64 research outputs found
Antileishmanial activity of Handroanthus serratifolius (Vahl) S. Grose (Bignoniaceae).
- Author
- Publication venue
- 'Hindawi Limited'
- Publication date
- 01/01/2017
- Field of study
This study aimed to evaluate the leishmanicidal activity of ethanol extract, fractions, and isolated substance from Handroanthus
serratifolius against Leishmania amazonensis. Furthermore, this activity was related to cytotoxicity, and the selectivity index was
determined.The ethanol extract was obtained by maceration of the stem powder, and the extract was subjected to fractionation on
chromatographic column. The lapachol was obtained by acid base extraction followed by purification in chromatographic column.
The antipromastigote activity and cytotoxicity tests were carried out by the cell viabilitymethod (MTT).Modified THP-1 cells were
infected with L. amazonensis promastigotes and treated for 24 h with different concentrations of the extract, fractions, and lapachol.
Theethanol extract, dichloromethane, and ethyl acetate fractions were not active against promastigotes (IC50 > 200 ?g/mL) or cytotoxic
(CC50 > 500 ?g/mL), and the selectivity index (SI)was greater than 2.5.The ethyl acetate fractionwas active only in promastigotes;
it is not cytotoxic (CC50 > 500 ?g/mL, SI > 5).The lapachol was selectively active only against amastigote (IS > 2.5, CC50 >
500 ?g/mL). In summary, lapachol and ethyl acetate fraction are promising against amastigote and promastigote forms, respectively
Global Retinoblastoma Presentation and Analysis by National Income Level
- Author
- Abdallah E.
- Abdullahi S. U.
- Abdulqader R. A.
- Adamou Boubacar S.
- Ademola-Popoola D. S.
- Adio A.
- Afshar A. R.
- Aggarwal P.
- Aghaji A. E.
- Ahmad A.
- Akib M. N. R.
- Al Ani M. H.
- Al Harby L.
- Al-Badri S. A. F.
- Al-Dahmash S. A.
- Al-Haddad C.
- Al-Hussaini H. H. Y.
- Al-Jadiry M. F.
- Al-Jumaly U.
- Al-Mafrachi A. A. R. M.
- Al-Shaheen A. A. S. M.
- Al-Shammary E. H.
- Alakbarova A.
- Alcasabas A. P. A.
- Alejos A.
- Alemany-Rubio E.
- Alfa Bio A. I.
- Alfonso Carreras Y.
- Ali A. M.
- Alia D. B.
- Alkatan H. M.
- All-Eriksson C.
- Almeida A. A.
- Alsawidi K. M.
- Amiruddin P. O.
- Antonino R.
- Astbury N. J.
- Atalay H. T.
- Atchaneeyasakul L. -O.
- Atsiaya R.
- Attaseth T.
- Aung T. H.
- Ayala S.
- Baizakova B.
- Balaguer J.
- Balayeva R.
- Balwierz W.
- Barranco H.
- Bascaran C.
- Beck Popovic M.
- Benavides R.
- Benmiloud S.
- Bennani Guebessi N.
- Berete R. C.
- Berry J. L.
- Bhaduri A.
- Bhat S.
- Biddulph S. J.
- Biewald E. M.
- Bobrova N.
- Boehme M.
- Boldt H. C.
- Bonanomi M. T. B. C.
- Bornfeld N.
- Bouda G. C.
- Bouguila H.
- Boumedane A.
- Bowman R.
- Brennan R. C.
- Brichard B. G.
- Buaboonnam J.
- Calderon-Sotelo P.
- Calle Jara D. A.
- Camuglia J. E.
- Cano M. R.
- Capra M.
- Cassoux N.
- Castela G.
- Castillo L.
- Catala-Mora J.
- Chantada G. L.
- Chaudhry S.
- Chaugule S. S.
- Chauhan A.
- Chawla B.
- Chernodrinska V. S.
- Chiwanga F. S.
- Chuluunbat T.
- Cieslik K.
- Cockcroft R. L.
- Comsa C.
- Correa Llano M. G.
- Correa Z. M.
- Corson T. W.
- Cowan-Lyn K. E.
- Csoka M.
- Cui X.
- Da Gama I. V.
- Dangboon W.
- Das A.
- Das S.
- Davanzo J. M.
- Davidson A.
- De Potter P.
- Delgado K. Q.
- Demirci H.
- Desjardins L.
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- Dodgshun A. J.
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- Eka Sutyawan I. W.
- El Kettani A.
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- Elder J. E.
- Elgalaly D.
- Elhaddad A. M.
- Elhassan M. M. A.
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- Evina T. G. A.
- Fabian I. D.
- Fadoo Z.
- Fandino A. C.
- Faranoush M.
- Fasina O.
- Fernandez D. D. P. G.
- Fernandez-Teijeiro A.
- Foster A.
- Frenkel S.
- Fu L. D.
- Fuentes-Alabi S. L.
- Gallie B. L.
- Gandiwa M.
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- Kivela T. T.
- Klett A.
- Komba Palet J. E. K.
- Krivaitiene D.
- Kruger M.
- Kulvichit K.
- Kuntorini M. W.
- Kyara A.
- Lachmann E. S.
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- Lam G. C.
- Larson S. A.
- Latinovic S.
- Laurenti K. D.
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- Leverant A. A.
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- Long Q. B.
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- Luna-Fineman S.
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- Martin Begue N.
- Mason J. O.
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- Mattosinho C. C. D. S.
- Matua M.
- Mayet I.
- Mbumba F. B.
- McKenzie J. D.
- Medina-Sanson A.
- Mehrvar A.
- Mengesha A. A.
- Menon V.
- Mercado G. J. V. D.
- Mets M. B.
- Midena E.
- Mishra D. K. C.
- Mndeme F. G.
- Mohamedani A. A.
- Mohammad M. T.
- Moll A. C.
- Montero M. M.
- Morales R. A.
- Moreira C.
- Mruthyunjaya P.
- Msina M. S.
- Msukwa G.
- Mudaliar S. S.
- Muma K. I.
- Munier F. L.
- Murgoi G.
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- Musa K. O.
- Mushtaq A.
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- Ndoye Roth P. A.
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- Nkumbe H.
- Nuruddin M.
- Nyaywa M.
- Obono-Obiang G.
- Oguego N. C.
- Olechowski A.
- Oliver S. C. N.
- Osei-Bonsu P.
- Ossandon D.
- Paez-Escamilla M. A.
- Pagarra H.
- Painter S. L.
- Paintsil V.
- Paiva L.
- Pal B. P.
- Palanivelu M. S.
- Papyan R.
- Parrozzani R.
- Parulekar M.
- Pascual Morales C. R.
- Paton K. E.
- Pawinska-Wasikowska K.
- Pe'Er J.
- Pena A.
- Peric S.
- Pham C. T. M.
- Philbert R.
- Plager D. A.
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- Polyakov V. G.
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- Purwanto I.
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- Rahman A.
- Rahman S.
- Rahmat J.
- Rajkarnikar P.
- Ramanjulu R.
- Ramasubramanian A.
- Ramirez-Ortiz M. A.
- Raobela L.
- Rashid R.
- Reddy M. A.
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- Renner L. A.
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- Ritter-Sovinz P.
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- Skalet A. H.
- Soebagjo H. D.
- Sorochynska T.
- Ssali G.
- Stacey A. W.
- Staffieri S. E.
- Stahl E. D.
- Stathopoulos C.
- Stirn Kranjc B.
- Stones D. K.
- Strahlendorf C.
- Suarez M. E. C.
- Sultana S.
- Sun X.
- Sundy M.
- Superstein R.
- Supriyadi E.
- Surukrattanaskul S.
- Suzuki S.
- Svojgr K.
- Sylla F.
- Tamamyan G.
- Tan D.
- Tandili A.
- Tarrillo Leiva F. F.
- Tashvighi M.
- Tateshi B.
- Teh K. H.
- Tehuteru E. S.
- Teixeira L. F.
- Theophile T.
- Toledano H.
- Trang D. L.
- Traore F.
- Trichaiyaporn S.
- Tuncer S.
- Tyau-Tyau H.
- Umar A. B.
- Unal E.
- Uner O. E.
- Urbak S. F.
- Ushakova T. L.
- Usmanov R. H.
- Valeina S.
- Van Hoefen Wijsard M.
- Varadisai A.
- Vasquez L.
- Vaughan L. O.
- Veleva-Krasteva N. V.
- Verma N.
- Victor A. A.
- Viksnins M.
- Villacis Chafla E. G.
- Vishnevskia-Dai V.
- Vora T.
- Wachtel A. E.
- Wackernagel W.
- Waddell K.
- Wade P. D.
- Wali A. H.
- Wang Y. -Z.
- Weiss A.
- Wilson M. W.
- Wime A. D. C.
- Wiwatwongwana A.
- Wiwatwongwana D.
- Wolley Dod C.
- Wongwai P.
- Xiang D.
- Xiao Y.
- Yam J. C.
- Yang H.
- Yanga J. M.
- Yaqub M. A.
- Yarovaya V. A.
- Yarovoy A. A.
- Ye H.
- Yousef Y. A.
- Yuliawati P.
- Zapata Lopez A. M.
- Zein E.
- Zhang C.
- Zhang Y.
- Zhao J.
- Zheng X.
- Zhilyaeva K.
- Zia N.
- Ziko O. A. O.
- Zondervan M.
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 01/01/2020
- Field of study
Importance: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. Objectives: To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis. Design, Setting, and Participants: A total of 278 retinoblastoma treatment centers were recruited from June 2017 through December 2018 to participate in a cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. Main Outcomes and Measures: Age at presentation, proportion of familial history of retinoblastoma, and tumor stage and metastasis. Results: The cohort included 4351 new patients from 153 countries; the median age at diagnosis was 30.5 (interquartile range, 18.3-45.9) months, and 1976 patients (45.4%) were female. Most patients (n = 3685 [84.7%]) were from low- A nd middle-income countries (LMICs). Globally, the most common indication for referral was leukocoria (n = 2638 [62.8%]), followed by strabismus (n = 429 [10.2%]) and proptosis (n = 309 [7.4%]). Patients from high-income countries (HICs) were diagnosed at a median age of 14.1 months, with 656 of 666 (98.5%) patients having intraocular retinoblastoma and 2 (0.3%) having metastasis. Patients from low-income countries were diagnosed at a median age of 30.5 months, with 256 of 521 (49.1%) having extraocular retinoblastoma and 94 of 498 (18.9%) having metastasis. Lower national income level was associated with older presentation age, higher proportion of locally advanced disease and distant metastasis, and smaller proportion of familial history of retinoblastoma. Advanced disease at diagnosis was more common in LMICs even after adjusting for age (odds ratio for low-income countries vs upper-middle-income countries and HICs, 17.92 [95% CI, 12.94-24.80], and for lower-middle-income countries vs upper-middle-income countries and HICs, 5.74 [95% CI, 4.30-7.68]). Conclusions and Relevance: This study is estimated to have included more than half of all new retinoblastoma cases worldwide in 2017. Children from LMICs, where the main global retinoblastoma burden lies, presented at an older age with more advanced disease and demonstrated a smaller proportion of familial history of retinoblastoma, likely because many do not reach a childbearing age. Given that retinoblastoma is curable, these data are concerning and mandate intervention at national and international levels. Further studies are needed to investigate factors, other than age at presentation, that may be associated with advanced disease in LMICs
Brazilian Consensus on Photoprotection
- Author
- Abarca J
- Abdel-Malek Z
- Abel E
- Acosta LR
- Adam J
- Ahmed AM
- Alaluf S
- Almutawa F
- Aloai JF
- Aloia JF
- Aloia JF
- Alonso-Lebrero JL
- Alves LM
- Anderson RR
- Andersson-Willman B
- Andrés-Lacueva C
- Aripuanã Cobério Terena
- Armstrong AW
- Avenel-Audran M
- Avenel-Audran M
- Bachrach S
- Bais AF
- Balk SJ
- Balk SJ
- Ball Arefiev KL
- Balogh TS
- Batista T
- Battie C
- Bauer A
- Bauer J
- Baumann L
- Bech-Thomsen N
- Becker JA
- Benvenuto-Andrade C
- Berneburg M
- Bernstein EF
- Biesalski HK
- Binkley N
- Binkley N
- Bischoff-Ferrari HA
- Bodekaer M
- Boisen AM
- Bouilly-Gauthier D
- Boyd AS
- Bradford PT
- Broekmans WM
- Bucay VW
- Buendía Eisman A
- Buendía-Eisman A
- Buller DB
- Buller DB
- Caccialanza M
- Camera E
- Capote R
- Carolina Reato Marçon
- Castanedo-Cazares JP
- Cestari T
- Chan AC
- Chen AC
- Chen L
- Chen T
- Chesney RW
- Chiu YE
- Cho HS
- Cho S
- Clemens TL
- Corrêa MP
- Corrêa MP
- Corrêa MP
- Costa FB
- Crane LA
- Crane LA
- Criado P
- Cross SE
- Cusack C
- D'Orazio J
- Dain SJ
- Darlington S
- Darvin ME
- Dattani JT
- Davis A
- Day AK
- de Gruijl FR
- de Laat A
- de Paula Corrêa M
- de Paula Corrêa M
- de Paula Corrêa M
- Denise Steiner
- Dennis LK
- Diffey BL
- Diffey BL
- Diffey BL
- Diffey BL
- Dlugos DJ
- Dobs AS
- Dominguez AR
- Draelos ZD
- Draelos ZD
- Draelos ZD
- Draelos ZD
- Duarte I
- Dumay O
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- Fitzpatrick TB
- Flávia Alvim Sant'anna Addor
- Flávia Naranjo Ravelli
- Fonseca V
- Fryer MJ
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- Jou PC
- Juliana Catucci Boza
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- O'Donoghue MN
- O'Riordan JL
- Olga Maria Rodrigues Ribeiro Leite
- Olsen EA
- Orentreich D
- Osterwalder U
- Otávio Sergio Lopes
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- Palombo P
- Parisi AV
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- Parrish JA
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- Petit-Frère C
- Pfeifer MT
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- Pichon LC
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- Pinnell SR
- Placzek M
- Polefka TG
- Pollack RJ
- Preece MA
- Prista LN
- Prochaska JO
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- Pujol JA
- Purim K
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- Quatrano NA
- Querings K
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- Ragi JM
- Ramasubramaniam R
- Ray AJ
- Reeder AI
- Reichrath J
- Rejnmark L
- Renata Leal Bregunci Meyer
- Rendon M
- Reynolds KD
- Rhodes LE
- Ribaya-Mercado JD
- Rigel DS
- Rittié L
- Roelandts R
- Rona C
- Ross AC
- Rudolf M
- Salih FM
- Saliou C
- Sambandan DR
- Saraiya M
- Sayre RM
- Sayre RM
- Scalbert A
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- Scarmo S
- Schagen SK
- Schalka S
- Schalka S
- Schalka S
- Schauder S
- Scheuer E
- Schieke SM
- Schieke SM
- Schlossman D
- Schlumpf M
- Schneider S
- Schroeder P
- Schwarz A
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- Sedrani SH
- Segal E
- Seite S
- Seité S
- Seité S
- Shaat NA
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- Sheehan JM
- Sheth VM
- Shuster S
- Sies H
- Sies H
- Signori V
- Silva A
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- Sklar LR
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- Sliney DH
- Sollitto RB
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- Stechschulte SA
- Stender IM
- Stengel FM
- Stengel FM
- Stern RS
- Stoebner-Delbarre A
- Suganuma K
- Suh KS
- Summers P
- Suppa M
- Svobodova A
- Swerdlow AJ
- Sérgio Schalka
- Tan JK
- Tatiana Steiner
- Teixeira SMMCG
- Teixeira SP
- Teulings HE
- Thieden E
- Thieden E
- Thomas K
- Thompson SC
- Tjellesen L
- Townsend JS
- Trueb RM
- Tuchinda C
- Tuchinda C
- Turnbull DJ
- Turrisi R
- Tânia Cestari
- Umezawa M
- Urasaki MBM
- Vachiramon V
- Vainio H
- van Dijk A
- Victor FC
- Vieth R
- Vitor Manoel Silva dos Reis
- Vitória Regina Pedreira de Almeida Rego
- Vázquez M
- Walder BK
- Walker SL
- Wang SQ
- Wang SQ
- Wang SQ
- Waterston K
- Watson RE
- Webb AR
- Webb AR
- Webb AR
- Webb AR
- Wei H
- Weisman Y
- Wesson KM
- Wexler RK
- Wilkinson RJ
- Williams S
- Wolf C
- Wolf R
- Wu Y
- Wysong A
- Yaar M
- Yashiro K
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2014
- Field of study
Brazil is a country of continental dimensions with a large heterogeneity of climates and massive mixing of the population. Almost the entire national territory is located between the Equator and the Tropic of Capricorn, and the Earth axial tilt to the south certainly makes Brazil one of the countries of the world with greater extent of land in proximity to the sun. The Brazilian coastline, where most of its population lives, is more than 8,500 km long. Due to geographic characteristics and cultural trends, Brazilians are among the peoples with the highest annual exposure to the sun. Epidemiological data show a continuing increase in the incidence of nonmelanoma and melanoma skin cancers. Photoprotection can be understood as a set of measures aimed at reducing sun exposure and at preventing the development of acute and chronic actinic damage. Due to the peculiarities of Brazilian territory and culture, it would not be advisable to replicate the concepts of photoprotection from other developed countries, places with completely different climates and populations. Thus the Brazilian Society of Dermatology has developed the Brazilian Consensus on Photoprotection, the first official document on photoprotection developed in Brazil for Brazilians, with recommendations on matters involving photoprotection
The 13th Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the SDSS-IV Survey Mapping Nearby Galaxies at Apache Point Observatory
- Author
- Aguirre Victor Silva
- Albareti Franco D
- Allende Prieto Carlos
- Almeida Andres
- Anders Friedrich
- Anderson Scott
- Andrews Brett H
- Aragon-Salamanca Alfonso
- Argudo-Fernandez Maria
- Armengaud Eric
- Aubourg Eric
- Avila-Reese Vladimir
- Badenes Carles
- Bailey Stephen
- Barbuy Beatriz
- Barger Kat
- Barrera-Ballesteros Jorge
- Bartosz Curtis
- Basu Sarbani
- Bates Dominic
- Battaglia Giuseppina
- Baumgarten Falk
- Baur Julien
- Bautista Julian
- Beers Timothy C
- Belfiore Francesco
- Bergmann Thaisa Storchi
- Bershady Matthew
- Bertran de Lis Sara
- Bird Jonathan C
- Bizyaev Dmitry
- Blanc Guillermo A
- Blanton Michael
- Blomqvist Michael
- Bolton Adam S
- Borissova J
- Bourboux Helion Du Mas des
- Bovy Jo
- Brandt William Nielsen
- Brinkmann Jonathan
- Brownstein Joel R
- Bundy Kevin
- Burtin Etienne
- Busca Nicolas G
- Camacho Chavez Hugo Orlando
- Cappellari Michele
- Carrera Ricardo
- Chen Yanping
- Cherinka Brian
- Cheung Edmond
- Chiappini Cristina
- Chojnowski Drew
- Chuang Chia-Hsun
- Chung Haeun
- Cirolini Rafael Fernando
- Clerc Nicolas
- Cohen Roger E
- Comerford Julia M
- Comparat Johan
- Cousinou Marie-Claude
- Covey Kevin
- Crane Jeffrey D
- Croft Rupert
- Cunha Katia
- Da Costa Luiz
- Darling Jeremy
- Davidson James W Jr
- Dawson Kyle
- De la Macorra Axel
- De la Torre Sylvain
- De Lee Nathan
- Delubac Timothee
- Diamond-Stanic Aleksandar M
- Diaz M Cano
- do Nascimento Janaina Correa
- Donor John
- Drory Niv
- Du Cheng
- Dwelly Tom
- Ebelke Garrett
- Eigenbrot Arthur
- Eisenstein Daniel J
- Elsworth Yvonne P
- Emsellem Eric
- Eracleous Michael
- Escoffier Stephanie
- Evans Michael L
- Falcon-Barroso Jesus
- Fan Xiaohui
- Favole Ginevra
- Fernandez-Alvar Emma
- Fernandez-Trincado JG
- Feuillet Diane
- Fleming Scott W
- Font-Ribera Andreu
- Freischlad Gordon
- Frinchaboy Peter
- Fu Hai
- Gao Yang
- Garcia Perez Ana E
- Garcia Rafael A
- Garcia-Dias R
- Garcia-Hernandez DA
- Gaulme Patrick
- Ge Junqiang
- Geimba Maia Marcio Antonio
- Geisler Douglas
- Gillespie Bruce
- Girardi Leo
- Goddard Daniel
- Gonzalez-Perez Violeta
- Grabowski Kathleen
- Green Paul
- Grier Catherine J
- Grier Thomas
- Guo Hong
- Guy Julien
- Hagen Alex
- Hall Matt
- Harding Paul
- Harley RE
- Hasselquist Sten
- Hawley Suzanne
- Hayes Christian R
- Hearty Fred
- Hekker Saskia
- Hernandez Toledo Hector
- Ho Shirley
- Hogg David W
- Holley-Bockelmann Kelly
- Holtzman Jon A
- Holzer Parker H
- Hu Jian
- Huber Daniel
- Hutchinson Timothy Alan
- Hwang Ho Seong
- Ibarra-Medel Hector J
- Ilha Gabriele Da Silva
- Ivans Inese I
- Ivory KeShawn
- Jaehnig Kurt
- Jensen Trey W
- Johnson Jennifer A
- Jones Amy
- Jose Downes Juan
- Jullo Eric
- Kallinger T
- Kinemuchi Karen
- Kirkby David
- Klaene Mark
- Kneib Jean-Paul
- Kollmeier Juna A
- Lacerna Ivan
- Lane Richard R
- Lang Dustin
- Laurent Pierre
- Law David R
- Le Goff Jean-Marc
- Leauthaud Alexie
- Li Chen
- Li Cheng
- Li Niu
- Li Ran
- Liang Fu-Heng
- Liang Yu
- Lima Marcos
- Lin Lihwai
- Lin Lin
- Lin Yen-Ting
- Liu Chao
- Long Dan
- Lopes A Roman
- Lucatello Sara
- MacDonald Nicholas
- Machado Alice Deconto
- Mackereth J Ted
- MacLeod Chelsea L
- Mahadevan Suvrath
- Maiolino Roberto
- Majewski Steven R
- Malanushenko Olena
- Malanushenko Viktor
- Mallmann Nicolas Dullius
- Manchado Arturo
- Maqueo Chew Yilen Gomez
- Maraston Claudia
- Marin Hector Gil
- Marques-Chaves Rui
- Martinez Valpuesta Inma
- Masters Karen L
- Mathur Savita
- McGreer Ian D
- Merloni Andrea
- Merrifield Michael R
- Meszaros Szabolcs
- Meza Andres
- Miglio Andrea
- Minchev Ivan
- Molaverdikhani Karan
- Montero-Dorta Antonio D
- Mosser Benoit
- Muna Demitri
- Myers Adam
- Nair Preethi
- Nandra Kirpal
- Ness Melissa
- Newman Jeffrey A
- Nichol Robert C
- Nidever David L
- Nitschelm Christian
- O'Connell Julia
- Oravetz Audrey
- Oravetz Daniel J
- Pace Zachary
- Padilla Nelson
- Palanque-Delabrouille Nathalie
- Pan Kaike
- Parejko John
- Paris Isabelle
- Park Changbom
- Peacock John A
- Peirani Sebastien
- Pellejero-Ibanez Marcos
- Penny Samantha
- Percival Jeffrey W
- Percival Will J
- Perez-Fournon Ismael
- Petitjean Patrick
- Pieri Matthew
- Pinsonneault Marc H
- Pisani Alice
- Prada Francisco
- Prakash Abhishek
- Price-Jones Natalie
- Raddick M Jordan
- Rahman Mubdi
- Raichoor Anand
- Rembold Sandro Barboza
- Reyna AM
- Rich James
- Richstein Hannah
- Ridl Jethro
- Riffel Rogemar A
- Riffel Rogerio
- Rix Hans-Walter
- Robin Annie C
- Rockosi Constance M
- Rodrigues Thaise S
- Rodriguez-Torres Sergio
- Roe Natalie
- Roman-Zuniga Carlos
- Ross Ashley J
- Rossi Graziano
- Ruan John
- Ruggeri Rossana
- Runnoe Jessie C
- Salazar-Albornoz Salvador
- Salvato Mara
- Sanchez Ariel G
- Sanchez Sebastian F
- Sanchez-Gallego Jose R
- Santiago Basilio Xavier
- Schiavon Ricardo
- Schimoia Jaderson S
- Schlafly Eddie
- Schlegel David J
- Schneider Donald P
- Schonrich Ralph
- Schultheis Mathias
- Schwope Axel
- Seo Hee-Jong
- Serenelli Aldo
- Sesar Branimir
- Shao Zhengyi
- Shetrone Matthew
- Shull Michael
- Skrutskie MF
- Slosar Anze
- Smith Michael
- Smith Verne V
- Sobeck Jennifer
- Somers Garrett
- Souto Diogo
- Stark David V
- Stassun Keivan G
- Steinmetz Matthias
- Stello Dennis
- Strauss Michael A
- Streblyanska Alina
- Stringfellow Guy S
- Suarez Genaro
- Sun Jing
- Taghizadeh-Popp Manuchehr
- Tang Baitian
- Tao Charling
- Tayar Jamie
- Tembe Mita
- Thomas Daniel
- Tinker Jeremy
- Tojeiro Rita
- Tremonti Christy
- Troup Nicholas
- Trump Jonathan R
- Unda-Sanzana Eduardo
- Valenzuela O
- Van den Bosch Remco
- Vargas-Magana Mariana
- Vazquez Jose Alberto
- Villanova Sandro
- Vivek M
- Vogt Nicole
- Wake David
- Walterbos Rene
- Wang Enci
- Wang Yuting
- Weaver Benjamin Alan
- Weijmans Anne-Marie
- Weinberg David H
- Westfall Kyle B
- Whelan David G
- Wilcots Eric
- Wild Vivienne
- Williams Rob A
- Wilson John
- Wood-Vasey WM
- Wylezalek Dominika
- Xiao Ting
- Yan Renbin
- Yang Meng
- Ybarra Jason E
- Yeche Christophe
- Yuan Fang-Ting
- Zakamska Nadia
- Zamora Olga
- Zasowski Gail
- Zhang Kai
- Zhao Cheng
- Zhao Gong-Bo
- Zheng Zheng
- Zheng Zheng
- Zhou Zhi-Min
- Zhu Guangtun
- Zinn Joel C
- Zou Hu
- Publication venue
- ASTROPHYSICAL JOURNAL SUPPLEMENT SERIES
- Publication date
- 01/01/2017
- Field of study
The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) began observations in July 2014. It pursues three core programs: APOGEE-2,MaNGA, and eBOSS. In addition, eBOSS contains two major subprograms: TDSS and SPIDERS. This paper describes the first data release from SDSS-IV, Data Release 13 (DR13), which contains new data, reanalysis of existing data sets and, like all SDSS data releases, is inclusive of previously released data. DR13 makes publicly available 1390 spatially resolved integral field unit observations of nearby galaxies from MaNGA,the first data released from this survey. It includes new observations from eBOSS, completing SEQUELS. In addition to targeting galaxies and quasars, SEQUELS also targeted variability-selected objects from TDSS and X-ray selected objects from SPIDERS. DR13 includes new reductions ofthe SDSS-III BOSS data, improving the spectrophotometric calibration and redshift classification. DR13 releases new reductions of the APOGEE-1data from SDSS-III, with abundances of elements not previously included and improved stellar parameters for dwarf stars and cooler stars. For the SDSS imaging data, DR13 provides new, more robust and precise photometric calibrations. Several value-added catalogs are being released in tandem with DR13, in particular target catalogs relevant for eBOSS, TDSS, and SPIDERS, and an updated red-clump catalog for APOGEE.This paper describes the location and format of the data now publicly available, as well as providing references to the important technical papers that describe the targeting, observing, and data reduction. The SDSS website, http://www.sdss.org, provides links to the data, tutorials and examples of data access, and extensive documentation of the reduction and analysis procedures. DR13 is the first of a scheduled set that will contain new data and analyses from the planned ~6-year operations of SDSS-IV.PostprintPeer reviewe
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
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- A. -G. Wu
- A. C. Ma
- A. K. Au
- Abdel-Aziz A. K.
- Abdelfatah S.
- Abdellatif M.
- Abdoli A.
- Abel S.
- Abeliovich H.
- Abildgaard M. H.
- Abudu Y. P.
- Acevedo-Arozena A.
- Adamopoulos I. E.
- Adeli K.
- Adolph T. E.
- Adornetto A.
- Aflaki E.
- Agam G.
- Agarwal A.
- Aggarwal B. B.
- Agnello M.
- Agostinis P.
- Agrewala J. N.
- Agrotis A.
- Aguilar P. V.
- Ahmad S. T.
- Ahmed Z. M.
- Ahumada-Castro U.
- Aits S.
- Aizawa S.
- Akkoc Y.
- Akoumianaki T.
- Akpinar H. A.
- Al-Abd A. M.
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- Al-Gharaibeh A.
- Alaoui-Jamali M. A.
- Alberti S.
- Alcocer-Gomez E.
- Alessandri C.
- Ali M.
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- Aliwaini S.
- Alizadeh J.
- Almacellas E.
- Almasan A.
- Alonso A.
- Alonso G. D.
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- Altieri D. C.
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- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
Global Retinoblastoma Presentation and Analysis by National Income Level.
- Author
- Abdallah Elhassan
- Abdullahi Shehu U
- Abdulqader Rula A
- Adamou Boubacar Sahadatou
- Ademola-Popoola Dupe S
- Adio Adedayo
- Afshar Armin R
- Aggarwal Priyanka
- Aghaji Ada E
- Ahmad Alia
- Akib Marliyanti NR
- Al Ani Mouroge H
- Al Harby Lamis
- Al-Badri Safaa AF
- Al-Dahmash Saad A
- Al-Haddad Christiane
- Al-Hussaini Hamoud HY
- Al-Jadiry Mazin F
- Al-Jumaily Usama
- Al-Mafrachi Ali ARM
- Al-Shaheen Athar ASM
- Al-Shammary Entissar H
- Alakbarova Aygun
- Alcasabas Ana Patricia A
- Alejos Amanda
- Alemany-Rubio Ernesto
- Alfa Bio Amadou I
- Alfonso Carreras Yvania
- Ali Amany M
- Alia Donjeta B
- Alkatan Hind M
- All-Eriksson Charlotta
- Almeida Argentino A
- Alsawidi Khalifa M
- Amiruddin Primawita O
- Antonino Romanzo
- Astbury Nicholas J
- Atalay Hatice T
- Atchaneeyasakul La-Ongsri
- Atsiaya Rose
- Attaseth Taweevat
- Aung Than H
- Ayala Silvia
- Baizakova Baglan
- Balaguer Julia
- Balayeva Ruhengiz
- Balwierz Walentyna
- Barranco Honorio
- Bascaran Covadonga
- Beck Popovic Maja
- Benavides Raquel
- Benmiloud Sarra
- Bennani Guebessi Nissrine
- Berete Rokia C
- Berry Jesse L
- Bhaduri Anirban
- Bhat Sunil
- Biddulph Shelley J
- Biewald Eva M
- Bobrova Nadia
- Boehme Marianna
- Boldt HC
- Bonanomi Maria Teresa BC
- Bornfeld Norbert
- Bouda Gabrielle C
- Bouguila Hédi
- Boumedane Amaria
- Bowman Richard
- Brennan Rachel C
- Brichard Bénédicte G
- Buaboonnam Jassada
- Calderón-Sotelo Patricia
- Calle Jara Doris A
- Camuglia Jayne E
- Cano Miriam R
- Capra Michael
- Cassoux Nathalie
- Castela Guilherme
- Castillo Luis
- Català-Mora Jaume
- Chantada Guillermo L
- Chaudhry Shabana
- Chaugule Sonal S
- Chauhan Argudit
- Chawla Bhavna
- Chernodrinska Violeta S
- Chiwanga Faraja S
- Chuluunbat Tsengelmaa
- Cieslik Krzysztof
- Cockcroft Ruellyn L
- Comsa Codruta
- Correa Llano Maria G
- Correa Zelia M
- Corson Timothy W
- Cowan-Lyn Kristin E
- Csóka Monika
- Cui Xuehao
- Da Gama Isac V
- Dangboon Wantanee
- Das Anirban
- Das Sima
- Davanzo Jacquelyn M
- Davidson Alan
- De Potter Patrick
- Delgado Karina Q
- Demirci Hakan
- Desjardins Laurence
- Diaz Coronado Rosdali Y
- Dimaras Helen
- Dodgshun Andrew J
- Donaldson Craig
- Donato Macedo Carla R
- Dragomir Monica D
- Du Bruyn Magritha
- Du Yi
- Edison Kemala S
- Eka Sutyawan I Wayan
- El Kettani Asmaa
- Elbahi Amal M
- Elder James E
- Elgalaly Dina
- Elhaddad Alaa M
- Elhassan Moawia M Ali
- Elzembely Mahmoud M
- Essuman Vera A
- Evina Ted Grimbert A
- Fabian Ido Didi
- Fadoo Zehra
- Fandiño Adriana C
- Faranoush Mohammad
- Fasina Oluyemi
- Fernández Delia DPG
- Fernández-Teijeiro Ana
- Foster Allen
- Frenkel Shahar
- Fu Ligia D
- Fuentes-Alabi Soad L
- Gallie Brenda L
- Gandiwa Moira
- Garcia Pacheco Henry N
- Garcia Juan L
- García Aldana David
- Gassant Pascale Y
- Geel Jennifer A
- Ghassemi Fariba
- Girón Ana V
- Gizachew Zelalem
- Global Retinoblastoma Study Group
- Goenz Marco A
- Gold Aaron S
- Goldberg-Lavid Maya
- Gole Glen A
- Gomel Nir
- Gonzalez Perez Graciela
- Gonzalez Efren
- González-Rodríguez Liudmira
- Graells Jaime
- Green Liz
- Gregersen Pernille A
- Grigorovski Nathalia DAK
- Guedenon Koffi M
- Gunasekera D Sanjeeva
- Gupta Himika
- Gupta Sanjiv
- Gündüz Ahmet K
- Hadjistilianou Theodora
- Hamel Patrick
- Hamid Syed A
- Hamzah Norhafizah
- Hansen Eric D
- Harbour J William
- Hartnett M Elizabeth
- Hasanreisoglu Murat
- Hassan Sadiq
- Hassan Shadab
- Hederova Stanislava
- Hernandez Jose
- Hernandez Lorelay Marie Carcamo
- Hessissen Laila
- Hordofa Diriba F
- Huang Laura C
- Hubbard GB
- Hummlen Marlies
- Husakova Kristina
- Hussein Al-Janabi Allawi N
- Ida Russo
- Ilic Vesna R
- Jairaj Vivekaraj
- Jeeva Irfan
- Jenkinson Helen
- Ji Xunda
- Jo Dong Hyun
- Johnson Kenneth P
- Johnson William J
- Jones Michael M
- Kabesha Theophile B Amani
- Kabore Rolande L
- Kaliki Swathi
- Kalinaki Abubakar
- Kantar Mehmet
- Kao Ling-Yuh
- Kardava Tamar
- Kebudi Rejin
- Kepak Tomas
- Keren-Froim Naama
- Khan Zohora J
- Khaqan Hussain A
- Khauv Phara
- Kheir Wajiha J
- Khetan Vikas
- Khodabande Alireza
- Khotenashvili Zaza
- Kim Jeong Hun
- Kim Jonathan W
- Kiratli Hayyam
- Kivelä Tero T
- Klett Artur
- Komba Palet Jess Elio Kosh
- Krivaitiene Dalia
- Kruger Mariana
- Kulvichit Kittisak
- Kuntorini Mayasari W
- Kyara Alice
- Lachmann Eva S
- Lam Carol PS
- Lam Geoffrey C
- Larson Scott A
- Latinovic Slobodanka
- Laurenti Kelly D
- Le Bao Han A
- Lecuona Karin
- Leverant Amy A
- Li Cairui
- Limbu Ben
- Long Quah Boon
- Lukamba Robert M
- Lumbroso Livia
- Luna-Fineman Sandra
- Lutfi Delfitri
- Lysytsia Lesia
- López Juan P
- Magrath George N
- Mahajan Amita
- Majeed Abdul Rahim
- Maka Erika
- Makan Mayuri
- Makimbetov Emil K
- Manda Chatonda
- Martín Begue Nieves
- Mason John O
- Mason Lauren
- Matende Ibrahim O
- Materin Miguel
- Mattosinho Clarissa CDS
- Matua Marchelo
- Mayet Ismail
- Mbumba Freddy B
- McKenzie John D
- Medina-Sanson Aurora
- Mehrvar Azim
- Mengesha Aemero A
- Menon Vikas
- Mercado Gary John VD
- Mets Marilyn B
- Midena Edoardo
- Mishra Divyansh KC
- Mndeme Furahini G
- Mohamedani Ahmed A
- Mohammad Mona T
- Moll Annette C
- Montero Margarita M
- Morales Rosa A
- Moreira Claude
- Mruthyunjaya Prithvi
- Msina Mchikirwa S
- Msukwa Gerald
- Mudaliar Sangeeta S
- Muma Kangwa I
- Munier Francis L
- Murgoi Gabriela
- Murray Timothy G
- Musa Kareem O
- Mushtaq Asma
- Mustak Hamzah
- Muyen Okwen M
- Naidu Gita
- Nair Akshay Gopinathan
- Naumenko Larisa
- Ndoye Roth Paule Aïda
- Nency Yetty M
- Neroev Vladimir
- Ngo Hang
- Nieves Rosa M
- Nikitovic Marina
- Nkanga Elizabeth D
- Nkumbe Henry
- Nuruddin Murtuza
- Nyaywa Mutale
- Obono-Obiang Ghislaine
- Oguego Ngozi C
- Olechowski Andrzej
- Oliver Scott CN
- Osei-Bonsu Peter
- Ossandon Diego
- Paez-Escamilla Manuel A
- Pagarra Halimah
- Painter Sally L
- Paintsil Vivian
- Paiva Luisa
- Pal Bikramjit P
- Palanivelu Mahesh Shanmugam
- Papyan Ruzanna
- Parrozzani Raffaele
- Parulekar Manoj
- Pascual Morales Claudia R
- Paton Katherine E
- Pawinska-Wasikowska Katarzyna
- Pe'er Jacob
- Peric Sanja
- Peña Armando
- Pham Chau TM
- Philbert Remezo
- Plager David A
- Pochop Pavel
- Polania Rodrigo A
- Polyakov Vladimir G
- Pompe Manca T
- Pons Jonathan J
- Portabella Silvia Alarcón
- Prat Daphna
- Prom Vireak
- Purwanto Ignatius
- Qadir Ali O
- Qayyum Seema
- Qian Jiang
- Rahman Ardizal
- Rahman Salman
- Rahmat Jamalia
- Rajkarnikar Purnima
- Ramanjulu Rajesh
- Ramasubramanian Aparna
- Ramirez-Ortiz Marco A
- Raobela Léa
- Rashid Riffat
- Reddy M Ashwin
- Reich Ehud
- Renner Lorna A
- Reynders David
- Ribadu Dahiru
- Riheia Mussagy M
- Ritter-Sovinz Petra
- Rojanaporn Duangnate
- Romero Livia
- Roy Soma R
- Saab Raya H
- Saakyan Svetlana
- Sabhan Ahmed H
- Sagoo Mandeep S
- Said Azza MA
- Saiju Rohit
- Salas Beatriz
- San Román Pacheco Sonsoles
- Sayalith Phayvanh
- Scanlan Trish A
- Schefler Amy C
- Schoeman Judy
- Sedaghat Ahad
- Seregard Stefan
- Seth Rachna
- Shah Ankoor S
- Shakoor Shawkat A
- Sharma Manoj K
- Sherief Sadik T
- Shetye Nandan G
- Shields Carol L
- Siddiqui Sorath Noorani
- Sidi Cheikh Sidi
- Silva Sónia
- Singh Arun D
- Singh Niharika
- Singh Usha
- Singha Penny
- Sitorus Rita S
- Skalet Alison H
- Soebagjo Hendrian D
- Sorochynska Tetyana
- Ssali Grace
- Stacey Andrew W
- Staffieri Sandra E
- Stahl Erin D
- Stathopoulos Christina
- Stirn Kranjc Branka
- Stones David K
- Strahlendorf Caron
- Suarez Maria Estela Coleoni
- Sultana Sadia
- Sun Xiantao
- Sundy Meryl
- Superstein Rosanne
- Supriyadi Eddy
- Surukrattanaskul Supawan
- Suzuki Shigenobu
- Svojgr Karel
- Sylla Fatoumata
- Sánchez Gissela L
- Tamamyan Gevorg
- Tan Deborah
- Tandili Alketa
- Tarrillo Leiva Fanny F
- Tashvighi Maryam
- Tateshi Bekim
- Teh Kok Hoi
- Tehuteru Edi S
- Teixeira Luiz F
- Theophile Tuyisabe
- Toledano Helen
- Trang Doan L
- Traoré Fousseyni
- Trichaiyaporn Sumalin
- Tuncer Samuray
- Tyau-Tyau Harba
- Umar Ali B
- Unal Emel
- Uner Ogul E
- Urbak Steen F
- Ushakova Tatiana L
- Usmanov Rustam H
- Valeina Sandra
- van Hoefen Wijsard Milo
- Varadisai Adisai
- Vasquez Liliana
- Vaughan Leon O
- Veleva-Krasteva Nevyana V
- Verma Nishant
- Victor Andi A
- Viksnins Maris
- Villacís Chafla Edwin G
- Vishnevskia-Dai Vicktoria
- Vora Tushar
- Wachtel Antonio E
- Wackernagel Werner
- Waddell Keith
- Wade Patricia D
- Wali Amina H
- Wang Yi-Zhuo
- Weiss Avery
- Wilson Matthew W
- Wime Amelia DC
- Wiwatwongwana Atchareeya
- Wiwatwongwana Damrong
- Wolley Dod Charlotte
- Wongwai Phanthipha
- Xiang Daoman
- Xiao Yishuang
- Yam Jason C
- Yang Huasheng
- Yanga Jenny M
- Yaqub Muhammad A
- Yarovaya Vera A
- Yarovoy Andrey A
- Ye Huijing
- Yousef Yacoub A
- Yuliawati Putu
- Zapata López Arturo M
- Zein Ekhtelbenina
- Zhang Chengyue
- Zhang Yi
- Zhao Junyang
- Zheng Xiaoyu
- Zhilyaeva Katsiaryna
- Zia Nida
- Ziko Othman AO
- Zondervan Marcia
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 01/01/2020
- Field of study
Importance: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. Objectives: To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis. Design, Setting, and Participants: A total of 278 retinoblastoma treatment centers were recruited from June 2017 through December 2018 to participate in a cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. Main Outcomes and Measures: Age at presentation, proportion of familial history of retinoblastoma, and tumor stage and metastasis. Results: The cohort included 4351 new patients from 153 countries; the median age at diagnosis was 30.5 (interquartile range, 18.3-45.9) months, and 1976 patients (45.4%) were female. Most patients (n = 3685 [84.7%]) were from low- and middle-income countries (LMICs). Globally, the most common indication for referral was leukocoria (n = 2638 [62.8%]), followed by strabismus (n = 429 [10.2%]) and proptosis (n = 309 [7.4%]). Patients from high-income countries (HICs) were diagnosed at a median age of 14.1 months, with 656 of 666 (98.5%) patients having intraocular retinoblastoma and 2 (0.3%) having metastasis. Patients from low-income countries were diagnosed at a median age of 30.5 months, with 256 of 521 (49.1%) having extraocular retinoblastoma and 94 of 498 (18.9%) having metastasis. Lower national income level was associated with older presentation age, higher proportion of locally advanced disease and distant metastasis, and smaller proportion of familial history of retinoblastoma. Advanced disease at diagnosis was more common in LMICs even after adjusting for age (odds ratio for low-income countries vs upper-middle-income countries and HICs, 17.92 [95% CI, 12.94-24.80], and for lower-middle-income countries vs upper-middle-income countries and HICs, 5.74 [95% CI, 4.30-7.68]). Conclusions and Relevance: This study is estimated to have included more than half of all new retinoblastoma cases worldwide in 2017. Children from LMICs, where the main global retinoblastoma burden lies, presented at an older age with more advanced disease and demonstrated a smaller proportion of familial history of retinoblastoma, likely because many do not reach a childbearing age. Given that retinoblastoma is curable, these data are concerning and mandate intervention at national and international levels. Further studies are needed to investigate factors, other than age at presentation, that may be associated with advanced disease in LMICs
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
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- Y Christen
- Y Curin
- Y Deugnier
- Y Deugnier
- Y Engin-Üstün
- Y Ge
- Y Gilgun-Sherki
- Y Haruna
- Y Honda
- Y Hua
- Y Ikeda
- Y Jiao
- Y Jung
- Y Ke
- Y Ke
- Y Kohgo
- Y Kohgo
- Y Levites
- Y Li
- Y Okatani
- Y Okatani
- Y Sai
- Y Sai
- Y Sun
- Y Takada
- Y Wang
- Y Wang
- Y Wei
- Y Wei
- Y Wu
- Y Wu
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhao
- Y Zheng
- YE Henrotin
- YF Chu
- YH Lee
- YH Suh
- YH Wei
- YJ Surh
- YJ Surh
- YJ Surh
- YK Wu
- YM Kim
- YS Keum
- YS Sohn
- YX Ma
- YZ Fang
- Z Cai
- Z Cai
- Z Cheng
- Z Pei
- Z Serdar
- Z Tong
- Z Tong
- Z Yu
- Z Zhang
- ZD Liu
- ZD Liu
- ZE Karanjawala
- ZE Suntres
- ZI Cabantchik
- ZZ Chong
- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
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- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
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- Zuryn S
- Zwerschke W
- Álvarez ÉMC
- Ávalos Y
- Önal G
- Üstün S
- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
- Author
- Aase Handberg
- Abhijna R Ballal
- Abhimanyu Thakur
- Abuelreich Sarah
- Achille Anselmo
- Adam L Maddox
- Adityas Purnianto
- Adrian E Morelli
- Adrian L Harris
- Adriana F Paes Leme
- Adriana T Larregina
- Afrodité Németh
- Afsareen Bano
- Agnieszka Razim
- Agustin Enciso-Martinez
- Ahmed Ge Ibrahim
- Ahmed Somaida
- Aija Linē
- Ainhoa Alberro
- Ajay P Singh
- Akbar L Marzan
- Akhil Srivastava
- Akira Yokoi
- Al Charest
- Alain R Brisson
- Alan J Zimmerman
- Albano Cáceres-Verschae
- Aled Clayton
- Aleksandra Inic-Kanada
- Aleksei Tikhonov
- Alena Ivanova
- Alessandra Ciullo
- Alessandro Gori
- Alessio Noghero
- Alex J Rai
- Alexander Otahal
- Alexander R Ivanov
- Alexis G Murillo Carrasco
- Alice Gualerzi
- Alicia Galinsoga
- Alicia Llorente
- Aliosha I Figueroa-Valdés
- Alireza Fazeli
- Alissa M Weaver
- Alok Raghav
- Alvaro Compañ-Bertomeu
- Amanda Khoo
- Amanda Salviano-Silva
- Amandine Bonifay
- Amankeldi A Salybekov
- Amélie Nadeau
- Amin Zakeri
- Amirmohammad Nasiri Kenari
- Amit K Srivastava
- Amy A Baxter
- Amy C Kauffman
- Amy H Buck
- An Hendrix
- Ana C Torrecilhas
- Ana I Salazar-Puerta
- Ana O'Loghlen
- Anabela Cordeiro-da-Silva
- Anaïs Bécot
- Anders T Boysen
- Andras G Miklosi
- Andras Saftics
- András I Försönits
- Andre J van Wijnen
- Andrea Galisova
- Andrea Ridolfi
- Andrea Zendrini
- Andreas Möller
- Andreia M Silva
- Andreina Schoeberlein
- Andreu Matamoros-Angles
- Andrew Devitt
- Andrew F Hill
- Andrew Lai
- Andrew Rowland
- André Cronemberger-Andrade
- André Görgens
- Andries Zijlstra
- Angela M Zivkovic
- Angelica Ortiz
- Angelo Musicò
- Ann M Wehman
- Anna Antoniou
- Anna C Berardi
- Anna Cifuentes-Rius
- Anna D Krasnodembskaya
- Anna Koncz
- Anna M Schmid
- Anna Romolo
- Annaïg J Rozo
- Annalisa Radeghieri
- Annie Frelet-Barrand
- Annika Pfeiffer
- Anthony W Ferrante Jr
- Antje M Zickler
- Antoine Karoichan
- Antonella Bongiovanni
- Antonia Hufnagel
- Antonia Reale
- Antonio da Silva Novaes
- Antonio Marcilla
- Apolonija Bedina-Zavec
- Apurba Dev
- Asa M Wheelock
- Ashish Kumar
- Ashley E Russell
- Ashok K Shetty
- Asima Bhattacharyya
- Attila Oláh
- Augusto Zani
- Aurelia Rughetti
- Aurelio Lorico
- Aurélie Ledreux
- Avital A Rodal
- Ayesha Saleem
- Ákos M Lőrincz
- Áurea M Gabriel
- Bagabas Reem
- Baharak Hosseinkhani
- Bahnisikha Barman
- Bairen Pang
- Bas Wm van Balkom
- Batuhan T Bozkurt
- Beate Vestad
- Benedetta Bussolati
- Benjamin Jurek
- Benjamin Mary
- Bergese Paolo
- Berglind E Benediktsdóttir
- Bernadett R Bodnár
- Bernd Giebel
- Bert Dhondt
- Berta Puig
- Beth Coyle
- Beth Holder
- Bianca C Pachane
- Biao Lu
- Bingdong Sui
- Birke J Benedikter
- Blenkiron Cherie
- Bo Li
- Bojana Milutinovic
- Bong Hwan Sung
- Bonita H Powell
- Brachyahu M Kestecher
- Bradley Whitehead
- Brian Dobosh
- Bridges Esther M.
- Brucale Marco
- Bruce A Stanton
- Burger Dylan
- Bussolati Benedetta
- Buzas Edit I.
- Byeong Hyeon Choi
- Cai Houjian
- Camille Ettelaie
- Camille V Trinidad
- Cansu Gorgun
- Carla Mazzeo
- Carlos Salomon
- Carmen Campos-Silva
- Carmen Carceller
- Carmen Fernandez-Becerra
- Carmen Jerónimo
- Carney Randy P.
- Carolina Balbi
- Carolina Soekmadji
- Caroline Gilbert
- Caroline J Reddel
- Catherine A Sánchez
- Catherine Martel
- Cecilia Bucci
- Cecilia Lässer
- Celine Elie-Caille
- Cécile E Malnou
- Changhai Tian
- Changjin Lee
- Chantal M Boulanger
- Charisse N Winston
- Charles J Blijdorp
- Charles P Lai
- Charlotte Lawson
- Chaya Brodie
- Chelsea N Davis
- Cherie Blenkiron
- Chiew Yong Ng
- Chihchen Chen
- Chitranshi Nitin
- Christian Neri
- Christian P Pallasch
- Christian Preußer
- Christina Nedeva
- Christopher Fernandez-Prada
- Chungmin Han
- Claudia M Radu
- Cláudio Pinheiro
- Clémence Belleannée
- Clotilde Billottet
- Clotilde Théry
- Cocucci Emanuele
- Colin L Hisey
- Cora L Alvarez
- Coralie L Guerin
- Crescitelli Rossella
- Crislyn D'Souza-Schorey
- Cristina Fornaguera
- Cristina Pr Xavier
- Cristóbal Cerda-Troncoso
- D Craig Hooper
- D Michiel Pegtel
- Daan Paget
- Dakota Gustafson
- Dalila Iannotta
- Daniel Bachurski
- Daniel H Kim
- Daniel J MacPhee
- Daniel S Lark
- Daniel W Hagey
- Daniela Boselli
- Daniela Freitas
- Daniela L Papademetrio
- Daniele D'Arrigo
- Daniele Noël
- Danielle J Beetler
- Danilo Mladenović
- David A Armstrong
- David A Routenberg
- David C Lyden
- David D Roberts
- David J Lundy
- David Juncker
- David Laurin
- David Otaegui
- David P Al-Adra
- David R Brigstock
- David Rf Carter
- David Rufino-Ramos
- David W Greening
- Davide Zocco
- Deanna F Shea
- Deborah Ci Goberdhan
- Delaram Khamari
- Denis Corbeil
- Dennis K Jeppesen
- Di Vizio Dolores
- Diego Kyburz
- Dilara C Ozkocak
- Dimitri Aubert
- Dina Ak Ahmed
- Dinesh Upadhya
- Dionysios C Watson
- Dirk P Dittmer
- Dirk Strunk
- Dmitry Ter-Ovanesyan
- Dolores Di Vizio
- Dominic Guanzon
- Donald G Phinney
- Dong Jun Park
- Dong-Gyu Jo
- Dong-Sup Lee
- Dongin Kim
- Dorian Forte
- Dorival M Rodrigues-Junior
- Doste R Mamand
- Driedonks Tom A. P.
- Dylan Burger
- Edina Gyukity-Sebestyén
- Edison Salas-Huenuleo
- Edit I Buzas
- Eduardo Marbán
- Eduardo Martínez-Martínez
- Eduardo Reategui
- Edveena Hanser
- Edwin van der Pol
- Efrat Levy
- Eisuke Dohi
- Elena Aikawa
- Elena Izquierdo
- Elena Khomyakova
- Elena S Martens-Uzunova
- Elena Vacchi
- Elham Hosseini-Beheshti
- Elias Sulaiman
- Elisa Lázaro-Ibáñez
- Elisa Tonoli
- Elise Madec
- Elizabeth R Dellar
- Elke Pogge von Strandmann
- Ellis K Fok
- Elżbieta Karnas
- Emanuele Cocucci
- Emilia Scharrig
- Emilio Di Ianni
- Emma Kc Symonds
- Enis Kostallari
- Eqbal Mohamadi
- Erdbrügger Uta
- Erez Eitan
- Eric Boilard
- Erica Bazzan
- Ernesto Gargiulo
- Esmahan Durmaz
- Estefanía Lozano-Andrés
- Esther M Bridges
- Esther Nm Nolte-'t Hoen
- Eszter Á Tóth
- Etienne Doré
- Etienne Moussay
- Eva Rohde
- Eva-Maria Krämer-Albers
- Evan A Gizzie
- Ewa K Zuba-Surma
- Ewa Ł Stępień
- Émilie Velot
- Fabian Braun
- Fabiana Geraci
- Fabienne Archer
- Fabrice Lucien
- Faezeh Shekari
- Faisal J Alibhai
- Falcon‐Perez Juan M.
- Farah Fatima
- Farrukh Aqil
- Fatah Kashanchi
- Fatemeh Momen-Heravi
- Fausto Almeida
- Federica Collino
- Federico Cocozza
- Federico Colombo
- Ferdinando Pucci
- Fernanda Jadue
- Fernando Souza-Fonseca-Guimaraes
- Flora Guerra
- Florian Puhm
- Fons Aj van de Loo
- Francesc E Borràs
- Francesca Perut
- Francesco Valle
- Francois Mullier
- Frank Rm Stassen
- Franz L Ricklefs
- Fred H Hochberg
- Frederic St-Denis-Bissonnette
- Frederik J Verweij
- Fu Qing‐Ling
- Fumihiko Urabe
- Gabrielis Kundrotas
- Gabriella Dobra
- Gabriella Pocsfalvi
- Gagan Deep
- Ganesh V Shelke
- Ganesha Poojary
- Ganna Stepanova
- Geneviève Bart
- Georges E Grau
- Georgia K Atkin-Smith
- Georgios Giamas
- Géraldine C Genard
- Ghasem Hosseini Salekdeh
- Gi-Hoon Nam
- Giorgia Melli
- Giovanni Camussi
- Giuseppina Poppa
- Gloria Alvarez-Llamas
- Goberdhan Deborah C. I.
- Gorjana Rackov
- Graca Raposo
- Gregory E Rice
- Gregory Lavieu
- Guanshu Liu
- Guido Jenster
- Guillaume van Niel
- Guoku Hu
- Guoping Li
- Hadi Valadi
- Hafiza Padinharayil
- Hakho Lee
- Han Sang Kim
- Hang Yin
- Hannah K Jackson
- Hanser Edveena
- Hao Chen
- Hao Zhang
- Hargita Hegyesi
- Harmeet Malhi
- Harris Adrian L.
- Harry Holthofer
- Harry Vm Spiers
- Haseeb Zubair
- Haughey Norman J.
- Heather H Pua
- Hendrix An
- Henrique Girão
- Heon-Jin Lee
- Hernando A Del Portillo
- Hernán González-King Garibotti
- Héctor Peinado
- Hidetoshi Tahara
- Hilal A Rather
- Hill Andrew F.
- Hiroaki Komuro
- Honami Naora
- Hongkuan Fan
- Houjian Cai
- Huaqi Su
- Hugo R Caires
- Hyo Jung An
- Hyungsoon Im
- Igea D'Agnano
- Igor V Kurochkin
- Ilaria Giusti
- Ilaria Prada
- Iliya Lefterov
- Imola Cs Szigyártó
- In-San Kim
- Indira Prasadam
- Inge Nelissen
- Ioannis Azoidis
- Irene Bertolini
- Irina Nazarenko
- Irma Schabussova
- Isabel Barranco
- Ivan J Vechetti
- Ivan Kh Poon
- Ivanov Alexander R.
- Ivica Marić
- J Brian Byrd
- Jacky G Goetz
- Jacob A Cleary
- Jamal Ghanam
- Jameel M Inal
- James G Patton
- Jan Lötvall
- Jan Van Deun
- Jana Zarubova
- Jane Howard
- Janine Stam
- Janis A Müller
- Janne Leivo
- Janos Zempleni
- Janusz Rak
- Jascinta P Santavanond
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- Valeria Barreca
- Valle Francesco
- van der Pol Edwin
- van Herwijnen Martijn J. C.
- Varga Zoltan
- Vasiliki Mahairaki
- Vasiliy S Chernyshev
- Vatsal Deliwala
- Veer Bala Gupta
- Vendula Pospichalova
- Vengala Rao Yenuganti
- Venkatesh Kumar Chetty
- Vera A Tang
- Vera Mugoni
- Vera Tscherrig
- Verity J Ford
- Verline Justilien
- Veronica Huber
- Veronika Kralj-Iglic
- Veronika Stoka
- Victor Bodart-Santos
- Vijaya Sunkara
- Vikramsingh Gujar
- Viktoria Szeifert
- Viktoria Weber
- Vincent Hyenne
- Vincent Yeung
- Vincenza Dolo
- Violaine Moreau
- Vito G D'Agostino
- Vivek Kumar Gupta
- Vladimir Bokun
- Vroniqa Ku'ulei-Lyn Faustino
- Vytautas Žėkas
- Wai-Leng Lee
- Wanessa F Altei
- Wauben Marca H. M.
- Wehman Ann M.
- Wei Duan
- Wei Guo
- Wei Seong Toh
- Welsh Joshua A.
- Wen-Wei Chang
- Wilfrid Boireau
- Wilfried W Bazié
- Willem Stoorvogel
- Williams Sarah
- Witwer Kenneth W.
- Wolfgang Holnthoner
- Wyatt N Vreeland
- Xabier Osteikoetxea
- Xandra O Breakefield
- Xavier Loyer
- Xiaomei Yan
- Xiaoqin Wang
- Xinhua Lei
- Xinlei Li
- Xiuming Liang
- Yagmur Yildizhan
- Yang You
- Yasuo Inoshima
- Yi Wen
- Yinghong Zhou
- Yingtang Gao
- Yiyao Huang
- Yoel Sadovsky
- Yohan Kim
- Yong Song Gho
- Yongkang Yang
- Yonis Bare
- Yoon-Kyoung Cho
- Yoshinobu Takakura
- Young-Gyun Park
- Yu Fujita
- Yu Xiao
- Yuki Yamamoto
- Yumi Kumagai
- Yunjie Wu
- Yunxi Chen
- Yusuke Yamamoto
- Yusuke Yoshioka
- Yvan Courageux
- Yvonne Couch
- Zach Troyer
- Zendrini Andrea
- Zheng Lei
- Zheng Zhao
- Zijlstra Andries
- Zimmerman Alan J.
- Zivile Useckaite
- Zoltan Varga
- Zoltán Varga
- Zoltán Wiener
- Zucai Suo
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly
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