Correction to: EGFR/Ras-induced CCL20 production modulates the tumour microenvironment

The article ‘EGFR/Ras-induced CCL20 production modulates the tumour microenvironment’, written by Andreas Hippe, Stephan Alexander Braun, Péter Oláh, Peter Arne Gerber, Anne Schorr, Stephan Seeliger, Stephanie Holtz, Katharina Jannasch, Andor Pivarcsi, Bettina Buhren, Holger Schrumpf, Andreas Kislat, Erich Bünemann, Martin Steinhoff, Jens Fischer, Sérgio A. Lira, Petra Boukamp, Peter Hevezi, Nikolas Hendrik Stoecklein, Thomas Hoffmann, Frauke Alves, Jonathan Sleeman, Thomas Bauer, Jörg Klufa, Nicole Amberg, Maria Sibilia, Albert Zlotnik, Anja Müller- Homey and Bernhard Homey, was originally published electronically on the publisher’s internet portal on 30 June 2020 without open access. With the author(s)’ decision to opt for Open Choice the copyright of the article changed on 16 September 2021 to © The Author(s) 2021 and the article is forthwith distributed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/ licenses/by/4.0/. Open Access funding enabled and organized by Projekt DEAL

Building in Hongkong. Field Excursion of the Department of Civil Engineering of the HTWG Konstanz 2012

Hongkong steht als Welthandelsmetropole auch für Superlative des Bauens. Dies gilt für die in britischer Zeit errichteten Bauten, aber auch für die nach der Übergabe an China entstandenen Hochhäuser und Brückenbauwerke. Der Exkursionsbericht der Fakultät Bauingenieurwesen der HTWG Konstanz gibt einen Eindruck von diesen Aktivitäten. Er schildert Brücken- und Hochhausbauten, Tunnelbaustellen und die Baustelle eines Klärschlammverbrennungswerks, die während einer Exkursionswoche im September 2012 besichtigt wurden. Darüber hinaus gibt er einen Einblick in die wirtschaftliche Dynamik der Stadt.As a global metropolis Hongkong also stands for outstanding building activities. The report depicts the impressions during a student field excursion of the Faculty of Civil Engineering of the University of Applied Sciences Konstanz, Germany, to construction sites in Hongkong in September 2012

Near-Real-Time Acoustic Monitoring of Beaked Whales and Other Cetaceans Using a Seaglider™

In most areas, estimating the presence and distribution of cryptic marine mammal species, such as beaked whales, is extremely difficult using traditional observational techniques such as ship-based visual line transect surveys. Because acoustic methods permit detection of animals underwater, at night, and in poor weather conditions, passive acoustic observation has been used increasingly often over the last decade to study marine mammal distribution, abundance, and movements, as well as for mitigation of potentially harmful anthropogenic effects. However, there is demand for new, cost-effective tools that allow scientists to monitor areas of interest autonomously with high temporal and spatial resolution in near-real time. Here we describe an autonomous underwater vehicle – a glider – equipped with an acoustic sensor and onboard data processing capabilities to passively scan an area for marine mammals in near-real time. The glider was tested extensively off the west coast of the Island of Hawai'i, USA. The instrument covered approximately 390 km during three weeks at sea and collected a total of 194 h of acoustic data. Detections of beaked whales were successfully reported to shore in near-real time. Manual analysis of the recorded data revealed a high number of vocalizations of delphinids and sperm whales. Furthermore, the glider collected vocalizations of unknown origin very similar to those made by known species of beaked whales. The instrument developed here can be used to cost-effectively screen areas of interest for marine mammals for several months at a time. The near-real-time detection and reporting capabilities of the glider can help to protect marine mammals during potentially harmful anthropogenic activities such as seismic exploration for sub-sea fossil fuels or naval sonar exercises. Furthermore, the glider is capable of under-ice operation, allowing investigation of otherwise inaccessible polar environments that are critical habitats for many endangered marine mammal species

Expression of yeast lipid phosphatase Sac1p is regulated by phosphatidylinositol-4-phosphate

<p>Abstract</p> <p>Background</p> <p>Phosphoinositides play a central role in regulating processes at intracellular membranes. In yeast, a large number of phospholipid biosynthetic enzymes use a common mechanism for transcriptional regulation. Yet, how the expression of genes encoding lipid kinases and phosphatases is regulated remains unknown.</p> <p>Results</p> <p>Here we show that the expression of lipid phosphatase Sac1p in the yeast <it>Saccharomyces cerevisiae </it>is regulated in response to changes in phosphatidylinositol-4-phosphate (PI(4)P) concentrations. Unlike genes encoding enzymes involved in phospholipid biosynthesis, expression of the <it>SAC1 </it>gene is independent of inositol levels. We identified a novel 9-bp motif within the 5' untranslated region (5'-UTR) of <it>SAC1 </it>that is responsible for PI(4)P-mediated regulation. Upregulation of <it>SAC1 </it>promoter activity correlates with elevated levels of Sac1 protein levels.</p> <p>Conclusion</p> <p>Regulation of Sac1p expression via the concentration of its major substrate PI(4)P ensures proper maintenance of compartment-specific pools of PI(4)P.</p

Mittelalter im Labor

Mit diesem Band präsentiert das Schwerpunktprogramm 1173 der Deutschen Forschungsgemeinschaft „Integration und Desintegration der Kulturen im europäischen Mittelalter“ erste Ergebnisse seiner Arbeit. Von Anfang an war ihm die Aufgabe gestellt, das mittelalterliche Europa in transkultureller Perspektive und auf Wegen einer transdisziplinären Wissenschaft zu erforschen und zu begreifen. Immer ging es darum, die disziplinär verfassten Einzelwissenschaften durch transdisziplinäre Arbeit zu ergänzen. Das wissenschaftliche Anliegen des Programms ist es, das europäische Mittelalter von seinen geografischen Rändern und seinen kulturellen Differenzen her zu erforschen und zu beschreiben. Der holistischen Frage nach der Einheit Europas wird die innere Vielfalt als gegenständlicher Ausgangspunkt entgegengesetzt. Europa wird nicht als abgeschlossenes, kohärentes Gebilde verstanden, sondern als ein Kontinent, dessen permanente Austausch- und Wechselbeziehungen zwischen den verschiedenen Regionen und Kulturen überhaupt erst zur Ausbildung seiner charakteristischen Merkmale geführt haben

Multimedia Stream Adaptation Services

During the last decade, a clear trend towards all-over-IP multimedia communication has evolved. There exists a great variety of stationary and mobile devices which allow streaming of digital audio and video content over IP networks. But this variety of multimedia enabled devices comes along with a great variety of different hardware and software capabilities and different access network technologies (having heterogeneous properties like bandwidth or packet loss rate). Even if two applications support a common set of media formats, it is often impossible to use such a common format because of resource constraints imposed by the different hardware capabilities and network types. Adaptation of media formats is thus required to allow communication between heterogeneous peers. A second problem is that although quality of service has been a very popular research topic for several years, we still have no end-to-end QoS support for users in the Internet. When QoS cannot be guaranteed, media adaptation is a means to cope with fluctuating resource availability. Performing adaptation at the source or at the sink of a media stream is in many cases the most efficient solution, but in some cases it is impossible to adapt a media stream on on

Session Paper

Ever since ancient times, even before the Roman conquest, there were people and groups in Gaul speaking Greek, so that in the towns of Roman Gaul the Greek communities later became motive factors of Christianisation. It comes as no surprise that many names with a Greek etymology are to be found in Gaul during the Merovingian and Carolingian eras: Eulalius, Euphronius, Eusebius and Eustasius are just a few examples among many. This paper intends to investigate whether it is possible to determine places in which the tradition of Greek personal names, for example as a result of veneration of saints, was prevalent. Knowledge of Greek having declined almost to extinction in Gaul by the end of the late Roman period, linguistic adaptations of names into the nascent Romance language become apparent, such as Evanzelia, Elarius, Nicesius, and Estefanus. In view of the tendency for proper names of Romance or Romanic origin, including those with a Greek etymology, to be replaced by Germanic names as the Franks increased their dominance from north to south, these declined, while at the same time we see a neologistic creativity in dealing with the various traditions of naming manifested in hybrid names. Examples of these hybrid names with originally Greek elements are: Christehildis and Christengaudus. However, such name formations remained the exception, while on the other hand a number of names of Greek origin could retain and maintain their position within the treasury of French personal names due to their assimilation and their correspondence with saints’ names

Coherence in resting-state EEG as a predictor for the recovery from unresponsive wakefulness syndrome

We investigated differences of EEG coherence within (short-range), and between (long-range) specified brain areas as diagnostic markers for different states in disorders of consciousness (DOC), and their predictive value for recovery from unresponsive wakefulness syndrome (UWS). EEGs of 73 patients and 24 controls were recorded and coma recovery scale- revised (CRS-R) scores were assessed. CRS-R of UWS patients was collected after 12 months and divided into two groups (improved/unimproved). Frontal, parietal, fronto-parietal, fronto-temporal, and fronto-occipital coherence was computed, as well as EEG power over frontal, parietal, occipital, and temporal areas. Minimally conscious patients (MCS) and UWS patients could not be differentiated based on their coherence patterns or on EEG power. Fronto-parietal and parietal coherence could positively predict improvement of UWS patients, i.e. recovery from UWS to MCS. Parietal coherence was significantly higher in delta and theta frequencies in the improved group, as well as the coherence between frontal and parietal regions in delta, theta, alpha, and beta frequencies. High parietal delta and theta, and high fronto-parietal theta and alpha coherence appear to provide strong early evidence for recovery from UWS with high predictive sensitivity and specificity. Short and long-range coherence can have a diagnostic value in the prognosis of recovery from UWS