Effects of ovarian stimulation protocols on outcomes of assisted reproductive technology in adenomyosis women: a retrospective cohort study

ObjectiveTo evaluate the effects of different ovarian stimulation protocols on in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes in infertile women with adenomyosis.MethodsWe carried out a retrospective cohort study among infertile women with adenomyosis receiving IVF/ICSI treatment, including 257 fresh embryo transfer (ET) cycles and 305 frozen embryo transfer (FET) cycles. In fresh ET cycles, ultra-long, long, short, and antagonist protocols were adopted. In FET cycles, patients received long-acting GnRH agonist (GnRHa) pretreatment or not. The primary outcome was clinical pregnancy rate (CPR), and the secondary outcomes included implantation rate (IR), miscarriage rate (MR), and live birth rate (LBR).ResultsIn fresh ET cycles, compared with ultra-long and long protocols, IR (49.7%, 52.1% versus 28.2%, P=0.001) and CPR (64.3%, 57.4% versus 35.6%, P=0.004) significantly decreased in the short protocol. Similarly, compared with ultra-long and long protocols, a decreased inclination of IR (49.7%, 52.1% versus 33.3%) and CPR (57.4%, 64.3% versus 38.2%) existed in the antagonist protocol, although no statistical significance was detected because of strict P adjustment of Bonferroni method (Padj=0.008). Compared with long protocol, LBR in short protocol decreased obviously (48.2% versus 20.3%, P<0.001). In FET cycles, no matter which origin of embryos, there were no statistical differences in IR, CPR, and LBR. For women ≥35 years receiving fresh ET, CPR was higher in ultra-long and long protocols (52.1%, 50.0% versus 20.0%, 27.5%, P=0.031) compared to antagonist and short protocols. For women ≥35 years receiving FET, compared with ultra-long and antagonist protocols, cycles with embryos originating from long and short protocols had higher proportions of long-acting GnRHa pretreatment (30.4%,30.00 versus 63.9%, 51.4%, P=0.009). IR (61.1%, 48.6% versus 32.6%, 25.0%, P=0.020) and CPR (58.3%, 48.6% versus 30.4%, 25.0%, P=0.024) in long and short protocols were higher than rates of ultra-long and antagonist protocols, but no statistical differences were supported because of strict Bonferroni method (Padj=0.008).ConclusionIn infertile women with adenomyosis, if a fresh embryo was planned for transfer, an ultra-long or long protocol might be beneficial. If antagonist and short protocols were used, whole embryos frozen followed by FET was recommended. In FET cycles, embryos derived from different protocols had no impact on pregnancy outcomes

Degradation of Formaldehyde over MnO2/CeO2 Hollow Spheres: Elucidating the Influence of Carbon Sphere Self-Sacrificing Templates

as a self-sacrificing template for formaldehyde (HCHO) removal. In the feed gas of 20 ppm of HCHO (balanced by N2) + 20 vol % O2, a HCHO removal efficiency of 70% was achieved at 20 °C and full conversion was reached at around 47 °C at GHSV = 50,000 mL (gcat h)−1 for MnO2/CeO2 hollow spheres. The catalytic performance and structural and chemical properties of MnO2/CeO2 hollow spheres for the removal of core carbon spheres were explored, and the influence of using the carbon sphere as a self-sacrificing template was proved by comparing with carbon@MnO2/CeO2 (a core carbon sphere with a MnO2/CeO2 shell) and nonmorphologic MnO2/CeO2. The properties of the MnO2/CeO2 hollow spheres are significantly improved compared to carbon@MnO2/CeO2 (removal efficiency of 45% at 150 °C) and MnO2/CeO2 (removal efficiency of 46% at 20 °C) as a result of an evolution in the interaction between Mn/Ce and carbon. This increase in the interaction strength seems to (i) increase the oxygen vacancy, (ii) promote the oxygen species mobility, and (iii) improve the chemical stability of the MnO2/CeO2 hollow spheres. We believe that these results are beneficial to the fabrication of binary transition metal oxides and applications of them in HCHO removal

Efficacy and safety of traditional Chinese medicine adjuvant therapy for severe pneumonia: evidence mapping of the randomized controlled trials, systematic reviews, and meta-analyses

Background and Objective: Severe pneumonia is a critical respiratory disease with high mortality. There is insufficient evidence on the efficacy and safety of traditional Chinese medicine (TCM) adjuvant therapy for severe pneumonia. This study aims to identify, describe, assess, and summarize the currently available high-quality design evidence on TCM adjuvant therapy for severe pneumonia to identify evidence gaps using the evidence mapping approach.Methods: Systematic searches were performed on English and Chinese online databases (PubMed, EMBASE, Cochrane Library, Web of Science, CNKI, WanFang Data, CQVIP, and SinoMed) to identify papers from inception until August 2023 for inclusion into the review. Randomized controlled trials (RCTs), systematic reviews (SRs), and meta-analyses concerning TCM adjuvant therapy for severe pneumonia or its complications in adults were included. The risk of bias in RCTs was evaluated by using the Cochrane Handbook ROB tool. The Assessment of Multiple Systematic Reviews 2 (AMSTAR-2), the Risk of Bias in Systematic Review (ROBIS) tool, and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system were used to assess the methodological quality, risk of bias, and evidence quality of SRs or meta-analyses, respectively. Then, a bubble plot was designed to visually display information in four dimensions.Results: A total of 354 RCTs and 17 SRs or meta-analyses met the inclusion criteria. The published RCTs had several flaws, such as unreasonable design, limited sample size, insufficient attention to non-drug therapy studies and syndrome differentiation, improper selection or use of outcome indicators, and failure to provide high-quality evidence. Sixteen SRs or meta-analyses of methodological quality scored “Critically Low” confidence. Twelve SRs or meta-analyses were rated as “High Risk.” Most outcomes were rated as “Low” evidence quality. We found that TCM combined with conventional treatment could improve the clinical total effective rate and the TCM syndromes efficacy. The combined approach could also shorten mechanical ventilation time, infection control time, and length of hospital and ICU stay; significantly reduce temperature, respiratory rate, heart rate, white blood cell counts, levels of C-reactive protein, procalcitonin, blood inflammatory factors, bacteriological response, and D-dimer; decrease CPIS, APACHE II score, and PSI score; improve pulmonary imaging features, arterial blood gas indicators (including arterial oxygen pressure, arterial oxygen saturation, and oxygen index), and lung function (including forced vital capacity and forced expiratory volume in the first second) for severe pneumonia compared with conventional treatment only (p < 0.05). There was no significant difference in adverse reactions and incidence of adverse events (p > 0.05). In addition, compared with conventional treatment only, most SRs or meta-analyses concluded that TCM combined with conventional treatment was “Beneficial” or “Probably beneficial.”Conclusion: TCM combined with conventional treatment had advantages in efficacy, clinical signs, laboratory results, and life quality outcomes of severe pneumonia, with no difference in safety outcomes compared with conventional treatment only. QingJin Huatan decoction is the most promising target, and Xuanbai Chengqi decoction has a “Probably beneficial” conclusion. XueBiJing injection and TanReQing injection are two commonly used Chinese herbal injections for treating severe pneumonia, and both are “Probably beneficial.” However, there was a need for multicenter RCTs with large sample sizes and high methodological quality in the future. In addition, the methodological design and quality of SRs or meta-analyses should be improved to form high-quality, evidence-based medical evidence and provide evidence for the effectiveness and safety of TCM adjuvant therapy for severe pneumonia

High Density Lipoprotein (HDL) Promotes Glucose Uptake in Adipocytes and Glycogen Synthesis in Muscle Cells

Background: High density lipoprotein (HDL) was reported to decrease plasma glucose and promote insulin secretion in type 2 diabetes patients. This investigation was designed to determine the effects and mechanisms of HDL on glucose uptake in adipocytes and glycogen synthesis in muscle cells. Methods and Results: Actions of HDL on glucose uptake and GLUT4 translocation were assessed with 1- [ 3 H]-2deoxyglucose and plasma membrane lawn, respectively, in 3T3-L1 adipocytes. Glycogen analysis was performed with amyloglucosidase and glucose oxidase-peroxidase methods in normal and palmitate-treated L6 cells. Small interfering RNA was used to observe role of scavenger receptor type I (SR-BI) in glucose uptake of HDL. Corresponding signaling molecules were detected by immunoblotting. HDL stimulated glucose uptake in a time- and concentration-dependent manner in 3T3-L1 adipocytes. GLUT4 translocation was significantly increased by HDL. Glycogen deposition got enhanced in L6 muscle cells paralleling with elevated glycogen synthase kinase3 (GSK3) phosphorylation. Meanwhile, increased phosphorylations of Akt-Ser473 and AMP activated protein kinase (AMPK) a were detected in 3T3-L1 adipocytes. Glucose uptake and Akt-Ser473 activation but not AMPK-a were diminished in SR-BI knock-down 3T3-L1 cells. Conclusions: HDL stimulates glucose uptake in 3T3-L1 adipocytes through enhancing GLUT4 translocation by mechanisms involving PI3K/Akt via SR-BI and AMPK signaling pathways, and increases glycogen deposition in L6 muscle cells throug

Recent Progress of Terahertz Spatial Light Modulators: Materials, Principles and Applications

Terahertz (THz) technology offers unparalleled opportunities in a wide variety of applications, ranging from imaging and spectroscopy to communications and quality control, where lack of efficient modulation devices poses a major bottleneck. Spatial modulation allows for dynamically encoding various spatial information into the THz wavefront by electrical or optical control. It plays a key role in single-pixel imaging, beam scanning and wavefront shaping. Although mature techniques from the microwave and optical band are not readily applicable when scaled to the THz band, the rise of metasurfaces and the advance of new materials do inspire new possibilities. In this review, we summarize the recent progress of THz spatial light modulators from the perspective of functional materials and analyze their modulation principles, specifications, applications and possible challenges. We envision new advances of this technique in the near future to promote THz applications in different fields

Enhanced Terahertz Amplification Based on Photo-Excited Graphene-Dielectric Hybrid Metasurface

Graphene under optical pump has been shown to be an attractive gain medium with negative dynamic conductivity at terahertz frequencies. However, the amplification over a monolayer graphene is very weak due to its one-atom thickness. In this paper, the proposed graphene-dielectric reflective metasurface effectively improved terahertz field localization and enhanced coherent amplification. The amplification coefficient of 35 was obtained at 3.38 THz at room temperature with an infrared pump intensity of 8 W/mm2. As pump intensity increased from 0 to 15 W/mm2, we observed a loss–gain–loss transition process, which was discussed in detail through coupled-mode theory. In addition, amplification at different frequencies was achieved by merely re-optimizing the geometric parameters of the dielectric resonators. This study offers an effective solution for enhancing terahertz radiation and developing terahertz lasers

Distribution of Clinical Traditional Chinese Medicine Syndromes in Patients with Severe Community-acquired Pneumonia

Background Severe community-acquired pneumonia (SCAP) progresses rapidly, with high mortality, multiple complications, and heavy economic burden. Despite the continuous improvement of clinical diagnosis and treatment programs, its morbidity and mortality remain high. Traditional Chinese Medicine (TCM) has proven its significant clinical efficacy in treating SCAP, but there is still no a standardized TCM-based clinical diagnosis and treatment protocol for SCAP, and insufficient research on the distribution of clinical TCM syndromes of SCAP. Objective To study the characteristics and distribution of clinical TCM symptoms of SCAP, providing ideas for clinical diagnosis and treatment of SCAP. Methods SCAP inpatients were recruited from Department of Respiratory Medicine, the First Affiliated Hospital of Henan University of CM from December 2012 to March 2021. Their symptoms and signs were summarized. Factor analysis and cluster analysis were performed on the data using SPSS Statistics (version 26.0) . Results One hundred and sixty-six patients were included, including 119 men and 47 women, the ratio is 2.53∶1, with an average age of (70.1±15.8) years old. Altogether, 13 TCM syndromes were summarized, among which phlegm-heat obstructed lung syndrome had a high prevalence〔34.33% (57 /166) 〕; cough and expectoration were prevalent in more than 50% of the patients. Twelve common factors were obtained by factor analysis of TCM symptoms, explaining 62.842% of the total variance. By cluster analysis, the common factors were clustered into four major categories: phlegm-heat obstructed lung syndrome, xiexian-zhengtuo syndrome, qi-yin deficiency syndrome, and phlegm-damp obstructed lung syndrome. Conclusion Men is accounting for a larger percentage of SCAP. Clinical TCM syndromes of SCAP mainly include phlegm-heat obstructed lung syndrome, xiexian-zhengtuo syndrome, qi-yin deficiency syndrome, and phlegm-damp obstructed lung syndrome

Potassium-Promoted Three-Dimensional Mesoporous Pt/MnO2 for Formaldehyde Elimination at Zero Degree

In this work, three-dimensional mesoporous MnO2, K/MnO2, Pt/MnO2 and K-Pt/MnO2 catalysts were prepared through hard-template method. The additional K/Pt had significantly improved the HCHO oxidation activity. The K-Pt/MnO2 catalyzed complete HCHO oxidation was achieved at 0 degrees C with space velocity (GHSV) at 50000 ml/(g.h). With the excellent catalytic performance, K-Pt/MnO2 exhibited a higher ratio of O-ads(surface adsorbed oxygen)/O-latt(surface lattice oxygen) and Mn3+/Mn4+ ions than the other catalysts. Meanwhile, it was still stable after running a 70h reaction. Overall, the K-Pt/MnO2 was a promising material for HCHO elimination

A bidirectional Mendelian randomization study investigating the relationship between genetically predicted systemic inflammatory regulators and chronic obstructive pulmonary disease

Research has shown a connection between inflammation and chronic obstructive pulmonary disease (COPD), however the relationship between inflammation mediators and COPD causation remains unknown. To investigate the causal relationship of mediators of inflammation and COPD, we conducted a two-sample Mendelian randomization (MR) study. In our study, we incorporated 41 regulators of inflammation from 8293 Finnish individuals from genome-wide association studies (GWASs) of COPD corresponding to GWAS summary data for 2115 cases and 454,233 healthy individuals in Europe. Our research validated that higher levels of interleukin 8 (IL-8) are related with a decrease occurrence of COPD (OR = 0.795, 95 % CI = 0.642–0.984, p = 0.035) but that elevated levels of interleukin 18(IL-18) and interleukin 2 (IL-2) may be connected to an amplified risk of COPD (OR = 1.247, 95 % CI = 1.011–1.538; p = 0.039; OR = 1.257, 95 % CI = 1.037–1.523, p = 0.020, respectively). According to our research, cytokines play a crucial role in the development of COPD, and further investigation is necessary to explore the potential of utilizing these cytokines as targets for treatment and prevention of COPD

Online Retailer’s Contingent Free-Shipping Decisions under Large-Scale Promotions Considering Delayed Delivery

Large-scale promotions lead to a huge number of orders, and the quantity of deliveries grows sharply, which puts considerable strain on cities’ logistics and imposes high related shipping costs. To alleviate these consequences, in this paper we provide a new contingent free shipping policy with delayed delivery (DD-CFS) for an online retailer during large-scale promotions and study its CFS threshold decisions, considering consumers’ different sensitivities to delivery time delays.We start by analyzing a consumer’s purchasing decision based on consumer utility theory. Next, we establish a mathematical model to help the online retailer find the optimal CFS threshold to maximize its expected profit. Finally, we analyze the benefit of delayed delivery to the online retailer and conduct a sensitivity analysis to examine the impacts of important parameters on the online retailer’s CFS threshold decisions, profit, and the value of the delayed delivery. We find that the DD-CFS policy can lead to more profits during the large-scale promotions period compared with the traditional CFS policy. As the delayed delivery time and the consumer’s negative attitude towards delayed delivery time increase, the online retailer should reduce the low CFS threshold value. On the other hand, as the shipping fee and the consumer’s negative attitude towards the shipping fee increase, the online retailer should raise the high and low CFS threshold values