Strangeness in the Scalar Form Factor of the Nucleon

The scalar form factor of the nucleon and related physical quantities are investigated in the framework of the semibosonized SU(3) Nambu-Jona-Lasinio soliton model. We take into account the rotational $1/N_c$ corrections and linear $m_s$ corrections. The strangeness content of the nucleon in the scalar form factor is discussed in detail. In particular, it is found that the $m_s$ corrections play an essential role of reducing the $\langle N | \bar{s} s | N \rangle$ arising from the leading order and rotational $1/N_c$ contributions. We obtain the \sigma_{\pi N} (0)=40.80\;\mbox{MeV}, \Delta \sigma = \sigma_{\pi N} (2m^{2}_{\pi})-\sigma_{\pi N} (0) = 18.18\;\mbox{MeV} and \langle r^2\rangle^{S}_{N} = 1.50\;\mbox{fm}^2. The results are in a remarkable agreement with empirical data analyzed by Gasser, Leutwyler, and Sainio~\cite{gls}.Comment: 13 pages, RevTex is used. 3 figures as uufiles are include

Analysis of discrepancies in Dalitz plot parameters in eta to 3 pion decay

We analyze the Dalitz plot parameters of eta to 3 pion decay in the framework of resummed chiral perturbation theory. This approach allows us to keep the uncertainties in the NNLO and higher orders under better control and estimate their influence. We cannot confirm the suspected discrepancy in the case of the charged decay parameter b, where even small uncertainties in higher orders could accommodate the difference. On the other hand, we find the experimental value of the neutral decay parameter alpha incompatible with an assumption of good convergence properties in the center of the Dalitz plot. We calculate pion-pion rescattering bubble corrections up to three loops and show that these might explain the discrepancy, especially for a low value of the pseudoscalar decay constant in the chiral limit. However, that could indicate a failure of convergence of the chiral series in this channel already at low energies around 500MeV.Comment: Presented at "Hadron Structure 2011", Tatranska Strba, Slovakia, June 2011. 4 pages, 1 figur

The Brain at High Altitude: From Molecular Signaling to Cognitive Performance

The brain requires over one-fifth of the total body oxygen demand for normal functioning. At high altitude (HA), the lower atmospheric oxygen pressure inevitably challenges the brain, affecting voluntary spatial attention, cognitive processing, and attention speed after short-term, long-term, or lifespan exposure. Molecular responses to HA are controlled mainly by hypoxia-inducible factors. This review aims to summarize the cellular, metabolic, and functional alterations in the brain at HA with a focus on the role of hypoxia-inducible factors in controlling the hypoxic ventilatory response, neuronal survival, metabolism, neurogenesis, synaptogenesis, and plasticity

Holzreste von spätglazialen Kiefern aus der tiefgründigen und tonreichen Permanentrutschung ‚Spiegelberg’, Kanton Schwyz (Schweiz)

Die Hauptstrasse Nr. 8 zwischen Schwyz und Sattel verläuft durch aktive und tiefgründige Permanentrutschungen. Im lehmigen, matrix-gestützten Gehängeschutt der Rutschung ‚Spiegelberg’ wurde zwischen 1979–81 die Gütschbrücke erstellt (LK: 690.314/211.943; 670 m ü.M.) und unter Anwendung von Gründungsschutzschächten im unterlagernden Fels fundiert. Beim Aushub des Schutzschachtes für den Pfeiler WL-Nord wurden in der Tiefe von 25 m bzw. 38 m unter Oberkante Terrain zwei Nadelbaumfragmente gefunden. Letzterer Holzfund lag wenige Meter über der Felsoberfläche. Die 14C-Altersdatierung der Holzfunde (beide Pinus sylvestris) ergaben kalibrierte Altersspannen zwischen 11.690–11.270 cal. a BP (2s) am Übergang vom Grönland Stadial 1 (GS-1; ‚Jüngere Dryas’) zum Holozän bzw. 13.830–13.640 cal. a BP (2s) zu Beginn der spätglazialen Wärmeschwankung GI-1c (Grönland Interstadial 1c; ‚Allerød’). Die vorliegenden Daten zeigen, dass die Hanginstabilitäten bei ‚Spiegelberg’ nach dem Zerfall des letzteiszeitlichen Muota/Reussgletschers zu Beginn des Spätglazials eingesetzt haben mussten, und die Waldkiefer schon kurz nach den Kälterückschlägen des GI-1d (‚Aegelsee-Schwankung’) bzw. des GS-1 am nördlichen Alpenrand präsent war.researc

Zugang zu Informationen in digitalen Sammlungen: Fokus Archive

Zugang zu Informationen in digitalen Sammlungen: Fokus Archiv

High-Altitude Cognitive Impairment Is Prevented by Enriched Environment Including Exercise via VEGF Signaling

Exposure to hypobaric hypoxia at high altitude (above 2500 m asl) causes cognitive impairment, mostly attributed to changes in brain perfusion and consequently neuronal death. Enriched environment and voluntary exercise has been shown to improve cognitive function, to enhance brain microvasculature and neurogenesis, and to be neuroprotective. Here we show that high-altitude exposure (3540 m asl) of Long Evans rats during early adulthood (P48–P59) increases brain microvasculature and neurogenesis but impairs spatial and visual memory along with an increase in neuronal apoptosis. We tested whether enriched environment including a running wheel for voluntary exercise (EE) can prevent cognitive impairment at high-altitude and whether apoptosis is prevented. We found that EE retained spatial and visual memory at high altitude, and prevented neuronal apoptosis. Further, we tested whether vascular endothelial growth factor (VEGF) signaling is required for the EE-mediated recovery of spatial and visual memory and the reduction in apoptosis. Pharmacological inhibition of VEGF signaling by oral application of a tyrosine kinase inhibitor (Vandetanib) prevented the recovery of spatial and visual memory in animals housed in EE, along with an increase in apoptosis and a reduction in neurogenesis. Surprisingly, inhibition of VEGF signaling also caused impairment in spatial memory in EE-housed animals reared at low altitude, affecting mainly dentate gyrus microvasculature but not neurogenesis. We conclude that EE-mediated VEGF signaling is neuroprotective and essential for the maintenance of cognition and neurogenesis during high-altitude exposure, and for the maintenance of spatial memory at low altitude. Finally, our data also underlines the potential risk of cognitive impairment and disturbed high altitude adaption from the use of VEGF-signaling inhibitors for therapeutic purposes

High-Altitude Cognitive Impairment Is Prevented by Enriched Environment Including Exercise via VEGF Signaling

Exposure to hypobaric hypoxia at high altitude (above 2500 m asl) causes cognitive impairment, mostly attributed to changes in brain perfusion and consequently neuronal death. Enriched environment and voluntary exercise has been shown to improve cognitive function, to enhance brain microvasculature and neurogenesis, and to be neuroprotective. Here we show that high-altitude exposure (3540 m asl) of Long Evans rats during early adulthood (P48-P59) increases brain microvasculature and neurogenesis but impairs spatial and visual memory along with an increase in neuronal apoptosis. We tested whether enriched environment including a running wheel for voluntary exercise (EE) can prevent cognitive impairment at high-altitude and whether apoptosis is prevented. We found that EE retained spatial and visual memory at high altitude, and prevented neuronal apoptosis. Further, we tested whether vascular endothelial growth factor (VEGF) signaling is required for the EE-mediated recovery of spatial and visual memory and the reduction in apoptosis. Pharmacological inhibition of VEGF signaling by oral application of a tyrosine kinase inhibitor (Vandetanib) prevented the recovery of spatial and visual memory in animals housed in EE, along with an increase in apoptosis and a reduction in neurogenesis. Surprisingly, inhibition of VEGF signaling also caused impairment in spatial memory in EE-housed animals reared at low altitude, affecting mainly dentate gyrus microvasculature but not neurogenesis. We conclude that EE-mediated VEGF signaling is neuroprotective and essential for the maintenance of cognition and neurogenesis during high-altitude exposure, and for the maintenance of spatial memory at low altitude. Finally, our data also underlines the potential risk of cognitive impairment and disturbed high altitude adaption from the use of VEGF-signaling inhibitors for therapeutic purposes.This research was supported by the Swiss National Science Foundation [Marie Heim-Vogtlin (MHV) - SNF grant PMPDP3_145480], the Institute of Veterinary Physiology and the Institute of Pharmacology and Toxicology at the University of Zurich, the Institute of Anatomy at the University of Freiburg, and the Institute of Neuroscience at the University of Basque, Spain

Convergence properties of η→3π\eta\to 3\pi decays in chiral perturbation theory

Theoretical efforts to describe and explain the $\eta\to 3\pi$ decays reach far back in time. Even today, the convergence of the decay widths and some of the Dalitz plot parameters seems problematic in low energy QCD. In the framework of resummed CHPT, we explore the question of compatibility of experimental data with a reasonable convergence of a carefully defined chiral series, where NNLO remainders are assumed to be small. By treating the uncertainties in the higher orders statistically, we numerically generate a large set of theoretical predictions, which are then confronted with experimental information. In the case of the decay widths, the experimental values can be reconstructed for a reasonable range of the free parameters and thus no tension is observed, in spite of what some of the traditional calculations suggest. The Dalitz plot parameters $a$ and $d$ can be described very well too. When the parameters $b$ and $\alpha$ are concerned, we find a mild tension for the whole range of the free parameters, at less than 2$\sigma$ C.L. This can be interpreted in two ways - either some of the higher order corrections are indeed unexpectedly large or there is a specific configuration of the remainders, which is, however, not completely improbable. Also, the distribution of the theoretical uncertainties is found to be significantly non-gaussian, so the consistency cannot be simply judged by the 1$\sigma$ error bars.Comment: 57 pages, 5 figure

Roy-Steiner-equation analysis of pion-nucleon scattering

We review the structure of Roy-Steiner equations for pion-nucleon scattering, the solution for the partial waves of the t-channel process $\pi\pi\to \bar N N$, as well as the high-accuracy extraction of the pion-nucleon S-wave scattering lengths from data on pionic hydrogen and deuterium. We then proceed to construct solutions for the lowest partial waves of the s-channel process $\pi N\to \pi N$ and demonstrate that accurate solutions can be found if the scattering lengths are imposed as constraints. Detailed error estimates of all input quantities in the solution procedure are performed and explicit parameterizations for the resulting low-energy phase shifts as well as results for subthreshold parameters and higher threshold parameters are presented. Furthermore, we discuss the extraction of the pion-nucleon $\sigma$-term via the Cheng-Dashen low-energy theorem, including the role of isospin-breaking corrections, to obtain a precision determination consistent with all constraints from analyticity, unitarity, crossing symmetry, and pionic-atom data. We perform the matching to chiral perturbation theory in the subthreshold region and detail the consequences for the chiral convergence of the threshold parameters and the nucleon mass.Comment: 101 pages, 28 figures; journal versio