in the auxiliary boson fields. The resulting
formalism embraces a cornucopia of possible phases. Remarkably,
superconductivity is a generic feature, while the Fermi liquid is not --
prompting us to conjecture that such a state may not be possible when the
interactions are sufficiently strong. Many aspects of our earlier discussions
of the nodal liquid and spin-charge separation find surprising incarnations in
this new framework.Comment: Modified dicussion of the hard-core model, correcting several
mistake
Discovery of a Dynamical Cold Point in the Heart of the Sagittarius dSph Galaxy with Observations from the APOGEE Project
The dynamics of the core of the Sagittarius (Sgr) dwarf spheroidal (dSph)
galaxy are explored using high-resolution (R~22,500), H-band, near-infrared
spectra of over 1,000 giant stars in the central 3 deg^2 of the system, of
which 328 are identified as Sgr members. These data, among some of the earliest
observations from the SDSS-III/Apache Point Observatory Galactic Evolution
Experiment (APOGEE) and the largest published sample of high resolution Sgr
dSph spectra to date, reveal a distinct gradient in the velocity dispersion of
Sgr from 11-14 km/s for radii >0.8 degrees from center to a dynamical cold
point of 8 km/s in the Sgr center --- a trend differing from that found in
previous kinematical analyses of Sgr over larger scales that suggest a more or
less flat dispersion profile at these radii. Well-fitting mass models with
either cored and cusped dark matter distributions can be found to match the
kinematical results, although the cored profile succeeds with significantly
more isotropic stellar orbits than required for a cusped profile. It is
unlikely that the cold point reflects an unusual mass distribution. The
dispersion gradient may arise from variations in the mixture of populations
with distinct kinematics within the dSph; this explanation is suggested (e.g.,
by detection of a metallicity gradient across similar radii), but not
confirmed, by the present data. Despite these remaining uncertainties about
their interpretation, these early test data (including some from instrument
commissioning) demonstrate APOGEE's usefulness for precision dynamical studies,
even for fields observed at extreme airmasses.Comment: 15 pages, 3 figure
The Apache Point Observatory Galactic Evolution Experiment: First Detection of High Velocity Milky Way Bar Stars
Commissioning observations with the Apache Point Observatory Galactic
Evolution Experiment (APOGEE), part of the Sloan Digital Sky Survey III, have
produced radial velocities (RVs) for ~4700 K/M-giant stars in the Milky Way
bulge. These high-resolution (R \sim 22,500), high-S/N (>100 per resolution
element), near-infrared (1.51-1.70 um; NIR) spectra provide accurate RVs
(epsilon_v~0.2 km/s) for the sample of stars in 18 Galactic bulge fields
spanning -1-32 deg. This represents the largest
NIR high-resolution spectroscopic sample of giant stars ever assembled in this
region of the Galaxy. A cold (sigma_v~30 km/s), high-velocity peak (V_GSR \sim
+200 km/s) is found to comprise a significant fraction (~10%) of stars in many
of these fields. These high RVs have not been detected in previous MW surveys
and are not expected for a simple, circularly rotating disk. Preliminary
distance estimates rule out an origin from the background Sagittarius tidal
stream or a new stream in the MW disk. Comparison to various Galactic models
suggests that these high RVs are best explained by stars in orbits of the
Galactic bar potential, although some observational features remain
unexplained.Comment: 7 pages, 4 figures, accepted for publication in ApJ Letter
Recommended from our members
Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss
Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition that primarily affects the motor system and shares many features with frontotemporal dementia (FTD). Evidence suggests that ALS is a âdying-backâ disease, with peripheral denervation and axonal degeneration occurring before loss of motor neuron cell bodies. Distal to a nerve injury, a similar pattern of axonal degeneration can be seen, which is mediated by an active axon destruction mechanism called Wallerian degeneration. Sterile alpha and TIR motif-containing 1 (Sarm1) is a key gene in the Wallerian pathway and its deletion provides long-term protection against both Wallerian degeneration and Wallerian-like, non-injury induced axonopathy, a retrograde degenerative process that occurs in many neurodegenerative diseases where axonal transport is impaired. Here, we explored whether Sarm1 signalling could be a therapeutic target for ALS by deleting Sarm1 from a mouse model of ALS-FTD, a TDP-43Q331K, YFP-H double transgenic mouse. Sarm1 deletion attenuated motor axon degeneration and neuromuscular junction denervation. Motor neuron cell bodies were also significantly protected. Deletion of Sarm1 also attenuated loss of layer V pyramidal neuronal dendritic spines in the primary motor cortex. Structural MRI identified the entorhinal cortex as the most significantly atrophic region, and histological studies confirmed a greater loss of neurons in the entorhinal cortex than in the motor cortex, suggesting a prominent FTD-like pattern of neurodegeneration in this transgenic mouse model. Despite the reduction in neuronal degeneration, Sarm1 deletion did not attenuate age-related behavioural deficits caused by TDP-43Q331K. However, Sarm1 deletion was associated with a significant increase in the viability of male TDP-43Q331K mice, suggesting a detrimental role of Wallerian-like pathways in the earliest stages of TDP-43Q331K-mediated neurodegeneration. Collectively, these results indicate that anti-SARM1 strategies have therapeutic potential in ALS-FTD
- âŠ