Analytic expression for Taylor-Couette stability boundary

We analyze the mechanism that determines the boundary of stability in Taylor-Couette flow. By simple physical argument we derive an analytic expression to approximate the stability line for all radius ratios and all speed ratios, for co- and counterrotating cylinders. The expression includes viscosity and so generalizes Rayleigh's criterion. We achieve agreement with linear stability theory and with experiments in the whole parameter space. Explicit formulae are given for limiting cases.Comment: 6 pages (LaTeX with REVTEX) including 4 figures (Postscript) Revised, discussion of two additional references. See also http://staff-www.uni-marburg.de/~esse

A Concept for Attribute-Based Authorization on D-Grid Resources

In Germany's D-Grid project numerous Grid communities are working together to provide a common overarching Grid infrastructure. The major aims of D-Grid are the integration of existing Grid deployments and their interoperability. The challenge lies in the heterogeneity of the current implementations: three Grid middleware stacks and different Virtual Organization management approaches have to be embraced to achieve the intended goals. In this article we focus oil the implementation of an attribute-based authorization infrastructure that not only leverages the well-known VO attributes but also campus attributes managed by a Shibboleth federation

Creep Modeling of Wood Using Time-Temperature Superposition

The time-temperature superposition principle was used to develop long-term compression creep and recovery models for southern pine exposed to constant environmental conditions using shortterm data. Creep (17-hour) and recovery (40-hour) data were obtained at constant temperature levels ranging from 70 F to 150 F and constant equilibrium moisture content (EMC) of 9%. The data were plotted against log-time, and the resultant curve segments were shifted along the log-time axis with respect to the curve for ambient conditions to construct a master curve applicable to ambient conditions (70 F, 9% EMC) and a longer time period. The master curves were represented by power functions, and they predicted up to 6.4 years of creep and 5.8 years of recovery response. The validity of the master curves for predicting creep of wood exposed to the normal interior environment in buildings was tested by conducting ten-month creep tests in the laboratory. The fluctuating environment caused geometry changes in the surface of the specimens affecting the collected long-term data. Therefore, a good comparison between the master curves and the long-term data was not possible

A Review Of Creep In Wood: Concepts Relevant To Develop Long-Term Behavior Predictions For Wood Structures

A review is presented of the effects of constant and transient moisture and temperature conditions on the time-dependent behavior of wood as a material and as a structural element. A rational approach towards the identification of long-term behavior of wooden structures is proposed. Utilizing the fact that wood is a combination of several polymers, polymer viscoelasticity concepts are suggested to enhance the predictive capabilities. A finite element procedure is outlined to indicate how design predictions can be made. Some attention is given to structures such as domes where creep of the wood could lead to structural instabilities

Endothelial preconditioning by transient oxidative stress reduces inflammatory responses of cultured endothelial cells to TNF-α

Brief episodes of ischemia can render an organ resistant to subsequent severe ischemia. This ‘ischemic preconditioning’ is ascribed to various mechanisms, including oxidative stress. We investigated whether preconditioning exists on an endothelial level. Human umbilical vein endothelial cells (HUVECs) were transiently confronted with oxidative stress (1 mM H2O2, 5 min). Adhesion molecules ICAM-1 and E-selectin and release of cytokines IL-6 and IL-8 to subsequent stimulation with TNF-α (2.5 ng/ml, 4 h) were measured (flow cytometry and immunoassay), as were nuclear translocation of the transcription factor NFkB (Western blotting, confocal microscopy) and redox status of HUVECs (quantification of glutathione by HPLC). TNF-α elevated IL-6 in the cell supernatant from 8.8 ± 1 to 41 ± 3 pg/ml and IL-8 from 0.5 ± 0.03 to 3 ± 0.2 ng/ml. ICAM-1 was increased threefold and E-selectin rose eightfold. Oxidative stress (decrease of glutathione by 50%) reduced post-TNF-α levels of IL-6 to 14 ± 3 and IL-8 to 1 ± 0.2; the rise of ICAM-1 was completely blocked and E-selectin was only doubled. The anti-inflammatory effects of preconditioning via oxidative stress were paralleled by reduction of the translocation of NFkB on stimulation with TNF-α, and antagonized by the intracellular radical scavenger N-acetylcysteine. ‘Anti-inflammatory preconditioning’ of endothelial cells by oxidative stress may account for the inhibitory effects of preconditioning on leukocyte adhesion in vivo

Shear-stress controlled dynamics of nematic complex fluids

Based on a mesoscopic theory we investigate the non-equilibrium dynamics of a sheared nematic liquid, with the control parameter being the shear stress $\sigma_{\mathrm{xy}}$ (rather than the usual shear rate, $\dot\gamma$). To this end we supplement the equations of motion for the orientational order parameters by an equation for $\dot\gamma$, which then becomes time-dependent. Shearing the system from an isotropic state, the stress- controlled flow properties turn out to be essentially identical to those at fixed $\dot\gamma$. Pronounced differences when the equilibrium state is nematic. Here, shearing at controlled $\dot\gamma$ yields several non-equilibrium transitions between different dynamic states, including chaotic regimes. The corresponding stress-controlled system has only one transition from a regular periodic into a stationary (shear-aligned) state. The position of this transition in the $\sigma_{\mathrm{xy}}$-$\dot\gamma$ plane turns out to be tunable by the delay time entering our control scheme for $\sigma_{\mathrm{xy}}$. Moreover, a sudden change of the control method can {\it stabilize} the chaotic states appearing at fixed $\dot\gamma$.Comment: 10 pages, 11 figure

A Strategy for Identifying the Grid Stars for the Space Interferometry Mission (SIM)

We present a strategy to identify several thousand stars that are astrometrically stable at the micro-arcsecond level for use in the SIM (Space Interferometry Mission) astrometric grid. The requirements on the grid stars make this a rather challenging task. Taking a variety of considerations into account we argue for K giants as the best type of stars for the grid, mainly because they can be located at much larger distances than any other type of star due to their intrinsic brightness. We show that it is possible to identify suitable candidate grid K giants from existing astrometric catalogs. However, double stars have to be eliminated from these candidate grid samples, since they generally produce much larger astrometric jitter than tolerable for the grid. The most efficient way to achieve this is probably by means of a radial velocity survey. To demonstrate the feasibility of this approach, we repeatedly measured the radial velocities for a pre-selected sample of 86 nearby Hipparcos K giants with precisions of 5-8 m/s. The distribution of the intrinsic radial velocity variations for the bona-fide single K giants shows a maximum around 20 m/s, which is small enough not to severely affect the identification of stellar companions around other K giants. We use the results of our observations as input parameters for Monte-Carlo simulations on the possible design of a radial velocity survey of all grid stars. Our favored scenario would result in a grid which consists to 68% of true single stars and to 32% of double or multiple stars with periods mostly larger than 200 years, but only 3.6% of all grid stars would display astrometric jitter larger than 1 microarcsecond. This contamination level is probably tolerable.Comment: LaTeX, 21 pages, 8 figures, accepted by PASP (February 2001 issue). Also available at http://beehive.ucsd.edu/ftp/pub/grid/kgiants.htm

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds.

Backbone N-methylation is common among peptide natural products and has a substantial impact on both the physical properties and the conformational states of cyclic peptides. However, the specific impact of N-methylation on passive membrane diffusion in cyclic peptides has not been investigated systematically. Here we report a method for the selective, on-resin N-methylation of cyclic peptides to generate compounds with drug-like membrane permeability and oral bioavailability. The selectivity and degree of N-methylation of the cyclic peptide was dependent on backbone stereochemistry, suggesting that conformation dictates the regiochemistry of the N-methylation reaction. The permeabilities of the N-methyl variants were corroborated by computational studies on a 1,024-member virtual library of N-methyl cyclic peptides. One of the most permeable compounds, a cyclic hexapeptide (molecular mass = 755 Da) with three N-methyl groups, showed an oral bioavailability of 28% in rat