Using a situational method engineering approach to identify reusable method fragments from the secure TROPOS methodology

Situational method engineering (SME) has as a focus a repository of method fragments, gleaned from extant methodologies and best practice. Using one such example, the OPF (OPEN Process Framework) repository, we identify deficiencies in the current SME support for securityrelated issues in the context of agent-oriented software engineering. Specifically, theoretical proposals for the development of reusable security-related method fragments from the agent-oriented methodology Secure Tropos are discussed. Since the OPF repository has already been enhanced by fragments from Tropos and other non-security-focussed agent-oriented software development methodologies, the only method fragments from Secure Tropos not already contained in this repository are those that are specifically security-related. These are identified, clearly defined and recommended for inclusion in the current OPF repository of method fragments. ©JOT 2010

Banking from Leeds, not London: regional strategy and structure at the Yorkshire Bank, 1859–1952

Industrial philanthropist Edward Akroyd created the Yorkshire Penny Savings Bank in 1859. Despite competition from the Post Office Savings Bank after 1861 and a serious reserve problem in 1911, it sustained his overall strategy to become a successful regional bank. Using archival and contemporary sources to build on recent scholarship illustrating how savings banks were integrated into local economies and the complementary roles of philanthropy and paternalism, we analyse an English regional bank's strategy, including an assessment of strategic innovation, ownership changes and management structure. This will demonstrate that the founder's vision continued, even though the 1911 crisis radically altered both strategy and structure

Microstructure and magnetic properties of as-quenched and heat-treated (Nd,Dy)FeB powders produced by high pressure gas atomization

The magnetic properties and microstructures of a series of as-quenched and heat-treated inert gas atomized (IGA) rare-earth rich (Nd,Dy)–Fe–B particles have been investigated. Heat treatment was found to substantially improve magnetic properties, with effects most pronounced in samples with higher Dy content and higher total rare earth (RE) content. The as-quenched particles consisted of an underquenched dendritic-like structure with the majority phase RE2Fe14B, and a fine network of RE-rich material between the grains. The heat-treated particles showed a change in microstructure which correlated with magnetic property changes. Particles which showed little change in magnetic properties showed no obvious change in microstructure. Particles which showed large changes in magnetic properties showed a large change in microstructure: most of the fine network of RE-rich interdendritic material disappeared, leaving behind only a few small isolated regions. This would seem to indicate that the predominant mechanism determining coercivity in these IGA RE-rich (Nd,Dy)–Fe–B powers is nucleation of reverse domains, rather than domain wall pinning at nonmagnetic intergranular material

NRF2 activation in Trp53;p16-deficient mice drives oral squamous cell carcinoma

UNLABELLED: Aberrant activation of the NRF2/NFE2L2 transcription factor commonly occurs in head and neck squamous cell carcinomas (HNSCC). Mouse model studies have shown that NRF2 activation alone does not result in cancer. When combined with classic oncogenes and at the right dose, NRF2 activation promotes tumor initiation and progression. Here we deleted the tumor suppressor genes p16INK4A and p53 (referred to as CP mice), which are commonly lost in human HNSCC, in the presence of a constitutively active NRF2E79Q mutant (CPN mice). NRF2E79Q expression in CPN mice resulted in squamous cell hyperplasia or dysplasia with hyperkeratosis in the esophagus, oropharynx, and forestomach. In addition, CPN mice displayed oral cavity squamous cell carcinoma (OSCC); CP mice bearing wild-type NRF2 expression did not develop oral cavity hyperplasia, dysplasia or OSCC. In both CP and CPN mice, we also observed predominantly abdominal sarcomas and carcinomas. Our data show that in the context of p53 and p16 tumor suppressor loss, NRF2 activation serves oncogenic functions to drive OSCC. CPN mice represent a new model for OSCC that closely reflects the genetics of human HNSCC. SIGNIFICANCE: Human squamous cancers frequently show constitutive NRF2 activation, associated with poorer outcomes and resistance to multiple therapies. Here, we report the first activated NRF2-driven and human-relevant mouse model of squamous cell carcinoma that develops in the background of p16 and p53 loss. The availability of this model will lead to a clearer understanding of how NRF2 contributes to the initiation, progression, and therapeutic response of OSCC

Important HIV-associated conditions in HIV-infected infants and children

This article is the last in a series of 6 articles that discussed the management of HIV-infected children in a clinically orientated, practical and concise fashion. The topics covered previously include; 1) Preventing and diagnosing HIV-infection in infants and children, 2) Initiating anti-retroviral therapy in HIV-infected infants and children, 3) Maintaining HIV-infected infants and children on anti-retroviral therapy, 4) Common opportunistic infection in HIV-infected children: Part 1-respiratory infections and 5) Part 2 non-respiratory infections. South African Family Practice Vol. 49 (4) 2007: pp.19-2

Low-Latency Telerobotics from Mars Orbit: The Case for Synergy Between Science and Human Exploration

Initial, science-directed human exploration of Mars will benefit from capabilities in which human explorers remain in orbit to control telerobotic systems on the surface (Figure 1). Low-latency, high-bandwidth telerobotics (LLT) from Mars orbit offers opportunities for what the terrestrial robotics community considers to be high-quality telepresence. Such telepresence would provide high quality sensory perception and situation awareness, and even capabilities for dexterous manipulation as required for adaptive, informed selection of scientific samples [1]. Astronauts on orbit in close communication proximity to a surface exploration site (in order to minimize communication latency) represent a capability that would extend human cognition to Mars (and potentially for other bodies such as asteroids, Venus, the Moon, etc.) without the challenges, expense, and risk of putting those humans on hazardous surfaces or within deep gravity wells. Such a strategy may be consistent with goals for a human space flight program that, are currently being developed within NASA

Mutation-aware fault prediction

We introduce mutation-aware fault prediction, which leverages additional guidance from metrics constructed in terms of mutants and the test cases that cover and detect them. We report the results of 12 sets of experiments, applying 4 di↵erent predictive modelling techniques to 3 large real world systems (both open and closed source). The results show that our proposal can significantly (p 0.05) improve fault prediction performance. Moreover, mutation based metrics lie in the top 5% most frequently relied upon fault predictors in 10 of the 12 sets of experiments, and provide the majority of the top ten fault predictors in 9 of the 12 sets of experiments.http://www0.cs.ucl.ac.uk/staff/F.Sarro/resource/papers/ISSTA2016-Bowesetal.pd

MODIS time series contribution for the estimation of nutritional properties of alpine grassland

This is an Accepted Manuscript of an article published by Taylor & Francis in European Journal of Remote Sensing on 17th February 2017, available online: https://doi.org/10.5721/EuJRS20164936Despite the Normalised Difference Vegetation Index (NDVI) has been used to make predictions on forage quality, its relationship with bromatological field data has not been widely tested. This relationship was investigated in alpine grasslands of the Gran Paradiso National Park (Italian Alps). Predictive models were built using remotely sensed derived variables (NDVI and phenological information computed from MODIS) in combination with geo-morphometric data as predictors of measured biomass, crude protein, fibre and fibre digestibility, obtained from 142 grass samples collected within 19 experimental plots every two weeks during the whole 2012 growing season. The models were both cross-validated and validated on an independent dataset (112 samples collected during 2013). A good predictability ability was found for the estimation of most of the bromatological measures, with a considerable relative importance of remotely sensed derived predictors; instead, a direct use of NDVI values as a proxy of bromatological variables appeared not to be supported