UV Surface Environment of Earth-like Planets Orbiting FGKM Stars Through Geological Evolution

The UV environment of a host star affects the photochemistry in the atmosphere, and ultimately the surface UV environment for terrestrial planets and therefore the conditions for the origin and evolution of life. We model the surface UV radiation environment for Earth-sized planets orbiting FGKM stars at the 1AU equivalent distance for Earth through its geological evolution. We explore four different types of atmospheres corresponding to an early Earth atmosphere at 3.9 Gyr ago and three atmospheres covering the rise of oxygen to present day levels at 2.0 Gyr ago, 0.8 Gyr ago and modern Earth (Following Kaltenegger et al. 2007). In addition to calculating the UV flux on the surface of the planet, we model the biologically effective irradiance, using DNA damage as a proxy for biological damage. We find that a pre-biotic Earth (3.9 Gyr ago) orbiting an F0V star receives 6 times the biologically effective radiation as around the early Sun and 3520 times the modern Earth-Sun levels. A pre-biotic Earth orbiting GJ 581 (M3.5V) receives 300 times less biologically effective radiation, about 2 times modern Earth-Sun levels. The UV fluxes calculated here provide a grid of model UV environments during the evolution of an Earth-like planet orbiting a range of stars. These models can be used as inputs into photo-biological experiments and for pre-biotic chemistry and early life evolution experiments.Comment: 10 pages, 5 figure

Effect of UV Radiation on the Spectral Fingerprints of Earth-like Planets Orbiting M dwarfs

We model the atmospheres and spectra of Earth-like planets orbiting the entire grid of M dwarfs for active and inactive stellar models with $T_{eff}$ = 2300K to $T_{eff}$ = 3800K and for six observed MUSCLES M dwarfs with UV radiation data. We set the Earth-like planets at the 1AU equivalent distance and show spectra from the VIS to IR (0.4$\mu$m - 20$\mu$m) to compare detectability of features in different wavelength ranges with JWST and other future ground- and spaced-based missions to characterize exo-Earths. We focus on the effect of UV activity levels on detectable atmospheric features that indicate habitability on Earth, namely: H$_2$O, O$_3$, CH$_4$, N$_2$O and CH$_3$Cl. To observe signatures of life - O$_2$/O$_3$ in combination with reducing species like CH$_4$, we find that early and active M dwarfs are the best targets of the M star grid for future telescopes. The O$_2$ spectral feature at 0.76$\mu$m is increasingly difficult to detect in reflected light of later M dwarfs due to low stellar flux in that wavelength region. N$_2$O, another biosignature detectable in the IR, builds up to observable concentrations in our planetary models around M dwarfs with low UV flux. CH$_3$Cl could become detectable, depending on the depth of the overlapping N$_2$O feature. We present a spectral database of Earth-like planets around cool stars for directly imaged planets as a framework for interpreting future lightcurves, direct imaging, and secondary eclipse measurements of the atmospheres of terrestrial planets in the HZ to design and assess future telescope capabilities.Comment: in press, ApJ (submitted August 18, 2014), 16 pages, 12 figure

Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke.

Stroke is the primary cause of disability due to the brain's limited ability to regenerate damaged tissue. After stroke, an increased inflammatory and immune response coupled with severely limited angiogenesis and neuronal growth results in a stroke cavity devoid of normal brain tissue. In the adult, therapeutic angiogenic materials have been used to repair ischaemic tissues through the formation of vascular networks. However, whether a therapeutic angiogenic material can regenerate brain tissue and promote neural repair is poorly understood. Here we show that the delivery of an engineered immune-modulating angiogenic biomaterial directly to the stroke cavity promotes tissue formation de novo, and results in axonal networks along thee generated blood vessels. This regenerated tissue produces functional recovery through the established axonal networks. Thus, this biomaterials approach generates a vascularized network of regenerated functional neuronal connections within previously dead tissue and lays the groundwork for the use of angiogenic materials to repair other neurologically diseased tissues

The connection between entropy and the absorption spectra of Schwarzschild black holes for light and massless scalar fields

We present heuristic arguments suggesting that if EM waves with wavelengths somewhat larger than the Schwarzschild radius of a black hole were fully absorbed by it, the second law of thermodynamics would be violated, under the Bekenstein interpretation of the area of a black hole as a measure of its entropy. Thus, entropy considerations make the well known fact that large wavelengths are only marginally absorbed by black holes, a natural consequence of thermodynamics. We also study numerically the ingoing radial propagation of a scalar field wave in a Schwarzschild metric, relaxing the standard assumption which leads to the eikonal equation, that the wave has zero spatial extent. We find that if these waves have wavelengths larger that the Schwarzschild radius, they are very substantially reflected, fully to numerical accuracy. Interestingly, this critical wavelength approximately coincides with the one derived from entropy considerations of the EM field, and is consistent with well known limit results of scattering in the Schwarzschild metric. The propagation speed is also calculated and seen to differ from the value $c$, for wavelengths larger than $R_{s}$, in the vicinity of $R_{s}$. As in all classical wave phenomena, whenever the wavelength is larger or comparable to the physical size of elements in the system, in this case changes in the metric, the zero extent 'particle' description fails, and the wave nature becomes apparent.Comment: 14 Pages, 4 figures. Accepted for publication in the Journal Entrop

Injectable and Spatially Patterned Microporous Annealed Particle (MAP) Hydrogels for Tissue Repair Applications.

Spatially patterned hydrogels are becoming increasingly popular in the field of regenerative medicine and tissue repair because of their ability to guide cell infiltration and migration. However, postfabrication technologies are usually required to spatially pattern a hydrogel, making these hydrogels difficult to translate into the clinic. Here, an injectable spatially patterned hydrogel is reported using hyaluronic acid (HA)-based particle hydrogels. These particle hydrogels are sequentially loaded into a syringe to form a pattern and, once injected, they maintain the pattern. The applicability of this hydrogel in a wound healing skin model, a subcutaneous implant model, as well as a stroke brain model is examined and distinct patterning in all models tested is shown. This injectable and spatially patterned hydrogel can be used to create physical or biochemical gradients. Further, this design can better match the scaffold properties within the physical location of the tissue (e.g., wound border vs wound center). This allows for better design features within the material that promote repair and regeneration