Analysis of circuit conditions for optimum intermodulation and gain in bipolar cascomp amplifiers with non-ideal error correction

The cascoded-compensation or ‘Cascomp’ amplifier offers excellent distortion reduction and thermal distortion rejection, but has not seen widespread use because of a limited gain and increased complexity compared with other topologies. The original theory showed that with the addition of an ideal error amplifier the circuit will completely compensate distortion for suitably chosen degeneration and bias values. This research presents a new, rigorous mathematical proof for conditions of compensation. The authors further develop the proof to include the non-idealities of the error amplifier. It is shown that there exists a second bias point, not exposed by the original analysis that offers improved gain while maintaining distortion cancellation. By reducing the error amplifier degeneration resistance, one can increase a Cascomp circuit's overall gain by several dB while maintaining theoretically perfect distortion compensation. A robust bias point is proposed, which takes the advantage of this new theory by optimising circuit values resulting in a comparatively broader and deeper third-order distortion null. The proposed theory is confirmed with simulation and measurement that show agreement within the bounds of process and component error limits

The Rise of Accelerated Seasoned Equity Underwritings

Seasoned equity offerings (SEOs) executed through accelerated underwritings have increased global market share recently, raising over $850 billion since 1998, and now account for over half (two-thirds) of the value of U.S. (European) SEOs. We examine 31,242 global SEOs, executed during 1991-2004, which raise over$2.9 trillion for firms and selling shareholders. Compared to fully marketed deals, accelerated offerings occur more rapidly, raise more money, and require fewer underwriters. Importantly, accelerated deals reduce total issuance cost by about 250 basis points. Accelerated deals sell equal fractions of primary and secondary shares, whereas in traditional SEOs primary shares dominate. Announcement period returns are comparable for traditional and accelerated offerings, while secondary and mixed offerings trigger more negative market responses than do primary offerings. We conclude that this rapid, worldwide shift towards accelerated underwriting creates a spot market for SEOs, and represents the long-predicted shift towards an auction model for seasoned equity sales.Equity Offerings, Underwriting, Investment Banking

A microrod-resonator Brillouin laser with 240 Hz absolute linewidth

We demonstrate an ultralow-noise microrod-resonator based laser that oscillates on the gain supplied by the stimulated Brillouin scattering optical nonlinearity. Microresonator Brillouin lasers are known to offer an outstanding frequency noise floor, which is limited by fundamental thermal fluctuations. Here, we show experimental evidence that thermal effects also dominate the close-to-carrier frequency fluctuations. The 6-mm diameter microrod resonator used in our experiments has a large optical mode area of ~100 {\mu}m$^2$, and hence its 10 ms thermal time constant filters the close-to-carrier optical frequency noise. The result is an absolute laser linewidth of 240 Hz with a corresponding white-frequency noise floor of 0.1 Hz$^2$/Hz. We explain the steady-state performance of this laser by measurements of its operation state and of its mode detuning and lineshape. Our results highlight a mechanism for noise that is common to many microresonator devices due to the inherent coupling between intracavity power and mode frequency. We demonstrate the ability to reduce this noise through a feedback loop that stabilizes the intracavity power.Comment: 11 pages, 5 figure

Visual Framing of Patriotism and National Identity on the Covers of Der Spiegel

Patriotism in Germany has been a controversial issue since the Nazi era. Despite the fear and hesitations surrounding the idea of German pride and national identity, Der Spiegel, one of Germany\u27s major national news magazines, showed an increasing visual presence of national identity symbols on its covers following key historical events: the building of the Berlin Wall, the reunification of Germany, the adoption of the euro, and the 2006 World Cup

Early Investigations and Recent Advances in Intraperitoneal Immunotherapy for Peritoneal Metastasis.

Peritoneal metastasis (PM) is an advanced stage malignancy largely refractory to modern therapy. Intraperitoneal (IP) immunotherapy offers a novel approach for the control of regional disease of the peritoneal cavity by breaking immune tolerance. These strategies include heightening T-cell response and vaccine induction of anti-cancer memory against tumor-associated antigens. Early investigations with chimeric antigen receptor T cells (CAR-T cells), vaccine-based therapies, dendritic cells (DCs) in combination with pro-inflammatory cytokines and natural killer cells (NKs), adoptive cell transfer, and immune checkpoint inhibitors represent significant advances in the treatment of PM. IP delivery of CAR-T cells has shown demonstrable suppression of tumors expressing carcinoembryonic antigen. This response was enhanced when IP injected CAR-T cells were combined with anti-PD-L1 or anti-Gr1. Similarly, CAR-T cells against folate receptor α expressing tumors improved T-cell tumor localization and survival when combined with CD137 co-stimulatory signaling. Moreover, IP immunotherapy with catumaxomab, a trifunctional antibody approved in Europe, targets epithelial cell adhesion molecule (EpCAM) and has shown considerable promise with control of malignant ascites. Herein, we discuss immunologic approaches under investigation for treatment of PM

Ages of the Whitewater and Fairhaven tills in southwestern Ohio and southeastern Indiana

Alloisoleucine/isoleucine (aIle/Ile) ratios obtained from fossil mollusc shells collected at localities in southwestern Ohio and southeastern Indiana, where they occur in silt beds associated with the Whitewater and Fairhaven tills, indicate a pre-Wisconsinan age for these tills, which had previously been thought to be early or middle Wisconsinan. The aIle/Ile ratios in shells from beneath the buried soil (Sidney soil) and till exposed near Sidney, Ohio, are most similar to values in shells obtained from Illinoian sediments at Clough Creek in Hamilton County, Ohio; Mechanicsburg southwest, Illinois; and Trousdale Mine in Vermillion Co., Indiana. The first well-developed weathering profile in the sequence above the implied Illinoian age silt at the Sidney cut, therefore, probably represents Sangamonian, early and middle Wisconsinan weathering. Molluscs from an organic silt, exposed near the base of the Bantas Fork cutbank section, also have aIle/Ile ratios that are similar to those measured in shell recovered from the silt at the Sidney cut and from the silt inclusion in inferred Illinoian till at Clough Creek. These data indicate that the organic silt is pre-Wisconsinan. Therefore, the Fairhaven Till, which overlies the silt at the Bantas Fork locality, could be pre-Wisconsinan and the weathering profile developed in the Fairhaven Till may be correlative with the Sangamon Soil of Illinois. The New Paris Interstade silt overlies Whitewater Till at the American Aggregates quarry at Richmond, Indiana. Shells from the silt have aIle/Ile ratios that are intermediate between those obtained from inferred Illinoian age sediments at Bantas Fork, Sidney cut, and Clough Creek, and magnetically reversed sediments at Handley Farm, near Connersville, Fayette County, Indiana. These data suggest a pre-Illinoian age for the silt unit and the underlying Whitewater Till

Integrated safety studies of the urate reabsorption inhibitor lesinurad in treatment of gout.

ObjectiveLesinurad (LESU) is a selective urate reabsorption inhibitor approved at 200 mg daily for use with a xanthine oxidase inhibitor (XOI) to treat hyperuricaemia in gout patients failing to achieve target serum urate on XOI. The aim of the study was to investigate the long-term safety of LESU + XOI therapy.MethodsSafety data were pooled from three 12-month phase III (core) trials evaluating LESU 200 and 400 mg/day combined with an XOI (LESU200+XOI and LESU400+XOI), and two 12-month extension studies using descriptive statistics. To adjust for treatment duration, treatment-emergent adverse events (TEAEs) were expressed as exposure-adjusted incidence rates (patients with events per 100 person-years).ResultsIn the core studies, exposure-adjusted incidence rates for total and total renal-related TEAEs were comparable for XOI alone and LESU200+XOI but higher with LESU400+XOI. Exposure-adjusted incidence rates for serum creatinine (sCr) elevations ⩾1.5×baseline were 2.9, 7.3 and 18.7, respectively. Resolution (sCr ⩽1.2×baseline) occurred in 75-90% of all events, with 66-75% occurring without any study medication interruption. Major adverse cardiovascular events were 3, 4 and 9 with XOI, LESU200+XOI and LESU400+XOI, respectively. Longer exposure in core+extension studies did not increase rates for any safety signals.ConclusionAt the approved dose of 200 mg once-daily combined with an XOI, LESU did not increase renal, cardiovascular or other adverse events compared with XOI alone, except for sCr elevations. With extended exposure in the core+extension studies, the safety profile was consistent with that observed in the core studies, and no new safety concerns were identified

The Use of the Decomposition Principle in Making Judgments

One hundred and fifty-one subjects were randomly divided into two groups of roughly equal size. One group was asked to respond to a decomposed version of a problem and the other group was presented with the direct form of the problem. The results provided support for the hypotheses that people can make better judgments when they use the principle of decomposition; and that decomposition is especially valuable for those problems where the subject knows little. The results suggest that accuracy may be improved if the subject provides the data and the computer analyzes it, than if both steps were done implicitly by the subjects

Differential phosphorylation of NG2 proteoglycan by ERK and PKCα helps balance cell proliferation and migration

Two distinct Thr phosphorylation events within the cytoplasmic domain of the NG2 proteoglycan help regulate the cellular balance between proliferation and motility. Protein kinase Cα mediates the phosphorylation of NG2 at Thr2256, resulting in enhanced cell motility. Extracellular signal–regulated kinase phosphorylates NG2 at Thr2314, stimulating cell proliferation. The effects of NG2 phosphorylation on proliferation and motility are dependent on β1-integrin activation. Differential cell surface localization of the two distinctly phosphorylated forms of NG2 may be the mechanism by which the NG2–β1-integrin interaction promotes proliferation in one case and motility in the other. NG2 phosphorylated at Thr2314 colocalizes with β1-integrin on microprotrusions from the apical cell surface. In contrast, NG2 phosphorylated at Thr2256 colocalizes with β1-integrin on lamellipodia at the leading edges of cells. Thus, phosphorylation and the resulting site of NG2–integrin localization may determine the specific downstream effects of integrin signaling