Perfusion‐Dependent Cerebral Autoregulation Impairment in Hemispheric Stroke

Objective: Loss of cerebral autoregulation (CA) plays a key role in secondary neurologic injury. However, the regional distribution of CA impairment after acute cerebral injury remains unclear because, in clinical practice, CA is only assessed within a limited compartment. Here, we performed large-scale regional mapping of cortical perfusion and CA in patients undergoing decompressive surgery for malignant hemispheric stroke. Methods: In 24 patients, autoregulation over the affected hemisphere was calculated based on direct, 15 to 20-minute cortical perfusion measurement with intraoperative laser speckle imaging and mean arterial blood pressure (MAP) recording. Cortical perfusion was normalized against noninfarcted tissue and 6 perfusion categories from 0% to >100% were defined. The interaction between cortical perfusion and MAP was estimated using a linear random slope model and Pearson correlation. Results: Cortical perfusion and CA impairment were heterogeneously distributed across the entire hemisphere. The degree of CA impairment was significantly greater in areas with critical hypoperfusion (40-60%: 0.42% per mmHg and 60-80%: 0.46% per mmHg) than in noninfarcted (> 100%: 0.22% per mmHg) or infarcted (0-20%: 0.29% per mmHg) areas (*p 100% (r = 0.36; *p < 0.05). Tissue integrity had no impact on the degree of CA impairment. Interpretation: In hemispheric stroke, CA is impaired across the entire hemisphere to a variable extent. Autoregulation impairment was greatest in hypoperfused and potentially viable tissue, suggesting that precise localization of such regions is essential for effective tailoring of perfusion pressure-based treatment strategies. ANN NEUROL 202

earthobservations/wetterdienst: Merge with wetterdienst-ui

Add capability to export data to Zarr format Add Wetterdienst Explorer UI. Thanks, @meteoDaniel! Add MAC ARM64 supoort with dependency restrictions Radar: Verify HDF5 responses instead of returning invalid data Add support for stations filtering via bbox and name Add support for units in distance filtering Rename station_name to name Rename filter methods to .filter_by_station_id and .filter_by_name, use same convention for bbox, filter_by_rank (previously nearby_number), filter_by_distance (nearby_distance) Mosmix: Use cached stations to improve performanc

earthobservations/wetterdienst: Start migrating from dogpile.cache to filesystem_spec

Start migrating from dogpile.cache to filesystem_spe

earthobservations/wetterdienst: Bugfix show method

Update readme on sandbox developer installation Fix show metho

earthobservations/wetterdienst: Fix DWD Mosmix generator

Make tidy method a abstract core method of Values class Fix DWD Mosmix generator to return all contained dataframe

earthobservations/wetterdienst: Several fixes

Fix missing station ids within values result Add details about time interval for NOAA GHCN stations Fix falsely calculated station distance

earthobservations/wetterdienst: Add units

Add origin and si unit mappings to services Use argument "si_units" in request classes to convert origin units to si, set to default Improve caching behaviour by introducing optional WD_CACHE_DIR and WD_CACHE_DISABLE environment variables. Thanks, @meteoDaniel! Add baseline test for ECCC observations Add DWD Observation hourly moisture to catalogu

earthobservations/wetterdienst: Add Wetterdienst Settings

Add Wetterdienst.Settings to manage general settings like tidy, humanize,... Rename DWD forecast to mosmix Instead of "kind" use "network" attribute to differ between different data products of a provider Change data source of NOAA GHCN after problems with timeouts when reaching the server Fix problem with timezone conversion when having dates that are already timezone awar

earthobservations/wetterdienst: Bugfix tidy method for DWD observation data

Bugfix tidy method for DWD observation dat

earthobservations/wetterdienst: Fix values coercing

Change integer dtypes in untidy format to float to prevent loosing information when converting unit