Utilization of Polysaccharide-Based High Internal Phase Emulsion for Nutraceutical Encapsulation: Enhancement of Carotenoid Loading Capacity and Stability

The main goal of the present work was to access the ability of high internal phase emulsions (HIPEs) to encapsulate fl-carotene. The carotenoid loading capacity of the HIPEs was around 20-fold higher when OSAstarch/chitosan complexes were used than when only OSA-starch was used. This impact could be mainly assigned to the capacity of the former HIPEs to trap carotenoid caystals in a stable form. The OSA-starch/chitosan complexes were shown to absorb on the oil droplets interface and form a 3D network in the aqueous phase, which helped to prevent droplet coalescence induced by fl-carotene crystal. The incorporation of fl-carotene within the oil droplets enhanced its resistance to chemical degradation when exposed to heat, ultraviolet radiation, or gastrointestinal conditions. Our results provide information that may aid the design and development of edible soft solids containing high carotenoid levels, which may be applied in food and pharmaceutical industry

Research Review on Artificial Intelligence Technology to Provide Design of Man-machine Interaction in Industry and Product Design

This paper discusses the human-computer interaction medium , interactive object , application of artificial intelligence and human-computer relationship in the era of artificial intelligence in the recent years. It’s focused on human-computer interaction of artificial intelligence , based on the in-depth research and insight into advanced technologies, products and designs in the field of artificial intelligence over the past year and combined with the experience of industry and academia. The development trend has formed the design insight in this field, and summarized eight trends of artificial intelligence humancomputer interaction. The application of artificial intelligence human-computer interaction design in universities and enterprises related to specific projects of industrial design provides important theoretical support and practical verification for the teaching and scientific research work of industrial design specialty and the further development and growth of industrial design industry in universities and colleges of our country. The application of artificial intelligence technology in universities and enterprises is also demonstrated

Effect of Homogenization Pressure on the Stability and in Vitro Digestion of Flaxseed Oil Emulsion

In this study, flaxseed oil body was taken as the research object, and stable flaxseed oil body emulsion rich in α-linolenic acid was obtained through homogenization treatment, which provides a new way for residents to increase the intake of ω-3 unsaturated fatty acids in daily diet. Under the same homogenous conditions (3 min) each time, changing the homogenization pressure (40, 80, 120 MPa) and the number of times (1~3 times) of flaxseed oil emulsions, the effects of homogenization on the properties, environmental stability ( pH, ionic strength, thermal, oxidation stability) and storage stability, and digestive properties of flaxseed oil emulsions were investigated. The results showed that the absolute value of potential zeta potential increased and the particle size decreased significantly when flaxseed oil body was homogenized at 120 MPa for three times (P0.05). The results of digestion showed that the homogenized flaxseed oil body emulsion had a higher release rate of fatty acids (FFA). In conclusion, the homogenization treatment significantly reduced the particle size of flaxseed oil emulsion, enhanced the storage stability and oxidation stability of flaxseed oil body, and accelerated the release rate of fatty acid

Effects of the different intensities of task-oriented training on the upper extremity motor function and self-care ability of stroke survivors: study protocol for a multiarm parallel-group randomised controlled trial in a tertiary hospital in China

Introduction Although task-oriented training (TOT) may provide added therapeutic value to stroke survivors, current TOT guidance offers insufficient advice on standardisation, particularly choices of intensity, for clinical practice. Therefore, this study aims to explore the effects of different intensities of TOT on motor function and self-care ability of stroke survivors.Methods and analysis This randomised controlled clinical trial will recruit 72 participants from a tertiary hospital, diagnosed with decreased self-care ability and upper limb motor dysfunction post-stroke. All participants will be randomly assigned to one of three experimental groups or the control group to undergo intervention for 8 weeks. The participants in the control group (n=18) will receive traditional occupational therapy, while those in the experimental groups will receive different intensities of TOT (50%, 75% and 100% intensity for groups A, B and C, respectively). This protocol designed a more innovative and optimised TOT programme to explore the optimal intensity of TOT on stroke survivors. The primary outcome is Canadian Occupational Performance Measure, and the secondary outcomes include Modified Barthel Index, Wolf Motor Function Test and Motor Activity Log.Ethics and dissemination The Second Affiliated Hospital of Hainan Medical University Ethics Committee approved the medical and ethical protocol for this study (LW2022015). All participants will sign an informed consent form. The results will be presented in scientific conferences and published in peer-reviewed journals.Trial registration number ChiCTR2200056390

Fabrication of Caseinate Stabilized Thymol Nanosuspensions via the pH-Driven Method: Enhancement in Water Solubility of Thymol

Thymol has been applied as a spice and antibacterial agent in commercial products. However, the utilization of thymol in the food and pharmaceutical field has recently been limited by its poor water solubility and stability. In this work, a caseinate-stabilized thymol nanosuspension was fabricated by pH-driven methods to overcome those limitations. Firstly, the chemical stability of thymol at different pH value conditions was investigated. The physiochemical properties of thymol nanosuspensions were then characterized, such as average particle size, zeta potential, encapsulation efficiency, and loading capacity. Meanwhile, the X-ray diffraction results showed that thymol was present as an amorphous state in the nanosuspensions. The thermal stability of thymol was slightly enhanced by encapsulation through this process, and the thymol nanosuspensions were stable during the long-term storage, and the average particle size of nanosuspensions showed that there was no aggregation of nanosuspensions during storage and high temperature. Finally, the antimicrobial activity of thymol nanosuspensions was evaluated by investigating the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against Salmomella enterca, Staphlococcus aureus, Escherichia coli, and Listeria monocytogenes. These results could provide useful information and implications for promoting the application of thymol in food, cosmetic, and pharmaceutical commercial products

The autism associated MET receptor tyrosine kinase engages early neuronal growth mechanism and controls glutamatergic circuits development in the forebrain

The human MET gene imparts a replicated risk for autism spectrum disorder (ASD), and is implicated in the structural and functional integrity of brain. MET encodes a receptor tyrosine kinase, MET, which plays a pleiotropic role in embryogenesis and modifies a large number of neurodevelopmental events. Very little is known, however, on how MET signaling engages distinct cellular events to collectively affect brain development in ASD-relevant disease domains. Here, we show that MET protein expression is dynamically regulated and compartmentalized in developing neurons. MET is heavily expressed in neuronal growth cones at early developmental stages and its activation engages small GTPase Cdc42 to promote neuronal growth, dendritic arborization, and spine formation. Genetic ablation of MET signaling in mouse dorsal pallium leads to altered neuronal morphology indicative of early functional maturation. In contrast, prolonged activation of MET represses the formation and functional maturation of glutamatergic synapses. Moreover, manipulating MET signaling levels in vivo in the developing prefrontal projection neurons disrupts the local circuit connectivity made onto these neurons. Therefore, normal time-delimited MET signaling is critical in regulating the timing of neuronal growth, glutamatergic synapse maturation and cortical circuit function. Dysregulated MET signaling may lead to pathological changes in forebrain maturation and connectivity, and thus contribute to the emergence of neurological symptoms associated with ASD.National Institute of Mental Health (NIMH) [K99MH087628, R00MH087628]; Institute for Mental Health Research.Published online 5 January 2016. 6 month embargo.This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]