N-Benzyl-4-hy­droxy-2-methyl-1,1-dioxo-2H-1λ6,2-benzothia­zine-3-carboxamide

In the title mol­ecule, C17H16N2O4S, the heterocyclic thia­zine ring adopts a half-chair conformation, with the S and N atoms displaced by 0.546 (4) and 0.281 (4) Å, respectively, on opposite sides of the mean plane formed by the remaining ring atoms. The mol­ecular structure is stabilized by an intra­molecular O—H⋯O hydrogen bond. The two aromatic rings are inclined to one another by 42.32 (11)°. In the crystal, mol­ecules are linked by pairs of N—H⋯O hydrogen bonds, forming inversion dimers. The dimers are linked via a series of C—H⋯O inter­actions, leading to the formation of a three-dimensional network

4-Hy­droxy-2-methyl-1,1-dioxo-N-phenyl-2H-1λ6,2-benzothia­zine-3-carboxamide

In the title mol­ecule, C16H14N2O4S, the thia­zine ring adopts a twist chair conformation with the N and adjacent C atom displaced by 0.966 (3) and 0.386 (4) Å, respectively, on the same side of the mean plane formed by the remaining ring atoms. The dihedral angle between the mean planes of the benzene rings is 37.65 (10)°. The mol­ecular structure features an intra­molecular O—H⋯O hydrogen bond, which generates an S(6) ring. In the crystal, mol­ecules are linked by N—H⋯O and C—H⋯O hydrogen bonds

2,3-Dihydro-1λ6,2-benzothia­zine-1,1,4-trione

In the title compound, C8H7NO3S, the benzene ring is oriented at a dihedral angle of 69.25 (7)° to the S and O atoms of the sulfonyl group. The heterocyclic ring approximates to an envelope, with the N atom in the flap position. In the crystal, mol­ecules are linked by N—H⋯Oc (c = carbon­yl) hydrogen bonds, forming C(5) chains along [001]. Two R 2 2(10) loops arise from pairs of C—H⋯O hydrogen bonds and a weak aromatic π–π stacking inter­action [centroid–centorid separation = 3.8404 (11) Å] also occurs

4-Hy­droxy-2-methyl-1,1-dioxo-2H-1λ6,2- benzothia­zine-3-carb­oxy­lic acid hemihydrate

In the title compound, C10H9NO5S·0.5H2O, two geometrically different organic mol­ecules are present. The benzene rings and the carboxyl­ate groups are oriented at dihedral angles of 13.44 (4) and 21.15 (18)°. In both mol­ecules, an intra­molecular O—H⋯O hydrogen bond generates an S(6) ring. In the crystal, both moleucles form inversion dimers linked by pairs of O—H⋯O hydrogen bonds to generate R 2 2(8) loops. The dimers are consolidated into chains extending along [100] by bridging O—H⋯O hydrogen bonds from the water mol­ecule. A weak C—H⋯O hydrogen bond also occurs

Uncovering Political Hate Speech During Indian Election Campaign: A New Low-Resource Dataset and Baselines

The detection of hate speech in political discourse is a critical issue, and this becomes even more challenging in low-resource languages. To address this issue, we introduce a new dataset named IEHate, which contains 11,457 manually annotated Hindi tweets related to the Indian Assembly Election Campaign from November 1, 2021, to March 9, 2022. We performed a detailed analysis of the dataset, focusing on the prevalence of hate speech in political communication and the different forms of hateful language used. Additionally, we benchmark the dataset using a range of machine learning, deep learning, and transformer-based algorithms. Our experiments reveal that the performance of these models can be further improved, highlighting the need for more advanced techniques for hate speech detection in low-resource languages. In particular, the relatively higher score of human evaluation over algorithms emphasizes the importance of utilizing both human and automated approaches for effective hate speech moderation. Our IEHate dataset can serve as a valuable resource for researchers and practitioners working on developing and evaluating hate speech detection techniques in low-resource languages. Overall, our work underscores the importance of addressing the challenges of identifying and mitigating hate speech in political discourse, particularly in the context of low-resource languages. The dataset and resources for this work are made available at https://github.com/Farhan-jafri/Indian-Election.Comment: Accepted to ICWSM Workshop (MEDIATE

Optimization of state-of-the-art fuzzy-metaheuristic ANFIS-based machine learning models for flood susceptibility prediction mapping in the Middle Ganga Plain, India

CRediT authorship contribution statement: Dr. Aman Arora and Dr. Alireza Arabameri have conceptualized the study, prepared the dataset, and optimized the models. Dr. Manish Pandey has helped in writing the manuscript. Prof. Masood A. Siddiqui, Prof. U.K. Shukla, Prof. Dieu Tien Bui, Dr. Varun Narayan Mishra, and Dr. Anshuman Bhardwaj have helped in improving the manuscript at different stages of this work.Peer reviewedPostprin

Can an Amino Acid Mixture Alleviate Gastrointestinal Symptoms in Neuroendocrine Tumor Patients?

Background: Neuroendocrine tumors, although relatively rare in incidence, are now the second most prevalent gastrointestinal neoplasm owing to indolent disease biology. A small but significant sub-group of neuroendocrine tumor patients suffer from diarrhea. This is usually secondary to carcinoid syndrome but can also be a result of short gut syndrome, bile acid excess or iatrogenic etiologies. Recently, an amino acid based oral rehydration solution (enterade® Advanced Oncology Formula) was found to have anti-diarrheal properties in preclinical models. Methods: A retrospective chart review of all NET patients treated with enterade® AO was performed after IRB approval. Results: Ninety-eight NET patients who had received enterade® AO at our clinic from May 2017 through June 2019 were included. Patients (N = 49 of 98) with follow up data on bowel movements (BMs) were included for final analysis. Eighty-four percent of patients (41/49) had fewer BMs after taking enterade® AO and 66% (27/41) reported more than 50% reduction in BM frequency. The mean number of daily BMs was 6.6 (range, 3–20) at baseline before initiation of therapy, while the mean number of BMs at 1 week time point post enterade® AO was 2.9 (range, 0–11). Conclusions: Our retrospective observations are encouraging and support prospective validation with appropriate controls in NET patients. This is first published report of the potential anti-diarrheal activity of enterade® AO in NET patients

Procjena dvadeset nemetričkih karakteristika zubne krune u različitim vrstama malokluzija na uzorku iz Indije, populacija New Delhija

Background: Dental phenotype shows variation in the form of various metric and non-metric traits, primarily due to gene-environment interplay. It gives an insight into the evolutionary trends, ancestry, and food habits. Recently, it has been explored for genetic affinity with several growth anomalies and development of craniofacial skeleton which is also responsible for dental and skeletal malocclusions. Objectives: The current study aims to investigate the non-metric dental crown traits (NDCTs) using Arizona State University Dental Anthropology system (ASUDAS) in different types of malocclusions in Delhi, National Capital Region (NCR) population. Materials and methods: The study design was observational and retrospective. The total sample comprised of 240 pairs of dental casts divided into four equal groups of 60 subjects each (30 male and 30 female), based on malocclusion. The four groups of malocclusions were: Angle’s Class I, Class II division 1, Class II division 2, Class III. The investigator was blinded for patient ID and sex before recording the data. The data for cast were recorded by three observers independently in a modified malocclusion- non-metric dental crown traits (M-NDCT) anthropological variants chart and statistically analyzed for association with different malocclusions and sex. Results: Significant differences were found in the expression of several NDCTs (both in presence and scoring) in different malocclusions. Class I malocclusion showed predominantly winging, shoveling –upper central and lateral incisor, protostylid, hypoconulid absence in lower second molar, and cusp number. Class II malocclusion showed double shoveling, interrupted groove, tuberculum dentale, canine mesial ridge, premolar accessory cusp, Carabelli’s trait, lingual cusp vari-ation, and seventh cusp in the lower left first molar. Class III malocclusion showed the absence of hypocone in upper second molar, deflecting wrinkle, distal trigonid crest, and Y groove in left lower second molar. Besides, sexual dimorphism was seen in shoveling –upper central and lateral incisor, canine mesial ridge, Carabelli’s trait, 3-cusp in upper second molar, and cusp number. Conclusions: Significant association was found between non-metric dental traits and malocclusions (Class I, Class division 1, Class II division 2, and Class III). Significant sex-linked differences were also found. Further studies can be performed at multicenter pan-India level or across ethnicities with a standard robust protocol and a large sample.Uvod: Dentalni fenotip pokazuje varijacije u obliku različitih metričkih i nemetričkih svojstava, uglavnom zbog međudjelovanja gena i okoline. Daje uvid u evolucijske trendove, podrijetlo i prehrambene navike. Nedavno je istražen njegov genetski afinitet s nekoliko anomalija rasta i razvoja kraniofacijalnog kostura koji je također odgovoran za dentalne i skeletne malokluzije. Ciljevi: U ovoj studiji autori istražuju nemetričke značajke zubne krune (NDCTs) korištenjem sustava dentalne antropologije Državnoga sveučilišta u Arizoni (ASUDAS) u različitim vrstama malokluzija u populaciji Delhija (regija glavnoga grada – NCR). Materijali i metode: Dizajn studije bio je promatrački i retrospektivan. Ukupni uzorak činilo je 240 pari gipsanih modela podijeljenih u četiri jednake skupine od po 60 ispitanika (30 muškaraca i 30 žena) na temelju malokluzije. Četiri skupine malokluzija bile su: Angleova klasa I, klasa II / 1, klasa II / 2 i klasa III. Istraživaču su bili nepoznati ID-i pacijenta i spol prije snimanja podataka. Podatke za gipsane modele očitala su tri neovisna promatrača u modificiranoj tablici antropoloških varijanti malokluzije – nemetričke značajke zubne krune (M-NDCT) radi povezanosti s različitim malokluzijama i spolom. Rezultati: Pronađene su znatne razlike u ekspresiji nekoliko NDCT-a (i u prisutnosti i u bodovanju) kod različitih malokluzija. Nepravilna okluzija klase I pokazala je pretežno rotirane gornje središnje sjekutiće, lopataste sjekutiće – gornji središnji i lateralni inciziv, protostilid, odsutnost hipokonulida u donjem drugom kutnjaku i broj kvržica. Klasa II malokluzije pokazala je dvostruki lopatasti sjekutić, isprekidanu brazdu, tuberculum dentale, mezijalni greben očnjaka, dodatnu kvržicu pretkutnjaka, Carabellijevo svojstvo, varijaciju lingvalne kvržice i sedmu kvržicu u donjemu lijevom prvom kutnjaku. Malokluzija klase III pokazala je odsutnost hipokonusa u gornjemu drugom kutnjaku, deflektirajuću boru, distalnu crista trigonida i Y-utor u lijevomu donjem drugom kutnjaku (26,7 %). Uz to, spolni dimorfizam uočen je u lopatastim sjekutićima – gornji središnji i lateralni sjekutić, mezijalni greben očnjaka, Carabellijevo svojstvo, tri kvržice u gornjemu drugom kutnjaku i broj kvržice. Zaključci: Pronađena je značajna povezanost između nemetričkih karakteristika zuba i malokluzija (klasa I, klasa 2/ 1, klasa II /2 i klasa III). Također su pronađene značajne spolno povezane razlike. Buduće studije mogu se provesti na multicentričnoj sveindijskoj razini sa standardnim robusnim protokolom i velikim uzorkom