1-(4-Chloro­phen­yl)-3-(2-nitro­phenyl)propane-1,2-dione

The title compound, C15H10ClNO4, belongs to the class of 1,2-diketones, which have important applications in both synthetic organic chemistry and supra­molecular chemistry. A dihedral angle of 9.03 (1)° is found between the mean planes of the two benzene rings. C—H⋯O inter­actions help to stabilize the crystal structure

1,4-Bis(4-chloro­phen­yl)butane-1,4-dione

The mol­ecule of title compound, C16H12Cl2O2, is centrosymmetric. Thus, the asymmetric unit comprises two half-mol­ecules. The two benzene rings are coplanar in each independent molecule (dihedral angles = 0°). The crystal packing exhibits inter­molecular C—H⋯O hydrogen bonds and C—H⋯π inter­actions

Complexation of Z-ligustilide with hydroxypropyl-β-cyclodextrin to improve stability and oral bioavailability

To improve the stability and oral bioavailability of Z-ligustilide (LIG), the inclusion complex of LIG with hydroxypropyl-β-cyclodextrin (HP-β-CD) was prepared by the kneading method and characterized by UV-Vis spectroscopy, differential thermal analysis (DTA) and Fourier transform infrared (FTIR) spectroscopy. LIG is capable of forming an inclusion complex with HP-β-CD and the stoichiometry of the complex was 1:1. Stability of the inclusion complex against temperature and light was greatly enhanced compared to that of free LIG. Further, oral bioavailability of LIG and the inclusion complex in rats were studied and the plasma drug concentration-time curves fitted well with the non-compartment model to estimate the absolute bioavailability, which was 7.5 and 35.9 %, respectively. In conclusion, these results show that LIG/HP-β-CD complexation can be of great use for increasing the stability and biological efficacy of LIG

(E)-2-Meth­oxy-4-(3-oxobut-1-en­yl)phenyl acetate

The title compound, C13H14O4, belongs to the class of α,β-unsaturated ketones, which have potential bactericidal, fungicidal, anti­tumor and anti-inflammatory properties. The C atoms and attached H atoms of the ethenyl part of the title mol­ecule are disordered over two orientations with refined occupancies of 0.583 (7) and 0.417 (3). Mol­ecules are connected by two inter­molecular C—H⋯O inter­actions, forming a dimer with symmetry

Preparation of Antheraea pernyi

The goal of this study was to fabricate Antheraea pernyi silk fibroin (ASF) microparticles using electrospinning under mild processing conditions. To improve processability of the ASF solution, poly(ethylene oxide) (PEO) was used to regulate viscosity of ASF solution for electrospinning. It was found that the blend of ASF with PEO could form a bead-on-string structure with well spherical particles. Furthermore, aqueous ethanol and ultrasonic treatments could disrupt the nanofibrillar string structure between particles and ultimately produced water-insoluble ASF particles with submicron scale. Cell viability studies indicated that the ASF microparticles were nontoxic to EA926 cells. Moreover, fluorescent images based on FITC labeling showed that the ASF microparticles were easily uptaken by the cells. Aqueous-based electrospinning provides a potentially useful option for the fabrication of ASF microparticles based on this unique fibrous protein