5,169 research outputs found

    Traffic-related and socioeconomic indicators in association with low birth weight and preterm births in eastern Massachusetts between 1996 and 2002

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    Previous evidence has suggested that physical and social characteristics of places are important factors in determining human health. These characteristics may define gradients of exposure, and as result, they may define gradients of population health outcomes. Exposures to air pollution have been shown to affect indicators of health, for example, increasing risk of adverse birth outcomes. The present work was carried out with the main goal to study the association between indicators of city-specific gradients of traffic and socioeconomic measures and low birth weight and preterm births in eastern Massachusetts

    A positive relationship between the abundance of ammonia oxidizing archaea and natural abundance δ15N of ecosystems

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    We present a significant relationship between the natural abundance isotopic composition of ecosystem pools and the abundance of a microbial gene. Natural abundance 15N of soils and soil DNA were analysed and compared with archaeal ammonia oxidizer abundance along an elevation gradient in northern Arizona and along a substrate age gradient in Hawai'i. There was a significant positive correlation between the abundance of archaeal amoA genes and natural abundance δ15N of total soil or DNA suggesting that ammonia oxidizing archaea play an important role in ecosystem N release. © 2013 Elsevier Ltd

    Global impacts of a Foreshock Bubble: Magnetosheath, magnetopause and ground-based observations

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    This research at Imperial College London was funded by STFC Grants ST/I505713/1, ST/K001051/1 and ST/G00725X/1. D.L. Turner is thankful for funding from NASA (THEMIS mission and Grant NNX14AC16G). We acknowledge NASA Contract NAS5-02099 and V. Angelopoulos for the use of data from the THEMIS Mission, specifically C.W. Carlson and J.P. McFadden for the use of ESA data; D. Larson and R.P. Lin for the use of SST data; J.W. Bonnell and F.S. Mozer for the use of EFI data; and K.H. Glassmeier, U. Auster and W. Baumjohann for the use of FGM data provided under the lead of the Technical University of Braunschweig and with financial support through the German Ministry for Economy and Technology and the German Center for Aviation and Space (DLR) under Contract 50 OC 0302

    The contribution of DNA ploidy to radiation sensitivity in human tumour cell lines

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    The contribution of DNA ploidy to radiation sensitivity was investigated in a group of eight human tumour cell lines. As previous studies suggest, while more aneuploid tumours tend to be more radioresistant, there is no significant relationship between ploidy and radiation sensitivity (SF2). The failure to observe a significant effect of ploidy on radiation sensitivity is due to the complex and multifactorial basis of radiation sensitivity. When we determined the relationship between survival and radiation-induced chromosome aberration frequency, a measure independent of most other modifiers of sensitivity, we observed a direct relationship between ploidy and mean lethal aberration frequency. The mean lethal frequency of aberrations increased from about 1 for diploid cells to about 2 for tetraploid cells. The mean lethal frequency of aberrations was independent of DNA repair variations. These observations demonstrate that changes in DNA ploidy are an important contributor to radiation sensitivity variations in human tumour cell lines. Therefore, any battery of predictive assays should include DNA ploidy measurements. © 1999 Cancer Research Campaig

    Definitions, Criteria and Global Classification of Mast Cell Disorders with Special Reference to Mast Cell Activation Syndromes: A Consensus Proposal

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    Activation of tissue mast cells (MCs) and their abnormal growth and accumulation in various organs are typically found in primary MC disorders also referred to as mastocytosis. However, increasing numbers of patients are now being informed that their clinical findings are due to MC activation (MCA) that is neither associated with mastocytosis nor with a defined allergic or inflammatory reaction. In other patients with MCA, MCs appear to be clonal cells, but criteria for diagnosing mastocytosis are not met. A working conference was organized in 2010 with the aim to define criteria for diagnosing MCA and related disorders, and to propose a global unifying classification of all MC disorders and pathologic MC reactions. This classification includes three types of `MCA syndromes' (MCASs), namely primary MCAS, secondary MCAS and idiopathic MCAS. MCA is now defined by robust and generally applicable criteria, including (1) typical clinical symptoms, (2) a substantial transient increase in serum total tryptase level or an increase in other MC-derived mediators, such as histamine or prostaglandin D 2, or their urinary metabolites, and (3) a response of clinical symptoms to agents that attenuate the production or activities of MC mediators. These criteria should assist in the identification and diagnosis of patients with MCAS, and in avoiding misdiagnoses or overinterpretation of clinical symptoms in daily practice. Moreover, the MCAS concept should stimulate research in order to identify and exploit new molecular mechanisms and therapeutic targets. Copyright (C) 2011 S. Karger AG, Base

    Hygge, Hope and Higher Education: A Case Study of Denmark

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    Higher education institutions have been profoundly reshaped by processes associated with neoliberalism. In this chapter, Larsen outlines the ways in which Denmark has ushered in marketdriven reforms to the Danish higher education system to enhance their institutional competitiveness over the past 30 years. Research on the impacts of neoliberal higher education reforms on faculty is reviewed and the author discusses her experiences (at a Canadian university) with market-driven, accountability reforms. The chapter shifts direction and provides the reader with an overview of the concept of hygge, an idealized Danish term that has connotations of coziness, safety, friendliness, and intimacy. Larsen recounts her experiences as a Canadian academic on sabbatical at a Danish university in 2017, illustrating the ways in which she experienced hygge in the Danish university setting. In the final section of the chapter, Larsen argues that hygge can be viewed as a retreat from the individualism, competition, market stratification and other challenges associated with neoliberalism. Hygge marks out the boundaries between the cold and heartless market-place and the warm and cozy home, and despite critiques that is instantiates exclusions, hygge offers hope to resist the alienation associated with neoliberalism and provide an alternative ethos for close and safe social relations within academia
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