Topical therapy with clobetasol propionate 0.025% for various dermatological conditions

Topical corticosteroids (TC) are the most commonly prescribed medications for the treatment of several dermatoses. Owing to their potent effect of relieving symptoms, these drugs are indicated for the use of inflammatory and pruritic presentations of dermatologic conditions. Clobetasol propionate (CP) is the most common TC used to treat itching, redness, and swelling caused by some skin conditions. It possesses anti-inflammatory, antipruritic, and vasoconstrictive properties. To exert its effect, CP binds to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor-mediated gene expression, thus resulting in the synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators. This case series discusses the efficacy, safety, and clinical experience of using CP 0.025% cream for the treatment of different dermatologic conditions

Clinico-epidemiological study of pityriasis rosea in children

Introduction: Pityriasis Rosea (PR) is an acute self limiting disorder, thought to represent a viral exanthema. In majority of cases, the first manifestation is “herald patch” or “mother patch” followed by secondary eruptions. The secondary eruptions appears in crops at an interval of one to two weeks following appearance of herald patch and run parallel to theline of skin cleavage, and mostly appears on the trunk and proximal portion of extremities. Method: A prospective cohort study on the clinico-epidemiological pattern of PR in participants of age group below 15 years was performed over a period of three years. Results: a total 782 patients with clinical diagnosis of PR were treated at our OPD, among them 73 patients fulfilled the study criteria and hence were analyzed and reported here. Out of these 39 (53.4%) were male and 34(46.6%) were female child. Frequency of PR was highest among age group 11 to 15 years (57.5%), followed by 35.6% in age group 5 to 10 years and was lowest among group below 5 years of age (6.9%). Pruritus was found in 53(72.6%) patients. Seasonal variation was evident, with highest incidence in summer season, followed by winter and rainy season. Conclusion: in children incidences of PR increases with the age, it was slightly higher in males and was more common during summer season. PR was found to be more commonly associated with upper respiratory tract infections in children as compared to adults, however disease was found to run a similar course as in adults