139 research outputs found

    Strategy-Proofness on Bankruptcy Problems with an Indivisible Object

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    We analyze bankruptcy problems with an indivisible object, where real owners and outside traders want to allocate an indivisible object among them with monetary compensation. The object might be a company that has gone bankrupt or a house left by a parent who has died, and so on. We show that there exists no rule satisfying strategyproofness and the ownership lower bound on any domains that include at least three common preferences

    Invited Review: Decoding the pathophysiological mechanisms that underlie RNA dysregulation in neurodegenerative disorders: a review of the current state of the art

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    Altered RNA metabolism is a key pathophysiological component causing several neurodegenerative diseases. Genetic mutations causing neurodegeneration occur in coding and noncoding regions of seemingly unrelated genes whose products do not always contribute to the gene expression process. Several pathogenic mechanisms may coexist within a single neuronal cell, including RNA/protein toxic gain-of-function and/or protein loss-of-function. Genetic mutations that cause neurodegenerative disorders disrupt healthy gene expression at diverse levels, from chromatin remodelling, transcription, splicing, through to axonal transport and repeat-associated non-ATG (RAN) translation. We address neurodegeneration in repeat expansion disorders [Huntington's disease, spinocerebellar ataxias, C9ORF72-related amyotrophic lateral sclerosis (ALS)] and in diseases caused by deletions or point mutations (spinal muscular atrophy, most subtypes of familial ALS). Some neurodegenerative disorders exhibit broad dysregulation of gene expression with the synthesis of hundreds to thousands of abnormal messenger RNA (mRNA) molecules. However, the number and identity of aberrant mRNAs that are translated into proteins – and how these lead to neurodegeneration – remain unknown. The field of RNA biology research faces the challenge of identifying pathophysiological events of dysregulated gene expression. In conclusion, we discuss current research limitations and future directions to improve our characterization of pathological mechanisms that trigger disease onset and progression

    The Separation of Powers and the British Constitution

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    This paper provides an account of the nature of the separation of powers and considers its application in the British constitution. It charts the developing understanding of the principle in British constitutional scholarship over the last century, and shows the ways in which the British constitution has shifted towards a modern understanding of the principle in the last twenty years.This paper provides an account of the nature of the separation of powers and considers its application in the British constitution. It charts the developing understanding of the principle in British constitutional scholarship over the last century, and shows the ways in which the British constitution has shifted towards a modern understanding of the principle in the last twenty years
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