158 research outputs found
Magnetic Nanoparticle Supported Catalyst for Atom Transfer Radical Polymerization
Magnetic nanoparticles were used to support an ATRP catalyst for the polymerization of methyl methacrylate (MMA) for minimized adverse effect of catalyst support and easy catalyst separation. the nanoparticle-supported catalyst mediated a living/controlled radical polymerization of MMA as effectively as unsupported catalysts. with the addition of 22 mol % of CuBr 2, the polymer molecular weights were well-controlled with an initiator efficiency of 0.85 and polydispersity lower than 1.2. the supported catalysts could be easily separated/isolated using an external magnetic field and reused with slightly decreased activity but further improved control. the activity of the recycled catalyst was regenerated by copper metal or in-situ regeneration using reducing agents such as alkylamine or tin (II) compounds. Block copolymerization using PEG macroinitiator and chain extension were conducted to confirm the livingness. Block copolymers with controlled molecular weights and low polydispersity were obtained using the fresh or reused supported catalysts. It was concluded that nanosized supports had reduced adverse effects on catalysis. © 2006 American Chemical Society
Game equilibrium based control analysis on the sustainable market structure of rare metal mineral resources – evidence from China
In rare metal mineral market, as a complex system, multiple decision-making among the stakeholders increases the complexity in its market structure and dynamic process. The unreasonable compensation pricing mechanism for the development of the rare metal mineral resources in China requires to be studied. Drawing on the methods of game theory model and chaos control analysis, this paper builds theoretical model of rare metal mineral market structure, corporating related parameters of rare metal in the game theory model, to conduct the chaotic nature and path analysis, expecting to solve the bottleneck problems that restrict the rare metal pricing and resource security and enhance the waste valorization for the sustainability. Specificly, a Cournot-Nash Equilibrium model is built to analyze the Cournot-equilibrium point, the stability of the Cournot Equilibrium point, the chaotic status, as well as the pattern to chaos of the game system in the rare metal mineral resource market, numerical simulation is used to verify the model. The conclusions facilitate the formulation of industrial economic policies and further improvement of managerial strategies to solve market problems
Graph-Based Radio Resource Management for Vehicular Networks
This paper investigates the resource allocation problem in device-to-device
(D2D)-based vehicular communications, based on slow fading statistics of
channel state information (CSI), to alleviate signaling overhead for reporting
rapidly varying accurate CSI of mobile links. We consider the case when each
vehicle-to-infrastructure (V2I) link shares spectrum with multiple
vehicle-to-vehicle (V2V) links. Leveraging the slow fading statistical CSI of
mobile links, we maximize the sum V2I capacity while guaranteeing the
reliability of all V2V links. We propose a graph-based algorithm that uses
graph partitioning tools to divide highly interfering V2V links into different
clusters before formulating the spectrum sharing problem as a weighted
3-dimensional matching problem, which is then solved through adapting a
high-performance approximation algorithm.Comment: 7 pages; 5 figures; accepted by IEEE ICC 201
Clinicopathological and prognostic value of epithelial cell adhesion molecule in solid tumours: a meta-analysis
BackgroundMalignant tumors, mainly solid tumors, are a significant obstacle to the improvement of life expectancy at present. Epithelial cell adhesion molecule (EpCAM), a cancer stem cell biomarker, showed widespread expression in most normal epithelial cells and most cancers. Although the clinical significance of EpCAM in various malignant solid tumors has been studied extensively, the latent relationships between EpCAM and pathological and clinical characteristics in solid tumors and differences in the roles of EpCAM among tumors have not been clearly determined. The destination point of this study was to analyze the value of EpCAM in solid tumors in clinicopathological and prognostic dimension using a meta-analysis approach.Method and materialsA comprehensive and systematic search of the researches published up to March 7th, 2022, in PubMed, EMBASE, Web of Science, Cochrane library and PMC databases was performed. The relationships between EpCAM overexpression, clinicopathological characteristics, and survival outcomes were analyzed. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) and odds ratios (ORs) were estimated as indicators of the degree of correlation. This research was registered on PROSPERO (International prospective register of systematic reviews), ID: CRD42022315070.ResultsIn total, 57 articles and 14184 cases were included in this study. High EpCAM expression had a significant coherence with a poorer overall survival (OS) (HR: 1.30, 95% CI: 1.08–1.58, P < 0.01) and a worse disease-free survival (DFS) (HR: 1.58, 95% CI: 1.28–1.95, P < 0.01), especially of gastrointestinal tumors’ OS (HR: 1.50, 95% CI: 1.15–1.95, P < 0.01), and DFS (HR: 1.84, 95% CI: 1.52–2.33, P < 0.01). The DFS of head and neck tumors (HR: 2.33, 95% CI: 1.51–3.61, P < 0.01) was also associated with the overexpression of EpCAM. There were no positive relationships between the overexpression of EpCAM and sex (RR: 1.03, 95% CI: 0.99–1.07, P = 0.141), T classification (RR: 0.93, 95% CI: 0.82–1.06, P = 0.293), lymph node metastasis (RR: 0.85, 95% CI: 0.54–1.32, P = 0.461), distant metastasis (RR: 0.97, 95% CI: 0.84–1.10, P = 0.606), vascular infiltration (RR: 1.05, 95% CI: 0.85–1.29, P = 0.611), and TNM stage (RR: 0.93, 95% CI: 0.83–1.04, P = 0.187). However, the overexpression of EpCAM exhibited a significant association with the histological grades (RR: 0.88, 95% CI: 0.80–0.97, P < 0.01).ConclusionBased on pooled HRs, the positive expression of EpCAM was totally correlated to a worse OS and DFS in solid tumors. The expression of EpCAM was related to a worse OS in gastrointestinal tumors and a worse DFS in gastrointestinal tumors and head and neck tumors. Moreover, EpCAM expression was correlated with the histological grade. The results presented pointed out that EpCAM could serve as a prognostic biomarker for gastrointestinal and head and neck tumors.Systematic review registrationhttps://www.crd.york.ac.uk/prospero, identifier CRD42022315070
Second generation Dirac cones and inversion symmetry breaking induced gaps in graphene/hexagonal boron nitride
Graphene/h-BN has emerged as a model van der Waals heterostructure, and the
band structure engineering by the superlattice potential has led to various
novel quantum phenomena including the self-similar Hofstadter butterfly states.
Although newly generated second generation Dirac cones (SDCs) are believed to
be crucial for understanding such intriguing phenomena, so far fundamental
knowledge of SDCs in such heterostructure, e.g. locations and dispersion of
SDCs, the effect of inversion symmetry breaking on the gap opening, still
remains highly debated due to the lack of direct experimental results. Here we
report first direct experimental results on the dispersion of SDCs in 0
aligned graphene/h-BN heterostructure using angle-resolved photoemission
spectroscopy. Our data reveal unambiguously SDCs at the corners of the
superlattice Brillouin zone, and at only one of the two superlattice valleys.
Moreover, gaps of 100 meV and 160 meV are observed at the
SDCs and the original graphene Dirac cone respectively. Our work highlights the
important role of a strong inversion symmetry breaking perturbation potential
in the physics of graphene/h-BN, and fills critical knowledge gaps in the band
structure engineering of Dirac fermions by a superlattice potential.Comment: Nature Physics 2016, In press, Supplementary Information include
Revisiting Multimodal Representation in Contrastive Learning: From Patch and Token Embeddings to Finite Discrete Tokens
Contrastive learning-based vision-language pre-training approaches, such as
CLIP, have demonstrated great success in many vision-language tasks. These
methods achieve cross-modal alignment by encoding a matched image-text pair
with similar feature embeddings, which are generated by aggregating information
from visual patches and language tokens. However, direct aligning cross-modal
information using such representations is challenging, as visual patches and
text tokens differ in semantic levels and granularities. To alleviate this
issue, we propose a Finite Discrete Tokens (FDT) based multimodal
representation. FDT is a set of learnable tokens representing certain
visual-semantic concepts. Both images and texts are embedded using shared FDT
by first grounding multimodal inputs to FDT space and then aggregating the
activated FDT representations. The matched visual and semantic concepts are
enforced to be represented by the same set of discrete tokens by a sparse
activation constraint. As a result, the granularity gap between the two
modalities is reduced. Through both quantitative and qualitative analyses, we
demonstrate that using FDT representations in CLIP-style models improves
cross-modal alignment and performance in visual recognition and vision-language
downstream tasks. Furthermore, we show that our method can learn more
comprehensive representations, and the learned FDT capture meaningful
cross-modal correspondence, ranging from objects to actions and attributes.Comment: Accepted to CVPR 202
Redox Regulation in Cancer Stem Cells
Reactive oxygen species (ROS) and ROS-dependent (redox regulation) signaling pathways and transcriptional activities are thought to be critical in stem cell self-renewal and differentiation during growth and organogenesis. Aberrant ROS burst and dysregulation of those ROS-dependent cellular processes are strongly associated with human diseases including many cancers. ROS levels are elevated in cancer cells partially due to their higher metabolism rate. In the past 15 years, the concept of cancer stem cells (CSCs) has been gaining ground as the subpopulation of cancer cells with stem cell-like properties and characteristics have been identified in various cancers. CSCs possess low levels of ROS and are responsible for cancer recurrence after chemotherapy or radiotherapy. Unfortunately, how CSCs control ROS production and scavenging and how ROS-dependent signaling pathways contribute to CSCs function remain poorly understood. This review focuses on the role of redox balance, especially in ROS-dependent cellular processes in cancer stem cells (CSCs). We updated recent advances in our understanding of ROS generation and elimination in CSCs and their effects on CSC self-renewal and differentiation through modulating signaling pathways and transcriptional activities. The review concludes that targeting CSCs by manipulating ROS metabolism/dependent pathways may be an effective approach for improving cancer treatment
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