Long-term outcomes of Ranibizumab treatment in neovascular age-related macular degeneration

AIM: To investigate 3-year results in our neovascular age-related macular degeneration(NV-AMD)patients treated with Ranibizumab.METHODS: Retrospective study. Visual acuity(VA), a full biomicroscopic examination(anterior segment and fundus), and optical coherence tomography(OCT)findings were noted at every visit. All patients were followed monthly. The VA values for the visits closest to 12, 24, and 36mo were analysed. Totally 101 eyes of 73 patients were enrolled. According to the initial VA, the patients were divided three groups: initial VA ≤ 35(Group 1), 36-54(Group 2), and ≥55 letters(Group 3). After three loading doses of 0.5 mg Ranibizumab if retreatment was needed, again, 0.5 mg Ranibizumab was administered.RESULTS: Totally 57 of the 101 eyes were from males and 44 were from females. The average age was 75.1y. The difference on the changes of VA among three groups at 24 and 36mo were statistically significant(P=0.002 and 0.0001 respectively). At the end of the 36-month follow-up the VA increase in Group 2 was significant(P=0.001). At the 12, 24 and 36mo visits most of the eyes showed no VA loss and most of these eyes were in Group 1. The average number of injections administered was 7.3 and the average number of visits was 23.9 during the follow-up. CONCLUSION: VA improvement was significant in those with mild initial VA(36-54 letters). Most eyes showed no VA loss regardless of the initial VA. No correlation between the final VA and the average number of injections

Idiopathic Hypertrophic Cranial Pachymeningitis Associated With Intermediate Uveitis

The authors report a case with idiopathic hypertrophic cranial pachymeningitis associated with intermediate uveitis. The patient complained of decreased vision in both eyes, especially the right. Ophthalmic examination revealed right optic disc pallor, bilateral vitritis, and cystoid macular edema. Magnetic resonance imaging revealed marked enhancement of a dural lesion. The macular edema responded well to medical treatment. Intermediate uveitis has not yet been reported in the context of idiopathic hypertrophic cranial pachymeningitis.Wo

A cluster of acute-onset postoperative endophthalmitis over a 1-month period: investigation of an outbreak caused by uncommon species

Aim To report the clinical course, treatment response and prognosis of eight cases which developed acute-onset postoperative endophthalmitis over a 1-month period

Screening for Retinopathy of Prematurity in a Tertiary Hospital in Istanbul: Incidence and Risk Factors

Purpose: To study the incidence and risk factors of retinopathy of prematurity (ROP) in premature infants examined in a tertiary hospital in Istanbul