Percezione e agire inclusivo a scuola nelle attività di Educazione Fisica. Risultati di una indagine esplorativa

Starting from a reflection around the dynamics of perception of the body with disabilities andthe consequent dynamics of social construction of the bodies, the contribution proposes theresults of a pilot survey conducted on a sample made up of 155 students of the Specializationcourse on didactic support activities to students with disabilities carried out at the MediterraneanUniversity of Reggio Calabria in the 2018/2019 academic year. The survey, conducted by administeringa questionnaire aimed at detecting the perception of inclusive action at school in physicaleducation activities aimed at students with motor and sensory disabilities, produced results inline with the literature, highlighting a general agreement with respect to the principles of inclusion,but a practical difficulty in adapting or modifying activities in order to include students withdisabilities

Experimental Demonstration of a 5G Network Slice Deployment Through the 5G-Transformer Architecture

44th European Conference on Optical Communications (ECOC 2018)This demo shows for the first time the capability of the proposed 5G-TRANSFORMER architecture to deploy a 5G network slice in minutes. The slice consists of a mix of physical and virtual mobile network functions deployed in an Openstack environment.This work was supported by the EC through the Horizon 2020 5G-TRANSFORMER project (grant agreement 761536)

Experimental Demonstration of a 5G Network Slice Deployment Exploiting Edge or Cloud Data-Centers

This paper has been presented at : Optical Fiber Communications Conference 2019The demo shows the 5G-TRANSFORMER architecture capability to deploy 5G network slices exploiting edge or cloud data-centers in minutes. Different slice deployments are shown to affect the performance of a dictionary mobile-app supported by them.This work has been partially funded by the EU H2020 "5G-Transformer'' Project (grant no. 761536

Heme catabolism by tumor-associated macrophages controls metastasis formation

Although the pathological significance of tumor-associated macrophage (TAM) heterogeneity is still poorly understood, TAM reprogramming is viewed as a promising anticancer therapy. Here we show that a distinct subset of TAMs (F4/80hiCD115hiC3aRhiCD88hi), endowed with high rates of heme catabolism by the stress-responsive enzyme heme oxygenase-1 (HO-1), plays a critical role in shaping a prometastatic tumor microenvironment favoring immunosuppression, angiogenesis and epithelial-to-mesenchymal transition. This population originates from F4/80+HO-1+ bone marrow (BM) precursors, accumulates in the blood of tumor bearers and preferentially localizes at the invasive margin through a mechanism dependent on the activation of Nrf2 and coordinated by the NF-κB1–CSF1R–C3aR axis. Inhibition of F4/80+HO-1+ TAM recruitment or myeloid-specific deletion of HO-1 blocks metastasis formation and improves anticancer immunotherapy. Relative expression of HO-1 in peripheral monocyte subsets, as well as in tumor lesions, discriminates survival among metastatic melanoma patients. Overall, these results identify a distinct cancer-induced HO-1+ myeloid subgroup as a new antimetastatic target and prognostic blood marker

Landscape of immune-related signatures induced by targeting of different epigenetic regulators in melanoma: implications for immunotherapy

Background Improvement of efficacy of immune checkpoint blockade (ICB) remains a major clinical goal. Association of ICB with immunomodulatory epigenetic drugs is an option. However, epigenetic inhibitors show a heterogeneous landscape of activities. Analysis of transcriptional programs induced in neoplastic cells by distinct classes of epigenetic drugs may foster identification of the most promising agents. Methods Melanoma cell lines, characterized for mutational and differentiation profile, were treated with inhibitors of DNA methyltransferases (guadecitabine), histone deacetylases (givinostat), BET proteins (JQ1 and OTX-015), and enhancer of zeste homolog 2 (GSK126). Modulatory effects of epigenetic drugs were evaluated at the gene and protein levels. Master molecules explaining changes in gene expression were identified by Upstream Regulator (UR) analysis. Gene set enrichment and IPA were used respectively to test modulation of guadecitabine-specific gene and UR signatures in baseline and on-treatment tumor biopsies from melanoma patients in the Phase Ib NIBIT-M4 Guadecitabine + Ipilimumab Trial. Prognostic significance of drug-specific immune-related genes was tested with Timer 2.0 in TCGA tumor datasets. Results Epigenetic drugs induced different profiles of gene expression in melanoma cell lines. Immune-related genes were frequently upregulated by guadecitabine, irrespective of the mutational and differentiation profiles of the melanoma cell lines, to a lesser extent by givinostat, but mostly downregulated by JQ1 and OTX-015. GSK126 was the least active drug. Quantitative western blot analysis confirmed drug-specific modulatory profiles. Most of the guadecitabine-specific signature genes were upregulated in on-treatment NIBIT-M4 tumor biopsies, but not in on-treatment lesions of patients treated only with ipilimumab. A guadecitabine-specific UR signature, containing activated molecules of the TLR, NF-kB, and IFN innate immunity pathways, was induced in drug-treated melanoma, mesothelioma and hepatocarcinoma cell lines and in a human melanoma xenograft model. Activation of guadecitabine-specific UR signature molecules in on-treatment tumor biopsies discriminated responding from non-responding NIBIT-M4 patients. Sixty-five % of the immune-related genes upregulated by guadecitabine were prognostically significant and conferred a reduced risk in the TCGA cutaneous melanoma dataset. Conclusions The DNMT inhibitor guadecitabine emerged as the most promising immunomodulatory agent among those tested, supporting the rationale for usage of this class of epigenetic drugs in combinatorial immunotherapy approaches. © 2022, The Author(s)

OpenFlow-Control of an OAM-Based Two-Layer Switch Supporting 100Gb/s Real Data-Traffic

A two-layer orbital angular momentum and wavelength based switch is presented and characterized up to 100Gb/s with coherent polarization-multiplexed real data traffic. The switch is successfully reconfigured by applying an OpenFlow based SDN control plane

Orchestration of Network Services Across Multiple Operators: The 5G Exchange Prototype

Future 5G networks will rely on the coordinated allocation of compute, storage, and networking resources in order to meet the functional requirements of 5G services as well as guaranteeing efficient usage of the network infrastructure. However, the 5G service provisioning paradigm will also require a unified infrastructure service market that integrates multiple operators and technologies. The 5G Exchange (5GEx) project, building heavily on the Software-Defined Network (SDN) and the Network Function Virtualization (NFV) functionalities, tries to overcome this market and technology fragmentation by designing, implementing, and testing a multi-domain orchestrator (MdO) prototype for fast and automated Network Service (NS) provisioning over multiple-technologies and spanning across multiple operators. This paper presents a first implementation of the 5GEx MdO prototype obtained by extending existing open source software tools at the disposal of the 5GEx partners. The main functions of the 5GEx MdO prototype are showcased by demonstrating how it is possible to create and deploy NSs in the context of a Slice as a Service (SlaaS) use-case, based on a multi-operator scenario. The 5GEx MdO prototype performance is experimentally evaluated running validation tests within the 5GEx sandbox. The overall time required for the NS deployment has been evaluated considering NSs deployed across two operators

Modular architecture providing convergent and ubiquitous intelligent connectivity for networks beyond 2030

The transition of the networks to support forthcoming beyond 5G (B5G) and 6G services introduces a number of important architectural challenges that force an evolution of existing operational frameworks. Current networks have introduced technical paradigms such as network virtualization, programmability and slicing, being a trend known as network softwarization. Forthcoming B5G and 6G services imposing stringent requirements will motivate a new radical change, augmenting those paradigms with the idea of smartness, pursuing an overall optimization on the usage of network and compute resources in a zero-trust environment. This paper presents a modular architecture under the concept of Convergent and UBiquitous Intelligent Connectivity (CUBIC), conceived to facilitate the aforementioned transition. CUBIC intends to investigate and innovate on the usage, combination and development of novel technologies to accompany the migration of existing networks towards Convergent and Ubiquitous Intelligent Connectivity (CUBIC) solutions, leveraging Artificial Intelligence (AI) mechanisms and Machine Learning (ML) tools in a totally secure environment