Electrical self-aligning connector

A self-aligning electrical connector device includes a receptacle component having a conically contoured interior and a plug component having a correspondingly contoured conical body receivable in the receptacle component. The plug component has a number of spaced conductive ring elements with a mating face and the receptacle component includes corresponding spaced conductive ring elements providing mating interface with the mating face of the ring elements of the plug component when connected to it. Each ring element of the receptacle component has several segmented portions which defect downwardly when the plug component is inserted. A biasing force is asserted against the face of the ring elements of the plug component providing positive electrical contact and connection between the ring elements of the components

Martian sample sites: Examples based on a global geologic perspective

Ten areas were selected that each include several rock units of varying lithology and age. These areas were chosen to optimize the geologic and chronologic data return from Mars. Geologic mapping and stratigraphic studies identify stratigraphic ages, rock types, and information on Martian geologic history that samples of a given site may yield. Volcanic rocks occur over much of the planet and in virtually all stratigraphic positions, and they are amenable to radioisotopic dating. Therefore, a reasonable and essential goal for a sample return mission is to return datable rocks from widely varying strata. Generally, about three or four major geologic units can be sampled at any of the given sites, most of which can probably be dated. The Mars Observer mission will aid greatly in interpreting lithology and defining contacts at the high resolution required to actually pinpoint good sample acquisition sites within these areas

Cytokine tuning of intestinal epithelial function

The intestine serves as both our largest single barrier to the external environment and the host of more immune cells than any other location in our bodies. Separating these potential combatants is a single layer of dynamic epithelium composed of heterogeneous epithelial subtypes, each uniquely adapted to carry out a subset of the intestine’s diverse functions. In addition to its obvious role in digestion, the intestinal epithelium is responsible for a wide array of critical tasks, including maintaining barrier integrity, preventing invasion by microbial commensals and pathogens, and modulating the intestinal immune system. Communication between these epithelial cells and resident immune cells is crucial for maintaining homeostasis and coordinating appropriate responses to disease and can occur through cell-to-cell contact or by the release or recognition of soluble mediators. The objective of this review is to highlight recent literature illuminating how cytokines and chemokines, both those made by and acting on the intestinal epithelium, orchestrate many of the diverse functions of the intestinal epithelium and its interactions with immune cells in health and disease. Areas of focus include cytokine control of intestinal epithelial proliferation, cell death, and barrier permeability. In addition, the modulation of epithelial-derived cytokines and chemokines by factors such as interactions with stromal and immune cells, pathogen and commensal exposure, and diet will be discussed

Bayesian Semiparametric Hierarchical Empirical Likelihood Spatial Models

We introduce a general hierarchical Bayesian framework that incorporates a flexible nonparametric data model specification through the use of empirical likelihood methodology, which we term semiparametric hierarchical empirical likelihood (SHEL) models. Although general dependence structures can be readily accommodated, we focus on spatial modeling, a relatively underdeveloped area in the empirical likelihood literature. Importantly, the models we develop naturally accommodate spatial association on irregular lattices and irregularly spaced point-referenced data. We illustrate our proposed framework by means of a simulation study and through three real data examples. First, we develop a spatial Fay-Herriot model in the SHEL framework and apply it to the problem of small area estimation in the American Community Survey. Next, we illustrate the SHEL model in the context of areal data (on an irregular lattice) through the North Carolina sudden infant death syndrome (SIDS) dataset. Finally, we analyze a point-referenced dataset from the North American Breeding Bird survey that considers dove counts for the state of Missouri. In all cases, we demonstrate superior performance of our model, in terms of mean squared prediction error, over standard parametric analyses.Comment: 29 pages, 3 figue