N-[2-(Cyclohexylamino)-2-oxoethyl]-N-(4-octyloxy) phenyl-prop-2-enamide

N-[2-(Cyclohexylamino)-2-oxoethyl]-N-(4-octyloxy)phenyl-prop-2-enamide was prepared in good yield by coupling of 4(octyloxy)aniline, Cyclohexyl isocyanide, paraformaldehyde and acrylic acid by multicomponent Ugi reaction, at room temperature. The structure of the newly synthesized tripeptoid derivative was well characterized using elemental analysis, FTIR, NMR and mass spectral data. © 2016 by the authors; licensee MDPI, Basel, Switzerland.DE-AC02-05CH11231, DOE, U.S. Department of EnergyMSMT CR-USA Kontakt II [LH14050]; Office of Science, Office of Basic Energy Sciences, of the U.S. Department of Energy [DE-AC02-05CH11231]; Ministry of Education, Youth and Sports of the Czech Republic - NPU Program I [LO1504

Ethyl({[acryloyl(furan-2-ylmethyl)amino]acetyl}amino)acetate

Ethyl({[acryloyl(furan-2-ylmethyl)amino]acetyl}amino)acetate was synthesized via Ugi four component (4C) reaction at ambient temperature. The protocol employs a reaction between formaldehyde, furfurylamine, acrylic acid, and ethyl 2-isocyanoacetate. The course of the reaction was found to be high yielding, and the resulting glycine ester derivative was well characterized by elemental analysis, FTIR, NMR spectroscopy, and mass spectrometric techniques. © 2017 by the authors; licensee MDPI, Basel, Switzerland.DE-AC02-05CH11231, DOE, U.S. Department of Energy; MŠMT, Ministerstvo Školství, Mládeže a TělovýchovyMSMT CR-USA Kontakt II [LH14050]; Molecular Foundry, Office of Science, Office of Basic Energy Sciences, of the U.S. Department of Energy [DE-AC02-05CH11231]; Ministry of Education, Youth and Sports of the Czech Republic - NPU Program I [LO1504

Ecofriendly synthesis of silver nanoparticles from garden rhubarb (rheum rhabarbarum)

Bioreduction of silver ions following one pot process is described to achieve Rheum rhabarbarum (RR) based silver nanoparticles (SNPs) which is termed as "RR-SNPs." The Ultraviolet-visible spectroscopy (UV-vis) confirms the characteristic surface plasmon resonance band for RR-SNPs in the range of 420-460 nm. The crystalline nature of SNPs was confirmed by X-ray diffraction (XRD) peaks at 38.2 degrees, 45.6 degrees, 64.2 degrees, and 76.8 degrees. Transmission electron microscopy (TEM) and scanning electronic microscopy (SEM) confirm the shape of synthesized SNPs. They are roughly spherical but uniformly distributed, and size varies from 60 to 80 nm. These biogenic SNPs show persistent zeta potential value of 34.8mV even after 120 days and exhibit potent antibacterial activity in presence of Escherichia coli (CCM 4517) and Staphylococcus aureus (CCM 4516). In addition, cytotoxicity of RR-SNPs against in vitro human epithelial carcinoma (HeLa) cell line showed a dose-response activity. The lethal concentration (LC50) value was found to be 28.5 mu g/mL for RR-SNPs in the presence of HeLa cells. These findings help us to evaluate their appropriate applications in the field of nanotechnology and nanomedicine

Green approach to synthesize silver nanoparticles from stem extract of Garden Rhubarb: Evaluation of their stability and dielectric performances

Recent advances in Nano-biotechnology, offer potential longer duration storage options for silver nanoparticles (SNPs) with preferable capping agents where a plentiful efforts have been given to minimize the toxicity effects SNPs. To overcome the toxicity scenario of SNPs, a novel green methodology was put forward in the present investigation. Biogenic SNPs were synthesized using water extract of Garden Rhubarb (GR) stems under ambient conditions. The method demonstrates an eco-friendly, instant and easy route for stable SNPs synthesis. The formation of instant SNPs was analyzed by visual observation and monitored by UV-visible (UV-vis) spectrophotometer. The characteristic surface plasmon resonance (SPR) band at 445 nm, revealed the formation of SNPs. The X-ray diffraction (XRD) pattern of green SNPs showed their crystalline structure. SEM and TEM studies revealed that the shape of SNPs was spherical and has approximate diameter within 100 nm range. The zeta potential measurements on 180th day after SNPs synthesis, revealed the stability and size distribution of SNPs. The values are 29.6mV, 28.1mV and 24.1mV for three varied compositions of AgNO3 (1mM) and GR extract. The high dielectric constant (ϵ′) has been observed for GR mediated SNPs, the ϵ′ values were found to reach the minimum value of 40000 at frequency 1MHz. Suitable tuning of the dielectric performances can conclusively prove their applications in multifunctional sensors, optical, and charge storage devices.NPUI Ministry of Education, Youth and Sports of the Czech Republic [LO1504

Green synthesis of silver nanoparticles and biopolymer nanocomposites: a comparative study on physico-chemical, antimicrobial and anticancer activity

The current report was intended towards comparative study of green-synthesized biogenic Rhubarb silver nanoparticles (RS-AgNPs) and chitosan crosslinked silver nanocomposites (CSHD-AgNCs). The physico-chemical characterization was done by UV-visible, FTIR, scanning electron microscopy (SUM), transmission electron microscopy (TEM), TGA, XRD and zeta potential(zeta). The analysis and spectroscopic characterization was done by SEM and TEM and their results reveal that the nanoparticles are spherical in shape, with average size ranges from 5 to 50 nm, and was gathered by face centered cubic (FCC) structure throughout the polymer matrix and stable without any protecting or capping reagents over 450 days. The antimicrobial property of RS-AgNPs and CSHD-AgNCs (zeta = +29.6 and +32.8 mV) was evaluated against E. coli and S. aureus and showed an effective inhibitory property. The RS-AgNPs and CSHD-AgNCs were assessed for their anticancer activity against HeLa cell line by MTT method, and it reveals a dose response activity, time and cell line-dependent cytotoxicity. Based on the results obtained, the RS-AgNPs exhibited higher toxicity over CSHD-AgNCs after 24 h incubation of HeLa cells with different concentrations and is negligible for the aqueous Rhubarb extract. It was concluded that the changes in anticancer activity towards HeLa cells due to biological activity of silver nanoparticles depend on their method of biosynthesis and their physico-chemical nature.Ministry of Education, Youth and Sports of the Czech Republic-NPU Program I [LO1504]; Slovak Grant Agency VEGA [2/0124/18

Chitosan–silver nanocomposites: New functional biomaterial for health-care applications

Chitosan–silver nanocomposites (CS-HDA-AgNCs) was prepared using chitosan, biogenic silver nanocomposites, and crosslinker, hexamethylene 1,6-di(amino carboxysulfonate) (HDA). The film is flexible and transparent. Its physical, mechanical, thermal, hydrophilicity, and swelling properties were improved by HDA (2.5%). The antimicrobial activity of CS-HDA-AgNCs were not displayed any remarkable zone of inhibition but showed toxic effect in the presence of normal 3T3 fibroblasts and cancer HeLa cells. It decreases to ca. 5–7% for both cell lines. In conclusion, it can be mentioned that the CS-HDA-AgNCs, a kind of new functional biomaterial, could be useful for health-care applications. © 2018 Taylor & Francis.Ministry of Education, Youth and Sports of the Czech Republic - NPU Program I [LO1504]; Slovak Grant Agency VEGA [2/0156/15

Peptoids and polypeptoids: biomimetic and bioinspired materials for biomedical applications

As material chemists and engineers aim to improve the properties of macromolecules for advanced biomedical applications, considerable attention has been paid to new classes of biomimetic polymers such as polypeptoids. Peptoid polymers can be synthesized from a wide variety of chemically diverse building blocks to create a broad family of functionally diverse materials. These materials have been shown to have a wide variety of biological activities and promising attributes. The ability to mimic nature’s self-organization has become important in the area of biomaterials science. In this short colloquy, we provide an overview of the chemistry of peptoid/peptoid polymers including several applications. The discovery of few remarkable peptoids/polypeptoids of biological interest outlined over the past few decades will be discussed. © 2017, Springer-Verlag Berlin Heidelberg.Ministry of Education, Youth and Sports of the Czech Republic [LH 14050]; Office of Science, Office of Basic Energy Sciences, of the U.S. Department of Energy [DE-AC02-05CH11231

‘Green’ synthesis of silver polymer Nanocomposites of poly (2-isopropenyl-2- oxazoline-co- N-vinylpyrrolidone) and its catalytic activity

Metal-polymer nanocomposites are of great interest and mainly focused on advanced catalytic and sensor applications. Resulting from this, new copolymers composed of poly(2-isopropenyl-2-oxazoline) (PIPOx) and poly(N-vinylpyrrolidone) (PNVP) segments were prepared from highly water soluble 2-isopropenyl-2- oxazoline (IPOx) and N-vinylpyrrolidone (NVP) monomers. Finally, silver polymer nanocomposites of poly(2-isopropenyl-2-oxazoline-co-N-vinylpyrrolidone) were synthesized and reporting for the first time. All polymerizations were done in an aqueous phase with potassium persulfate as an initiator at 60 °C. The reaction time varied from 1 to 6 h in accordance with stoichiometric ratios of PIPOx and PNVP, leading to insoluble copolymers; which are termed as PIPOx_PNVP (75:25), PIPOx_PNVP (50:50), PIPOx_PNVP (25:75) and PIPOx_PNVP (10:90). Only, PIPOx_PNVP (10:90) showed adequate swelling behavior in water and some other organic solvents. All the polymers were distinguished by various physicochemical spectroscopic techniques such as UV/Visible spectroscopy, Scanning electron microscope (SEM), Transmission electron microscopy (TEM), X-ray diffraction (XRD), and FTIR analysis. Thermogravimetry (TGA) and Differential scanning calorimetry (DSC) were used to investigate thermal stability of the samples. The metalo-polymer nanocomposites (PIPOx_PNVP-SNCs) showed an apparently improved stability even when the composites were stored in air, at room temperature. The PIPOx_PNVP-SNCs showed a remarkable catalytic activity during the reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) in the presence of sodium borohydride. © 2018, Springer Nature B.V.2/0124/18; LO1504, APVV, Agentúra na Podporu Výskumu a Vývoja; APVV-SK-CZ-2013-0206, MŠMT, Ministerstvo Školství, Mládeže a Tělovýchovy; MSMT-7 AMB14SK02