Sarcoidosis of the spleen : rare indications for splenectomy : own experience

The article presents two patients who underwent laparoscopic splenectomy because of splenic sarcoidosis. In onepatient sarcoidosis was diagnosed based on the chest X-ray and computed tomography (CT) scans. Further imagingallowed for the diagnosis of systemic spread of the disease with bone marrow and splenic involvement. The latterlocation was confirmed by pathological examination after the operation. The indication for splenectomy was hypersplenismwith concurrent thrombocytopenia. In the second patient, an abdominal ultrasound scan (US) showed suspiciousfocal lesions in the spleen. Histological examination proved it to be a rare isolated splenic form of sarcoidosis

Karyometric comparison of splenic and gastric marginal zone lymphomas

Background: Marginal zone lymphomas are indolent B-cell lymphomas associated with autoimmunity and chronic inflammation. The two most frequent variants are mucosa associated lymphoid tissues marginal zone lymphomas and splenic marginal zone lymphomas. The aim of the study was to determine if it is possible to classify splenic and gastric lymphomas according to karyometric features

Microvascular density and mast cells in benign and malignant pheochromocytomas

Pheochromocytomas, uncommon adrenal tumors, have an uncertain behavior. Recently, PASS criteria were proposed for differentiating between benign and malignant cases. These are not perfect, however. The aim of the study was to investigate angiogenesis and mast cell density in context of the clinical behavior and morphologic characteristics of pheochromocytomas. Mean intratumoral chymase positive cell count was 14.50 for malignant, 15.73 for benign cases; mean subcapsular chymase positive cell count was 12.50 for malignant, 11.27 for benign cases.Mean intratumoral tryptase positive cell count was 17.50 for malignant and 17.91 for benign cases; mean subcapsular tryptase positive cell count was 15.25 for malignant and 15.73 for benign cases.Mean intratumoral CD31 positive vessel count was 46.98 for malignant and 51.02 for benign cases; mean subcapsular CD31 positive vessel count was 44.86 for malignant and 39.81 for benign cases. Mean intratumoral CD105 positive vessel count was 37.84 for malignant and 35.95 for benign cases; mean subcapsular CD105 positive vessel count was 26.36 for malignant and 22.03 for benign cases. The differences between benign and malignant cases were not significant. All the vascular counts were correlated with mast cells counts. PASS index was inversely correlated with mast cell counts

Sarcoidosis of the spleen – rare indications for splenectomy. Own experience

The article presents two patients who underwent laparoscopic splenectomy because of splenic sarcoidosis. In onepatient sarcoidosis was diagnosed based on the chest X-ray and computed tomography (CT) scans. Further imagingallowed for the diagnosis of systemic spread of the disease with bone marrow and splenic involvement. The latterlocation was confirmed by pathological examination after the operation. The indication for splenectomy was hypersplenismwith concurrent thrombocytopenia. In the second patient, an abdominal ultrasound scan (US) showed suspiciousfocal lesions in the spleen. Histological examination proved it to be a rare isolated splenic form of sarcoidosis

Sclerosing angiomatoid nodular transformation of the spleen treated by laparoscopic partial splenectomy

The authors describe a case of sclerosing angiomatoid nodular transformation (SANT) of the spleen treated at the 2(nd) Department of Surgery, Jagiellonian University, Medical College. The patient was a 23-year-old woman. Clinically she presented with 2-year history of recurrent mild fever, diffuse joint pain, abdominal discomfort and iron deficiency anaemia of chronic disease. The laboratory tests revealed a non-characteristic chronic inflammatory response. A splenic solid lesion 9 cm in diameter was found on abdominal computed tomography. The patient underwent uneventful laparoscopic resection of the upper half of the splenic parenchyma. The resected tumour showed characteristic histological and immunophenotypical findings of SANT as previously described in the literature. In long-term follow-up, improvement of preoperative symptoms and abnormalities in the blood tests was documented