Radiofrequency ablation of surface v/s intraparenchymal hepatocellular carcinoma in cirrhotic patients

Objective: To retrospectively evaluate the safety and technical efficacy of percutaneous radiofrequency ablation (RFA) of surface hepatocellular carcinoma (HCC) in comparison to intraparenchymal HCC in cirrhotic patients. Materials and Methods: Surface lesions were defined as tumours located or reaching within 1cm of liver capsule including exophytic lesions. Seventy-four surface HCC including 21 exophytic in 58 patients (surface group) and 60 intraparenchymal HCC in 54 patients (intraparenchymal group) measuring up to 4 cm in maximum extent underwent percutaneous [ultrasound (US) or computed tomography-guided (CT-guided)] RFA. The response to the treatment was assessed by contrast enhanced CT/magnetic resonance imaging (MRI) done at 1, 3, 6, 9, and 12 months of RFA and thereafter every 4–6 months. In case of features suggesting residual disease, a repeat RFA was performed. The technical success after single-session RFA, complications and disease recurrence rates were calculated and compared between two groups. Results: Technical success achieved after first session of RFA in surface HCC was 95% (70/74) and intraparenchymal HCC was 97% (58/60). Hundred percent secondary success rate was achieved in both groups after second repeat RFA in residual lesion. No major difference in complication and local recurrence rate in both group on follow-up in surface HCC and intraparenchymal HCC. No case of needle track, peritoneal seeding, and treatment mortality was found. Conclusions: The complication rate and efficacy of RFA for surface and exophytic HCC's were comparable to that of intraparenchymal HCC. Hence surface and exophytic lesions should not be considered a contraindication for RFA in cirrhotic patients

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Not AvailableBread wheat is grown in the sub - tropical and tropical regions world - wide. Terminal - heat stress is a major abiotic stress in wheat and global warming due to climate change has negatively impacted its production and productivity. We evaluated 96 accessions of bread wheat germplasm, which included 79 indigenous and 17 exotic collections, by investigating 16 morpho - physiological and yield - related traits during two successive Rabi seasons of 2018 - 19 and 2019 - 20 under non - stressed and heat - stressed (as a delayed sown crop) environments. Heat susceptibility index (HSI) was used to classify tolerant (HSI 1.0) accessions. The heat - stress showed negative impact on the phenotypic expression of 14 morpho - physiological and yield related traits by reducing the traits more prominently in susceptible accessions than the tolerant. However, early ground cover showed the increased expression in the tolerant accessions and higher variability in the germplasm under the heat - stress. Grain length / width ratio (LWR) also improved in the germplasm under heat - stress, while, there was a marked increase in LWR of the susceptible accessions mainly due to relatively higher decrease of grain width in these accessions under heat - stress. The plot yield associated positively with its contributing traits namely yield per plant, number of grains per plant, number of grains per spike, grain weight per spike and plant biomass under both the non - stressed and the heat - stressed environments, but its association with chlorophyll fl uorescence was only under heat - stress. The germplasm accessions IC574476 (HD2967), IC393878 (WH157), IC296383 (WR544), EC534487 (PAU351), IC519900 (HD2932) and IC539221 [EIGN - I - (04 - 05) / 149] produced high yield and were stable across the environments. The identifi ed bread wheat germplasm lines could be used as potential parents for bi - parental and multi - parental populations.Not Availabl

Not Available

Not AvailableBread wheat is grown in the sub - tropical and tropical regions world - wide. Terminal - heat stress is a major abiotic stress in wheat and global warming due to climate change has negatively impacted its production and productivity. We evaluated 96 accessions of bread wheat germplasm, which included 79 indigenous and 17 exotic collections, by investigating 16 morpho - physiological and yield - related traits during two successive Rabi seasons of 2018 - 19 and 2019 - 20 under non - stressed and heat - stressed (as a delayed sown crop) environments. Heat susceptibility index (HSI) was used to classify tolerant (HSI 1.0) accessions. The heat - stress showed negative impact on the phenotypic expression of 14 morpho - physiological and yield related traits by reducing the traits more prominently in susceptible accessions than the tolerant. However, early ground cover showed the increased expression in the tolerant accessions and higher variability in the germplasm under the heat - stress. Grain length / width ratio (LWR) also improved in the germplasm under heat - stress, while, there was a marked increase in LWR of the susceptible accessions mainly due to relatively higher decrease of grain width in these accessions under heat - stress. The plot yield associated positively with its contributing traits namely yield per plant, number of grains per plant, number of grains per spike, grain weight per spike and plant biomass under both the non - stressed and the heat - stressed environments, but its association with chlorophyll fl uorescence was only under heat - stress. The germplasm accessions IC574476 (HD2967), IC393878 (WH157), IC296383 (WR544), EC534487 (PAU351), IC519900 (HD2932) and IC539221 [EIGN - I - (04 - 05) / 149] produced high yield and were stable across the environments. The identifi ed bread wheat germplasm lines could be used as potential parents for bi - parental and multi - parental populations.Not Availabl