365 research outputs found
EFFECTS OF SEAT POSITION ON THE JOINT MOMENTS OF THE LOWER EXTREMITIES DURING CYCLING IN THE ELDERLY
The purpose of this study was to quantify the joint moments of the lower extremities with different seat positions during cycling in elderly. Fifteen older adults performed cycling on a self-developed bicycle ergometer at three horizontal and three vertical seat positions. The pedals were instrumented with six-component load cells to measure pedal reaction forces; and a motion capture system was used to measure body segment kinematic data. Both data sets were used to calculate joint moments during a crank cycle. The results showed that seat positions affected joint moments significantly, especially the horizontal positions. A more posterior seat position led to a more balanced loading at the hip and knee, with less peak muscle loadings. The results will be helpful for cycle design and fitting for the elderly
Comparison and prediction of pullout strength of conical and cylindrical pedicle screws within synthetic bone
<p>Abstract</p> <p>Background</p> <p>This study was designed to derive the theoretical formulae to predict the pullout strength of pedicle screws with an inconstant outer and/or inner diameter distribution (conical screws). For the transpedicular fixation, one of the failure modes is the screw loosening from the vertebral bone. Hence, various kinds of pedicle screws have been evaluated to measure the pullout strength using synthetic and cadaveric bone as specimens. In the literature, the Chapman's formula has been widely proposed to predict the pullout strength of screws with constant outer and inner diameters (cylindrical screws).</p> <p>Methods</p> <p>This study formulated the pullout strength of the conical and cylindrical screws as the functions of material, screw, and surgery factors. The predicted pullout strength of each screw was compared to the experimentally measured data. Synthetic bones were used to standardize the material properties of the specimen and provide observation of the loosening mechanism of the bone/screw construct.</p> <p>Results</p> <p>The predicted data from the new formulae were better correlated with the mean pullout strength of both the cylindrical and conical screws within an average error of 5.0% and <it>R</it><sup>2 </sup>= 0.93. On the other hand, the average error and <it>R</it><sup>2 </sup>value of the literature formula were as high as -32.3% and -0.26, respectively.</p> <p>Conclusion</p> <p>The pullout strength of the pedicle screws was the functions of bone strength, screw design, and pilot hole. The close correlation between the measured and predicted pullout strength validated the value of the new formulae, so as avoid repeating experimental tests.</p
Recent progress and debates in molecular physiology of Na+ uptake in teleosts
How teleosts take up Na+ from the surrounding freshwater (FW) as well as the underlying mechanisms associated with this process have received considerable attention over the past 85 years. Owing to an enormous ion gradient between hypotonic FW and fish body fluids, teleosts gills have to actively absorb Na+ (via ionocytes) to compensate for the passive loss of Na+. To date, three models have been proposed for Na+ uptake in teleost ionocytes, including Na+/H+ exchanger (NHE)-mediated, acid-sensing ion channel (ASIC)-mediated, Na+-Cl- co-transporter (NCC)-mediated pathways. However, some debates regarding these models and unclear mechanisms still remain. To better understand how teleosts take up Na+ from FW, this mini-review summarizes the main progress and related regulatory mechanisms of Na+ uptake, and discusses some of the challenges to the current models
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