EXPERIENCE OF ORGANIZING THE PREVENTING MEASURES FOR «ATYPICAL PNEUMONIA» DELIVERY AND SPREADING IN KRASNOYARSK TERRITORY

Analysis of measures for preventing the delivery and spreading of «atypical pneumonia» in Krasnoyarsk region is presented. Effect of counteracting with this infectious disease of the executive authority organs, State Surveillance service, public health and other interested institutions is emphasized. Further preventing measures against «atypical pneumonia» are determined

ffect of Thermomechanical Properties on Microstructure and Mechanical Properties of Fe40–xMn40Co10Cr10Nx (x = 0; 1) High Entropy Alloys

Высокоэнтропийные сплавы Fe40–xMn40Co10Cr10Nх после холодной прокатки отжигались в интервале температур 700–1000 °C в течение 10 мин. В сплавах происходило выделение сигма-фазы, объемная доля которой уменьшалась как при увеличении температуры отжига, так и при повышении концентрации азота. Прочность сплавов уменьшалась с повышением температуры отжига, пластичность при этом росла.High entropy Fe40–xMn40Co10Cr10Nх alloys after cold rolling were annealed at 700–1000 °C for 10 minutes. Sigma phase precipitated in the alloys, and the volume fraction of the phase decreased both with an increase in the annealing temperature and with an increase in the nitrogen concentration. The strength of the alloys decreased with increasing annealing temperature, while ductility increased.Работа выполнена при финансовой поддержке Российского научного фонда, грант №18-19-00003. Авторы благодарны центру коллективного пользования Технологии и материалы» НИУ «БелГУ» за помощь в проведении исследований.The work was carried out with the financial support of the Russian science foundation, grant No. 18-19-00003. The authors are grateful to the center for collective use “Technologies and materials” of the National Research University “BelSU” for their assistance in conducting research

Effect of Annealing Temperature on Microstructure and Mechanical Properties of High Entropy Alloy Fe40–хMn40Co10Cr10Nx (x = 0,5; 2)

Было исследовано влияние прокатки и отжига на микроструктуру и механические свойства высокоэнтропийного сплава Fe40–xMn40Co10Cr10Nх. Образцы сплава были подвергнуты прокатке до степени деформации 80 % с последующим отжигом в интервале температур 700–1000 °C в течение 10 мин. Отжиг сопровождался увеличением пластичности сплава и деградацией прочностных характеристик. Рассмотрено влияние температуры отжига на параметры микроструктуры.In the present work the effect of cold rolling (80% reduction) and annealing at 700–1000 °C for 10 minutes on microstructure and mechanical properties of high entropy Fe40–xMn40Co10Cr10Nх alloy was investigated. Annealing led to increasing of plasticity and degradation of strength characteristics. Effect of annealing temperature on microstructure evolution is discussed.Работа выполнена при финансовой поддержке Российского научного фонда, грант №18-19-00003. Авторы благодарны центру коллективного пользования Технологии и материалы» НИУ «БелГУ» за помощь в проведении исследований.The work was carried out with the financial support of the Russian science foundation, grant No. 18-19-00003. The authors are grateful to the center for collective use “Technologies and materials” of the National Research University “BelSU” for their assistance in conducting research

Structure of the Vesicular Stomatitis Virus N0-P Complex

Replication of non-segmented negative-strand RNA viruses requires the continuous supply of the nucleoprotein (N) in the form of a complex with the phosphoprotein (P). Here, we present the structural characterization of a soluble, heterodimeric complex between a variant of vesicular stomatitis virus N lacking its 21 N-terminal residues (NΔ21) and a peptide of 60 amino acids (P60) encompassing the molecular recognition element (MoRE) of P that binds RNA-free N (N0). The complex crystallized in a decameric circular form, which was solved at 3.0 Å resolution, reveals how the MoRE folds upon binding to N and competes with RNA binding and N polymerization. Small-angle X-ray scattering experiment and NMR spectroscopy on the soluble complex confirms the binding of the MoRE and indicates that its flanking regions remain flexible in the complex. The structure of this complex also suggests a mechanism for the initiation of viral RNA synthesis

Особливості формування ендотеліопатії за наявності хронічного ендометриту до настання вагітності у жінок з прееклампсією

Стаття присвячена змінам концентрації оксиду азоту та циркулюючих десквамованих ендотеліоцитів у вагітних з різним ступенем прееклампсії в залежності від наявності явищ хронічного ендометриту до настання вагітності;The article is devoted to the changes of the nitric oxide concentration and the amount of desquamating endothelial cells in pregnant women with varying degrees of pre-eclampsia, depending on the presence or absence of phenomena of chronic endometritis before the pregnancy

НЕКРОТИЗИРУЮЩИЙ ФАСЦИИТ У ДЕТЕЙ

The authors presented a review of literature of necrotizing fasciitis in children. A rare case of necrotizing fasciitis in 3-year-old child is described. The difficulties of differential diagnostics of the given disease are presented.Представлен обзор литературы по некротизирующему фасцииту у детей. Описан редкий случай развития некротизирующего фасциита у ребенка 3 лет. Показаны трудности диагностики и дифференциальной диагностики данного заболевания

Structure and Behavior of Human α-Thrombin upon Ligand Recognition: Thermodynamic and Molecular Dynamics Studies

Thrombin is a serine proteinase that plays a fundamental role in coagulation. In this study, we address the effects of ligand site recognition by alpha-thrombin on conformation and energetics in solution. Active site occupation induces large changes in secondary structure content in thrombin as shown by circular dichroism. Thrombin-D-Phe-Pro-Arg-chloromethyl ketone (PPACK) exhibits enhanced equilibrium and kinetic stability compared to free thrombin, whose difference is rooted in the unfolding step. Small-angle X-ray scattering (SAXS) measurements in solution reveal an overall similarity in the molecular envelope of thrombin and thrombin-PPACK, which differs from the crystal structure of thrombin. Molecular dynamics simulations performed with thrombin lead to different conformations than the one observed in the crystal structure. These data shed light on the diversity of thrombin conformers not previously observed in crystal structures with distinguished catalytic and conformational behaviors, which might have direct implications on novel strategies to design direct thrombin inhibitors

Clostridium difficile infection.

Infection of the colon with the Gram-positive bacterium Clostridium difficile is potentially life threatening, especially in elderly people and in patients who have dysbiosis of the gut microbiota following antimicrobial drug exposure. C. difficile is the leading cause of health-care-associated infective diarrhoea. The life cycle of C. difficile is influenced by antimicrobial agents, the host immune system, and the host microbiota and its associated metabolites. The primary mediators of inflammation in C. difficile infection (CDI) are large clostridial toxins, toxin A (TcdA) and toxin B (TcdB), and, in some bacterial strains, the binary toxin CDT. The toxins trigger a complex cascade of host cellular responses to cause diarrhoea, inflammation and tissue necrosis - the major symptoms of CDI. The factors responsible for the epidemic of some C. difficile strains are poorly understood. Recurrent infections are common and can be debilitating. Toxin detection for diagnosis is important for accurate epidemiological study, and for optimal management and prevention strategies. Infections are commonly treated with specific antimicrobial agents, but faecal microbiota transplants have shown promise for recurrent infections. Future biotherapies for C. difficile infections are likely to involve defined combinations of key gut microbiota