Role of a plausible nuisance contributor in the declining obesity-mortality risks over time.

CONTEXT: Recent analyses of epidemiological data including the National Health and Nutrition Examination Survey (NHANES) have suggested that the harmful effects of obesity may have decreased over calendar time. The shifting BMI distribution over time coupled with the application of fixed broad BMI categories in these analyses could be a plausible nuisance contributor to this observed change in the obesity-associated mortality over calendar time. OBJECTIVE: To evaluate the extent to which observed temporal changes in the obesity-mortality association may be due to a shifting population distribution for body mass index (BMI), coupled with analyses based on static, broad BMI categories. DESIGN, SETTING, AND PARTICIPANTS: Simulations were conducted using data from NHANES I and III linked with mortality data. Data from NHANES I were used to fit a true model treating BMI as a continuous variable. Coefficients estimated from this model were used to simulate mortality for participants in NHANES III. Hence, the population-level association between BMI and mortality in NHANES III was fixed to be identical to the association estimated in NHANES I. Hazard ratios (HRs) for obesity categories based on BMI for NHANES III with simulated mortality data were compared to the corresponding estimated HRs from NHANES I. MAIN OUTCOME MEASURES: Change in hazard ratios for simulated data in NHANES III compared to observed estimates from NHANES I. RESULTS: On average, hazard ratios for NHANES III based on simulated mortality data were 29.3% lower than the estimates from NHANES I using observed mortality follow-up. This reduction accounted for roughly three-fourths of the apparent decrease in the obesity-mortality association observed in a previous analysis of these data. CONCLUSIONS: Some of the apparent diminution of the association between obesity and mortality may be an artifact of treating BMI as a categorical variable

Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer.

INTRODUCTION: Colorectal cancer remains the second leading cause of cancer death in the United States, and new strategies to prevent, detect, and treat the disease are needed. The receptor, guanylate cyclase C (GUCY2C), a tumor suppressor expressed by the intestinal epithelium, has emerged as a promising target. Areas covered: This review outlines the role of GUCY2C in tumorigenesis, and steps to translate GUCY2C-targeting schemes to the clinic. Endogenous GUCY2C-activating ligands disappear early in tumorigenesis, silencing its signaling axis and enabling transformation. Pre-clinical models support GUCY2C ligand supplementation as a novel disease prevention paradigm. With the recent FDA approval of the GUCY2C ligand, linaclotide, and two more synthetic ligands in the pipeline, this strategy can be tested in human trials. In addition to primary tumor prevention, we also review immunotherapies targeting GUCY2C expressed by metastatic lesions, and platforms using GUCY2C as a biomarker for detection and patient staging. Expert commentary: Results of the first GUCY2C targeting schemes in patients will become available in the coming years. The identification of GUCY2C ligand loss as a requirement for colorectal tumorigenesis has the potential to change the treatment paradigm from an irreversible disease of genetic mutation, to a treatable disease of ligand insufficiency

On Being Better but not Smarter than Others: The Muhammad Ali Effect

Past research suggests that people believe that they perform socially desirable behaviors more frequently and socially undesirable behaviors less frequently than others (Goethals, 1986; Messick, Bloom, Boldizar, & Samuelson, 1985). The present research examined whether this perception also characterizes people\u27s thinking about intelligent and unintelligent behaviors. In Study 1, subjects wrote lists of behaviors that they or others did. Subjects indicated that they performed more good and intelligent behaviors and fewer bad and unintelligent behaviors than others, although the magnitude of these differences was greater for good and bad acts than for intelligent and unintelligent ones. In Study 2, a different group of subjects judged the frequency with which the behaviors generated in the first study occur. While self-ascribed good behaviors were related as occurring more frequently than the good acts of others, self-ascribed intelligent behaviors were not judged as more frequent than the intelligent acts of others. Study 3 replicated this effect using a different methodology, finding that subjects indicated they would be more likely than their peers to perform moral behaviors, but no more likely to perform intellectual behaviors. A theoretical framework is proposed in which people\u27s positive beliefs about themselves are constrained by the publicity, specificity, and objectivity of the dimensions on which these beliefs are held

Cultural Differences in Perception of Heroes: Greece, India, and the USA

Abstract: Hypothesis: The cultural background of an individual will have a significant effect on their perception of heroes. The purpose of this study was to investigate how one’s cultural background may affect one’s perception of heroes. The results of Study 1 revealed significant cultural differences in ratings of heroic traits. Study 2 employed a trait-sorting and hero-sorting task to explore underlying categories of traits and heroes across cultures. The results again revealed substantial cultural differences, suggesting that heroes, heroic traits, and heroism in general are all constructions of one’s culture and nationality

From Farm Results Demonstrations to Multistate Impact Designs: Cooperative Extension Navigates its Way Through Evaluation Pathways

This article explores how evaluation has been developed and expanded within the Cooperative Extension system, from the beginning of agricultural education in America in 1800 to the present day. Important periods across the history of Extension evaluation have been identified and categorized according to major themes and significant contributions of Extension individuals and organizations. Challenges for the future of evaluation within Extension are discussed

[Introduction to] Handbook of Heroism and Heroic Leadership

Over the past decade, research and theory on heroism and heroic leadership has greatly expanded, providing new insights on heroic behavior. The Handbook of Heroism and Heroic Leadership brings together new scholarship in this burgeoning field to build an important foundation for further multidisciplinary developments. In its three parts, Origins of Heroism, Types of Heroism, and Processes of Heroism, distinguished social scientists and researchers explore topics such as morality, resilience, courage, empathy, meaning, altruism, spirituality, and transformation. This handbook provides a much-needed consolidation and synthesis for heroism and heroic leadership scholars and graduate students.https://scholarship.richmond.edu/bookshelf/1293/thumbnail.jp

THE RELATIONSHIP BETWEEN MUSCULOSKELETAL STRENGTH, PHYSIOLOGICAL CHARACTERISTICS, AND KNEE KINESTHESIA FOLLOWING FATIGUING EXERCISE

Fatiguing exercise may result in impaired functional joint stability and increased risk of unintentional injury. While there are several musculoskeletal and physiological characteristics related to fatigue onset, their relationship with proprioceptive changes following fatigue has not been examined. The purpose of this study was to establish the relationship between musculoskeletal and physiological characteristics and changes in proprioception, measured by threshold to detect passive motion (TTDPM), following fatiguing exercise. Twenty, physically active females participated (age: 28.65 ± 5.6 years, height: 165.6 ± 4.3 cm, weight: 61.8 ± 8.0 kg, BMI: 22.5± 2.3 kg/m2, BF: 23.3 ± 5.4%). During Visit 1, subjects completed an exercise history and 24-hour dietary questionnaire, and body composition, TTDPM familiarization, isokinetic knee strength, and maximal oxygen uptake/lactate threshold assessments. During Visit 2, subjects completed TTDPM and isometric knee strength testing prior to and following a fatiguing exercise protocol. Wilcoxon signed rank tests determined TTDPM and isometric knee strength changes from pre- to post- fatigue. Spearman’s rho correlation coefficients determined the relationship between strength and physiological variables with pre- to post-fatigue changes in TTDPM and with pre-fatigue and post-fatigue TTDPM in extension and flexion (α=0.05). No significant differences were demonstrated from pre-fatigue to post-fatigue TTDPM despite a significant decrease in isometric knee flexion strength (P<0.01) and flexion/extension ratio (P<0.05) following fatigue. No significant correlations were observed between strength or physiological variables and changes in TTDPM from pre- to post-fatigue in extension or flexion. Flexion/extension ratio was significantly correlated with pre-fatigue TTDPM in extension (r=-0.231, P<0.05). Peak oxygen uptake was significantly correlated with pre-fatigue (r=-0.500, P<0.01) and post-fatigue (r=-0.520, P<0.05) TTDPM in extension. No significant relationships were demonstrated between musculoskeletal and physiological characteristics and changes in TTDPM following fatigue. The results suggest that highly trained individuals may have better proprioception, and that the high fitness level of subjects in this investigation may have contributed to absence of TTDPM deficits following fatigue despite reaching a high level of perceptual and physiological fatigue. Future studies should consider various subject populations, other musculoskeletal strength characteristics, and different modalities of proprioception to determine the most important contributions to proprioceptive changes following fatigue