The Ursinus Weekly, January 21, 1957

Annual Lorelei scheduled for Friday, February 15, 9 p.m. • Programs planned by Newman Club • Collegeville central office to change • Pre-meds hear Briody; Plan future programs • Die Germania hears poetical works read • Bells for finals • Student teachers fete advisors and UC department heads • Chi Alpha has speeches, discussion on evangelism • Bosworth talks to Y meeting on youth delinquency • Meaning of evaluation • St. John Terrell to speak at U.C. Forum on February 13 • Frosh class has Showboat dance • YM-YW to sponsor used book center • Phila. Museum of Art to present feature films • APO inducts new advisors, members • Editorial: Most valuable • Letters to the editor • Charge of the pink lemonade • Memo on dancing • That dose of kerosene • Heavyweight pin in 15 sec. decides Garnet win, Bruins maul Albright • Cubs top Haverford; Lose to PMC, Swarthmore • Matmen to meet Lafayette Tuesday • Mermaids begin early practice • Cagers run lose streak to ten; Drop to last in M.A.C. • Revised exam schedule • Home thanks Beta Sig for Christmas party • Curtain Club to present The Valiant Feb. 26https://digitalcommons.ursinus.edu/weekly/1420/thumbnail.jp

The Ursinus Weekly, June 4, 1956

Class of 1956 receives degrees, June 4: Dr. Millard E. Gladfelter speaks at Commencement • Bishop Fred P. Corson speaks at Baccalaureate • Armstrong appears on TV • UC grad made battalion soldier of month in May • Alpha Sig chooses leaders • Franchises given by SGAs; Other matters discussed • Eighteen annual prizes awarded at graduation, June 4 • Annual Alumni Day program takes place Sat., June 2 • Totals of Chest drive announced • Dr. Creager lectures at Pine Mt. Institute • Phi Psi elects new officers • Walker new head of FTA • Henry-Wilson engagement • Editorial: State of the government • Time and fruit flies, 1956 • Thoughts after four years at Ursinus • Graduation conversation • Crying in the wilderness: Problem of girls\u27 rules • A little more about a little word • Letters to the editor • Bruin nine drops last game to P.M.C. Cadets, 3-0; Team ends with 8-7-1 record; Slotter is new captain • Baseball team season statistics • Football practice to start in September • Dunn elected new softball captain • Curtis I team captures campus softball crown • Cross to captain next year\u27s tennis • Trackmen end year with 2-6 record; Ruth & Lawhead elected co-captains • Rosies elect officers • Open letter to students sent by Chest committee • \u2756 Summer school to open July 9 • Names of hall prexies for coming year announced • Sigma Rho releases names of officers and total of scholarship fundhttps://digitalcommons.ursinus.edu/weekly/1454/thumbnail.jp

1959 Ruby Yearbook

A digitized copy of the 1959 Ruby, the Ursinus College yearbook.https://digitalcommons.ursinus.edu/ruby/1062/thumbnail.jp

The Ursinus Weekly, February 18, 1957

Visiting group to complete U.C. evaluation this week • Twenty students enter at mid-year • Men\u27s council hears suggestions • Curtain Club to present The Valiant on Feb. 26 • W.F. Speilman, member of UC maintenance staff, dies • Chest drive dates released • Y association to hear refugees • Senate decides on WSGA revisions • Frosh women\u27s representatives chosen; To be installed on Color Day, Thursday • St. John Terrell addresses Forum on drama history • Peirce - Pauli engagement • Dave Burger made king of annual Lorelei, Fri., Feb. 15 • Selective Service rules published by administration • Snyder receives Ph.D. degree Feb. 9 • S.R.C. discusses mental health • Two UC women attend confab on religious work • Chess Club plays F&M • Editorial: Word of welcome and some comments on evaluation • May Day • Brotherhood Week and the work of the National Conference of Christians and Jews • IRC to hear talk tonight on U.S. and Phillipines • Age of service • Cagers lose to Fords in overtime; Lose to Garnet five Saturday, 84-64 • Ursinus mermaids defeat Drexel Wed. • Belles register two net shutouts • William Yost resigns from court post • Padula stopped as matmen score win over E\u27town, Sat. • Chi Alpha hears Baker, sponsors weekly talks • Newman Club to hear discussion on J.H. Newman • Y heads discuss activities, plans at retreat, Sat. • Pre-med society hears Mercurio; Plans dinner • Fourteen go on mid-year trip to Washington, D.C. • Reed and Barton contest to run through Feb., Mar.https://digitalcommons.ursinus.edu/weekly/1421/thumbnail.jp

The Ursinus Weekly, November 12, 1956

Freshman class chooses officers, MSGA members • MSGA discusses school activities • Famous Japanese to speak at Forum • Ursinus group attends integration conference • Editors to speak at vespers • Dean\u27s list for 1956 autumn term announced • Pre-medders hear Jeff Dean; Visit Hahnemann • Y mock balloting predicts actual results • Farese - Donia engagement • Fraternities and sororities end Fall rushing, accept new members • Our town to be presented November 15, 16 and 17 • Duke to address Chi Alpha tonight • Accounting forum to be held Thurs. • Naval officer to visit UC Tuesday • Book sales close • Editorial: The mare\u27s nest • Letters to the editor • The king and his six sons • Play review: Plum tree • Stranger at my gates • Unbeaten hockey belles stop Temple win streak, 3-0 • Gros, Woodbury, Irwin gain honors in hockey tourney • Runs by Famous, Paine, Rohm lead Bears to 20-6 romp over Aggies • Booters bow to Drexel in 5th loss, 5-3; Tie Lehigh at 2-2 • Bears win holiday; Tie Haverford, 7-7 • Phila. orchestra to present tragic cyclehttps://digitalcommons.ursinus.edu/weekly/1415/thumbnail.jp

A meta-analysis of individual participant data reveals an association between circulating levels of IGF-I and prostate cancer risk

The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3) and prostate cancer risk, we pooled individual participant data from 17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the ORs for prostate cancer based on the study-specific fifth of each analyte. Overall, IGF-I, IGF-II, IGFBP-2, and IGFBP-3 concentrations were positively associated with prostate cancer risk (Ptrend all ≤ 0.005), and IGFBP-1 was inversely associated weakly with risk (Ptrend = 0.05). However, heterogeneity between the prospective and cross-sectional studies was evident (Pheterogeneity = 0.03), unless the analyses were restricted to prospective studies (with the exception of IGF-II, Pheterogeneity = 0.02). For prospective studies, the OR for men in the highest versus the lowest fifth of each analyte was 1.29 (95% confidence interval, 1.16-1.43) for IGF-I, 0.81 (0.68-0.96) for IGFBP-1, and 1.25 (1.12-1.40) for IGFBP-3. These associations did not differ significantly by time-to-diagnosis or tumor stage or grade. Aftermutual adjustment for each of the other analytes, only IGF-I remained associated with risk. Our collaborative study represents the largest pooled analysis of the relationship between prostate cancer risk and circulating concentrations of IGF-I, providing strong evidence that IGF-I is highly likely to be involved in prostate cancer development.</p

Liver Fibrosis and Metabolic Alterations in Adults With alpha-1-antitrypsin Deficiency Caused by the Pi*ZZ Mutation

BACKGROUND & AIMS: Alpha-1 antitrypsin deficiency (AATD) is among the most common genetic disorders. Severe AATD is caused by a homozygous mutation in the SERPINA1 gene that encodes the Glu342Lys substitution (called the Pi*Z mutation, Pi*ZZ genotype). Pi*ZZ carriers may develop lung and liver diseases. Mutation- associated lung disorders have been well studied, but less is known about the effects in liver. We assessed the liver disease burden and associated features in adults with this form of AATD. METHODS: We collected data from 554 Pi*ZZ adults (403 in an exploratory cohort, 151 in a confirmatory cohort), in 9 European countries, with AATD who were homozygous for the Pi*Z mutation, and 234 adults without the Pi*Z mutation (controls), all without pre-existing liver disease. We collected data on demographic parameters, comorbidities, lung- and liver-related health, and blood samples for laboratory analysis. Liver fibrosis was assessed non-invasively via the serum tests Aspartate Aminotransferase to Platelet Ratio Index and HepaScore and via transient elastography. Liver steatosis was determined via transient elastography-based controlled attenuation parameter. We performed histologic analyses of livers from transgenic mice that overexpress the AATD-associated Pi*Z variant. RESULTS: Serum levels of liver enzymes were significantly higher in Pi*ZZ carriers vs controls. Based on non-invasive tests for liver fibrosis, significant fibrosis was suspected in 20%–36% of Pi*ZZ carriers, whereas signs of advanced fibrosis were 9- to 20-fold more common in Pi*ZZ carriers compared to non-carriers. Male sex; age older than 50 years; increased levels of alanine aminotransferase, aspartate aminotransferase, or g-glutamyl transferase; and low numbers of platelets were associated with higher liver fibrosis burden. We did not find evidence for a relationship between lung function and liver fibrosis. Controlled attenuation parameter 280 dB/m, suggesting severe steatosis, was detected in 39% of Pi*ZZ carriers vs 31% of controls. Carriers of Pi*ZZ had lower serum concentrations of triglyceride and low- and very-lowdensity lipoprotein cholesterol than controls, suggesting impaired hepatic secretion of lipid. Livers from Pi*Zoverexpressing mice had steatosis and down-regulation of genes involved in lipid secretion. CONCLUSIONS: In studies of AATD adults with the Pi*ZZ mutation, and of Pi*Z-overexpressing mice, we found evidence of liver steatosisinfo:eu-repo/semantics/publishedVersio

Liver Phenotypes of European Adults Heterozygous or Homozygous for Pi∗Z Variant of AAT (Pi∗MZ vs Pi∗ZZ genotype) and Noncarriers

Homozygosity for the Pi∗Z variant of the gene that encodes the alpha-1 antitrypsin peptide (AAT), called the Pi∗ZZ genotype, causes a liver and lung disease called alpha-1 antitrypsin deficiency. Heterozygosity (the Pi∗MZ genotype) is a risk factor for cirrhosis in individuals with liver disease. Up to 4% of Europeans have the Pi∗MZ genotype; we compared features of adults with and without Pi∗MZ genotype among persons without preexisting liver disease.info:eu-repo/semantics/publishedVersio

New Models for Large Prospective Studies: Is There a Better Way?

Large prospective cohort studies are critical for identifying etiologic factors for disease, but they require substantial long-term research investment. Such studies can be conducted as multisite consortia of academic medical centers, combinations of smaller ongoing studies, or a single large site such as a dominant regional health-care provider. Still another strategy relies upon centralized conduct of most or all aspects, recruiting through multiple temporary assessment centers. This is the approach used by a large-scale national resource in the United Kingdom known as the “UK Biobank,” which completed recruitment/examination of 503,000 participants between 2007 and 2010 within budget and ahead of schedule. A key lesson from UK Biobank and similar studies is that large studies are not simply small studies made large but, rather, require fundamentally different approaches in which “process” expertise is as important as scientific rigor. Embedding recruitment in a structure that facilitates outcome determination, utilizing comprehensive and flexible information technology, automating biospecimen processing, ensuring broad consent, and establishing essentially autonomous leadership with appropriate oversight are all critical to success. Whether and how these approaches may be transportable to the United States remain to be explored, but their success in studies such as UK Biobank makes a compelling case for such explorations to begin

Inhibition of Specific NF-κB Activity Contributes to the Tumor Suppressor Function of 14-3-3σ in Breast Cancer

14-3-3σ is frequently lost in human breast cancers by genetic deletion or promoter methylation. We have now investigated the involvement of 14-3-3σ in the termination of NF-κB signal in mammary cells and its putative role in cancer relapse and metastasis. Our results show that 14-3-3σ regulates nuclear export of p65-NF-κB following chronic TNFα stimulation. Restoration of 14-3-3σ in breast cancer cells reduces migration capacity and metastatic abilities in vivo. By microarray analysis, we have identified a genetic signature that responds to TNFα in a 14-3-3σ-dependent manner and significantly associates with different breast and other types of cancer. By interrogating public databases, we have found that over-expression of this signature correlates with poor relapse-free survival in breast cancer patients. Finally, screening of 96 human breast tumors showed that NF-κB activation strictly correlates with the absence of 14-3-3σ and it is significantly associated with worse prognosis in the multivariate analysis. Our findings identify a genetic signature that is important for breast cancer prognosis and for future personalized treatments based on NF-κB targeting