Generalized thick strip modelling for vortex-induced vibration of long flexible cylinders

We propose a generalized strip modelling method that is computationally efficient for the VIV prediction of long flexible cylinders in three-dimensional incompressible flow. In order to overcome the shortcomings of conventional strip-theory-based 2D models, the fluid domain is divided into “thick” strips, which are sufficiently thick to locally resolve the small scale turbulence effects and three dimensionality of the flow around the cylinder. An attractive feature of the model is that we independently construct a three-dimensional scale resolving model for individual strips, which have local spanwise scale along the cylinder's axial direction and are only coupled through the structural model of the cylinder. Therefore, this approach is able to cover the full spectrum for fully resolved 3D modelling to 2D strip theory. The connection between these strips is achieved through the calculation of a tensioned beam equation, which is used to represent the dynamics of the flexible body. In the limit, however, a single “thick” strip would fill the full 3D domain. A parallel Fourier spectral/hp element method is employed to solve the 3D flow dynamics in the strip-domain, and then the VIV response prediction is achieved through the strip-structure interactions. Numerical tests on both laminar and turbulent flows as well as the comparison against the fully resolved DNS are presented to demonstrate the applicability of this approach

Routing and Staffing when Servers are Strategic

Traditionally, research focusing on the design of routing and staffing policies for service systems has modeled servers as having fixed (possibly heterogeneous) service rates. However, service systems are generally staffed by people. Furthermore, people respond to workload incentives; that is, how hard a person works can depend both on how much work there is, and how the work is divided between the people responsible for it. In a service system, the routing and staffing policies control such workload incentives; and so the rate servers work will be impacted by the system's routing and staffing policies. This observation has consequences when modeling service system performance, and our objective is to investigate those consequences. We do this in the context of the M/M/N queue, which is the canonical model for large service systems. First, we present a model for "strategic" servers that choose their service rate in order to maximize a trade-off between an "effort cost", which captures the idea that servers exert more effort when working at a faster rate, and a "value of idleness", which assumes that servers value having idle time. Next, we characterize the symmetric Nash equilibrium service rate under any routing policy that routes based on the server idle time. We find that the system must operate in a quality-driven regime, in which servers have idle time, in order for an equilibrium to exist, which implies that the staffing must have a first-order term that strictly exceeds that of the common square-root staffing policy. Then, within the class of policies that admit an equilibrium, we (asymptotically) solve the problem of minimizing the total cost, when there are linear staffing costs and linear waiting costs. Finally, we end by exploring the question of whether routing policies that are based on the service rate, instead of the server idle time, can improve system performance.Comment: First submitted for journal publication in 2014; accepted for publication in Operations Research in 2016. Presented in select conferences throughout 201

Cosmological Constraints from Moments of the Thermal Sunyaev-Zel'dovich Effect

In this paper, we explain how moments of the thermal Sunyaev-Zel'dovich (tSZ) effect can constrain both cosmological parameters and the astrophysics of the intracluster medium (ICM). As the tSZ signal is strongly non-Gaussian, higher moments of tSZ maps contain useful information. We first calculate the dependence of the tSZ moments on cosmological parameters, finding that higher moments scale more steeply with sigma_8 and are sourced by more massive galaxy clusters. Taking advantage of the different dependence of the variance and skewness on cosmological and astrophysical parameters, we construct a statistic, ||/^1.4, which cancels much of the dependence on cosmology (i.e., sigma_8) yet remains sensitive to the astrophysics of intracluster gas (in particular, to the gas fraction in low-mass clusters). Constraining the ICM astrophysics using this statistic could break the well-known degeneracy between cosmology and gas physics in tSZ measurements, allowing for tight constraints on cosmological parameters. Although detailed simulations will be needed to fully characterize the accuracy of this technique, we provide a first application to data from the Atacama Cosmology Telescope and the South Pole Telescope. We estimate that a Planck-like full-sky tSZ map could achieve a <1% constraint on sigma_8 and a 1-sigma error on the sum of the neutrino masses that is comparable to the existing lower bound from oscillation measurements.Comment: 11 pages, 12 figures, to be submitted to Phys. Rev. D; v2: 14 pages, 16 figures, matches PRD accepted version (changes from v1 include additional calculations with primordial non-Gaussianity and a new appendix discussing the tSZ kurtosis

Recombinant gamma interferon induces hypertriglyceridemia and inhibits post-heparin lipase activity in cancer patients.

Animals suffering from malignancy or chronic infection develop characteristic metabolic abnormalities, including a well-defined hypertriglyceridemic state. These abnormalities have been attributed to release of one or more mediators from activated macrophages. We report that cancer patients receiving RIFN-gamma, a potent macrophage activator, at doses of greater than or equal to 0.25 mg/m2/d i.m. show marked increases in triglyceride but not in cholesterol levels (pretreatment triglyceride level of 180 +/- 190 mg/dl [mean +/- SD] vs. a day-14 level of 370 +/- 242 mg/dl, n = 23, p less than 0.001 by the paired t test). This hypertriglyceridemia was characterized by an increase in very low-density lipoproteins and a decrease in plasma post-heparin lipase activity, consistent with defective triglyceride clearance (mean pretreatment lipase level of 2.1 mumol/ml/h vs. a day-14 level of 1.2 mumol/ml/h, n = 6, p = 0.02 by the paired t test). rIFN-gamma did not directly inhibit lipoprotein lipase enzymatic activity in vitro. Other possible mechanisms of action, such as suppression of lipase by an rIFN-gamma-induced mediator released from activated macrophages, or a direct effect of interferon on lipase biosynthesis, require further investigation. Our observations provide evidence that factors produced by the immune system can regulate lipid metabolism in man

The seasonal and spatial variability of small-scale turbulence at the Iberian margin

Turbulence measurements were made off the northwest coast of Spain in January and August 1998. In winter the water column was vertically mixed to about 100 to 150 m, due to the combined effects of the vertical convection of warm northward-moving water and wind stress. A highly dissipative surface boundary layer was present at all times to a depth (of about 20 m) that correlated well with the local wind and wave amplitude. Below this layer dissipation levels decreased from about 10-7 m2 s-3 at a rate that was commensurate with 'law of the wall' boundary theory. Near the coast local brackish surface stratification served to depress mixing below the pycnocline. In summer, when the water column was thermally stratified, average dissipation levels were typically an order of magnitude smaller than in winter, even though the wind stress in the ocean was of similar magnitude. Bursts of enhanced mixing were occasionally observed in an internal wave field on the shelf. Dissipation levels were higher on the northern side of an upwelling filament (up to 10-7 m2 s-3) than in other parts of the ocean. Although eddy viscosity levels on the shelf and in the ocean were almost identical (about 8 cm2 s-1), eddy diffusion on the shelf (0.37 cm2 s-1) was about three times larger than in the ocean. This may indicate a higher frequency of mixing events on the shelf. The summer data were used to determine a mixing length (of about 0.3 ± 0.05 m) using an algorithm that mimicked the way that turbulence closure models compute dissipation from vertical shear and buoyancy over grid scales of several meters. The correlation between dissipation and the gradient Richardson number was poor and it is suggested that at the scales of the observations, and of some models, buoyancy is just as likely to act as a source of mixing as it is to act as a sink