A KINEMATIC DESCRIPTION OF THE POST PUBESCENT WINDMILL SOFTBALL PITCHING MOTION

The purpose of this study was to describe the kinematics of the windmill softball pitch. Throughout the first three phases of the movement, both the pelvis and the trunk were rotated to a closed position while the throwing shoulder was flexed and externally rotated, and the throwing elbow was flexed. During the latter stages of the movement, the pelvis and torso opened up to face the plate, the throwing shoulder moved through an arc of hyperextension and was internally rotated while the throwing elbow extended. The kinematics identified may contribute to overuse injuries commonly reported by post pubescent softball pitchers. However, due to the limited data describing the windmill softball pitch, addition research is needed

Active reset of a radiative cascade for entangled-photon generation beyond the continuous-driving limit

The emission rate of entangled photons from cascaded few-level systems is limited by the dynamics of the radiative transitions. Here, we overcome the continuous driving limit for a semiconductor quantum dot via an active reset of the radiative cascade. We show theoretically and experimentally the driving regime to enable the generation of entangled photon pairs with higher fidelity and emission rate than the optimum continuously driven state. Finally, we electrically generate entangled photon pairs with an average fidelity of (79.5±1.1)% at a record clock rate of 1.15 GHz

1GHz clocked distribution of electrically generated entangled photon pairs

Quantum networks are essential for realising distributed quantum computation and quantum communication. Entangled photons are a key resource, with applications such as quantum key distribution, quantum relays, and quantum repeaters. All components integrated in a quantum network must be synchronised and therefore comply with a certain clock frequency. In quantum key distribution, the most mature technology, clock rates have reached and exceeded 1GHz. Here we show the first electrically pulsed sub-Poissonian entangled photon source compatible with existing fiber networks operating at this clock rate. The entangled LED is based on InAs/InP quantum dots emitting in the main telecom window, with a multi-photon probability of less than 10% per emission cycle and a maximum entanglement fidelity of 89%. We use this device to demonstrate GHz clocked distribution of entangled qubits over an installed fiber network between two points 4.6km apart

Variants in the fetal genome near FLT1 are associated with risk of preeclampsia.

: Preeclampsia, which affects approximately 5% of pregnancies, is a leading cause of maternal and perinatal death. The causes of preeclampsia remain unclear, but there is evidence for inherited susceptibility. Genome-wide association studies (GWAS) have not identified maternal sequence variants of genome-wide significance that replicate in independent data sets. We report the first GWAS of offspring from preeclamptic pregnancies and discovery of the first genome-wide significant susceptibility locus (rs4769613; P = 5.4 × 10(-11)) in 4,380 cases and 310,238 controls. This locus is near the FLT1 gene encoding Fms-like tyrosine kinase 1, providing biological support, as a placental isoform of this protein (sFlt-1) is implicated in the pathology of preeclampsia. The association was strongest in offspring from pregnancies in which preeclampsia developed during late gestation and offspring birth weights exceeded the tenth centile. An additional nearby variant, rs12050029, associated with preeclampsia independently of rs4769613. The newly discovered locus may enhance understanding of the pathophysiology of preeclampsia and its subtypes.<br/

Normal growth and intravascular volume status with good metabolic control during peritoneal dialysis in infancy

Peer reviewe

Texts to condemne us. A study of the prose works of Thomas Nashe.

The purpose of my thesis is to re-assess the prose works of Thomas Nashe and repudiate the conventional critical judgement that his texts suffer from an `inexplicable themelessness'. Instead, I have stressed two sustaining features of Nashe's work. Firstly, I argue that the rhapsodic composition of the texts is only apparently formless and that this method of composition was recognised and appreciated by an Elizabethan audience. Secondly, I have analysed recurring images and textual and narrative devices in the works, by reference to the notion of carnival. I argue that Nashe's work was, and can be, profitably read for its coherent depiction of a late-mediaeval anti-world, prodigal, grotesque, spendthrift, egalitarian and immensely productive. It celebrates the suspension of all hierarchical rank, privileges, norms and prohibitions and is a temporary liberation for the oppressed from their everyday world. Its characteristic mode of understanding the world is through the corporeal vocabulary of laughter. The fragmented and rhapsodic construction of the texts - with their competing voices and genres - is an organic extension of their subject matter. Parody of social, political and literary conventions flatters its readers by making them (if only temporarily) legislators of their own desires. Pursuing these themes enables my thesis to make sense of other, puzzling aspects of Nashe's work, particularly the excess and violence of works like The Unfortunate Traveller. I read this text as a stage on which carnival and law are most clearly opposed. The prose works of Thomas Nashe should be read as a pursuit of the `extemporall veine' of eloquent speech, praised by conventional rhetoric and liberated for Nashe by his use of popular forms in preference to the morally self-possessed author of the didactic text. In this sense, his apparently `themeless' texts cohere as a real and sustained imaginative contemplation of aspects of the human condition

Binding and degradation of nerve growth factor by PC12 pheochromocytoma cells.

The specific binding of various concentrations of 125I-labeled nerve growth factor (NGF) to PC12 cells at 37 degrees C reached maxima after 90 min and then declined to 25% of maximal binding after 10 h. Decreased binding was accompanied by degradation of 125I-NGF and the appearance of acid-soluble biologically inactive 125I (mainly 125I-monoiodotyrosine) in the medium as well as a decrease in the number of surface NGF receptors. The time-dependent decrease in binding and the degradation of 125I-NGF were inhibited by low temperature and the lysosomotropic agent chloroquine while degradation was inhibited by metabolic energy inhibitors in the absence of glucose. Chloroquine also produced an increase in the accumulation of 125I-NGF which was not readily removed from the cells. These data suggest that 125I-NGF bound to PC12 cells is efficiently internalized by receptor-mediated endocytosis and degraded by the lysosomes. It appears from other data that this process does not produce the intracellular signals regulating neurite outgrowth