Reliability analysis of the internet of things using Space Fault Network

The Internet of Things (IoT) is a network topology structure based on the interconnection of many nodes. It realizes the basic functions of IoT through the transmission of information, data, and energy between the nodes. To study the reliability of Internet of Things Network Topology (IoTNT) structure, we must abstract IoT as network topology and study the reliability of the network itself from the topology structure. This paper attempts to apply the Space Fault Network (SFN) to the study the reliability of IoTNT. To achieve this goal, the nodes and edges of IoTNT are equivalent to events and connections of SFN respectively. A structure analysis method based on SFN is proposed and used to study the reliability of IoTNT. At the same time, the influence of possible logical relationship between nodes on the reliability of IoTNT is studied. According to the SFN structure representation methods (SFNSRMs), considering different network structures and induced modes, the analysis methods and calculation methods of the evolution process of target event are given. An example is given to illustrate the analysis and calculation process. The research provides the new methods for the reliability study of IoT and the development of SFN

Obesity Prevalence and Dietary Intake of Antioxidants in Native American Adolescents

Antioxidants are well known for possessing anti-inflammatory properties, which can reduce the risk of chronic disease and obesity. However, very little research has been done to examine antioxidant intake among adolescent minority populations such as Native American adolescents. Our study examined the significance of antioxidant intake among Native American adolescents at an urban residential high school in Southern California. Our study population consisted of 183 male and female Native American adolescents, 14-18 years of age, representing 43 tribes from across the United States. Students' primary source of meals was provided by the school food service. Based on the BMI calculations, the rate of obesity within our population was 38% for males and 40% for females, more than two-fold the national rate indicated by NHANESIII data. We used the Harvard School of Public Health Youth/Adolescent Questionnaire (HSPH YAQ), a semi-quantitative food frequency questionnaire, to examine antioxidant nutrient intake and evaluate the differences in the intake between normal and obese weight students. Statistical analysis of the results showed that intakes of vitamins C, E, and lycopene were the antioxidant nutrients found to be significantly different between normal and obese weight students and intakes of these nutrients were found to be higher among normal weight students (p-values = 0.02451, 0.00847, and 0.04928, respectively). These results suggest that dietary intake of antioxidants could be increased among Native American adolescents. Further research is needed to confirm our findings and identify effective ways for school food service to incorporate antioxidant rich foods into school menus

A unified mechanism for intron and exon definition and back-splicing.

The molecular mechanisms of exon definition and back-splicing are fundamental unanswered questions in pre-mRNA splicing. Here we report cryo-electron microscopy structures of the yeast spliceosomal E complex assembled on introns, providing a view of the earliest event in the splicing cycle that commits pre-mRNAs to splicing. The E complex architecture suggests that the same spliceosome can assemble across an exon, and that it either remodels to span an intron for canonical linear splicing (typically on short exons) or catalyses back-splicing to generate circular RNA (on long exons). The model is supported by our experiments, which show that an E complex assembled on the middle exon of yeast EFM5 or HMRA1 can be chased into circular RNA when the exon is sufficiently long. This simple model unifies intron definition, exon definition, and back-splicing through the same spliceosome in all eukaryotes and should inspire experiments in many other systems to understand the mechanism and regulation of these processes

Rabbit and Human Non-Keratinising Stratified Squamous Oesophageal Epithelium Displays Similar Microridge Structure by Scanning Electron Microscopy

Since the oesophageal epithelium of common laboratory animals, rats and mice, is keratinized it is unsuitable for comparison with typical non-keratinized stratified squamous human epithelium. It is thus important to find a suitable animal model for the study of human oesophageal tissue changes. This study investigated the microridge structure of immature and adult rabbit specimens, and adult human biopsies by scanning electron microscopy and morphometry. The investigation revealed a similarity between typical squamous human and adult rabbit oesophageal mucosal epithelium. While human epithelium specimens subdivided into two other groups (non-typical squamous and non-squamous); all typical squamous human biopsies were from patients who had normal endoscopy reports and no reflux symptoms. The surface cells of typical squamous human epithelium displayed complex microridge patterns (64% of cell surface) but patterns in non-typical squamous specimens were more variable (38%) (P \u3c 0.001) and cell boundaries less obvious. Rabbit squames displayed clear microridge patterns with an elevation in the percentage of cell surface covered by microridges, with increasing age, from immature to adult specimens (P \u3c 0.001). There was no statistically significant differences between adult rabbit, and \u27typical squamous\u27 human biopsies (range 51-65%), results which suggest potential use of a rabbit model to study changes in human oesophageal tissue

A Statistical Study of the Subauroral Polarization Stream Over North American Sector Using the Millstone Hill Incoherent Scatter Radar 1979- 2019 Measurements

This work conducts a statistical study of the subauroral polarization stream (SAPS) feature in the North American sector using Millstone Hill incoherent scatter radar measurements from 1979 to 2019, which provides a comprehensive SAPS climatology using a significantly larger database of radar observations than was used in seminal earlier works. Key features of SAPS and associated electron density (Ne), ion temperature (Ti), and electron temperature (Te) are investigated using a superposed epoch analysis method. The characteristics of these parameters are investigated with respect to magnetic local time, season, geomagnetic activity, solar activity, and interplanetary magnetic field (IMF) orientation, respectively. The main results are as follows: (1) Conditions for SAPS are more favorable for dusk than near midnight, for winter compared to summer, for active geomagnetic periods compared to quiet time, for solar minimum compared to solar maximum, and for IMF conditions with negative By and negative Bz. (2) SAPS is usually associated with a midlatitude trough of 15- 20% depletion in the background density. The SAPS- related trough is more pronounced in the postmidnight sector and near the equinoxes. (3) Subauroral ion and electron temperatures exhibit a 3- 8% (50- 120 K) enhancement in SAPS regions, which tend to have higher percentage enhancement during geomagnetically active periods and at midnight. Ion temperature enhancements are more favored during low solar activity periods, while the electron temperature enhancement remains almost constant as a function of the solar cycle. (4) The electron thermal content, Te- à - Ne, in the SAPS associated region is strongly dependent on 1/Ne, with Te exhibiting a negative correlation with respect to Ne.Key PointsKey features of North American SAPS and associated Ne, Ti, and Te were analyzed using four decade Millstone Hill IS radar measurementsNorth American SAPS climatology in terms of MLT, season, geomagnetic activity, solar activity, and IMF condition was comprehensively studiedBoth ion and electron temperatures exhibit moderate enhancement around SAPS, with similar geomagnetic but different solar activity dependencePeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/163417/2/jgra56052_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/163417/1/jgra56052.pd

Depth versus surface: A critical review of subdural and depth electrodes in intracranial electroencephalographic studies

Intracranial electroencephalographic (IEEG) recording, using subdural electrodes (SDEs) and stereoelectroencephalography (SEEG), plays a pivotal role in localizing the epileptogenic zone (EZ). SDEs, employed for superficial cortical seizure foci localization, provide information on two-dimensional seizure onset and propagation. In contrast, SEEG, with its three-dimensional sampling, allows exploration of deep brain structures, sulcal folds, and bihemispheric networks. SEEG offers the advantages of fewer complications, better tolerability, and coverage of sulci. Although both modalities allow electrical stimulation, SDE mapping can tessellate cortical gyri, providing the opportunity for a tailored resection. With SEEG, both superficial gyri and deep sulci can be stimulated, and there is a lower risk of afterdischarges and stimulation-induced seizures. Most systematic reviews and meta-analyses have addressed the comparative effectiveness of SDEs and SEEG in localizing the EZ and achieving seizure freedom, although discrepancies persist in the literature. The combination of SDEs and SEEG could potentially overcome the limitations inherent to each technique individually, better delineating seizure foci. This review describes the strengths and limitations of SDE and SEEG recordings, highlighting their unique indications in seizure localization, as evidenced by recent publications. Addressing controversies in the perceived usefulness of the two techniques offers insights that can aid in selecting the most suitable IEEG in clinical practice

Episodic Occurrence of Field‐Aligned Energetic Ions on the Dayside

The tens of kiloelectron volt ions observed in the ring current region at L ~ 3–7 generally have pancake pitch angle distributions, that is, peaked at 90°. However, in this study, by using the Van Allen Probe observations on the dayside, unexpectedly, we have found that about 5% time, protons with energies of ~30 to 50 keV show two distinct populations, having an additional field‐aligned population overlapping with the original pancake population. The newly appearing field‐aligned populations have higher occurrence rates at ~12–16 magnetic local time during geomagnetically active times. In particular, we have studied eight such events in detail and found that the source regions are located around 12 to 18 magnetic local time which coincides with our statistical result. Based on the ionospheric and geosynchronous observations, it is suggested that these energetic ions with field‐aligned pitch angle distributions probably are accelerated near postnoon in association with ionospheric disturbances that are triggered by tail injections.Plain Language SummaryProtons of different sources have different pitch angle distributions (PADs). For example, warm plasma cloak protons, which come directly from the ionosphere, have field‐aligned PADs, while ring current protons that generally originate from tail plasma sheet have pancake‐shaped PADs. In this study, unexpectedly, we have found that about 5% of the time on the dayside, protons of ring current energies show two distinct populations according to their PADs: higher fluxes of field‐aligned populations overlapping with the original pancake populations. The newly appeared field‐aligned populations have higher occurrence rates at ~12–16 magnetic local time during geomagnetically active times. In order to find the mechanism that generates these field‐aligned energetic proton populations, we have studied eight such events in detail by using the low‐altitude DMSP, POES satellites, and the NOAA‐LANL satellite at the geosynchronous orbit. The results imply that these energetic ions with field‐aligned PADs probably are accelerated by ionospheric disturbances that are triggered by tail injections. These results provide evidence of another possibly important source of the ring current ions.Key PointsWe have found that about 5% of the time on the dayside, protons with energies of ~30 to 50 keV have strong field‐aligned PADsThe field‐aligned PADs have higher occurrence rates at ~12‐16 MLT during geomagnetically active timesThese energetic field‐aligned ions possibly are accelerated by ionospheric disturbances triggered by tail injectionsPeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153687/1/grl60102_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/153687/2/grl60102.pd

Epilepsy Center Characteristics and Geographic Region Influence Presurgical Testing in the United States

bjective Persons with drug‐resistant epilepsy may benefit from epilepsy surgery and should undergo presurgical testing to determine potential candidacy and appropriate intervention. Institutional expertise can influence use and availability of evaluations and epilepsy surgery candidacy. This census survey study aims to examine the influence of geographic region and other center characteristics on presurgical testing for medically intractable epilepsy. Methods We analyzed annual report and supplemental survey data reported in 2020 from 206 adult epilepsy center directors and 136 pediatric epilepsy center directors in the United States. Test utilization data were compiled with annual center volumes, available resources, and US Census regional data. We used Wilcoxon rank‐sum, Kruskal–Wallis, and chi‐squared tests for univariate analysis of procedure utilization. Multivariable modeling was also performed to assign odds ratios (ORs) of significant variables. Results The response rate was 100% with individual element missingness \u3c 11% across 342 observations undergoing univariate analysis. A total of 278 complete observations were included in the multivariable models, and significant regional differences were present. For instance, compared to centers in the South, those in the Midwest used neuropsychological testing (OR = 2.87, 95% confidence interval [CI] = 1.2–6.86; p = .018) and fluorodeoxyglucose–positron emission tomography (OR = 2.74, 95% CI = = 1.14–6.61; p = .025) more commonly. For centers in the Northeast (OR = .46, 95% CI = .23–.93; p = .031) and West (OR = .41, 95% CI = .19–.87; p = .022), odds of performing single‐photon emission computerized tomography were lower by nearly 50% compared to those in the South. Center accreditation level, demographics, volume, and resources were also associated with varying individual testing rates. Significance Presurgical testing for drug‐resistant epilepsy is influenced by US geographic region and other center characteristics. These findings have potential implications for comparing outcomes between US epilepsy centers and may inject disparities in access to surgical treatment

Association Between Characteristics of National Association of Epilepsy Centers and Reported Utilization of Specific Surgical Techniques

Background and Objective Nearly one-third of persons with epilepsy will continue having seizures despite trialing multiple antiseizure medications. Epilepsy surgery may be beneficial in these cases, and evaluation at a comprehensive epilepsy center is recommended. Numerous palliative and potentially curative approaches exist, and types of surgery performed may be influenced by center characteristics. This article describes epilepsy center characteristics associated with epilepsy surgery access and volumes in the United States. Methods We analyzed National Association of Epilepsy Centers 2019 annual report and supplemental survey data obtained with responses from 206 adult epilepsy center directors and 136 pediatric epilepsy center directors in the United States. Surgical treatment volumes were compiled with center characteristics, including US Census region. We used multivariable modeling with zero-inflated Poisson regression models to present ORs and incidence rate ratios of receiving a given surgery type based on center characteristics. Results The response rate was 100% with individual element missingness less than 4% across 352 observations undergoing univariate analysis. Multivariable models included 319 complete observations. Significant regional differences were present. The rates of laser interstitial thermal therapy (LITT) were lower at centers in the Midwest (incidence rate ratio [IRR] 0.74, 95% CI 0.59–0.92; p = 0.006) and Northeast (IRR 0.77, 95% CI 0.61–0.96; p = 0.022) compared with those in the South. Conversely, responsive neurostimulation implantation rates were higher in the Midwest (IRR 1.45, 95% CI 1.1–1.91; p = 0.008) and West (IRR 1.91, 95% CI 1.49–2.44; p \u3c 0.001) compared with the South. Center accreditation level, institution type, demographics, and resources were also associated with variations in access and rates of potentially curative and palliative surgical interventions. Discussion Epilepsy surgery procedure volumes are influenced by US epilepsy center region and other characteristics. These variations may affect access to specific surgical treatments for persons with drug resistant epilepsy across the United States

Application of kernel functions for accurate similarity search in large chemical databases

Background Similaritysearch in chemical structure databases is an important problem with many applications in chemical genomics, drug design, and efficient chemical probe screening among others. It is widely believed that structure based methods provide an efficient way to do the query. Recently various graph kernel functions have been designed to capture the intrinsic similarity of graphs. Though successful in constructing accurate predictive and classification models, graph kernel functions can not be applied to large chemical compound database due to the high computational complexity and the difficulties in indexing similarity search for large databases. Results To bridge graph kernel function and similarity search in chemical databases, we applied a novel kernel-based similarity measurement, developed in our team, to measure similarity of graph represented chemicals. In our method, we utilize a hash table to support new graph kernel function definition, efficient storage and fast search. We have applied our method, named G-hash, to large chemical databases. Our results show that the G-hash method achieves state-of-the-art performance for k-nearest neighbor (k-NN) classification. Moreover, the similarity measurement and the index structure is scalable to large chemical databases with smaller indexing size, and faster query processing time as compared to state-of-the-art indexing methods such as Daylight fingerprints, C-tree and GraphGrep. Conclusions Efficient similarity query processing method for large chemical databases is challenging since we need to balance running time efficiency and similarity search accuracy. Our previous similarity search method, G-hash, provides a new way to perform similarity search in chemical databases. Experimental study validates the utility of G-hash in chemical databases