Improving the Socio-emotional Well-being of the Older Generation through the Implementation of Territorial Marketing

This article is based on the analysis of the possibility of using Berkman's conceptual model of mechanism of social networks influence on human health to improve the well-being of the older generation in Russia. The emphasis is put on the development of social contacts of older people through the implementation of territorial marketing. Objective and subjective indicators of well-being of older people are directly related to the characteristics and peculiarities of the territory where they live and carry out their activities (city, region, country). In this context, marketing of territory can be regarded as an activity aimed at creating and maintaining comfortable living conditions of different age groups, taking into considerations their characteristics. Special attention is paid to the social and emotional mechanisms of social support, social influence, social inclusion, social participation, interpersonal contacts and access to resources and benefits the territory of older generation. Specificity of older adults segmentation of the region (the city) is defined. The importance of active cooperation of various age groups identified in the process of territorial segmentation of the market is particularly stressed, in terms of improving the lives of older adults

Earthquakes, Volcanoes and God: Comparative Perspectives from Christianity and Islam

This paper asserts that both Christian and Islamic traditions of faith affect the ways in which people both try to make sense of, and respond to, disasters. This contention is supported by the results of empirical research, which demonstrates that differing Islamic and Christian perspectives on human suffering caused by disasters are neither as diverse, nor are they so intractable, as is commonly supposed. Today pastoral convergence between the two traditions may also be discerned, together with a general acceptance of the policies of both State agencies and Non-Governmental Organisations (NGOs) which are concerned with hazard relief and the propagation of policies of disaster risk reduction (DRR). Indeed some important disaster relief NGOs have emerged from Islamic and Christian faith communities and are supported by charitable donations

Мотивация персонала международной сетевой компании №1International г. Новосибирск

Объект исследования: мотивация персонала. Предмет исследования: методы мотивации персонала в сетевой компании. Цель работы: выявить мотивационные методы сетевой компании New Life International, а также исследовать взаимосвязь между особенностями мотивации и успешностью профессиональной деятельности. Область применения: развитие технологии по совершенствованию мотивационной системы сетевых компаний. Социальная значимость работы: по итогам проделанной работы будут выявлены факторы, влияющие на мотивацию менеджеров, с целью устранения текучести кадров в сетевой компании New Life International.Object of the study: staff motivation. The subject of the research: methods of staff motivation in a network company. The purpose of the work: to identify the motivational methods of the network company New Life International, as well as to explore the relationship between the features of motivation and the success of professional activity. Scope: development of technology to improve the motivational system of grid companies. Social significance of the work: based on the results of the work done, factors that affect the motivation of managers will be identified, in order to eliminate staff turnover in the network company New Life International

A genetic variant in the pre-miR-27a oncogene is associated with a reduced familial breast cancer risk

MicroRNAs (miRNAs) regulate pathways involved in cell differentiation, proliferation, development, and apoptosis by degradation of target mRNAs and/or repression of their translation. Although the single nucleotide polymorphisms (SNPs) in miRNAs target sites have been studied, the effects of SNPs in miRNAs are largely unknown. In our study, we first systematically sequenced miRNA genes reported to be involved in breast cancer to identify/verify SNPs. We analyzed four SNPs, one located in the pre-miRNA and the other three located in miRNA flanking regions, for a putative association with breast cancer risk. The SNP rs895819, located in the terminal loop of pre-miRNA-27a, showed a protective effect. In a large familial breast cancer study cohort, the rare [G] allele of rs895819 was found to be less frequent in the cases than in the controls, indicating a reduced familial breast cancer risk ([G] vs. [A]: OR = 0.88, 95% CI 0.78–0.99, P = 0.0287). Furthermore, age stratification revealed that the protective effect was mainly observed in the age group < 50 years of age ([G] vs. [A]: OR = 0.83, 95% CI 0.70–0.98, P = 0.0314), whereas no significant effect was observed in the age group ≥ 50 years of age, indicating a possible hormone-related effect. It has been shown that artificial mutations in the terminal loop of miR-27a can block the maturation process of the miRNA. We hypothesize that the G-variant of rs895819 might impair the maturation of the oncogenic miR-27a and thus, is associated with familial breast cancer risk

Prognosis of 368 women with primary breast cancer diagnosed during pregnancy: results from an international collaborative trial

Objective: We aimed to add to the limited outcome data on breast cancer during pregnancy (BCP), and compared disease-free survival (DFS), and overall survival (OS) between patients with BCP and breast cancer not diagnosed during pregnancy, adjusted for known prognostic factors. Methods: We analyzed a pro- and retrospectively compiled multi-centric registry of BCP patients (www.cancerinpregnancy.org and GBG/BIG 0203). Outcome was compared to a control group of patients who did not have associated pregnancies. The main analysis is a Cox proportional hazards regression of disease free survival (DFS) and overall survival (OS) on exposure (pregnant or not). The analysis was weighted by propensity score matching to correct for any bias that may have been associated with differences in baseline characteristics, with the following set of covariates: age, stage, grade, hormone receptor status, HER2 status, histology, type of chemotherapy and trastuzumab. Sensitivity analysis was also performed on age only, and also on chemotherapy only. Results: From April 2003-December 2011, 447 women with BCP were registered, 368 women with BCP were eligible for this analysis. The control group consisited of 2739 women (ratio 1:7.44)

Treatment of breast cancer during pregnancy: an observational study

Background Little is known about the treatment of breast cancer during pregnancy. We aimed to determine whether treatment for breast cancer during pregnancy is safe for both mother and child. Methods We recruited patients from seven European countries with a primary diagnosis of breast cancer during pregnancy; data were collected retrospectively if the patient was diagnosed before April, 2003 (when the registry began), or prospectively thereafter, irrespective of the outcome of pregnancy and the type and timing of treatment. The primary endpoint was fetal health for up to 4 weeks after delivery. The registry is ongoing. The study is registered with ClinicalTrials.gov, number NCT00196 Findings From April, 2003, to December, 2011, 447 patients were registered, 413 of whom had early breast cancer. Median age was 33 years (range 22-51). At the time of diagnosis, median gestational age was 24 weeks (range 5-40). 197 (48%) of 413 women received chemotherapy during pregnancy with a median of four cycles (range one to eight). 178 received an anthracycline, 15 received cyclophosphamide, methotrexate, and fluorouracil, and 14 received a taxane. Birthweight was affected by chemotherapy Interpretation Although our data show that infants exposed to chemotherapy in utero had a lower birthweight at gestational age than did those who were unexposed, and had more complications, these differences were not clinically significant and, since none of the infants was exposed to chemotherapy in the first trimester, were most likely related to premature delivery. Delay of cancer treatment did not significantly affect disease-free survival for mothers with early breast cancer. Because prete