Caracterização química e fitoquímica, toxicidade e atividade antioxidante In Vitro, de Clones de Pedúnculos de Caju (Anacardium Occidentale L.) / Chemical and phytochemical characterization, Toxicity and In Vitro antioxidant activity of Cashew Stalk Clones (Anacardium Occidentale L.)

A cultura do caju tem grande importância na fruticultura brasileira, principalmente no Nordeste, representando uma atividade de grande expressão econômica e social na região. Foram utilizados quatro clones obtidos a partir da Estação Experimental da Embrapa Tropical como o CCP 06, CCP 76, BRS 189 e BRS 226, tendo destaque na composição fitoquímica, proteína, toxicidade, fenóis, fitoesteróis e atividade antioxidante total. Este estudo tem como objetivo avaliar a qualidade e a atividade antioxidante total de hastes de diferentes clones de cajueiro anão, desenvolvido pela Embrapa Tropical, através da caracterização física e química, selecionando os clones que apresentaram os melhores resultados.  

Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo

According to The World Alzheimer Report 2023 by Alzheimer’s Disease International (ADI) estimates that 33 to 38.5 million people worldwide suffer from Alzheimer’s Disease (AD). A crucial hallmark associated with this disease is associated with the deficiency of the brain neurotransmitter acetylcholine, due to an affected acetylcholinesterase (AChE) activity. Marine organisms synthesize several classes of compounds, some of which exhibit significant AChE inhibition, such as petrosamine, a coloured pyridoacridine alkaloid. The aim of this work was to characterize the activity of petrosamine isolated for the first time from a Brazilian marine sponge, using two neurotoxicity models with aluminium chloride, as exposure to aluminium is associated with the development of neurodegenerative diseases. The in vitro model was based in a neuroblastoma cell line and the in vivo model exploited the potential of zebrafish (Danio rerio) embryos in mimicking hallmarks of AD. To our knowledge, this is the first report on petrosamine’s activity over these parameters, either in vitro or in vivo, in order to characterize its full potential for tackling neurotoxicity