An Innovative Approach for Gob-Side Entry Retaining With Thick and Hard Roof: A Case Study

An innovative roadway layout in a Chinese colliery based on gob-side entry retaining (GER) with thick and hard roof (THR) was introduced. Suspended roof is left with a large area in GER with THR, which leads to large area roof weighting (LARW). LARW for GER with THR and mechanism of shallow-hole blasting to force roof caving in GER were expounded. Key parameters of shallow-hole blasting to force roof caving are proposed. LS-DYNA3D was used to validate the rationality of those key parameters, and UDEC was used to discuss and validate shallow-hole blasting to force roof-caving effect by contrast to the model without blasting and the model with shallow-hole blasting. Moreover, shallow-hole blasting technology to force roof caving for GER with THR was carried out in the Chinese colliery as a case study. Field test indicates that shallow-hole blasting technology effectively controls ground deformation of GER with THR and prevents LARW

Anti-Lung-Cancer Activity and Liposome-Based Delivery Systems of β

In the past decade, β-elemene played an important role in enhancing the effects of many anticancer drugs and was widely used in the treatment of different kinds of malignancies and in reducing the side effects of chemotherapy. Further study showed that it is also a promising anti-lung cancer drug. However, the clinical application of β-elemene was limited by its hydrophobic property, poor stability, and low bioavailability. With the development of new excipients and novel technologies, plenty of novel formulations of β-elemene have improved dramatically, which provide a positive perspective in terms of clinical application for β-elemene. Liposome as a drug delivery system shows great advantages over traditional formulations for β-elemene. In this paper, we summarize the advanced progress being made in anti-lung cancer activity and the new liposomes delivery systems of β-elemene. This advancement is expected to improve the level of pharmacy research and provide a stronger scientific foundation for further study on β-elemene

Mega-TTS: Zero-Shot Text-to-Speech at Scale with Intrinsic Inductive Bias

Scaling text-to-speech to a large and wild dataset has been proven to be highly effective in achieving timbre and speech style generalization, particularly in zero-shot TTS. However, previous works usually encode speech into latent using audio codec and use autoregressive language models or diffusion models to generate it, which ignores the intrinsic nature of speech and may lead to inferior or uncontrollable results. We argue that speech can be decomposed into several attributes (e.g., content, timbre, prosody, and phase) and each of them should be modeled using a module with appropriate inductive biases. From this perspective, we carefully design a novel and large zero-shot TTS system called Mega-TTS, which is trained with large-scale wild data and models different attributes in different ways: 1) Instead of using latent encoded by audio codec as the intermediate feature, we still choose spectrogram as it separates the phase and other attributes very well. Phase can be appropriately constructed by the GAN-based vocoder and does not need to be modeled by the language model. 2) We model the timbre using global vectors since timbre is a global attribute that changes slowly over time. 3) We further use a VQGAN-based acoustic model to generate the spectrogram and a latent code language model to fit the distribution of prosody, since prosody changes quickly over time in a sentence, and language models can capture both local and long-range dependencies. We scale Mega-TTS to multi-domain datasets with 20K hours of speech and evaluate its performance on unseen speakers. Experimental results demonstrate that Mega-TTS surpasses state-of-the-art TTS systems on zero-shot TTS, speech editing, and cross-lingual TTS tasks, with superior naturalness, robustness, and speaker similarity due to the proper inductive bias of each module. Audio samples are available at https://mega-tts.github.io/demo-page

Exploring the Potential Pharmacologic Mechanism of Heterophyllin B in the Treatment of Esophageal Cancer by Network Pharmacology

This study used the method of network pharmacology to preliminarily predict the mechanism of Heterophyllin B(HB) inhibiting Esophageal Cancer(EC). We found the HB targets in the TCMSP and PuChem databases, and searched all EC-related targets in the GeneCards database. Taken the intersection of HB and EC as potential targets for inhibiting EC, and used Cytoscape 3.7.1 software to perform topological analysis on potential targets to obtain core targets. Used the start Analysisi function in the DAVID database to analyzed the biological process of the core target, and visualized it with the the R language tool. As a result, 75 potential targets for inhibiting EC were obtained, of which MMP9, MMP2, CCND1, STAT3, CXCR4, BDKRB1and PTGS2 were the main core targets. HB inhibits the occurrence of EC through Pathways in cancer, TNF signaling pathway, Bladder cancer, Small cell lung cancer, Rheumatoid arthritis related pathways, mainly involving proteolysis, collagen catabolic process, extracellular matrix disassembly, positive regulation of cell proliferation, positive regulation of cytosolic calcium ion concentration biological processes. This study initially revealed the molecular mechanism of HB inhibiting EC, and provided a reference for HB to expand new indications

Establishment of porcine and human expanded potential stem cells.

We recently derived mouse expanded potential stem cells (EPSCs) from individual blastomeres by inhibiting the critical molecular pathways that predispose their differentiation. EPSCs had enriched molecular signatures of blastomeres and possessed developmental potency for all embryonic and extra-embryonic cell lineages. Here, we report the derivation of porcine EPSCs, which express key pluripotency genes, are genetically stable, permit genome editing, differentiate to derivatives of the three germ layers in chimeras and produce primordial germ cell-like cells in vitro. Under similar conditions, human embryonic stem cells and induced pluripotent stem cells can be converted, or somatic cells directly reprogrammed, to EPSCs that display the molecular and functional attributes reminiscent of porcine EPSCs. Importantly, trophoblast stem-cell-like cells can be generated from both human and porcine EPSCs. Our pathway-inhibition paradigm thus opens an avenue for generating mammalian pluripotent stem cells, and EPSCs present a unique cellular platform for translational research in biotechnology and regenerative medicine

THE RESEARCH OF EXPLOIT PROBLEM AND STRATEGY FOR TU NATION FOLK CUSTOMS TOURISM IN XIAOZHUANG VILLAGE, HUZHU COUNTY, QINGHAI PROVINCE

Great achievements have been made in the folk-custom tourism of Xiaozhuang village in Huzhu County over the past years; however, a variety of problems is still there. Based on the case of Xiaozhuang village, this paper discussed the problems according to the survey; and the possible solutions are also proposed

Risk analysis of autonomous vehicle test scenarios using a novel analytic hierarchy process method

Abstract Scenario‐based test methods are employed to assess the safety and performance of autonomous vehicles. The analytic hierarchy process (AHP) method is a common assessment method for determining the criticality of test scenarios. However, the AHP method is subjective and less reproducible when performed by different persons, as the elements of pairwise comparison values that are directly linked to the outcome must be assigned by the person involved. This paper proposes a novel AHP method that automatically generates pairwise comparison values by optimizing the correlation between performance metrics and risk of test scenarios by simulation. Performance metrics are defined as the minimum relative distances and corresponding relative velocities between vehicles, and the risk of the test scenario is determined by the pairwise comparison values of AHP. The novel AHP method was evaluated using a cut‐in scenario. The results showed that the minimum relative distance and the risk determined by the novel AHP method achieved a better correlation coefficient of −0.96, which is better than the conventional AHP of −0.828 and Fuzzy AHP of −0.824. These results suggest that the criticality of the test scenarios determined by the novel AHP method can more accurately reflect real‐world driving environments

#378 : Intrauterine Suture of Levonorgestrel Intrauterine Device Under Hysteroscopy

Background and Aims: Levonorgestrel-releasing intrauterine system (LNG-IUS) is an effective and long-term treatment for adenomyosis, especially for patients who have severe dysmenorrhea symptoms but a strong desire to preserve their uterus. However, expulsion of the device for patients with an enlarged uterus remains a problem. In this study, an LNG-IUS was stitched on the posterior wall of the uterus under hysteroscopy, which can be an alternative method to this problem. Methods: 21 patients with adenomyosis who had previously been treated with the LNG-IUS and experienced expulsion for at least one time were enrolled. The fixation of the LNG-IUD on the posterior wall of the uterus was performed with a 4-0 Ethicon polypropylene non-absorbable suture through an endoscopic needle driver and a knot-pushing device. Results: During the postoperative follow-up, all patients experienced complete remission of their symptoms: a significant decrease in menstrual flow, relief of dysmenorrhea, and improvement in quality of life. No expulsion of device and other compilations were found. Conclusions: In patients with adenomyosis suffering from dysmenorrhea or heavy menstrual blood loss, suture fixation of an LNG-IUS using the hysteroscopic cold knife surgery system is a minimally invasive and effective alternative treatment for patients with an enlarged uterus and decreases the risk of LNG-IUS expulsion

The deformation, cracking and failure behavior of lithological layered coal disk in Brazilian experiment

The cracking characterization of lithological layered coal disk under tensile stress is important for hydraulic fracturing in coal seam gas recovery. With digital image correlation and acoustic emission techniques, the cracking and fracture pattern of layered coal disk in Brazilian test were investigated considering different anisotropy angle between axial load and stratification plane and loading rate. The results show that both tensile and shear cracks developed in coal disk, and the crack initiation deviated from the center for most coal samples, closely related to stratification orientation, but irrespective of loading rate. The anisotropy angle in a range of 0°–45° favors the shear slip along stratification, leading to shear stick slip in both pre- and post-peak stages. However, the tensile cracks dominate in the early loading stage and then shear cracks start to be significant after the tensile cracks intersect with stratification plane. The stress state changed when the tensile cracks intersect with stratification plane, making crack deviate from the original propagation path. In addition, the tensile strength is related to the anisotropy angle. The maximum tensile strength occurs when the anisotropy angle α = 0° and the minimum tensile strength appears when the anisotropy angle α = 30°