Data Mesh: Motivational Factors, Challenges, and Best Practices

With the increasing importance of data and artificial intelligence, organizations strive to become more data-driven. However, current data architectures are not necessarily designed to keep up with the scale and scope of data and analytics use cases. In fact, existing architectures often fail to deliver the promised value associated with them. Data mesh is a socio-technical concept that includes architectural aspects to promote data democratization and enables organizations to become truly data-driven. As the concept of data mesh is still novel, it lacks empirical insights from the field. Specifically, an understanding of the motivational factors for introducing data mesh, the associated challenges, best practices, its business impact, and potential archetypes, is missing. To address this gap, we conduct 15 semi-structured interviews with industry experts. Our results show, among other insights, that industry experts have difficulties with the transition toward federated governance associated with the data mesh concept, the shift of responsibility for the development, provision, and maintenance of data products, and the concept of a data product model. In our work, we derive multiple best practices and suggest organizations embrace elements of data fabric, observe the data product usage, create quick wins in the early phases, and favor small dedicated teams that prioritize data products. While we acknowledge that organizations need to apply best practices according to their individual needs, we also deduct two archetypes that provide suggestions in more detail. Our findings synthesize insights from industry experts and provide researchers and professionals with guidelines for the successful adoption of data mesh

Targeting the host response in sepsis: current approaches and future evidence

Sepsis, a dysregulated host response to infection characterized by organ failure, is one of the leading causes of death worldwide. Disbalances of the immune response play an important role in its pathophysiology. Patients may develop simultaneously or concomitantly states of systemic or local hyperinflammation and immunosuppression. Although a variety of effective immunomodulatory treatments are generally available, attempts to inhibit or stimulate the immune system in sepsis have failed so far to improve patients’ outcome. The underlying reason is likely multifaceted including failure to identify responders to a specific immune intervention and the complex pathophysiology of organ dysfunction that is not exclusively caused by immunopathology but also includes dysfunction of the coagulation system, parenchymal organs, and the endothelium. Increasing evidence suggests that stratification of the heterogeneous population of septic patients with consideration of their host response might led to treatments that are more effective. The purpose of this review is to provide an overview of current studies aimed at optimizing the many facets of host response and to discuss future perspectives for precision medicine approaches in sepsis

Transient Dynamic System Behavior of Pressure Actuated Cellular Structures in a Morphing Wing

High aspect ratio aircraft have a significantly reduced induced drag, but have only limited installation space for control surfaces near the wingtip. This paper describes a multidisciplinary design methodology for a morphing aileron that is based on pressure-actuated cellular structures (PACS). The focus of this work is on the transient dynamic system behavior of the multi-functional aileron. Decisive design aspects are the actuation speed, the resistance against external loads, and constraints preparing for a future wind tunnel test. The structural stiffness under varying aerodynamic loads is examined while using a reduced-order truss model and a high-fidelity finite element analysis. The simulations of the internal flow investigate the transient pressurization process that limits the dynamic actuator response. The authors present a reduced-order model based on the Pseudo Bond Graph methodology enabling time-efficient flow simulation and compare the results to computational fluid dynamic simulations. The findings of this work demonstrate high structural resistance against external forces and the feasibility of high actuation speeds over the entire operating envelope. Future research will incorporate the fluid–structure interaction and the assessment of load alleviation capability

Sex determining region Y-box 2 (SOX2) amplification is an independent indicator of disease recurrence in sinonasal cancer.

The transcription factor SOX2 (3q26.3-q27) is an embryonic stem cell factor contributing to the induction of pluripotency in terminally differentiated somatic cells. Recently, amplification of the SOX2 gene locus has been described in squamous cell carcinoma (SCC) of different organ sites. Aim of this study was to investigate amplification and expression status of SOX2 in sinonasal carcinomas and to correlate the results with clinico-pathological data. A total of 119 primary tumor samples from the sinonasal region were assessed by fluorescence in-situ hybridization and immunohistochemistry for SOX2 gene amplification and protein expression, respectively. Of these, 59 were SSCs, 18 sinonasal undifferentiated carcinomas (SNUC), 10 carcinomas associated with an inverted papilloma (INVC), 19 adenocarcinomas (AD) and 13 adenoid cystic carcinomas (ACC). SOX2 amplifications were found in subsets of SCCs (37.5%), SNUCs (35.3%), INVCs (37.5%) and ADs (8.3%) but not in ACCs. SOX2 amplification resulted in increased protein expression. Patients with SOX2-amplified sinonasal carcinomas showed a significantly higher rate of tumor recurrences than SOX2 non-amplified tumors. This is the first study assessing SOX2 amplification and expression in a large cohort of sinonasal carcinomas. As opposed to AD and ACC, SOX2 amplifications were detected in more than 1/3 of all SCCs, SNUCs and INVCs. We therefore suggest that SNUCs are molecularly closely related to SCCs and INVCs and that these entities represent a subgroup of sinonasal carcinomas relying on SOX2 acquisition during oncogenesis. SOX2 amplification appears to identify sinonasal carcinomas that are more likely to relapse after primary therapy, suggesting that these patients might benefit from a more aggressive therapy regime

30 W ultra-stable laser light at 2128 nm for future gravitational-wave observatories

Thermal noise of the dielectric mirror coatings can limit laser-optical high-precision measurements. Coatings made of amorphous silicon and silicon nitride could provide a remedy for both gravitational-wave detectors and optical clocks. However, the absorption spectra of these materials require laser wavelengths around 2 $\mu$m. For GW detectors, ultra-stable laser light of tens or hundreds of watts is needed. Here, we report the production of nearly 30 W of ultra-stable laser light at 2128 nm by frequency conversion of 1064 nm light from a master oscillator power amplifier system. We achieve an external conversion efficiency of (67.5 $\pm$ 0.5) % via optical parametric oscillation and a relative power noise in the range of $10^{-6}$/$\sqrt{\text{Hz}}$ at 100 Hz, which is almost as low as that of the input light and underlines the potential of our approach.Comment: 4 pages, 3 figures, LIGO Document P230036

project report Promise2007

Das Projekt Promise2007 befasste sich mit der Erstellung und Auswertung einer Statistik zur Mitgliedersituation im Berufsverband Medizinischer Informatiker e.V.. Mit dem Ziel mehr über die Mitglieder und ihre derzeitige Situation zu erfahren wurde das Projekt an der Fachhochschule Hannover initiiert. Statistisch erfasst wurden Fragen zum Beschäftigungsverhältnis, zu Aus- und Weiterbildung, der beruflichen Situation und persönliche Angaben. Die Ergebnisse wurden ausgewertet und daraus wichtige Erkenntnisse für den BVMI e.V. abgeleitet, welche auf die weitere Verbandsarbeit Einfluss nehmen