La Sardegna negli "anni della Rinascita"

Sommario: 1. La Sardegna negli anni Cinquanta. - 2. Il dibattito sul Piano di Rinascita. - 3. La legge 588 e i piani di attuazione della Rinascita. - 4. Il "fallimento" del Piano. - 5. Il problema del banditismo. - 6. La Commissione d'inchiesta Medici e la legge 268

L'Alimentazione popolare

Studio sulla cultura del mangiare in Sardegna: la ricchezza delle pietanze, i sapori e le bevande, tutte tradizioni che negli ultimi trent'anni sono state sottoposte ad un processo di standardizzazione che tocca aspetti un tempo sacri e inviolabili

The "Click-tail approach" for the design and synthesis of novel carbonic anhydrase inhibitors

The Carbonic Anhydrases (CAs) are a family of zinc enzymes deputed to the interconversion of carbonic dioxide to hydrogen carbonate. Herein, we report on a sustainable modular strategy, also called "clicktail approach", used to obtain two series of 4-(4-substituted-lH-l,2,3-triazol-lyl) benzenesulfonamides. Design and synthesis strategies, x-ray derived CA-ligand binding mode and enzyme-based inhibition results will be presented

Searching for novel carbonic anhydrase inhibitors: from virtual screening to the lab bench

Carbonic Anhydrases (CAs) are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide to bicarbonate both in prokaryotes and eukaryotes. In this context, Computer Aided Drug Design strategies have emerged as powerful tools in the modern drug discovery paradigm. In particular, using ligand- and pharmacophore-based virtual screening approaches, we identified novel chemical entities with original chemotypes, that showed an interesting and selective inhibitory activity in nanomolar/low micromolar range toward CA I and CAII, isoforms. Herein, we present the hit-to-lead optimization process for these prototypes

Study of hydrogels based on polyacrilamide as new controlled release dosage forms produced by frontal polymerization

The work purpose was the evaluation of the potential application of the Frontal Polymerization (FP) technique as a new method for the preparation of controlled release dosage forms based on polyacrilamide, in which the drug loading and the polymer preparation occur at the same time

Interaction Studies between Carbonic Anhydrase and a Sulfonamide Inhibitor by Experimental and Theoretical Approaches

The most used approaches in structure-based drug design possess peculiar characteristics with advantages and limitations, and thus the management of complementary data from various techniques is of particular interest to synergistically achieve the development of effective enzyme inhibitors. In this Letter, we describe the application of experimental and computational techniques to study the interactions between human carbonic anhydrases and sulfonamide inhibitors. In particular, a series of affinity-labeled carbonic anhydrase inhibitors containing sulfonamido photoprobes was designed and synthesized, and one of these compounds, a benzophenone derivative, was chosen as a model photoprobe/inhibitor. A photoaffinity labeling method followed by mass spectrometry analysis was then applied to elucidate the inhibitor binding site, and a comparison with X-ray crystallography and molecular dynamics simulation data was carried out, highlighting that to have a comprehensive view of the protein/inhibitor complex stabilization all three kinds of experiments are necessary

Indagini preliminari su ripartizione e morfologia della prateria a <i>Posidonia oceanica</i> nella rada di Alghero = Preliminary investigations on distribution and morphology of a <i>Posidonia oceanica</i> meadow in the bay of Alghero

An extensive side scan sonar survey has been conducted in the gulf of Alghero (N Sardinia, Italy) in order to map the main morphological and habitat features of the seafloor. The local Posidonia oceanica meadow covers a total area of 13 km2, extending from 2.5 to 35 meters depth and is medially divided by an ancient river channel developed during the last glacial stage

Multiple non-species-specific pathogens possibly triggered the mass mortality in Pinna nobilis

The fan mussel, Pinna nobilis, represents the largest bivalve endemic to the Mediterranean Sea. Since 2016, dramatic mass mortality of this species has been observed in several areas. The first surveys suggested that Haplosporidium pinnae (currently considered species-specific) was the main etiological agent, but recent studies have indicated that a multifactorial disease may be responsible for this phenomenon. In this study, we performed molecular diagnostic analyses on P. nobilis, P. rudis, and bivalve heterologous host species from the island of Sardinia to shed further light on the pathogens involved in the mass mortality. The results support the occurrence of a multifactorial disease and that Mycobacterium spp. and H. pinnae are not necessarily associated with the illness. Indeed, our analyses revealed that H. pinnae is not species-specific for P. nobilis, as it was present in other bivalves at least three years before the mass mortality began, and species of Mycobacterium were also found in healthy individuals of P. nobilis and P. rudis. We also detected the species Rhodococcus erythropolis, representing the first report in fan mussels of a bacterium other than Mycobacterium spp. and Vibrio spp. These results depict a complicated scenario, further demonstrating how the P. nobilis mass mortality event is far from being fully understoo

La Provincia di Sassari: ambiente, storia, civiltà

Essere cittadino di una provincia non significa soltanto abitarvi. Significa anche lavorarvi, esercitarvi una attività che vada a vantaggio del benessere individuale e insieme del benessere della collettività. Per fare questo, per raggiungere meglio questo obiettivo, la realtà in cui si vive e si lavora bisogna conoscerla meno superficialmente di quanto normalmente non succeda. E' una constatazione che si può fare per tutti coloro che abitano in un luogo, ma che si deve fare in modo particolare quando lo strumento di conoscenza che si propone è un libro come questo

A sensor fusion algorithm for an integrated angular position estimation with inertial measurement units

This work presents an orientation tracking system for 6D inertial measurements units. The system was modeled with MathWorks Simulink and experimentally tested with the Cube Demo board by SensorDynamics, used to simulate a 3D gyro and a 3D accelerometer. Quaternions were used to represent the angular position and an Extended Kaiman filter was used for the sensor fusion algorithm. The goal was to obtain an integrated system that could be easily integrated within the logic of the new 6D sensor family produced by SensorDynamics. We propose a Kaiman filter simplification for a fixed point arithmetic implementation to reduce the system complexity with negligible performance degradation