12 research outputs found
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Efficient Front-Rear Coupling in Neutrophil Chemotaxis by Dynamic Myosin II Localization.
Efficient chemotaxis requires rapid coordination between different parts of the cell in response to changing directional cues. Here, we investigate the mechanism of front-rear coordination in chemotactic neutrophils. We find that changes in the protrusion rate at the cell front are instantaneously coupled to changes in retraction at the cell rear, while myosin II accumulation at the rear exhibits a reproducible 9-15-s lag. In turning cells, myosin II exhibits dynamic side-to-side relocalization at the cell rear in response to turning of the leading edge and facilitates efficient turning by rapidly re-orienting the rear. These manifestations of front-rear coupling can be explained by a simple quantitative model incorporating reversible actin-myosin interactions with a rearward-flowing actin network. Finally, the system can be tuned by the degree of myosin regulatory light chain (MRLC) phosphorylation, which appears to be set in an optimal range to balance persistence of movement and turning ability
Recommended from our members
Efficient Front-Rear Coupling in Neutrophil Chemotaxis by Dynamic Myosin II Localization.
Efficient chemotaxis requires rapid coordination between different parts of the cell in response to changing directional cues. Here, we investigate the mechanism of front-rear coordination in chemotactic neutrophils. We find that changes in the protrusion rate at the cell front are instantaneously coupled to changes in retraction at the cell rear, while myosin II accumulation at the rear exhibits a reproducible 9-15-s lag. In turning cells, myosin II exhibits dynamic side-to-side relocalization at the cell rear in response to turning of the leading edge and facilitates efficient turning by rapidly re-orienting the rear. These manifestations of front-rear coupling can be explained by a simple quantitative model incorporating reversible actin-myosin interactions with a rearward-flowing actin network. Finally, the system can be tuned by the degree of myosin regulatory light chain (MRLC) phosphorylation, which appears to be set in an optimal range to balance persistence of movement and turning ability
Ethical Employment Context and Ethical Decision-Making in Hospitality Organizations Located in Mexico and the United States
Ethics Programs, Perceived Corporate Social Responsibility and Job Satisfaction
corporate social responsibility, job satisfaction, organizational ethics,
The Spiraling and Spillover of Misconduct: Perceived Workplace Bullying, Subclinical Psychopathy, and Businesspersons’ Recognition of an Ethical Issue
Role Conflict, Mindfulness, and Organizational Ethics in an Education-Based Healthcare Institution
Investigating the Effects of Gender on Consumers’ Moral Philosophies and Ethical Intentions
moral philosophies, ethical reasoning, ethical intentions, gender,