Psychiatric and psychosocial outcome of orthotopic liver transplantation

Background. The study aimed to explore the prevalence of psychiatric disorders among orthotopic liver transplantation (OLT) recipients, and to investigate how psychiatric morbidity was linked to health-related quality of life (HRQOL). Methods: We recruited 75 patients who had undergone OLT a median of 3.8 years previously (range = 5-129 months). Psychiatric morbidity was assessed using the Structural Clinical Interview for the IDSM-III-R. Psychometric observer-rating and self-rating scales were administered to evaluate cognitive functioning (SKT), depressive symptomatology (HAMD(17)), Posttraumatic stress symptoms (PTSS-10), social support (SSS), and HRQOL (SF-36 Health Status Questionnaire). Treatment characteristics were obtained from medical records. Results: 22.7% (n = 17) of our sample had a current or probable psychiatric diagnosis according to DSM-III-R: 2.7% full posttraumatic stress disorder (PTSD) (n = 2), 2.7% major depressive disorder (MDD) comorbid to full PTSD (n = 2), 1.3% MDD comorbid to partial PTSD (n = 1), and 16% partial PTSD (n = 12). Patients with PTSD symptoms demonstrated lower cognitive performance, higher severity of depressive symptoms and more unfavorable perception of social support. OLT-related PTSD symptomatology was associated with maximal decrements in HRQOL. The duration of intensive care treatment, the number of medical complications, and the occurrence of acute rejection were positively correlated with the risk of PTSD symptoms subsequent to OLT. Conclusion: OLT-related PTSD symptomatology impairing HRQOL is a complication for a subgroup of OLT recipients. Health-care providers should be aware of the possible presence of PTSD in OLT survivors. Copyright (C) 2002 S. KargerAG, Basel

Role of social environment and social clustering in spread of opinions in co-evolving networks

Taking a pragmatic approach to the processes involved in the phenomena of collective opinion formation, we investigate two specific modifications to the co-evolving network voter model of opinion formation, studied by Holme and Newman [1]. First, we replace the rewiring probability parameter by a distribution of probability of accepting or rejecting opinions between individuals, accounting for the asymmetric influences in relationships among individuals in a social group. Second, we modify the rewiring step by a path-length-based preference for rewiring that reinforces local clustering. We have investigated the influences of these modifications on the outcomes of the simulations of this model. We found that varying the shape of the distribution of probability of accepting or rejecting opinions can lead to the emergence of two qualitatively distinct final states, one having several isolated connected components each in internal consensus leading to the existence of diverse set of opinions and the other having one single dominant connected component with each node within it having the same opinion. Furthermore, and more importantly, we found that the initial clustering in network can also induce similar transitions. Our investigation also brings forward that these transitions are governed by a weak and complex dependence on system size. We found that the networks in the final states of the model have rich structural properties including the small world property for some parameter regimes. [1] P. Holme and M. Newman, Phys. Rev. E 74, 056108 (2006)

Extremism propagation in social networks with hubs

One aspect of opinion change that has been of academic interest is the impact of people with extreme opinions (extremists) on opinion dynamics. An agent-based model has been used to study the role of small-world social network topologies on general opinion change in the presence of extremists. It has been found that opinion convergence to a single extreme occurs only when the average number of network connections for each individual is extremely high. Here, we extend the model to examine the effect of positively skewed degree distributions, in addition to small-world structures, on the types of opinion convergence that occur in the presence of extremists. We also examine what happens when extremist opinions are located on the well-connected nodes (hubs) created by the positively skewed distribution. We find that a positively skewed network topology encourages opinion convergence on a single extreme under a wider range of conditions than topologies whose degree distributions were not skewed. The importance of social position for social influence is highlighted by the result that, when positive extremists are placed on hubs, all population convergence is to the positive extreme even when there are twice as many negative extremists. Thus, our results have shown the importance of considering a positively skewed degree distribution, and in particular network hubs and social position, when examining extremist transmission

Analysis of a threshold model of social contagion on degree-correlated networks

We analytically determine when a range of abstract social contagion models permit global spreading from a single seed on degree-correlated random networks. We deduce the expected size of the largest vulnerable component, a network's tinderbox-like critical mass, as well as the probability that infecting a randomly chosen individual seed will trigger global spreading. In the appropriate limits, our results naturally reduce to standard ones for models of disease spreading and to the condition for the existence of a giant component. Recent advances in the distributed, infinite seed case allow us to further determine the final size of global spreading events, when they occur. To provide support for our results, we derive exact expressions for key spreading quantities for a simple yet rich family of random networks with bimodal degree distributions.Comment: 7 Pages, 1 figure, submitted to Phys. Rev.

Lymphocyte subsets and the role of Th1/Th2 balance in stressed chronic pain patients

Background: The complex regional pain syndrome (CRPS) and fibromyalgia (FM) are chronic pain syndromes occurring in highly stressed individuals. Despite the known connection between the nervous system and immune cells, information on distribution of lymphocyte subsets under stress and pain conditions is limited. Methods: We performed a comparative study in 15 patients with CRPS type I, 22 patients with FM and 37 age- and sex-matched healthy controls and investigated the influence of pain and stress on lymphocyte number, subpopulations and the Th1/Th2 cytokine ratio in T lymphocytes. Results: Lymphocyte numbers did not differ between groups. Quantitative analyses of lymphocyte subpopulations showed a significant reduction of cytotoxic CD8+ lymphocytes in both CRPS (p < 0.01) and FM (p < 0.05) patients as compared with healthy controls. Additionally, CRPS patients were characterized by a lower percentage of IL-2-producing T cell subpopulations reflecting a diminished Th1 response in contrast to no changes in the Th2 cytokine profile. Conclusions: Future studies are warranted to answer whether such immunological changes play a pathogenetic role in CRPS and FM or merely reflect the consequences of a pain-induced neurohumoral stress response, and whether they contribute to immunosuppression in stressed chronic pain patients. Copyright (c) 2008 S. Karger AG, Basel

Dilemmas of public election

In this brief comment, the public choice theory aims to distinguish the dilemmas and conflicts in formal and empirical. The hypothesis argues that the reality more complex than the principles of choice of Pareto and Liberalism*. Both the ethics and politics are taking decisions that are not always in line with the requirements of rationality and complete informatio

The Epidemics of Donations: Logistic Growth and Power-Laws

This paper demonstrates that collective social dynamics resulting from individual donations can be well described by an epidemic model. It captures the herding behavior in donations as a non-local interaction between individual via a time-dependent mean field representing the mass media. Our study is based on the statistical analysis of a unique dataset obtained before and after the tsunami disaster of 2004. We find a power-law behavior for the distributions of donations with similar exponents for different countries. Even more remarkably, we show that these exponents are the same before and after the tsunami, which accounts for some kind of universal behavior in donations independent of the actual event. We further show that the time-dependent change of both the number and the total amount of donations after the tsunami follows a logistic growth equation. As a new element, a time-dependent scaling factor appears in this equation which accounts for the growing lack of public interest after the disaster. The results of the model are underpinned by the data analysis and thus also allow for a quantification of the media influence

Cultural corridors: An analysis of persistence in impacts on local development — A neo-Weberian perspective on South-East Europe

Culture matters for economic development. This postulate has been a main conceptual concern for “old” institutional economics (OIE) and has lately also been tested through neoclassically inspired econometric techniques. This conceptual foundation has been confirmed in several quantitative studies on developed countries, in particular cases from the USA, Germany, and Italy. In less developed regions with a wealth of cultural heritage, particularly in South-East Europe, this postulate is still an underexplored issue from the perspective of advanced econometric approaches. Our goal is to examine the impact of the so-called South-East European cultural corridors on welfare — and especially on total employment — at the local or regional level. Accounting for gross value added and sectoral specialization, we examine the effect of such corridors by considering the distance to a cultural corridor: namely, the East Trans-Balkan Road (crossing Romania, Bulgaria, and Greece) as an explanatory factor for regional development, particularly employment. Using the European University Institute (EUI) European Regional Dataset (ERD), as well as the geo-data from the Cultural Corridors of the South-East Europe website, we estimate a regression model using a 2SLS instrumental variable (IV) approach, with a pooled dataset at the NUTS 3 level (Eurostat) from 1980 to 2011. We then triangulate the results by using the distance to the cultural corridor concerned as a treatment effect in a propensity-score-matching and difference-in-differences exploratory analysis. The findings confirm the importance of distance to the cultural corridor under investigation as a strong predictor for local socio-economic development. The results further suggest that the slow evolution of culture over time is likely to lead to the gradual emergence of new geographical cultural centers and a new cultural path-dependence build-up of persistence chains

Chapitre 9 - Une perspective One Health pour l’assainissement humain et animal intégré et le recyclage des nutriments

Introduction Améliorer l’état de la santé et préserver les ressources naturelles pour un développement durable font partie des Objectifs du millénaire pour le développement (OMD) (Nations unies, 2006). L’assainissement environnemental est un facteur important de l’état de la santé humaine. Avec 2,4 milliards de personnes dans le monde qui manquent des moyens d’assainissement adaptés et 1,1 milliard de personnes qui vivent sans u..