The effect of cocaine on gastric mucosal PGE2, LTC4 and ulcerations

The association between cocaine use and acute gastroduodenal perforation is known. The effect of cocaine and stress on gastric mucosal ulceration and the levels of prostaglandin E2 (PGE2) and leukotriene C4 (LTC4) was studied in 40 Sprague–Dawley rats. Controls received intraperitoneal (i.p.) saline, ten received i.p. cocaine (35 mg/kg), ten were stressed by the cold restraint method, and ten had i.p. cocaine and stress. Cocaine alone did not induce ulceration, but decreased PGE2 levels. Stress alone caused ulceration, but was not associated with a change in either PGE2 or LTC4 levels. When combined with stress, however, cocaine caused a three-fold increase in ulceration and a significant increase in PGE2 and LTC4 levels. Stress may predispose the cocaine addict to loss of gastroduodenal mucosal integrity, which is related to an imbalance of PGE2 and LTC4 synthesis

MODULATION OF LOW ENERGY BEAM TO GENERATE PREDEFINED BUNCH TRAINS FOR THE NSLS-II TOP-OFF INJECTION*

Abstract The NSLS II linac will produce a bunch train, 80-150 bunches long with 2 ns bunch spacing. Having the ability to tailor the bunch train can lead to the smaller bunch to bunch charge variation in the storage ring. A stripline is planned to integrate into the linac baseline to achieve this tailoring. The stripline must have a fast field rise and fall time to tailor each bunch. The beam dynamics is minimally affected by including the extra space for the stripline. This paper discusses the linac beam dynamics with stripline, and the optimal design of the stripline

Short pulse generation by laser slicing at NSLSII

We discuss an upgrade R&D project for NSLSII to generate sub-pico-second short x-ray pulses using laser slicing. We discuss its basic parameters and present a specific example for a viable design and its performance. Since the installation of the laser slicing system into the storage ring will break the symmetry of the lattice, we demonstrate it is possible to recover the dynamical aperture to the original design goal of the ring. There is a rapid growth of ultrafast user community interested in science using sub-pico-second x-ray pulses. In BNL's Short Pulse Workshop, the discussion from users shows clearly the need for a sub-pico-second pulse source using laser slicing method. In the proposal submitted following this workshop, NSLS team proposed both hard x-ray and soft x-ray beamlines using laser slicing pulses. Hence there is clearly a need to consider the R&D efforts of laser slicing short pulse generation at NSLSII to meet these goals

Conceptual Design of the NSLS-II Injection System.

We present the conceptual design of the NSLS-II injection system [1,2]. The injection system consists of a low-energy linac, booster and transport lines. We review two different injection system configurations; a booster located in the storage ring tunnel and a booster housed in a separate building. We briefly discuss main parameters and layout of the injection system components

NSLS-II Beam Diagnostics Overview

A new 3rd generation light source (NSLS-II) is in the early stages of construction at Brookhaven National Laboratory. The NSLS-II facility will provide ultra high brightness and flux with exceptional beam stability. It presents several challenges for diagnostics and instrumentation, related to the extremely small emittance. In this paper, we present an overview of all planned instrumentation systems, results from research and development activities; and then focus on other challenging aspects

MODULATION OF LOW ENERGY BEAM TO GENERATE PREDEFINED BUNCH TRAINS FOR THE NSLS-II TOP-OFF INJECTION

The NSLS II linac will produce a bunch train, 80-150 bunches long with 2 ns bunch spacing. Having the ability to tailor the bunch train can lead to the smaller bunch to bunch charge variation in the storage ring. A stripline is planned to integrate into the linac baseline to achieve this tailoring. The stripline must have a fast field rise and fall time to tailor each bunch. The beam dynamics is minimally affected by including the extra space for the stripline. This paper discusses the linac beam dynamics with stripline, and the optimal design of the stripline. A stripline is to be integrated in the linac to match the storage ring uniform bunch charge requirement, which simplifies the gun pulser electronics and looses the edge uniform requirement. It is located at low energy to lower the stripline power supply requirement and limit the dumped electron radiation. By turning off the stripline, the beam dynamics through linac is comparable with the baseline design. More advanced ideas can be explored. If a DC corrector along with the stripline is used, the core bunch trains gets kick from the stripline while the head and the tail of bunch train just gets a DC kick. The stripline power supply waveform is a single flat top waveform with fast rise and drop and the pulse length is {approx}200 ns long or 100 bunches, which may be easier from the power supply view point. We are also considering the bunch by bunch charge manipulation to match the storage ring uniform bunch charge distribution requirement. By modulating the flat top waveform at 250 MHz with adjustable amplitude, each the bunch center is either at 45 degree or 135 degree. Only the head or tail of the bunch is trimmed out. Although each bunch center deviation from idea center is very different at low energy, it is gradually minimized with beam energy increase

Simulations And Experiments of Electron Beams Pre-Modulated at the Photo cathode

The University of Maryland and the Source Development Laboratory at Brookhaven National Laboratory have been collaborating on a project that explores the use of electron beam pre-modulation at the cathode to control the longitudinal structure of the electron beam. This technique could be applied to creating deliberate modulations which can lead to the generation of terahertz radiation, or creating a smooth profile in order to suppress radiation. This paper focuses on simulations that explore some of the pre-modulated cases achieved experimentally